WO1990014094A1 - Injectable clarithromycin composition - Google Patents

Injectable clarithromycin composition Download PDF

Info

Publication number
WO1990014094A1
WO1990014094A1 PCT/US1990/003063 US9003063W WO9014094A1 WO 1990014094 A1 WO1990014094 A1 WO 1990014094A1 US 9003063 W US9003063 W US 9003063W WO 9014094 A1 WO9014094 A1 WO 9014094A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
clarithromycin
acid
oil
stabilizing agent
Prior art date
Application number
PCT/US1990/003063
Other languages
English (en)
French (fr)
Inventor
Ho-Wah Hui
Chung-Chiang Hsu
John B. Cannon
Michael W. Lovell
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to CA002056445A priority Critical patent/CA2056445A1/en
Priority to KR1019910701690A priority patent/KR920700655A/ko
Publication of WO1990014094A1 publication Critical patent/WO1990014094A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10C—WORKING-UP PITCH, ASPHALT, BITUMEN, TAR; PYROLIGNEOUS ACID
    • C10C3/00—Working-up pitch, asphalt, bitumen
    • C10C3/002—Working-up pitch, asphalt, bitumen by thermal means
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10C—WORKING-UP PITCH, ASPHALT, BITUMEN, TAR; PYROLIGNEOUS ACID
    • C10C3/00—Working-up pitch, asphalt, bitumen
    • C10C3/06—Working-up pitch, asphalt, bitumen by distillation
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • D01F9/08—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of inorganic material
    • D01F9/12—Carbon filaments; Apparatus specially adapted for the manufacture thereof
    • D01F9/14—Carbon filaments; Apparatus specially adapted for the manufacture thereof by decomposition of organic filaments
    • D01F9/145—Carbon filaments; Apparatus specially adapted for the manufacture thereof by decomposition of organic filaments from pitch or distillation residues
    • D01F9/155—Carbon filaments; Apparatus specially adapted for the manufacture thereof by decomposition of organic filaments from pitch or distillation residues from petroleum pitch
PCT/US1990/003063 1989-05-26 1990-05-25 Injectable clarithromycin composition WO1990014094A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002056445A CA2056445A1 (en) 1989-05-26 1990-05-25 Injectable clarithromycin composition
KR1019910701690A KR920700655A (ko) 1989-05-26 1990-05-25 주사가능한 클라리트로마이신 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35828389A 1989-05-26 1989-05-26
US358,283 1989-05-26

Publications (1)

Publication Number Publication Date
WO1990014094A1 true WO1990014094A1 (en) 1990-11-29

Family

ID=23409043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/003063 WO1990014094A1 (en) 1989-05-26 1990-05-25 Injectable clarithromycin composition

Country Status (9)

Country Link
EP (1) EP0473707A4 (ko)
JP (1) JP2963537B2 (ko)
KR (1) KR920700655A (ko)
AU (1) AU630469B2 (ko)
CA (1) CA2056445A1 (ko)
GR (1) GR1002177B (ko)
IL (1) IL94516A (ko)
NZ (1) NZ233827A (ko)
WO (1) WO1990014094A1 (ko)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2278780A (en) * 1993-05-27 1994-12-14 Sandoz Ltd Macrolide antibiotic emulsions
WO1995026191A1 (de) * 1994-03-26 1995-10-05 Boehringer Ingelheim Vetmedica Gmbh Injizierbare lösungen von dirithromycin
EP0758549A1 (en) * 1994-04-26 1997-02-19 Nobuhiro Narita Medicinal composition as a remedy for nonsmall cell lung cancer
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5932243A (en) * 1993-05-27 1999-08-03 Novartis Ag Galenical formulations
US6017948A (en) * 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
WO2003049716A1 (en) * 2001-12-13 2003-06-19 Ranbaxy Laboratories Limited Stable topical formulation of clarithromycin
WO2005016308A1 (en) * 2003-08-06 2005-02-24 Sd Pharmaceuticals, Inc. Macrolides containing oil-in-water emulsions
DE4447972B4 (de) * 1993-05-27 2007-12-27 Novartis Ag Galenische Formulierungen
US7871632B2 (en) 2004-07-12 2011-01-18 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US8268876B2 (en) 2006-03-08 2012-09-18 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
US8349882B2 (en) 2006-03-08 2013-01-08 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
US8513296B2 (en) 2007-09-05 2013-08-20 Pola Pharma Inc. Pharmaceutical composition
US8952044B2 (en) 2009-08-25 2015-02-10 Pola Pharma Inc. Antimycotic pharmaceutical composition
WO2015068397A1 (ja) 2013-11-08 2015-05-14 株式会社アクティバスファーマ マクロライド系抗菌剤のナノ微粒子を含有する水性懸濁液剤
US9050271B2 (en) 2009-04-09 2015-06-09 Pola Pharma Inc. Antimycotic pharmaceutical composition
US9480678B2 (en) 2007-09-05 2016-11-01 Pola Pharma Inc. Antifungal pharmaceutical composition
US9968591B2 (en) 2007-09-05 2018-05-15 Pola Pharma Inc. Antifungal composition
WO2018185557A1 (en) * 2017-04-03 2018-10-11 The Center For Digestive Diseases Administration of antibiotic compounds for the treatment of streptococcal infections for the treatment of psoriasis
US10130610B2 (en) 2009-04-09 2018-11-20 Pola Pharma Inc. Antimycotic pharmaceutical composition

