WO1994010981A1 - Prolonged-action pharmaceutical preparation - Google Patents
Prolonged-action pharmaceutical preparation Download PDFInfo
- Publication number
- WO1994010981A1 WO1994010981A1 PCT/JP1993/001672 JP9301672W WO9410981A1 WO 1994010981 A1 WO1994010981 A1 WO 1994010981A1 JP 9301672 W JP9301672 W JP 9301672W WO 9410981 A1 WO9410981 A1 WO 9410981A1
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- WIPO (PCT)
- Prior art keywords
- group
- hydrogen atom
- hydroxy
- independently
- compound
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Definitions
- the present invention relates to a long-acting pharmaceutical preparation containing a macrocyclic compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, which is noted for its excellent immunosuppressive activity. More specifically, a compound in the form of a so-called microsphere containing the compound (I) or a salt thereof, which is used for intramuscular injection, other injections, topical administration such as eye drops, inhalation, joint injection, and the like. Furthermore, the present invention relates to a long-acting pharmaceutical preparation which can be adapted to various administration forms including oral administration and rectal injection.
- a macrocyclic compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof which is noted for its excellent immunosuppressive activity. More specifically, a compound in the form of a so-called microsphere containing the compound (I) or a salt thereof, which is used for intramuscular injection, other injections, topical administration such as eye drops, inhalation, joint injection, and the like.
- the present invention relates to
- a) represents two adjacent hydrogen atoms
- R 2 may be an alkyl group
- R 7 may be a hydrogen atom, a hydroxy group, a protected And may represent a hydroxy group or an alkyloxy group, or together with R 1 may represent an oxo group
- R 8 and R 9 are independently a hydrogen atom or a hydroxy group
- R 1Q is a hydrogen atom, an alkyl group, an alkyl group, an alkenyl group, or an at least one hydroxy group substituted by one or more hydroxy groups.
- X represents an oxo group, (hydrogen atom, hydroxy group), (hydrogen atom, hydrogen atom), or a group represented by the formula —CH 20 —
- Y represents an oxo group, (hydrogen atom, hydroxy group), ( A hydrogen atom, a hydrogen atom), or a group represented by the formula N—NRHR 12 or N—O R 13
- R 11 and R 12 independently represent a hydrogen atom, an alkyl group, an aryl group or a trisyl group,
- R I3 , R 14 , R 15 , R 16 , R ' ⁇ R 18 , R 19 , R 22 and R 23 independently represent a hydrogen atom or an alkyl group
- R 2 ° and R 21 are independently Okiso group or each independently (R 2 ° a, hydrogen atom), and (R 21 a, hydrogen atom) may be, R 2 ° a and R 21 a is independently a hydroxy group, Ruokishi group, Moshiku is, a group I Table formula OCH 2 OCH 2 CH 2 OCH 3 , or R 21 a is Table Wa protected human Dorokishi group, further R 2 ° a and R 21 a are both And may represent an oxygen atom in the epoxide ring,
- n 1, 2 or 3.
- Y, and R 23 together with the carbon atom to which they are attached, are a saturated or unsaturated 5- or 6-membered nitrogen, sulfur and Or a heterocyclic group containing an oxygen atom, which may be an alkyl group, a hydroxy group, an alkyl group substituted by one or more hydroxy groups, or an alkyloxy group. Or a benzyl group and a compound represented by the formula — CH 2 Se (C 6 H 5 ).
- the salt is known as a substance having an immunosuppressive effect (see JP-A-61-148181, European Patent Publication No. 0323042), heart, liver, kidney, bone marrow, skin, cornea, lung, Spleen, small intestine, muscle, nerve, limb It is expected to be used in various medical fields such as organ transplantation.
- the compound (I) and a pharmaceutically acceptable salt thereof can be obtained in the same manner as disclosed in the above two patent publications.
