WO1989002730A1 - Recipient pour stockage separe - Google Patents

Recipient pour stockage separe Download PDF

Info

Publication number
WO1989002730A1
WO1989002730A1 PCT/JP1988/000980 JP8800980W WO8902730A1 WO 1989002730 A1 WO1989002730 A1 WO 1989002730A1 JP 8800980 W JP8800980 W JP 8800980W WO 8902730 A1 WO8902730 A1 WO 8902730A1
Authority
WO
WIPO (PCT)
Prior art keywords
piercing
chamber
storage
container
separation
Prior art date
Application number
PCT/JP1988/000980
Other languages
English (en)
Japanese (ja)
Inventor
Norisuke Kira
Kazuhiko Sudo
Original Assignee
Terumo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Kabushiki Kaisha filed Critical Terumo Kabushiki Kaisha
Priority to DE3850781T priority Critical patent/DE3850781T2/de
Priority to EP88908369A priority patent/EP0395758B1/fr
Priority to DE1988908369 priority patent/DE395758T1/de
Publication of WO1989002730A1 publication Critical patent/WO1989002730A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2027—Separating means having frangible parts

Definitions

  • the present invention relates to a container for separating and storing two or more substances, and more particularly, to a method for dissolving a solute in a storage chamber in a solute storage member storing a solute such as a powdery or liquid drug.
  • the present invention relates to a separation container in which a solvent such as a liquid can be sent, and a solute such as a powdery or liquid drug can be mixed and dissolved aseptically.
  • solute drugs are dissolved in a solvent dissolution medium just before being injected intravenously into a patient. There are many reasons for this, but the typical one is that once a drug is dissolved in a lysis solution, its effectiveness can only be maintained for a short period of time. For this reason, when administering powdered drugs such as antibiotics conventionally contained in a solute container forming a solute container village to a patient, the following method is used in conventional methods. Methods were generally adopted.
  • an appropriate amount of a physiological saline solution, a 5% glucose injection solution or the like is sucked with a syringe, and the powdered drug is contained in the solute container. Then, the needle of the syringe was pierced, the lysing solution was injected, and after the powdered drug was dissolved, the patient was again sucked with the syringe and injected into the patient.
  • a second example is containing a powdered drug, as disclosed in, for example, Japanese Patent Publication No. 59-500600
  • the solute container and the bag enclosing the dissolving solution are aseptically connected by an adapter forming a communicating means holding the piercing needle and the breakage portion, and the dissolving solution is stored with the powdered drug.
  • the drug solution was injected into the solute container, and the powdered drug was dissolved. This solution was returned to the bag again, and the patient was infused intravenously.
  • a sleeve formed of a flexible material that is arranged so as to surround the piercing needle and that expands and contracts in response to the movement of the needle is shown.
  • a solute vessel containing a powdered drug and a lysing solution as disclosed, for example, in U.S. Pat. No. 4,844,920.
  • an assembling bag which are aseptically connected to each other by a needle or an adabuta having a broken part, and the lysing solution is put into the solute container. Dissolve the powdered drug, then use the empty bag as an air vent to completely dissolve the antibiotics, etc., return the solution back to the bag, and inject the solution intravenously into the patient.
  • the above-mentioned conventional example still has various problems to be solved. That is, in the case of the first example, the solution, the syringe, and the container containing the powdered drug are separately prepared, and these operations are performed in a facility such as a clean bench capable of performing aseptic work. Operation complexity, There is also a risk of bacterial contamination.
  • a sterile facility such as a clean bench is not required, the piercing portion provided in the solute container containing the powdered drug and the piercing needle on the adapter are not required.
  • the solute container and the adapter are connected incorrectly, or the operator is required when necessary, because there is no means to positively maintain the separated state during normal non-use.
  • problems such as the complicated connection operation and the complicated structure of the adapter.
  • the piercing portion provided on the solute container and the piercing needle on the adapter are actively separated when not in use. There was a danger of accidentally piercing the connection between the solute container and the adabuta, because there was no means to maintain the condition. Further, in the case S of this example, the liquid in which the powdered drug is dissolved enters the empty bag during the use operation, and the liquid is returned to the bag containing the dissolved liquid again.
  • problems such as the difficulty of