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946137B2 (en) * 2001-10-19 2005-09-20 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61291520A (ja) * 1985-06-19 1986-12-22 Daigo Eiyou Kagaku Kk エリスロマイシン脂肪乳剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87219A0 (en) * 1987-08-07 1988-12-30 Abbott Lab Erythromycin formulations for oral administration
US5338761A (en) * 1988-09-29 1994-08-16 Shiseido Company Ltd. Emulsified composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61291520A (ja) * 1985-06-19 1986-12-22 Daigo Eiyou Kagaku Kk エリスロマイシン脂肪乳剤

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6565859B1 (en) 1993-05-27 2003-05-20 Novartis Ag Galenical formulations
DE4418115B4 (de) * 1993-05-27 2009-07-23 Novartis Ag Galenische Formulierungen
GB2278780B (en) * 1993-05-27 1998-10-14 Sandoz Ltd Macrolide formulations
DE4447972B4 (de) * 1993-05-27 2007-12-27 Novartis Ag Galenische Formulierungen
US5932243A (en) * 1993-05-27 1999-08-03 Novartis Ag Galenical formulations
GB2278780A (en) * 1993-05-27 1994-12-14 Sandoz Ltd Macrolide antibiotic emulsions
US7025975B2 (en) 1993-05-27 2006-04-11 Novartis Ag Galenical formulations
WO1995026191A1 (de) * 1994-03-26 1995-10-05 Boehringer Ingelheim Vetmedica Gmbh Injizierbare lösungen von dirithromycin
EP0758549A1 (en) * 1994-04-26 1997-02-19 Nobuhiro Narita Medicinal composition as a remedy for nonsmall cell lung cancer
EP0758549A4 (en) * 1994-04-26 1997-07-02 Nobuhiro Narita MEDICAL COMPOSITION AS A MEDICINE FOR NON-SMALL CELL CANCER
US5955467A (en) * 1995-06-05 1999-09-21 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of poorly water soluble camptothecin analogues and NMP
US5958937A (en) * 1995-06-05 1999-09-28 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of poorly water soluble camptothecin analogues and NMP
US5880133A (en) * 1995-06-05 1999-03-09 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of highly lipophilic camptothecin derivatives
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6017948A (en) * 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
WO2003049716A1 (en) * 2001-12-13 2003-06-19 Ranbaxy Laboratories Limited Stable topical formulation of clarithromycin
WO2005016308A1 (en) * 2003-08-06 2005-02-24 Sd Pharmaceuticals, Inc. Macrolides containing oil-in-water emulsions
US7871632B2 (en) 2004-07-12 2011-01-18 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US8026250B2 (en) 2004-07-12 2011-09-27 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US8222268B2 (en) 2004-07-12 2012-07-17 Adventrx Pharmaceuticals, Inc. Methods for reducing vein irritation
US8349882B2 (en) 2006-03-08 2013-01-08 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
US8268876B2 (en) 2006-03-08 2012-09-18 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
US9480678B2 (en) 2007-09-05 2016-11-01 Pola Pharma Inc. Antifungal pharmaceutical composition
US8513296B2 (en) 2007-09-05 2013-08-20 Pola Pharma Inc. Pharmaceutical composition
US9968591B2 (en) 2007-09-05 2018-05-15 Pola Pharma Inc. Antifungal composition
US10130610B2 (en) 2009-04-09 2018-11-20 Pola Pharma Inc. Antimycotic pharmaceutical composition
US9050271B2 (en) 2009-04-09 2015-06-09 Pola Pharma Inc. Antimycotic pharmaceutical composition
US8952044B2 (en) 2009-08-25 2015-02-10 Pola Pharma Inc. Antimycotic pharmaceutical composition
KR20160079781A (ko) 2013-11-08 2016-07-06 액티버스 파마 컴퍼니 리미티드 매크롤라이드계 항균제의 나노미립자를 함유하는 수성 현탁액제
WO2015068397A1 (ja) 2013-11-08 2015-05-14 株式会社アクティバスファーマ マクロライド系抗菌剤のナノ微粒子を含有する水性懸濁液剤
US10792248B2 (en) 2013-11-08 2020-10-06 Activus Pharma Co., Ltd. Aqueous suspension preparation comprising nanoparticles of macrolide antibacterial agent
KR20210054068A (ko) 2013-11-08 2021-05-12 액티버스 파마 컴퍼니 리미티드 매크롤라이드계 항균제의 나노미립자를 함유하는 수성 현탁액제
KR102345084B1 (ko) 2013-11-08 2021-12-29 액티버스 파마 컴퍼니 리미티드 매크롤라이드계 항균제의 나노미립자를 함유하는 수성 현탁액제
WO2018185557A1 (en) * 2017-04-03 2018-10-11 The Center For Digestive Diseases Administration of antibiotic compounds for the treatment of streptococcal infections for the treatment of psoriasis