- Streptomyces' Kackensis No.9993 Pierce No. 927) or Streptomyces'Hygroscovicus' Subsp. Macrolides produced by culture are FR-900506, They are numbered FR-900520, FR-900523, FR-900525.
- compound (I) or a pharmaceutically acceptable salt thereof represented by the expression “compound (I)”
- compound (I) or a pharmaceutically acceptable salt thereof is expected to be an immunosuppressive substance. Its effect has been confirmed as a rejection inhibitor after transplant surgery. However, in order to suppress the rejection after the above-mentioned operation, it is necessary to continue administration for a long period of time without being alert, and development of a dosage form having excellent sustainability has been desired.
- the present invention has been made in view of the above-mentioned circumstances, and has a sustained release over a long period of time by giving an excellent sustained-release property after being administered to a living body. It should be provided.
- the long-acting pharmaceutical preparation of the present invention is obtained by encapsulating the active ingredient comprising the compound (I) in microparticles made of a biodegradable polymer substance that is pharmaceutically acceptable.
- lower shall mean a group having from 1 to 6 carbon atoms.
- alkyl groups include straight or branched chain aliphatic hydrocarbon residues such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, neopentyl, hexyl and the like. And lower alkyl groups.
- alkenyl groups include straight or branched chain aliphatic hydrocarbon residues containing one double bond, such as vinyl, propyl, butenyl, methylpropyl And lower alkenyl groups such as phenyl, pentenyl and hexenyl.
- aryl group examples include phenyl, trinole, xylyl, cumenyl, mesityl, naphthyl and the like.
- Suitable protecting groups in the "protected hydroxy group” include, for example, lower alkylthiomethyl groups such as methylthiomethyl, ethylthiomethyl, propylthiomethyl, isopropylthiomethyl, butylthiomethyl, isobutylthiomethyl and hexylthiomethyl. ! a 1 - (lower alkylthio) (lower) alkyl group, further preferred correct C ⁇ C 4 alkylthio Omechiru group as ones, most preferred correct ones and to methylthiomethyl group; e.g.
- Trisubstituted silyl groups such as lower alkyl-diarylsilyl and the like, more preferably tri (C ⁇ CJ alkylsilyl group and ( ⁇ ⁇ ( ⁇ alkyldifluorosilyl group, most preferably tertiary) A butyl-dimethylsilyl group and a tertiary butyl-diphenylsilyl group;
- Aliphatic acryl groups include, for example, carboxy such as formyl, acetyl, propylpionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, carboxyacetyl, carboxypropionyl, carboxybutyryl, carboxyhexanolyl, etc.
- a lower alkanoyl group which may have one or more suitable substituents such as, for example, cyclopropyloxyacetyl, cyclobutyloxypropionyl, cycloheptyloxybutyryl, mentyl It has one or more suitable substituents such as lower alkyl, such as xyacetyl, menthoxypropionyl, menthoxybutyryl, menthyloxypentanoyl, menthyloxyhexanoyl, etc.
- cyclo (lower) alkoxy (lower) alkanoy Carboxymethyl carbamoyl, carboxyethyl carbamoyl, carboxypropyl carbamoyl, carboxybutyl carbamoyl, carboxypentyl carbamoyl, carboxyhexyl carbamoyl, etc.
- trimethylsilinolemethoxycarborethylcarbamoyl trimethylsilylethoxycarbonylpropyl-potassium rubamoyl, triethylsilylethoxycarbonylpropyl-potassium rubamoyl, tertiary butyldimethylsilylethoxycarbonyl propyl potassium rubamoyl, trimethylsilylpropoxy Tri (lower) alkylsilyl (lower) such as carbonylbutyl carbamoyl group 1-Lucoxycarbonyl (lower) Protected carboxy such as alkyl rubamoyl group (lower) Carboxyl such as alkyl rubamoyl group or lower having one or more suitable substituents such as protected carboxy. Alkyl rubamoyl group and the like.