  • the present invention solves the above-mentioned problems of the conventional separation and storage container, and has a simple structure.
  • the piercing section of one of the two receiving members and the piercing element that can pierce the piercing element when necessary are actively kept apart from each other, and the piercing section is operated when used.
  • the user easily and reliably performs the above-described piercing operation, and aseptically connects the chamber of one of the storage members and the chamber of the other storage member that contains the other substance to perform the required mixing (dissolution).
  • An object of the present invention is to provide a medicine container which can perform an action and is easy to operate.
  • a first housing member having an outlet and a first chamber in which a first substance is accommodated, and a second accommodation member which accommodates a second substance and has a piercing portion.
  • a stimulating element that allows the piercing portion of the second housing member to pierce with a predetermined piercing resistance when necessary, and a piercing element that extends into the first chamber, and
  • a closing portion that closes communication between the first chamber and the piercing element and is separable when required, and has a closing portion that allows the communication to be performed when the first chamber is separated; It is assumed that there is a communication means' for aseptically communicating between the first chamber and the second chamber, and a further configuration.
  • the present invention provides a method for controlling the communication between a second housing member and a first chamber, wherein the second housing member surrounds the stimulating element and is always pierced by the second housing member.
  • the piercing element and the piercing element are held in the chick state, and when an external force of a predetermined value or more along the axial direction of the piercing element is applied, the piercing element is plastically deformed along the axial direction. Then, the piercing part is allowed to pierce the piercing element and the holding means for maintaining the piercing state is provided, and the piercing element is stimulated by the piercing element. It has been made Later, by separating the closing part of the communication means, aseptic communication between the first chamber and the second chamber is performed through the communication means. It proposes a separate storage container.
  • the holding means can positively hold the piercing element of the second housing member and the piercing element of the communication means in a separated state, It is possible to prevent accidentally performing a piercing operation.
  • the external force that is, the force applied by the operator
  • the holding means is plastically deformed. As a result, the piercing operation is performed, and the piercing state is securely held by the plastically deformed holding means.
  • the separation and storage container of the present invention has a small number of components, has a simple structure, and has a sterile condition because the communicating portion forming the communicating means is sealed. If the external force in the axial direction does not apply to the guide cover serving as the holding means, the guide force bar will not be plastically deformed, so the piercing needle that forms the piercing element of the communicating part There is almost no chance of accidentally piercing the piercing section. However, since there are no empty knocks, the melting operation is easy.
  • the predetermined value of the external force for plastically deforming the holding means is set in the dog based on the piercing resistance of the piercing element to the piercing portion.
  • 3 K gf or more preferably in the range of 3 K gf to 5 K gf, particularly preferred. It is assumed to be 3.5 K gf.
  • the holding means is constituted by a guide cover integrally formed in a bellows shape by blow molding of a thermoplastic resin, for example.
  • the outwardly protruding ridges of the guide cover in the form of a jar are thinner and easier than the valleys that are recessed inward. Since it can be formed into a shape, suitable characteristics as a guide cover can be obtained.
  • FIGS. 1 to 4 show an embodiment of the present invention.
  • FIG. 1 is a perspective view of a medicine container covered with a packaging material
  • FIG. FIG. 3 is an enlarged perspective view of the medicine container in the state
  • FIG. 3 is an enlarged vertical sectional view of the medicine container shown in FIG. a)
  • (b), (c) and (d) are explanatory views showing the usage state of the medicine container, respectively
  • FIG. 5 is a perspective view of the medicine container showing another embodiment of the present invention. .
  • FIG. 1 is a perspective view of a drug storage container forming a separation storage container of the present invention covered with a packaging material
  • FIG. 2 is a perspective view of the drug storage container. It is.
  • 1 and 1 indicate a drug container