Also Published As

Publication number Publication date
JPH04505762A (ja) 1992-10-08
IL94516A (en) 1994-12-29
GR1002177B (en) 1996-03-07
EP0473707A4 (en) 1992-12-09
AU5811090A (en) 1990-12-18
CA2056445A1 (en) 1990-11-27
AU630469B2 (en) 1992-10-29
IL94516A0 (en) 1991-03-10
NZ233827A (en) 1991-06-25
JP2963537B2 (ja) 1999-10-18
EP0473707A1 (en) 1992-03-11
GR900100402A (el) 1991-10-10
KR920700655A (ko) 1992-08-10

Similar Documents

Publication Publication Date Title
AU630469B2 (en) Injectable clarithromycin composition
US5085864A (en) Injectable formulation for lipophilic drugs
EP0215313B1 (en) Emulsion compositions for the parenteral and/or oral administration of sparingly water soluble ionizable hydrophobic drugs
EP0327280B1 (en) Cyclosporin compositions
US5474979A (en) Nonirritating emulsions for sensitive tissue
NO844144L (no) Legemiddeltilberedning
JP2002527465A (ja) ペンテチン酸塩を含有するプロポフォール組成物
US20080132582A1 (en) Propofol formulation containing reduced oil and surfactants
JPS6144809A (ja) ４−ビフエニリル酢酸系化合物含有脂肪乳剤
US4849451A (en) Fat emulsion containing prostaglandin
JP2007501253A (ja) マクロライド含有水中油エマルジョン
EP0426029A1 (en) Injectable formulation for lipophilic drugs
EP0257454A1 (en) Oil-in-water type fat emulsion of 1-[2-(2,4-dichlorophenyl)-3-methyl-1-pentenyl]-1H-imidazole
JP2939082B2 (ja) 安定なビタミンａパルミテート及びビタミンｅ類可溶化点眼剤
EP0418004B1 (en) Preventive and therapeutic agent for hepatitis
JP3132085B2 (ja) 脂肪乳剤
EP1377315B1 (en) Pharmaceutical compositions of rapmycins
Levy et al. Efficacy evaluation of a novel submicron amphotericin B emulsion in murine candidiasis
AU737983B2 (en) An oil composition of dihydropolyprenols
JPH06227990A (ja) 安定な局所的処方剤
WO2000059472A1 (en) Propofol compositions containing preservative additives
JPH1160491A (ja) アムホテリシンｂ含有製剤
KR20000073825A (ko) 클라리스로마이신-함유 건조리포좀 조성물
JP2002020268A (ja) 脂溶性物質含有内服液剤

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1990909022

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2056445

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 1990909022

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1990909022

Country of ref document: EP