- aromatic acyl group examples include one or more suitable substituents such as nitro such as benzoyl, toluoyl, xyloyl, naphthoyl, nitrobenzyl, dinitrobenzyl, and nitronaphthyl.
- Haloyl groups such as benzenesulfonyl, toluenesulfonyl, xylenesulfonyl, naphthalenesulfonyl, fluorobenzenesulfonyl, chlorobenzenesulfonyl, bromobenzenesulfonyl, benzenesulfonyl, etc.
- Examples include an arenesulfonyl group which may have one or more suitable substituents.
- Examples of the aliphatic acryl group substituted with an aromatic group include phenylacetyl, phenylpropionyl, phenylbutyryl,
- al (lower) alkanoyl groups which may have one or more suitable substituents such as trihalo (lower) alkyl.
- Ashiru group is a preferred correct Ashiru group is al, may have a local Bokishi C, -C 4 Arukanoiru group, a cycloalkyl Le moiety (( ⁇ - (-) cyclo having two alkyl (C 5 ⁇ C 6) Alkyloxy (C! CJ alkanoyl group, camphorsulfonyl group, carboxy (( ⁇ ⁇ (: alkyl group rubamoyl group, tri (( ⁇ ⁇ (: alkylsilyl (C! CJ alkoxy carbonyl ((! ⁇ Group, benzoyl group which may have one or two nitro groups, benzenesulfonyl group having halogen, ( ⁇ ⁇ ( ⁇ alkoxy and trino,
- alkyl-containing phenyl C ⁇ CJ alkanoyl groups, among which the most preferred ones are acetyl, carboxypropionyl, menthyloxyacetyl, camphorsulfonyl, benzoyl, Nitrobenzene, dinitrate benzoyl, iodobenzenesulfonyl and 2-trifluoromethyl-2-methoxy-2-phenylacetyl.
- the "heterocyclic group containing a nitrogen atom, a sulfur atom and a Z or oxygen atom comprising a 5- or 6-membered ring” include a pyrrolyl group and a tetrahydrofuryl group.
- the pharmaceutically acceptable salt of the compound (I) is a non-toxic, pharmaceutically acceptable conventional salt, for example, an alkali metal salt such as sodium salt, potassium salt, etc., for example, calcium Salts with inorganic or organic bases such as alkaline earth metal salts such as salts, magnesium salts, etc., ammonium salts, for example, triethylamine salts, and amine salts such as N-benzyl-N-methylamine salts.
- a conformer or an asymmetric carbon atom or an optical isomer or a geometric isomer due to a double bond is present.
- One or more pairs of such stereoisomers may exist, and such a conformer or isomer is also included in the scope of the present invention.
- microparticles made of a biodegradable polymer substance used in the present invention are generally called microspheres, and the microspheres themselves belong to a known technique.
- microsizing (I) has not been known so far, and a compound (I) having such a macrocycle can be formulated into a microsphere without particular difficulty. However, it was not known at all whether it could produce an excellent sustained-release effect even if it was formulated.
- biodegradable polymer substances such as polylactic acid (PLA) and lactic acid-glycolic acid copolymer (PLGA) are used as microsphere constituents, It has been found that the compound (I) dispersed in the granules can release the compound (I) slowly with excellent stability.
- PLA polylactic acid
- PLGA lactic acid-glycolic acid copolymer
- biodegradable polymer substance used in the present invention examples include, in addition to the above PLA and PLGA, polyglycolic acid, polyalkyl ⁇ -cyanoacrylate, poly ⁇ -caprolactone, and polyamino. Acids, polyhydroxybutyric acid, polyhydroxyvaleric acid, polyhydroxybutyric acid monohydroxyvaleric acid copolymer and the like are exemplified as particularly suitable.
- the content of compound (I) in the microparticles produced using the above biodegradable polymer substance is appropriately determined according to the purpose of administration to humans or animals and the administration route (site). It is recommended that the content be 0.11 to 50% by weight, preferably 0.1 to 20% by weight.