  • the drug container 1 is made of a flexible synthetic resin sheet
  • the storage chamber 2 and the storage chamber 3 are independent of each other. And are integrally formed.
  • the medicine container 1 is entirely covered with a rectangular packaging material 4, and is a solvent described below, which is sealed in the storage chamber 2 by the packaging material 4. The stability of the dissolution solution S is guaranteed.
  • Dissolution liquid S for example, physiological
  • a discharge port 5 is provided at the lower part of the storage chamber 2, and the discharge port 5 is further covered with an aluminum tube 6, so that the solution S does not go outside. ing .
  • Boundary part 1 b is shaped
  • a communication section 9 is provided as communication means having a bottle needle or a piercing needle 8 forming a communication element.
  • the communicating portion has a cylindrical shape in which an end in the storage chamber 2 is closed, and a notch is formed in an inner peripheral surface so that the closing portion 7 is easily broken by an external force.
  • the bottle needle 8 is provided with a return blade 8a, which makes it difficult for the piercing portion 11 to be described later to be pulled out.
  • the middle part of the cylindrical communication part 9 is held at the boundary part 1b.
  • Glass or resin solute storage member 3 ⁇ 4 formed vial or solute container 10 is stored in storage room 3, and powder 1 is contained in chamber 1 Ob in this vial 10.
  • the antibiotic A which is a solute, enters.
  • a rubber stopper 11 is inserted into the mouth 10a of this nodal 10 to form a piercing portion through which the above-mentioned bottle needle 8 can be pierced, and is fixed by a mouthpiece 1 la ( ( Figure 3).
  • a guide cover 12 in the form of a bellows is provided between the mouth 10a of the vial 10 and the bottom 3a of the storage chamber 3 formed by the boundary lb in FIG. I have.
  • the guides 1 and 2 constitute the holding means.
  • the guide cover 12 applies an external force greater than a predetermined value by an operator's hand from the outside in the axial direction of the bottle needle 8, that is, the bottle needle 8 of the communication portion 9 is connected to the vial 10.
  • a material that plastically deforms when it is put in the direction that penetrates the rubber plug 11 fitted into the mouth 10a for example, a metal material such as aluminum or a thermoplastic material such as polypropylene. It is composed of resin.
  • the bottle needle 8 is held at a separated position as shown in FIG. 3, and the rubber stopper 11 can be pierced.
  • the lysing solution S does not accidentally enter the vial 10.
  • the guide cover 12 guides the bottle needle 8 to prevent the bottle needle 8 from being accidentally pierced except for the rubber stopper 11. Further, if the guide cover 12 is deformed and contracted, since it is plastically deformed, the deformed state is maintained, so that the piercing state of the bottle needle 8 is reliably maintained. As shown in FIG. 3, one end 12a of the guide cover 12 surrounds the mouth 10a of the dial and the rubber stopper 11 as well as the Fixed to dial 10. The other end 12b of the guide canopy 12 extends in the axial direction while surrounding the bottle needle 8 and is fixed to the bottom 3a.
  • the peaks of the guide cover 12 that protrude outward in the radial direction are formed. Since the portion 12c is thinner than the valley portion 12d which is recessed inward in the radial direction, better stretchability than the guide cover 12 can be obtained.
  • the prescribed value of the external force that causes the guide cover 12 to plastically deform is equivalent to the resistance when the needle 8 pierces the rubber stopper 11 of the nominal 10, that is, the piercing resistance. Or higher.
  • the piercing resistance is about 3 Kgf. Therefore, the predetermined value of the guide cover 2 is set to 3 Kgf as the minimum value in this case. Good.
  • the upper limit of the predetermined value corresponds to the external force that can be applied by the operator, but the predetermined value is set in the range of 3 Kgf to 5 Kgf in consideration of the easiness of operation, and particularly preferably 3 Kgf. It is 5 Kgf.
  • the guide cover 1 2. is formed of a metal material, it is preferable to use a method of press molding.
  • the packaging material 4 shown in FIG. 1 that covers the medicine container 1 is removed.
  • the bottle needle 8 of the communication part 9 is guided by a predetermined external force into the rubber stopper 11 fitted to the boiler 10 Oa of the neutral 10 housed in the storage room 3.
  • the cover 12 ⁇ is plastically deformed in the axial direction and contracted by being plastically pierced (see FIG. 4 (a)).
  • the closed portion 7 of the communication portion 9 is not broken or separated and the vial 10
  • the reservoir and the storage chamber 2 are communicated via the communication part 9 (see FIG. 4 (b)).
