ES8105269A1 - Un metodo para la preparacion del peptido h-sar-lys-sar-gln-nh2 - Google Patents

Un metodo para la preparacion del peptido h-sar-lys-sar-gln-nh2

Info

Publication number
ES8105269A1
ES8105269A1 ES490945A ES490945A ES8105269A1 ES 8105269 A1 ES8105269 A1 ES 8105269A1 ES 490945 A ES490945 A ES 490945A ES 490945 A ES490945 A ES 490945A ES 8105269 A1 ES8105269 A1 ES 8105269A1
Authority
ES
Spain
Prior art keywords
peptides
preparation
sar
gln
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490945A
Other languages
English (en)
Other versions
ES490945A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/095,744 external-priority patent/US4250086A/en
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES490945A0 publication Critical patent/ES490945A0/es
Publication of ES8105269A1 publication Critical patent/ES8105269A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE PEPTIDO H-SAR-LYS-SAR-GLN-NH2. CONSTA DE LAS SIGUIENTES ETAPAS: 1. FORMACION DEL FRAGMENTO I, QUE CONSTA DE Z-SAR-EPSILON-Z''-LYS-OH, MEDIANTE. A) PROTECCION DEL GRUPO AMINO DE SARCOSINA. B) PROTECCION DEL GRUPO EPSILON-AMINO DE L-LISINA. C) ACTIVACION DE LA SARCOSINA FORMADA PARA FORMAR UNA SARCOSINA PROTEGIDA CARBOXI-ACTIVADA. D) REACCION DE LA SARCOSINA PROTEGIDA CARBOXI-ACTIVADA CON LA L-LISINA EPSILON-PROTEGIDA. 2. FORMACION DEL FRAGMENTO II, QUE CONSTA DE H-SAR-GLN-NH2, MEDIANTE: A) PREPARACION DE Z''''-CLN-NH2. B) ELIMINACION DEL GRUPO PROTECTOR DE LA Z''''-GLN-NH2 PARA FORMAR L-GENTAMIN AMIDA DESPROTEGIDA. C) REACCION DE L-GLUTAMIN CARBOXI ACTIVADA, FORMANDOSE Z-SAR-GLN-NH2.Z-SAR-GLN-NH2. 3. UNION DE LOS FRAGMENTOS I Y II PARA FORMAR TETRAPEPTIDO PROTEGIDO DE LOS GRUPOS PROTECTORES. 4. AISLAMIENTO Y PURIFICACION DEL TETRAPEPTIDO RESULTANTE H-SAR-LYS-SAR-GLN-NH2.
ES490945A 1979-04-26 1980-04-25 Un metodo para la preparacion del peptido h-sar-lys-sar-gln-nh2 Expired ES8105269A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3364179A 1979-04-26 1979-04-26
US06/095,744 US4250086A (en) 1979-11-19 1979-11-19 Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2

Publications (2)

Publication Number Publication Date
ES490945A0 ES490945A0 (es) 1981-05-16
ES8105269A1 true ES8105269A1 (es) 1981-05-16

Family

ID=26709949

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490945A Expired ES8105269A1 (es) 1979-04-26 1980-04-25 Un metodo para la preparacion del peptido h-sar-lys-sar-gln-nh2

Country Status (16)

Country Link
EP (1) EP0018793B1 (es)
JP (3) JPH01193296A (es)
AU (1) AU536981B2 (es)
CA (1) CA1156220A (es)
DE (1) DE3065502D1 (es)
DK (1) DK149631C (es)
ES (1) ES8105269A1 (es)
FI (1) FI801344A (es)
GR (1) GR67297B (es)
IE (1) IE49765B1 (es)
IL (1) IL59918A (es)
NO (1) NO152050C (es)
NZ (1) NZ193471A (es)
PH (2) PH17633A (es)
PT (1) PT71146B (es)
YU (1) YU42666B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298523A (en) * 1980-06-17 1981-11-03 Ortho Pharmaceutical Corporation Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
CN103351324A (zh) * 2013-07-01 2013-10-16 太仓市恒益医药化工原料厂 一种用于9-芴甲氧羰酰琥珀酰亚胺制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2932635A (en) * 1957-02-22 1960-04-12 Roussel Uclaf Alpha-peptides of lysine and method of preparing same
FR2391994A1 (fr) * 1977-05-25 1978-12-22 Anvar Nouveaux polypeptides a activite thymique ou a activite antagoniste et leurs procedes de synthese
NZ189101A (en) * 1977-12-08 1984-07-06 Ortho Pharma Corp Polypeptides having the ability to induce differentiation of both th-1+ t-lymphocytes and bu-1+ b-lymphocytes;pharmaceutical compositions

Also Published As

Publication number Publication date
ES490945A0 (es) 1981-05-16
YU114780A (en) 1984-02-29
DK149631C (da) 1987-01-26
GR67297B (es) 1981-06-29
JPH01193297A (ja) 1989-08-03
DK149631B (da) 1986-08-18
NZ193471A (en) 1984-07-06
IL59918A0 (en) 1980-06-30
FI801344A (fi) 1980-10-27
CA1156220A (en) 1983-11-01
YU42666B (en) 1988-10-31
JPH01193296A (ja) 1989-08-03
IE49765B1 (en) 1985-12-11
DE3065502D1 (en) 1983-12-15
IE800838L (en) 1980-10-26
PH16655A (en) 1983-12-09
AU536981B2 (en) 1984-05-31
IL59918A (en) 1983-05-15
EP0018793A2 (en) 1980-11-12
PH17633A (en) 1984-10-12
AU5775980A (en) 1980-10-30
PT71146A (en) 1980-05-01
NO801215L (no) 1980-10-27
PT71146B (en) 1981-08-07
JPH01193298A (ja) 1989-08-03
EP0018793B1 (en) 1983-11-09
DK180480A (da) 1980-10-27
NO152050C (no) 1985-07-24
EP0018793A3 (en) 1981-01-07
NO152050B (no) 1985-04-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301