- the size of the microparticles is not particularly limited. In short, the size of the microparticles only needs to be able to pass through the injection needle, and is generally 200 ⁇ m or less.
- the method for producing the microparticles of the present invention is not particularly limited, but a typical method is as follows.
- a biodegradable polymer substance is dissolved using an organic solvent such as methylene chloride, acetonitrile, and dioxane.
- an organic solvent such as methylene chloride, acetonitrile, and dioxane.
- a method is disclosed in which compound (I) is dissolved in the solution, a crystallization medium is added to the solution to precipitate microparticles, which are emulsified, separated, and freeze-dried.
- the microparticles contain the compound (I), but the diameter of the microparticles tends to decrease as the amount of the organic solvent added increases, and increases when the amount of the organic solvent added is small. I understood.
- the amount of the organic solvent to be added is 1 to 50 times (vZw), preferably 1 to 10 times, the biodegradable polymer substance.
- a hydrophilic solvent such as an aqueous solution of gelatin, polyvinyl alcohol, lower alcohols (such as methanol and ethanol), and ketones (such as acetate) is preferable.
- the amount of the crystallization medium to be added is 0.1 to 10% by weight, preferably 0.25 to 10% by weight. It is better to use 2% by weight.
- microparticles thus provided are dispersed in a dispersion medium suitable for the administration route and then administered.
- a dispersion medium suitable for the administration route and then administered.
- the microparticles are dispersed in distilled water for injection or physiological saline.
- the microparticles of the present invention, or the microparticles may be dispersed in the above-mentioned dispersion medium to give an appropriate administration form, such as an injection or an oral preparation, which is pharmaceutically acceptable.
- additives include surfactants, solubilizing agents, tonicity agents, soothing agents, excipients, thickeners, stabilizers, preservatives, and the like.
- the pharmaceutical composition of the present invention can also be effectively used when the compounds disclosed below are contained as an active ingredient.
- sustained-release preparation of the present invention can be produced by using cyclosporin-rapamycin or the like.
- R 1 , R 2 , R 8 , R 23 hydrogen
- R 7 , R 9 hydroxy group
- R 10 aryl group
- R 14, R 15, R 16 , R 17, R 18, R 19, R 22 methylation group
- R 3 , R 4 another bond between the carbon atoms to which it is bonded
- R 5 , R 6 Another bond between the carbon atom to which it is bonded The compound still in the free state was selected.
- This compound has a particularly excellent immunosuppressive action, and is hereinafter referred to as FK506.
- FK506 (0.05 g), methylene chloride (2 ml, 4 ml, 8 ml), and PLGA (0.5 g) were mixed to form a homogeneous solution, to which a 1% aqueous gelatin solution (200 ml) was added. 0 ml) was added to crystallize microspheres. This was put in a homomixer and emulsified under the conditions of 6 ° C. ⁇ 500 rpm ⁇ 5 min. After nitrogen gas was passed through the emulsion to distill off the solvent, the solution was filtered through a mesh of 100 zm and centrifuged at 250 rpm x 5 min. The filtrate was washed with water, centrifuged again, re-dispersed in water, and lyophilized. The diameter of the obtained microparticles was as follows.
- the compound (I) having a macrocycle such as FK506 can be provided as stable microparticles, and the compound can be provided as a human. Alternatively, when administered to animals, it shows stable sustained release over a very long period. In addition, since it can be provided as a drug suitable for local administration, it is possible to administer a larger amount of drug required without concern about systemic toxicity than in the case of systemic administration.
- the pharmaceutical composition of the present invention is prepared as a suspension formulation by adding a dispersing medium at the time of use, it has excellent storage stability, and does not cause crystallization of the active ingredient even when in contact with body fluids. It was confirmed to show availability.
- This pharmaceutical composition also has the advantage that it is easy to swallow for children and that the dosage can be easily adjusted.