  • the dissolving solution S sealed in the storage chamber 2 is injected into the vial 10 via the communication section 9 with the storage chamber 2 up and the vial 10 down. Dissolve the antibiotic A in the vial 10 in powder. The solution obtained by dissolving the powdered antibiotic A is returned to the storage chamber 2 with the vial 10 upward and the storage chamber 2 downward. The above procedure is repeated to completely dissolve the antibiotic A in the powder in the vial 10 (see Fig. 4 (c)).
  • the hole 1a of the medicine container 1 is passed through the hanger 14 of the infusion stand 13 and the medicine container 1 is hung on the hanger 14 (see FIG. 4 (d)). That is, the medicine container 1 is hung on the hanger 14 with the storage chamber 2 containing the liquid in which the powdered antibiotic A is dissolved down.
  • the infusion set 15 includes a bottle needle 1 _ 6 piercing the discharge ⁇ 5, a drip tube 1, a clamp 18, and an intravenous needle 19 pierced into a blood vessel or the like of the patient M. And a tube 20 connecting them.
  • the IV needle of the infusion set 15 19 is pierced into the blood vessel or the like of the patient M, the bottle needle 16 is removed from the aluminum cap 6 placed on the discharge port 5, and pierced into the discharge port 5 to clean the bottle. Adjust the method 18 and inject the liquid in which the antibiotic A in the powder in the storage chamber 2 of the medicine container 1 is dissolved into the patient M by intravenous drip.
  • the packaging material 4 (Fig. 1) was prepared after the antibiotic A was dissolved in the dissolution solution S by the piercing operation described above, and before being set in the infusion stand 13. You can remove it.
  • FIG. 5 shows another embodiment of the present invention, and since it has substantially the same configuration as the embodiment shown in FIG. 2, the same parts are denoted by the same symbols and their description is omitted. I do.
  • the medicine storage container 1 has a flexible synthetic resin sheet in which the independent storage chamber 2 and the storage chamber 3 are integrally formed.
  • the storage room 2 and the storage room 30 are integrated.
  • the storage chamber 30 has a cylindrical shape with a janitor-shaped portion 3'0a formed on the outer peripheral surface.
  • a hanging device 21 is attached to the end face of the storage room 3 ⁇ .
  • the other configuration and operation are the same as those in the embodiment shown in FIG.
  • 30a ensures that the guide cover 12 is plastically deformed in the axial direction, and the piercing state of the penetration element 8 is confirmed. It has effects such as the following.
  • the configuration of the storage chamber 2 and the solute container 10 disclosed in the above embodiment is reversed, and In addition to the configuration in which a piercing portion is provided and a piercing element is provided on the solute container side, various modifications are possible without departing from the gist of the present invention. However, it is not limited to this.
  • the separation container according to the present invention is preferably used as an infusion bag for connecting a transfusion set to inject a drug intravenously into a patient. It can be widely used in fields where powdery or liquid solutes need to be aseptically dissolved in solvents.
  • the present invention is applicable not only to the field of medicine for treating drugs and the like, but in the embodiment, the drug container is disclosed as an example of the separation container of the present invention. Therefore, the scope of the present invention is not limited to those related to “drugs” in a narrow sense.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Une section de communication (9) possède une aiguille de perçage (8) servant à transpercer une section perçable (11) d'un récipient de soluté (10) contenant par exemple un médicament, et une section de fermeture (7) qui est séparable à l'intérieur d'une chambre de stockage (2) contenant un solvant. La section de communication (9) est disposée entre le récipient de soluté et la chambre de stockage, et un couvercle de guidage en forme de soufflet (12) recouvre l'aiguille de perçage. Cet agencement permet de maintenir l'aiguille séparée de la section perçable lorsque le récipient n'est pas utilisé; pendant l'utilisation, le couvercle de guidage subit une déformation plastique sous l'effet d'une force externe dépassant une valeur déterminée, ce qui permet de commencer et d'entretenir l'action de perçage. Grâce à la séparation successive de la section de fermeture, le soluté et le solvant sont mélangés à travers la section de communication, ce qui garantit une dissolution stérile.
PCT/JP1988/000980 1987-09-28 1988-09-27 Recipient pour stockage separe WO1989002730A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE3850781T DE3850781T2 (de) 1987-09-28 1988-09-27 Behälter für getrennte lagerung.
EP88908369A EP0395758B1 (fr) 1987-09-28 1988-09-27 Recipient pour stockage separe
DE1988908369 DE395758T1 (de) 1987-09-28 1988-09-27 Behaelter fuer getrennte lagerung.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62/243080 1987-09-28
JP24308087A JPS6485653A (en) 1987-09-28 1987-09-28 Drug receiving container

