WO1991003239A1 - Utilisation des anticomplements pour le traitement des paradontoses - Google Patents

Utilisation des anticomplements pour le traitement des paradontoses Download PDF

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Publication number
WO1991003239A1
WO1991003239A1 PCT/FR1990/000635 FR9000635W WO9103239A1 WO 1991003239 A1 WO1991003239 A1 WO 1991003239A1 FR 9000635 W FR9000635 W FR 9000635W WO 9103239 A1 WO9103239 A1 WO 9103239A1
Authority
WO
WIPO (PCT)
Prior art keywords
complement
glutamic acid
glutamate
gum arabic
saliva
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1990/000635
Other languages
English (en)
French (fr)
Inventor
Léon Georges CHEVANCE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO1991003239A1 publication Critical patent/WO1991003239A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Definitions

  • the present invention relates to the pharmaceutical industry. It relates to a new use of a substance chosen from anticomplements soluble in saliva and not aggressive towards the gingival mucosa, for obtaining a medicament intended for use in human and veterinary therapy in as a treatment agent, locally in the mouth, gingivo-dental pathological manifestations precursors of periodontosis.
  • the invention also relates to medicaments for the local treatment of gingivo-dental pathological manifestations precursors of periodontosis, characterized in that they contain an active proportion of at least one complement inhibitor soluble in saliva and nonaggressive for the gum lining.
  • the complement inhibitor is part of the group comprising L-glutamic acid, sodium L-glutamate, magnesium and sodium salts of glutamic N-acetylaspartic acid, arabic go ⁇ ame and their associations.
  • the complement inhibitor is mixed with a chewing gum.
  • a medicament according to the invention contains a mixture of gum arabic and another complement inhibitor, it can advantageously be packaged in lozenges of approximately 0.5 to 1.5 grams, containing about 92 to 96 parts by weight of gum arabic and about 4 to 8 parts by weight of monosodium salt of L-glutamic acid.
  • a medicament according to the invention may contain, in addition, at least one sweetening and / or flavoring substance, and / or at least one other substance endowed with a therapeutic activity, in particular antibiotic.
  • Preparation 100 grams of gum arabic reduced to a fine powder are intimately mixed with 6 grams of monosodium glutamate. It is pasted at normal room temperature with distilled water while kneading to obtain a homogeneous soft paste. The water is evaporated by simple exposure to air, or under vacuum, or by heating to less than 100 ° C., to obtain a solid cake approximately 0.5 cm thick, which is cut into tablets about 1 cm square.
  • No preservative additive is generally necessary, no more than a sweetener or flavor, the taste of the tablets evoking that of a meat broth.
  • sugar or, preferably, a synthetic sweetener as well as a food flavor.
  • a patient suffering from painful inflammation of the gums and small bleeding caused by brushing his teeth, is prescribed to suck twice a day, after essential dental hygiene care, two tablets (four times a day) let it melt slowly in the mouth, preferably in contact with the painful parts.
  • the present invention also relates to a process for the preparation of a human or veterinary therapeutic composition vis-à-vis gingivo-dental pathological manifestations precursors of periodontosis, said process being characterized in that an anticomplementally soluble means is used in saliva and not aggressive towards the gingival mucosa.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/FR1990/000635 1989-08-30 1990-08-29 Utilisation des anticomplements pour le traitement des paradontoses Ceased WO1991003239A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8911379A FR2651128A1 (fr) 1989-08-30 1989-08-30 Nouvelle utilisation des anticomplements pour le traitement des parodontoses.
FR89/11379 1989-08-30

Publications (1)

Publication Number Publication Date
WO1991003239A1 true WO1991003239A1 (fr) 1991-03-21

Family

ID=9384994

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1990/000635 Ceased WO1991003239A1 (fr) 1989-08-30 1990-08-29 Utilisation des anticomplements pour le traitement des paradontoses

Country Status (4)

Country Link
EP (1) EP0418110A1 (enExample)
AU (1) AU6349990A (enExample)
FR (1) FR2651128A1 (enExample)
WO (1) WO1991003239A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA020866B1 (ru) * 2013-02-28 2015-02-27 Замертон Холдингс Лимитед Пептиды с цитопротекторной активностью и фармацевтическая композиция

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237018A (ja) * 1984-05-09 1985-11-25 Tanpei Seiyaku Kk 口腔内付着性組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4843419B1 (enExample) * 1970-08-07 1973-12-18
US3847895A (en) * 1971-09-30 1974-11-12 Gaf Corp Substituted sulfophenyl-azo-naphthylazo-anilide compounds
FR2193590B1 (enExample) * 1972-07-27 1975-10-17 Philagro Sa
JPS57128662A (en) * 1981-02-02 1982-08-10 Showa Denko Kk Amino acid mixture composition
JPS61293912A (ja) * 1985-06-24 1986-12-24 Teisan Seiyaku Kk 配合剤及びその製造法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237018A (ja) * 1984-05-09 1985-11-25 Tanpei Seiyaku Kk 口腔内付着性組成物

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Arzneim. Forsch. /Drug Res., Volume 31, No. 7, 1981, (Aulendorf, DE), G. POCH: "Quantitative Ermittlung Potenzierender oder Hemmender Kombinationswirkungen Gleichsinnig Wirkender Pharmaka", pages 1135-1140, voir l'article en entier *
Immunopharmacology, Volume 8, 1984, (Amsterdam, NL), A. TAKADA et al.: "Inhibition of the Activation of the First Component of Complement, C1, by Various Amino Acids of Peptides", pages 27-35 voir figures 4,7-8; discussion *
Journal of Periodontal Research, Volume 17, No. 3, 1982, (Copenhague, DK), E.T. LALLY et al.: "Biosynthesis of Complement Components in Chronically Inflamed Gingiva", pages 257-262 voir resume; discussion *
Journal of Pharmaceutical Sciences, Volume 66, No. 10, Octobre 1977, (Washington, US), B.J. JOHNSON: "Complement: A Host Defense Mechanism Ready for Pharmacological Manipulation?", pages 1367-1377 voir page 1372; page 1374 *
Klinische Monatsblatter fur Augenheilkunde, Volume 190, No. 4, 1987, (Stuttgart, DE), O.P. VAN BIJSTERVELD: "Conjonctivites Allergiques Subaigues et Chroniques", pages 340-341 voir l'article en entier *

Also Published As

Publication number Publication date
EP0418110A1 (fr) 1991-03-20
FR2651128B1 (enExample) 1994-08-19
AU6349990A (en) 1991-04-08
FR2651128A1 (fr) 1991-03-01

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