- the preparation of the present invention is characterized in that, due to the pharmacological action of the tricyclo compound (I), organs such as heart, kidney, liver, bone marrow, skin, cornea, lung, kidney, small intestine, limbs, muscle, nerve, intervertebral disc, trachea, etc. Or rejection during tissue transplantation; graft-versus-host reaction with bone marrow transplantation; Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, Hashimoto's thyroiditis, multiple sclerosis, myasthenia gravis, type I diabetes; and pathogenic microorganisms (eg, Aspergillus' Fumigasis, Fusarium. Oxysporma, trichophyton, asteroides, etc.).
- organs such as heart, kidney, liver, bone marrow, skin, cornea, lung, kidney, small intestine, limbs, muscle, nerve, intervertebral disc,
- the preparation of the tricyclic compound (I) is also useful for the treatment and prevention of the following diseases.
- Inflammatory and hyperproliferative skin diseases and immunologically mediated skin diseases eg, psoriasis, atopic dermatitis, contact dermatitis, eczema dermatitis, seborrheic dermatitis, lichen planus, pemphigus
- Bullous pemphigoid epidermolysis bullosa, urticaria, vascular edema, vasculitis, erythema, cutaneous eosinophilia, erythematous lupus, acne and alopecia areata);
- Ocular diseases of autoimmune diseases e.g., keratoconjunctivitis, spring conjunctivitis, Behcet's disease related uveitis, keratitis, herpes keratitis, keratoconus keratitis, corneal epithelial dystrophy, corneal vitiligo, eyes Pemphigus, Mohr's ulcer, scleritis, Graves' eye disorder, Folk toe Koyanagi-Harada syndrome, sarcoidosis, etc.);
- autoimmune diseases e.g., keratoconjunctivitis, spring conjunctivitis, Behcet's disease related uveitis, keratitis, herpes keratitis, keratoconus keratitis, corneal epithelial dystrophy, corneal vitiligo, eyes Pemphigus, Mohr's ulcer, scleritis, Graves' eye disorder
- Reversible obstructive airway disease eg, bronchial asthma, allergic asthma, endogenous asthma, exogenous asthma and dusty asthma), especially chronic or refractory asthma (eg, late asthma and airway responsiveness) hyperactivity), and bronchitis, etc.
- mucosal and vascular inflammation e.g. gastric ulcer, vascular damage caused by ischemia and thrombosis, ischemic bowel disease, enteritis, necrotizing enterocolitis, intestinal damage due to burns, leuco Bok Lien 8 4 —Mediated disease;
- Intestinal inflammation Z allergies eg pediatric steatosis, proctitis, favorable Acid-associated gastroenteritis, mastocytosis, Crohn's disease and ulcerative colitis
- food-related allergic diseases with symptomatic manifestations remote from the gastrointestinal tract (eg migraine, rhinitis and eczema);
- Nephropathy eg, interstitial nephritis, Good Bastian syndrome, hemolytic uremic syndrome and diabetic nephropathy
- Neurological diseases eg, polymyositis, Guillain-Barre syndrome, Meniere's disease, polyneuritis, polyneuritis, solitary neuritis and radiculopathy;
- Endocrine disorders eg, hyperthyroidism and Basedow's disease
- blood disorders eg, pure erythroblastosis, aplastic anemia, dysplastic anemia, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, Agranulocytosis, pernicious anemia, megaloblastic anemia and erythropoiesis insufficiency