Publications (1)

Publication Number Publication Date
WO1989002730A1 true WO1989002730A1 (fr) 1989-04-06

Family

ID=17098480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1988/000980 WO1989002730A1 (fr) 1987-09-28 1988-09-27 Recipient pour stockage separe

Country Status (4)

Country Link
EP (1) EP0395758B1 (fr)
JP (1) JPS6485653A (fr)
DE (1) DE3850781T2 (fr)
WO (1) WO1989002730A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003775A1 (fr) * 1988-10-11 1990-04-19 Fresenius Ag Recipient pour la conservation separee et sterile d'au moins deux substances et pour leur melange
US5409141A (en) * 1992-03-13 1995-04-25 Nissho Corporation Two component mixing and delivery system
CN103702651A (zh) * 2011-08-11 2014-04-02 费森尤斯医疗德国有限公司 用于透析的容器
US8967374B2 (en) 2006-05-18 2015-03-03 Dr. Py Institute Llc Delivery device with separate chambers connectable in fluid communication when ready for use, and related method
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9527627B2 (en) 2011-05-18 2016-12-27 Fresenius Medical Care Deutschland Gmbh Connector for dialysis container, container equipped with such connector, manufacturing and filling method for such connectors and containers
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US11109849B2 (en) 2012-03-06 2021-09-07 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411499A (en) * 1988-01-25 1995-05-02 Baxter International Inc. Needleless vial access device
JPH077965Y2 (ja) * 1990-11-14 1995-03-01 昭和電工株式会社 輸液バッグ
US5776125A (en) 1991-07-30 1998-07-07 Baxter International Inc. Needleless vial access device
IT1251658B (it) * 1991-10-07 1995-05-19 Inge Spa Dispositivo monouso preferibilmente per impiego igienico-sanitario.
US5352191A (en) * 1991-10-25 1994-10-04 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
JPH05212090A (ja) * 1992-02-04 1993-08-24 Material Eng Tech Lab Inc 輸液容器
JP3256583B2 (ja) * 1992-12-10 2002-02-12 株式会社リコー 電子写真用トナー及びその製法
DE4314090C2 (de) * 1993-04-29 1997-09-04 Wolfgang Dr Vilmar Medizinisches Besteck zur Herstellung einer Medikamentenlösung
US5547797A (en) * 1993-08-05 1996-08-20 Minolta Co., Ltd. Developer for developing electrostatic latent images
ES1037919Y (es) * 1997-07-16 1998-11-01 Inibsa Lab Cartucho contenedor de dos liquidos.
US5976115A (en) * 1997-10-09 1999-11-02 B. Braun Medical, Inc. Blunt cannula spike adapter assembly
US5989237A (en) 1997-12-04 1999-11-23 Baxter International Inc. Sliding reconstitution device with seal
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
AR021220A1 (es) 1998-09-15 2002-07-03 Baxter Int DISPOSITIVO DE CONEXIoN PARA ESTABLECER UNA COMUNICACIoN FLUíDA ENTRE UN PRIMER RECIPIENTE Y UN SEGUNDO RECIPIENTE.
DE10005813A1 (de) * 2000-02-10 2001-08-23 Wolfgang Vilmar Mischbesteck
