WO1994004463A3 - PROCEDE DE PREPARATION DE GENERATEURS DE RHENIUM-188 ET DE TECHNETIUM-99m - Google Patents

PROCEDE DE PREPARATION DE GENERATEURS DE RHENIUM-188 ET DE TECHNETIUM-99m Download PDF

Info

Publication number
WO1994004463A3
WO1994004463A3 PCT/US1993/007812 US9307812W WO9404463A3 WO 1994004463 A3 WO1994004463 A3 WO 1994004463A3 US 9307812 W US9307812 W US 9307812W WO 9404463 A3 WO9404463 A3 WO 9404463A3
Authority
WO
WIPO (PCT)
Prior art keywords
anion
metallic cation
technetium
rhenium
generators
Prior art date
Application number
PCT/US1993/007812
Other languages
English (en)
Other versions
WO1994004463A2 (fr
Inventor
Gary J Ehrhardt
Robert G Wolfangel
Edward A Deutsch
Original Assignee
Univ Missouri
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Missouri, Mallinckrodt Medical Inc filed Critical Univ Missouri
Priority to AU50817/93A priority Critical patent/AU662081B2/en
Priority to PL93307528A priority patent/PL172772B1/pl
Priority to EP93920211A priority patent/EP0656873B1/fr
Priority to CA002141868A priority patent/CA2141868C/fr
Priority to KR1019950700682A priority patent/KR100217973B1/ko
Priority to SK237-95A priority patent/SK23795A3/sk
Priority to DE69316902T priority patent/DE69316902T2/de
Publication of WO1994004463A2 publication Critical patent/WO1994004463A2/fr
Publication of WO1994004463A3 publication Critical patent/WO1994004463A3/fr
Priority to NO950625A priority patent/NO950625L/no
Priority to FI950771A priority patent/FI104420B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G1/00—Methods of preparing compounds of metals not covered by subclasses C01B, C01C, C01D, or C01F, in general
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application

Landscapes

  • Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Procédé de préparation d'un générateur de radionuclides servant à produire Tc-99m ou Re-188. On prépare une solution claire contenant un cation métallique et un anion comprenant W-188 ou Mo-99. Le cation métallique est présent dans la solution en tant que complexe dissous du cation métallique et d'un agent complexant et/ou l'anion est présent dans la solution en tant que complexe dissous de l'anion et d'un agent complexant. Le(s) complexe(s) dissous sont décomposés, afin de former une boue liquide contenant un précipité du cation métallique et de l'anion. Le précipité est transféré vers un réservoir d'élution d'un générateur de radionuclides.
PCT/US1993/007812 1992-08-21 1993-08-19 PROCEDE DE PREPARATION DE GENERATEURS DE RHENIUM-188 ET DE TECHNETIUM-99m WO1994004463A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU50817/93A AU662081B2 (en) 1992-08-21 1993-08-19 Process for preparing Rhenium-188 and technetium-99m generators
PL93307528A PL172772B1 (en) 1992-08-21 1993-08-19 Method of preparing for operation the rhenium-88 and technetium-99m generators
EP93920211A EP0656873B1 (fr) 1992-08-21 1993-08-19 PROCEDE DE PREPARATION DE GENERATEURS DE RHENIUM-188 ET DE TECHNETIUM-99m
CA002141868A CA2141868C (fr) 1992-08-21 1993-08-19 Methode pour la preparation de generateurs de rhenium 188 et de technetium 99m
KR1019950700682A KR100217973B1 (ko) 1992-08-21 1993-08-19 레늄-188 및 테크네튬-99m 발생기의 제조방법
SK237-95A SK23795A3 (en) 1992-08-21 1993-08-19 Process for preparation of radionuclide generators for production of technetium-99m and rhenium 188 and preparation of gels containing molybdenum-99 or wolframate-188
DE69316902T DE69316902T2 (de) 1992-08-21 1993-08-19 VERFAHREN ZUR HERSTELLUNG VON GENERATOREN AUS RHENIUM-188 AND TECHNETIUM-99m
NO950625A NO950625L (no) 1992-08-21 1995-02-20 Fremgangsmåte for fremstilling av rhenium-188- og technetium-99m-generatorer
FI950771A FI104420B (fi) 1992-08-21 1995-02-20 Menetelmä molybdeeni-99:ä ja volframi-188:a sisältävän geelin valmistamiseksi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/933,385 US5382388A (en) 1992-08-21 1992-08-21 Process for the preparation of rhenium-188 and technetium-99m generators
US07/933,385 1992-08-21