- erythroblastosis eg, hyperthyroidism and Basedow's disease
- blood disorders eg, pure erythroblastosis, aplastic anemia, dysplastic anemia, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, Agranulocytosis, pernicious anemia, megaloblastic anemia and erythropoiesis insufficiency
- Bone disease eg, osteoporosis
- Respiratory diseases eg, sarcoidosis, pulmonary fibrosis and idiopathic interstitial pneumonia
- Skin diseases eg, dermatomyositis, vitiligo vulgaris, ichthyosis vulgaris, photosensitivity and cutaneous T-cell lymphoma
- Circulatory system diseases eg, arteriosclerosis, atherosclerosis, aortitis syndrome, polyarteritis nodosa and cardiomyopathy
- collagen diseases eg, scleroderma, Pegena-granulomas and Siggren's syndrome
- Periodontal disease eg gingiva, periodontal, alveolar bone, (tooth) cement Damage
- Nephrotic syndrome eg, glomerulonephritis
- Reactive oxygen-mediated diseases eg, ischemic blood flow damage to organs (eg, heart, liver, kidney, gastrointestinal tract, etc.) resulting from organ damage (storage, transplantation or ischemic disease (thrombosis, myocardial infarction, etc.)): Intestinal disorders (eg, endotoxin shock, pseudomembranous colitis, colitis due to drugs or radiation): Renal disorders (eg, ischemic acute renal failure, chronic renal failure: lung disorders (eg, lung oxygen or Poisoning by drugs (eg, paracoat, bleomycin), lung cancer, emphysema): eye diseases (eg, cataracts, iron deposition (iron sclerosis), retinitis, pigmentation, senile spot alteration, vitreous scar, alkaline Burn cornea): dermatitis (eg, erythema multiforme, flocculant immunoglobulin A dermatitis, cement dermatitis): and other diseases (eg, ging
- Bechi Tsu Bok disease e.g., intestinal, vascular type, nervous type, oral cavity, skin, eye, vulva, articulation, epididymis, lung, kidney
- Bechi Tsu Bok disease e.g., intestinal, vascular type, nervous type, oral cavity, skin, eye, vulva, articulation, epididymis, lung, kidney
- the preparation of the tricyclic compound (I) has a liver regenerating action and a stimulating action on hypertrophy and hyperplasia of Z or hepatocytes. Therefore, these compounds are useful for liver disease [eg, immunogenic disease (autologous).
- Autoimmune liver disease chronic autoimmune liver disease such as primary biliary cirrhosis or sclerosing cholangitis), partial liver resection, acute liver necrosis (eg, toxic, diarrhea hepatitis, shock or acidless) Hepatitis B, non-A non-B hepatitis, cirrhosis (eg, alcoholic cirrhosis) and liver dysfunction (eg, fulminant hepatitis, late-onset hepatitis, and acute to chronic liver dysfunction) )] Is useful for treatment and prevention.
- acute liver necrosis eg, toxic, diarrhea hepatitis, shock or acidless
- Hepatitis B non-A non-B hepatitis
- cirrhosis eg, alcoholic cirrhosis
- liver dysfunction eg, fulminant hepatitis, late-onset hepatitis, and acute to chronic liver dysfunction
- Tris-mouth compound (I) has pharmacological effects such as potentiating chemotherapy, preventing and treating cytomegalovirus and AIDS virus infection, suppressing carcinogenesis, and anti-inflammatory activity. Useful for various diseases.