EP2289566A1 (fr) * 2001-12-21 2011-03-02 Ferrosan Medical Devices A/S Dispositif médical contenant un agent hémostatique et kit contenant le dispositif médical
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
WO2004053051A2 (fr) 2002-12-11 2004-06-24 Ferrosan A/S Tampons a prelevements a base de gelatine
US7048724B2 (en) * 2002-12-17 2006-05-23 Denver Biomedicals, Inc. Device for withdrawing body fluids
EP1670409A1 (fr) 2003-09-30 2006-06-21 Coloplast A/S Dispositif de soins de blessure
US7641851B2 (en) 2003-12-23 2010-01-05 Baxter International Inc. Method and apparatus for validation of sterilization process
EP1713521B1 (fr) 2004-01-30 2010-07-28 Ferrosan A/S Pulverisations et compositions hemostatiques
DE102004021990B3 (de) * 2004-05-04 2005-11-10 Fresenius Kabi Deutschland Gmbh Medizinischer Behälter zum Verabreichen einer Flüssigkeit aus einer Trägerlösung und einem zugemischten Medikament
US7520919B2 (en) 2004-06-22 2009-04-21 Gambro Lundia Ab Transducer-protector device for medical apparatus
KR20070046093A (ko) 2004-07-09 2007-05-02 훼로산 아크티에 셀스카브 히알루론산을 포함하는 지혈 조성물
KR20140108306A (ko) * 2011-12-29 2014-09-05 가부시키가이샤 오츠카 세이야쿠 고죠 노출방지 커버, 이것을 구비한 노출방지 커버 모듈, 약액 공급 시스템 및 약액 공급 방법
ES2629294T3 (es) 2014-07-02 2017-08-08 Paolo Gobbi Frattini S.R.L. Envase flexible con una cámara estéril y hermética para la reconstitución y la administración de sustancias medicinales o nutricionales fluidas instilables en el cuerpo de un paciente
US9456956B1 (en) * 2015-09-29 2016-10-04 Siemens Medical Solutions Usa, Inc. Aseptic assembling of pharmaceutical containers
JP6642339B2 (ja) * 2016-08-30 2020-02-05 ニプロ株式会社 透析液分析用標準試薬キット
US20190192556A1 (en) * 2016-08-30 2019-06-27 Nipro Corporation Standard reagent kit for analysis of dialysis fluid, and aqueous solutions for standard reagent, dialysis fluid and substitution fluid for artificial kidney
JP7003493B2 (ja) * 2017-08-28 2022-02-04 ニプロ株式会社 透析液分析用標準試薬キット
EP3427781A3 (fr) * 2017-07-11 2019-05-01 Pharma Resources GmbH Médicament et système de dispositif pour des thérapies d'aérosol sous pression dans un espace creux d'un mammifère
US11446209B2 (en) * 2018-04-13 2022-09-20 Fresenius Kabi Ab Arrangement and method for providing a formulation for parenteral nutrition
EP3773411A1 (fr) * 2018-04-13 2021-02-17 Fresenius Kabi AB Récipient pour système de mélange, système de mélange pour nutrition parentérale et procédé de mélange

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS561559Y2 (fr) * 1976-08-12 1981-01-14
JPS57500412A (fr) * 1979-11-05 1982-03-11
JPH0523551B2 (fr) * 1985-05-14 1993-04-05 Mitsubishi Electric Corp
JPH0614708Y2 (ja) * 1989-10-17 1994-04-20 ホシザキ電機株式会社 飲料の保温・保冷装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4589879A (en) * 1983-11-04 1986-05-20 Baxter Travenol Laboratories, Inc. Cannula assembly having closed, pressure-removable piercing tip