Publications (2)

Publication Number Publication Date
WO1994004463A2 WO1994004463A2 (fr) 1994-03-03
WO1994004463A3 true WO1994004463A3 (fr) 1994-03-31

Family

ID=25463840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007812 WO1994004463A2 (fr) 1992-08-21 1993-08-19 PROCEDE DE PREPARATION DE GENERATEURS DE RHENIUM-188 ET DE TECHNETIUM-99m

Country Status (15)

Country Link
US (1) US5382388A (fr)
EP (1) EP0656873B1 (fr)
JP (1) JP2843441B2 (fr)
KR (1) KR100217973B1 (fr)
AT (1) ATE163000T1 (fr)
AU (1) AU662081B2 (fr)
CA (1) CA2141868C (fr)
CZ (1) CZ38995A3 (fr)
DE (1) DE69316902T2 (fr)
FI (1) FI104420B (fr)
HU (1) HU218827B (fr)
MX (1) MX9305069A (fr)
PL (1) PL172772B1 (fr)
SK (1) SK23795A3 (fr)
WO (1) WO1994004463A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001852A1 (fr) * 1995-06-28 1997-01-16 Mallinckrodt Medical, Inc. Generatuers a technetium-99m
US5862193A (en) * 1997-08-20 1999-01-19 The Curators Of The University Of Missouri Production of 186 Re, 188 Re and other radionuclides via inorganic szilard-chalmers process
CA2214089A1 (fr) * 1996-08-26 1998-02-26 Wei Jia Production de radionucleides 186re, 188re et autres par le procede mineral szilard-chalmers
US5802439A (en) * 1997-02-19 1998-09-01 Lockheed Martin Idaho Technologies Company Method for the production of 99m Tc compositions from 99 Mo-containing materials
US5802438A (en) * 1997-02-19 1998-09-01 Lockheed Martin Idaho Technologies Company Method for generating a crystalline 99 MoO3 product and the isolation 99m Tc compositions therefrom
IL122094A (en) * 1997-11-03 2003-07-06 Israel Atomic Energy Comm In situ-generated solid radiation source based on tungsten<188>/rhenium<188> and the use thereof
US6157036A (en) * 1998-12-02 2000-12-05 Cedars-Sinai Medical Center System and method for automatically eluting and concentrating a radioisotope
US6998052B2 (en) * 2002-04-12 2006-02-14 Pg Research Foundation Multicolumn selectivity inversion generator for production of ultrapure radionuclides
JP4578425B2 (ja) * 2006-03-20 2010-11-10 行政院原子能委員會核能研究所 テクネチウム−９９ｍ過テクネチウム酸溶液の濃縮装置及びその方法
KR101401373B1 (ko) 2012-10-05 2014-05-30 주식회사 엔바이로코리아 진단용 및 치료용 방사성 동위원소 제조장치 및 그 방법
US9449726B2 (en) 2013-05-31 2016-09-20 Washington University 100Mo compounds as accelerator targets for production of 99mTc
EP3174068B1 (fr) * 2015-11-30 2018-06-20 Orano Med Nouveau procédé et appareil pour la production de radionucléides de haute pureté
US11286172B2 (en) 2017-02-24 2022-03-29 BWXT Isotope Technology Group, Inc. Metal-molybdate and method for making the same
US11363709B2 (en) 2017-02-24 2022-06-14 BWXT Isotope Technology Group, Inc. Irradiation targets for the production of radioisotopes