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- Epidemiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69326015T DE69326015T2 (de) | 1992-11-18 | 1993-11-11 | Pharmazeutische zubereitung mit verlängerter wirkung |
US08/424,498 US5601844A (en) | 1992-11-18 | 1993-11-11 | Sustained release medicinal preparation |
JP51193194A JP3520517B2 (ja) | 1992-11-18 | 1993-11-11 | 医薬用持続性製剤 |
AU54340/94A AU5434094A (en) | 1992-11-18 | 1993-11-11 | Prolonged-action pharmaceutical preparation |
EP93924826A EP0669127B1 (en) | 1992-11-18 | 1993-11-11 | Prolonged-action pharmaceutical preparation |
DK93924826T DK0669127T3 (da) | 1992-11-18 | 1993-11-11 | Farmaceutisk præparat med forlænget virkning |
GR990402272T GR3031179T3 (en) | 1992-11-18 | 1999-09-08 | Prolonged-action pharmaceutical preparation. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4/308885 | 1992-11-18 | ||
JP30888592 | 1992-11-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994010981A1 true WO1994010981A1 (en) | 1994-05-26 |
Family
ID=17986438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1993/001672 WO1994010981A1 (en) | 1992-11-18 | 1993-11-11 | Prolonged-action pharmaceutical preparation |
Country Status (11)
Country | Link |
---|---|
US (1) | US5601844A (ja) |
EP (1) | EP0669127B1 (ja) |
JP (1) | JP3520517B2 (ja) |
CN (1) | CN1093571A (ja) |
AT (1) | ATE183083T1 (ja) |
AU (1) | AU5434094A (ja) |
DE (1) | DE69326015T2 (ja) |
DK (1) | DK0669127T3 (ja) |
ES (1) | ES2134860T3 (ja) |
GR (1) | GR3031179T3 (ja) |
WO (1) | WO1994010981A1 (ja) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06345646A (ja) * | 1993-06-08 | 1994-12-20 | Fujisawa Pharmaceut Co Ltd | ローション剤 |
US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
US20060280774A1 (en) * | 1995-06-02 | 2006-12-14 | Allergan, Inc. | Compositions and methods for treating glaucoma |
US5910492A (en) * | 1995-06-05 | 1999-06-08 | Takeda Chemical Industries, Ltd. | Osteogenic promoting pharmaceutical composition |
ATE254450T1 (de) | 1995-09-19 | 2003-12-15 | Fujisawa Pharmaceutical Co | Aerosolzusammensetzungen |
ZA9710927B (en) | 1996-12-06 | 1998-06-15 | Fujisawa Pharmaceutical Co | Pharmaceutical composition. |
US5849800A (en) * | 1997-03-28 | 1998-12-15 | The Penn State Research Foundation | Use of amantadine for treatment of Hepatitis C |
US6127520A (en) | 1997-04-15 | 2000-10-03 | Regents Of The University Of Michigan | Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles |
US6113738A (en) * | 1998-03-16 | 2000-09-05 | Nalco Chemical Company | Use of additives to breakdown and stabilize wax during fiber recycle |
CA2319431C (en) | 1998-03-16 | 2008-01-22 | Nalco Chemical Company | Contaminant dispersants useful in recycling of treated containers |
WO1999049863A1 (fr) * | 1998-03-26 | 1999-10-07 | Fujisawa Pharmaceutical Co., Ltd. | Preparations a liberation prolongee |
US6399649B1 (en) | 1998-09-24 | 2002-06-04 | Boston Medical Center Corporation | Compositions and methods for the treatment of chronic lymphocytic leukemia |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
AU3649502A (en) | 2000-11-29 | 2002-06-11 | Oculex Pharm Inc | Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor |
PT1539157E (pt) | 2002-09-18 | 2013-10-04 | Univ Pennsylvania | Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal |
US20050048099A1 (en) * | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
DK1663217T3 (da) * | 2003-08-29 | 2010-11-08 | Lifecycle Pharma As | Faste dispersioner indeholdende tacrolimus |
EP1663216B1 (en) | 2003-08-29 | 2011-11-02 | Veloxis Pharmaceuticals A/S | Modified release compositions comprising tacrolimus |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
BRPI0608152A2 (pt) | 2005-02-09 | 2009-11-10 | Macusight Inc | formulações para tratamento ocular |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