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS561559Y2 (fr) * 1976-08-12 1981-01-14
JPS57500412A (fr) * 1979-11-05 1982-03-11
JPH0523551B2 (fr) * 1985-05-14 1993-04-05 Mitsubishi Electric Corp
JPH0614708Y2 (ja) * 1989-10-17 1994-04-20 ホシザキ電機株式会社 飲料の保温・保冷装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0395758A4 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003775A1 (fr) * 1988-10-11 1990-04-19 Fresenius Ag Recipient pour la conservation separee et sterile d'au moins deux substances et pour leur melange
US5409141A (en) * 1992-03-13 1995-04-25 Nissho Corporation Two component mixing and delivery system
US8967374B2 (en) 2006-05-18 2015-03-03 Dr. Py Institute Llc Delivery device with separate chambers connectable in fluid communication when ready for use, and related method
US9902508B2 (en) 2006-05-18 2018-02-27 Dr. Py Institute Llc Delivery device with separate chambers connectable in fluid communication when ready for use, and related method
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9527627B2 (en) 2011-05-18 2016-12-27 Fresenius Medical Care Deutschland Gmbh Connector for dialysis container, container equipped with such connector, manufacturing and filling method for such connectors and containers
CN103702651A (zh) * 2011-08-11 2014-04-02 费森尤斯医疗德国有限公司 用于透析的容器
CN103702651B (zh) * 2011-08-11 2016-08-17 费森尤斯医疗德国有限公司 用于透析的容器
US10022299B2 (en) 2011-08-11 2018-07-17 Fresenius Medical Care Deutschland Gmbh Container for dialysis
US11109849B2 (en) 2012-03-06 2021-09-07 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US9999703B2 (en) 2012-06-12 2018-06-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US10799611B2 (en) 2012-06-12 2020-10-13 Ferrosan Medical Devices A/S Dry haemostatic composition
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10595837B2 (en) 2013-06-21 2020-03-24 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US11103616B2 (en) 2013-12-11 2021-08-31 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Also Published As

Publication number Publication date
DE3850781T2 (de) 1995-02-23
EP0395758A1 (fr) 1990-11-07
EP0395758A4 (en) 1990-12-27
JPS6485653A (en) 1989-03-30
DE3850781D1 (de) 1994-08-25
EP0395758B1 (fr) 1994-07-20
JPH0236261B2 (fr) 1990-08-16

Similar Documents

Publication Publication Date Title
WO1989002730A1 (fr) Recipient pour stockage separe
JP4838304B2 (ja) 中空針を有する容器
EP0079326A2 (fr) Dispositif de transfert de fluide
HU207664B (en) Joining shape anf throwable equipment containing the same
JPH06239352A (ja) 溶解液注入セット
WO1993025175A1 (fr) Recipient a usage medical
JPH0852196A (ja) 薬剤連結口を有する輸液容器
US5649907A (en) Device for dissolving and delivering a drug in a transfusion liquid
US8133204B1 (en) Medicament dispenser
US3938518A (en) Syringe attachment device
US6764463B1 (en) Method and needleless apparatus for the storage of a first substance followed by subsequent mixing with a second substance and transfer without ambient air incursion
KR20200005600A (ko) 약물 용기를 위한 충전-마감 캐리어
JP5977734B2 (ja) 穿刺針一体型アダプタおよび穿刺針一体型アダプタの使用方法
DK201500380A1 (en) Intravenous Bag
JP2732610B2 (ja) 医療用液体収納容器
JP3003949B2 (ja) 医療用容器
JP2004290218A (ja) 薬剤入り多室バッグ及びポート部材
KR101118835B1 (ko) 약제용기 일체형 수액용기
WO1996025136A1 (fr) Recipient pour transfusions
JP3025851B2 (ja) 個別密封容器に収容した２種薬剤の無菌保持混合装置
US10980709B2 (en) Device for reconstituting and administering drugs
JPH04329957A (ja) 個別密封容器に収容した２種薬剤の無菌保持混合装置
JPH1128243A (ja) 医療用容器
ES2954845T3 (es) Bomba compacta de recarga rápida de seguridad para la administración de fármacos
JP4158446B2 (ja) 既充填蛇腹容器

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BE DE FR GB IT SE

WWE Wipo information: entry into national phase

Ref document number: 1988908369

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1988908369

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1988908369

Country of ref document: EP