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846341A (en) * 1970-03-16 1974-11-05 Inst Francais Du Petrole Process for manufacturing iron molybdate catalysts of high strength and the use of the resulting catalysts in the catalytic oxidation of alcohols to aldehydes
US3928233A (en) * 1972-08-16 1975-12-23 Union Oil Co Hydrogenative conversion catalysts
US3980709A (en) * 1973-12-11 1976-09-14 Daicel, Ltd. Catalyst for preparation of α,β-unsaturated aldehydes and process for preparing the aldehydes
US4000085A (en) * 1969-02-07 1976-12-28 Institut Francais Du Petrole, Des Carburants Et Lubrifiants Et Entreprise De Recherches Et D'activities Petrolieres Elf Process for manufacturing gels containing iron and molybdenum and the uses thereof
US4012340A (en) * 1971-02-01 1977-03-15 Chiyoda Kako Kensetsu Kabushiki Kaisha Process for preparing catalysts for hydrodesulfurization
US4141861A (en) * 1975-01-16 1979-02-27 Institut Francais Du Petrole Gels containing iron and molybdenum
US4280053A (en) * 1977-06-10 1981-07-21 Australian Atomic Energy Commission Technetium-99m generators
US4738834A (en) * 1984-02-24 1988-04-19 Australia Nuclear Science & Technology Organization Treatment of technetium containing solutions
US4778672A (en) * 1985-11-27 1988-10-18 University Of Cincinnati Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution
US4859431A (en) * 1986-11-10 1989-08-22 The Curators Of The University Of Missouri Rhenium generator system and its preparation and use
US4916103A (en) * 1987-11-27 1990-04-10 Basf Aktiengesellschaft Preparation of a catalytically active composition for the gas phase oxidation of propylene to acrolein and acrylic acid
US4990787A (en) * 1989-09-29 1991-02-05 Neorx Corporation Radionuclide generator system and method for its preparation and use
US5053186A (en) * 1989-10-02 1991-10-01 Neorx Corporation Soluble irradiation targets and methods for the production of radiorhenium

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145636A (en) * 1989-10-02 1992-09-08 Neorx Corporation Soluble irradiation targets and methods for the production of radiorhenium
US5186913A (en) * 1991-04-26 1993-02-16 Martin Marietta Energy Systems, Inc. Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000085A (en) * 1969-02-07 1976-12-28 Institut Francais Du Petrole, Des Carburants Et Lubrifiants Et Entreprise De Recherches Et D'activities Petrolieres Elf Process for manufacturing gels containing iron and molybdenum and the uses thereof
US3846341A (en) * 1970-03-16 1974-11-05 Inst Francais Du Petrole Process for manufacturing iron molybdate catalysts of high strength and the use of the resulting catalysts in the catalytic oxidation of alcohols to aldehydes
US4012340A (en) * 1971-02-01 1977-03-15 Chiyoda Kako Kensetsu Kabushiki Kaisha Process for preparing catalysts for hydrodesulfurization
US3928233A (en) * 1972-08-16 1975-12-23 Union Oil Co Hydrogenative conversion catalysts
US3980709A (en) * 1973-12-11 1976-09-14 Daicel, Ltd. Catalyst for preparation of α,β-unsaturated aldehydes and process for preparing the aldehydes
US4141861A (en) * 1975-01-16 1979-02-27 Institut Francais Du Petrole Gels containing iron and molybdenum
US4280053A (en) * 1977-06-10 1981-07-21 Australian Atomic Energy Commission Technetium-99m generators
US4738834A (en) * 1984-02-24 1988-04-19 Australia Nuclear Science & Technology Organization Treatment of technetium containing solutions
US4778672A (en) * 1985-11-27 1988-10-18 University Of Cincinnati Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution
US4859431A (en) * 1986-11-10 1989-08-22 The Curators Of The University Of Missouri Rhenium generator system and its preparation and use
US4916103A (en) * 1987-11-27 1990-04-10 Basf Aktiengesellschaft Preparation of a catalytically active composition for the gas phase oxidation of propylene to acrolein and acrylic acid
US4990787A (en) * 1989-09-29 1991-02-05 Neorx Corporation Radionuclide generator system and method for its preparation and use
US5053186A (en) * 1989-10-02 1991-10-01 Neorx Corporation Soluble irradiation targets and methods for the production of radiorhenium