US20070178138A1 (en) * | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
WO2007092620A2 (en) | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
CA2645488C (en) | 2006-03-23 | 2014-09-02 | Macusight, Inc. | Formulations comprising rapamycin and methods using same for vascular permeability-related diseases or conditions |
US20070298073A1 (en) * | 2006-06-23 | 2007-12-27 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8802128B2 (en) * | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
CA2688381C (en) | 2007-05-30 | 2016-10-11 | Lifecycle Pharma A/S | Once daily oral dosage form comprising tacrolimus |
US8222272B2 (en) | 2008-04-11 | 2012-07-17 | Roxane Laboratories, Inc. | Pharmaceutical formulation and process comprising a solid dispersion of macrolide (tacrolimus) |
PT2575769T (pt) | 2010-02-17 | 2016-09-22 | Veloxis Pharmaceuticals As | Composição de tacrolímus estabilizada |
AR101476A1 (es) | 2014-08-07 | 2016-12-21 | Acerta Pharma Bv | Métodos para tratar cánceres, enfermedades inmunes y autoinmunes, y enfermedades inflamatorias en base a la tasa de ocupación de la tirosin quinasa de bruton (btk) y a la tasa de resíntesis de la tirosin quinasa de bruton (btk) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61148181A (ja) * | 1984-12-03 | 1986-07-05 | Fujisawa Pharmaceut Co Ltd | Fr―900506物質およびその製造法 |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8608080D0 (en) * | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
EP0346427B1 (en) * | 1987-12-09 | 1995-03-29 | FISONS plc | Macrocyclic compounds |
US5196437A (en) * | 1990-02-13 | 1993-03-23 | Fujisawa Pharmaceutical Company, Ltd. | Method for treating hepatic diseases and regenerating liver tissue using FK 506 and related compounds |
CA2012978C (en) * | 1990-02-13 | 2002-02-26 | Thomas E. Starzl | Treatment of hepatic diseases using fk 506 and related compounds |
US5260301A (en) * | 1990-03-01 | 1993-11-09 | Fujisawa Pharmaceutical Co., Ltd. | Pharmaceutical solution containing FK-506 |
JPH0449232A (ja) * | 1990-06-15 | 1992-02-18 | Fujisawa Pharmaceut Co Ltd | 懸濁用組成物または懸濁液並びにそれらの製造法 |
ATE150304T1 (de) * | 1990-09-04 | 1997-04-15 | Fujisawa Pharmaceutical Co | Tricyclische verbindungen enthaltende salben |
IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
-
1993
- 1993-11-11 JP JP51193194A patent/JP3520517B2/ja not_active Expired - Fee Related
- 1993-11-11 AU AU54340/94A patent/AU5434094A/en not_active Abandoned
- 1993-11-11 DK DK93924826T patent/DK0669127T3/da active
- 1993-11-11 AT AT93924826T patent/ATE183083T1/de not_active IP Right Cessation
- 1993-11-11 DE DE69326015T patent/DE69326015T2/de not_active Expired - Lifetime
- 1993-11-11 US US08/424,498 patent/US5601844A/en not_active Expired - Lifetime
- 1993-11-11 EP EP93924826A patent/EP0669127B1/en not_active Expired - Lifetime
- 1993-11-11 ES ES93924826T patent/ES2134860T3/es not_active Expired - Lifetime
- 1993-11-11 WO PCT/JP1993/001672 patent/WO1994010981A1/ja active IP Right Grant
- 1993-11-17 CN CN93121437A patent/CN1093571A/zh active Pending
-
1999
- 1999-09-08 GR GR990402272T patent/GR3031179T3/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61148181A (ja) * | 1984-12-03 | 1986-07-05 | Fujisawa Pharmaceut Co Ltd | Fr―900506物質およびその製造法 |
JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1093571A (zh) | 1994-10-19 |
DE69326015T2 (de) | 2000-02-03 |
US5601844A (en) | 1997-02-11 |
EP0669127B1 (en) | 1999-08-11 |
DK0669127T3 (da) | 1999-12-06 |
EP0669127A4 (en) | 1995-11-02 |
ATE183083T1 (de) | 1999-08-15 |
AU5434094A (en) | 1994-06-08 |
JP3520517B2 (ja) | 2004-04-19 |
DE69326015D1 (de) | 1999-09-16 |
ES2134860T3 (es) | 1999-10-16 |
EP0669127A1 (en) | 1995-08-30 |
GR3031179T3 (en) | 1999-12-31 |
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