Also Published As

Publication number Publication date
WO1994004463A2 (fr) 1994-03-03
KR950702941A (ko) 1995-08-23
CZ38995A3 (en) 1995-10-18
EP0656873A1 (fr) 1995-06-14
FI950771A (fi) 1995-02-20
KR100217973B1 (ko) 1999-09-01
ATE163000T1 (de) 1998-02-15
AU5081793A (en) 1994-03-15
DE69316902T2 (de) 1998-05-28
HU218827B (hu) 2000-12-28
FI104420B (fi) 2000-01-31
FI950771A0 (fi) 1995-02-20
DE69316902D1 (de) 1998-03-12
AU662081B2 (en) 1995-08-17
EP0656873A4 (fr) 1995-08-09
PL307528A1 (en) 1995-05-29
SK23795A3 (en) 1995-07-11
PL172772B1 (en) 1997-11-28
HU9500520D0 (en) 1995-04-28
US5382388A (en) 1995-01-17
MX9305069A (es) 1994-04-29
JP2843441B2 (ja) 1999-01-06
CA2141868C (fr) 2000-04-11
JPH08500572A (ja) 1996-01-23
HUT72346A (en) 1996-04-29
EP0656873B1 (fr) 1998-02-04

Similar Documents

Publication Publication Date Title
WO1994004463A3 (fr) PROCEDE DE PREPARATION DE GENERATEURS DE RHENIUM-188 ET DE TECHNETIUM-99m
CA2075297A1 (fr) Methode de production d&#39;actinium-225 et de bismuth-213
HU901163D0 (en) Process for the production of medical preparations containing radionuclide complexes of aminophosphonic macroring acids
DE3174705D1 (en) Synthesis of tumor antigenic determinant
GB1510664A (en) Bone-seeking technetium-99m imidodiphosphonate complex
UA29383C2 (uk) Готовий до споживання, стерильний, апірогенний розчин антрациклінового глікозиду для ін`єкцій, який призначений для використання при лікуванні пухлин
AU6501794A (en) Chelating agents of the type xn1s1o1 for radioactive isotopes, metal complexes thereof, and their use in diagnosis and therapy
DE3479503D1 (en) Process for the preparation of an antithrombin iii-heparin, e.g. an antithrombin iii-heparinoid concentrate
CA2046308A1 (fr) Composes colloides marques par une substance radioactive, leur utilisation et procede pour leur preparation
CA2063551A1 (fr) Mode de preparation du radionucleide gazeux pour radiodiagnostic et appareil
ES8204212A1 (es) Perfeccionamientos en sistemas generadores de esotopos.
ATE118920T1 (de) Verbessertes radionukliderzeugungssystem und verfahren zu seiner herstellung und seinem gebrauch.
NO950625L (no) Fremgangsmåte for fremstilling av rhenium-188- og technetium-99m-generatorer
JPS56134515A (en) Manufacture of a type crystalline zeolite powder
Dadachov et al. 188 W-188 Re gel generators based on metal tungstates
PL312794A1 (en) Tris(isonitril)copper sulphates(i) for production of complexes of radioactive nuclides
Chirby et al. Adsorption of 153Sm-EDTMP on calcium hydroxyapatite
Colombetti et al. Effect of chemical and radiochemical impurities from eluants on 99mTc-labeling efficiency
AU6501894A (en) Chelators of type xn1s1x&#39; for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses
GB9018209D0 (en) Boronic acid adducts of technetium-99m dioxime complexes
GB1365405A (en) Radionuclide generator and method for producing same
GB1388565A (en) Process for recharging a fission product technetium-99m generator
ES8105269A1 (es) Un metodo para la preparacion del peptido h-sar-lys-sar-gln-nh2
GB2016198A (en) Method and container for production of diagnostic scanning agents
COMBI Cometary atmospheres: Modeling the spatial distribution of observed neutral radicals[Interim Report, 1 Jun. 1984- 31 Aug. 1984]

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU BR CA CZ FI HU JP KR NO PL SK US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU BR CA CZ FI HU JP KR NO PL SK US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2141868

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PV1995-389

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 1993920211

Country of ref document: EP

Ref document number: 950771

Country of ref document: FI

WWE Wipo information: entry into national phase

Ref document number: 23795

Country of ref document: SK

Ref document number: 1019950700682

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1993920211

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV1995-389

Country of ref document: CZ

WWR Wipo information: refused in national office

Ref document number: PV1995-389

Country of ref document: CZ

WWG Wipo information: grant in national office

Ref document number: 1993920211

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 950771

Country of ref document: FI