WO1987003869A3 - Dervies pharmaceutiquement actifs d'acides glutamiques et aspartiques - Google Patents

Dervies pharmaceutiquement actifs d'acides glutamiques et aspartiques Download PDF

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Publication number
WO1987003869A3
WO1987003869A3 PCT/EP1986/000724 EP8600724W WO8703869A3 WO 1987003869 A3 WO1987003869 A3 WO 1987003869A3 EP 8600724 W EP8600724 W EP 8600724W WO 8703869 A3 WO8703869 A3 WO 8703869A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
polypeptydes
carbon atoms
active
glutamic
Prior art date
Application number
PCT/EP1986/000724
Other languages
English (en)
Other versions
WO1987003869A2 (fr
Inventor
Francesco Makovec
Rolando Chiste
Claudio Lucio Rovati
Angelo Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Priority to DE8787901263T priority Critical patent/DE3679333D1/de
Priority to AT87901263T priority patent/ATE63539T1/de
Publication of WO1987003869A2 publication Critical patent/WO1987003869A2/fr
Publication of WO1987003869A3 publication Critical patent/WO1987003869A3/fr
Priority to DK425487A priority patent/DK169666B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Nouveaux dérivés d'acides D,L-glutamiques et d'acides D,L-aspartiques de formule (I) dans laquelle n vaut 1 ou 2, R1 est un groupe phényle monosubstitué ou bisubstitué par des halogènes tels que du chlore et du fluore ou par un groupe méthyle dans les positions 3 et 4, et R2 est constitué d'un groupe d'alkyle linéaire ramifié comportant de 4 à 7 atomes de carbone (de préférence un groupe pentyle), et R3 est un groupe alkyle possédant de 3 à 6 atomes de carbone au total et contenant un atome d'oxygène sous forme d'une liaison d'éther, comme par exemple les groupes 2-éthoxyéthyle, 3-méthoxypropyle, 3-éthoxypropyle etc ou sous forme d'un groupe hydroxyle tel que par exemple 3-hydroxypropyle etc. Ces composés présentent une activité antagoniste vis-à-vis des polypeptides bio-actifs et s'utilisent en particulier dans le traitement des maladies des voies digestives, du système nerveux central et de l'anorexie et de toutes les affections (tumeurs par exemple) dans lesquelles sont impliqués des polypeptides bio-actifs exogènes ou endogènes.
PCT/EP1986/000724 1985-12-17 1986-12-08 Dervies pharmaceutiquement actifs d'acides glutamiques et aspartiques WO1987003869A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE8787901263T DE3679333D1 (de) 1985-12-17 1986-12-08 Pharmazeutisch aktive derivate von glutamin- und asparaginsaeuren.
AT87901263T ATE63539T1 (de) 1985-12-17 1986-12-08 Pharmazeutisch aktive derivate von glutaminund asparaginsaeuren.
DK425487A DK169666B1 (da) 1985-12-17 1987-08-14 Farmaceutisk aktive derivater af D,L-glutamin- og D,L-asparaginsyre, fremgangsmåde til deres fremstilling samt farmaceutisk sammensætning og sammensætning til anvendelse ved husdyrbrug indeholdende sådanne derivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT68062A/85 1985-12-17
IT8568062A IT1215169B (it) 1985-12-17 1985-12-17 Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
WO1987003869A2 WO1987003869A2 (fr) 1987-07-02
WO1987003869A3 true WO1987003869A3 (fr) 1987-08-13

Family

ID=11307569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000724 WO1987003869A2 (fr) 1985-12-17 1986-12-08 Dervies pharmaceutiquement actifs d'acides glutamiques et aspartiques

Country Status (13)

Country Link
US (1) US4769389A (fr)
EP (1) EP0286643B1 (fr)
JP (1) JPS62181246A (fr)
AU (1) AU595858B2 (fr)
CA (1) CA1269110A (fr)
DK (1) DK169666B1 (fr)
ES (1) ES2081777A6 (fr)
GR (1) GR862921B (fr)
IE (1) IE59534B1 (fr)
IT (1) IT1215169B (fr)
PT (1) PT83952B (fr)
WO (1) WO1987003869A2 (fr)
ZA (1) ZA869460B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
IT1196849B (it) * 1986-12-16 1988-11-25 Rotta Research Lab Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
IT1217123B (it) * 1987-02-05 1990-03-14 Rotta Research Lab Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
US5105007A (en) * 1987-10-19 1992-04-14 Abbott Laboratories Phenylacetylglutamine (PAG) analytical test
EP0411668B2 (fr) * 1989-08-04 1998-11-11 MERCK SHARP & DOHME LTD. Antagonistes centraux de cholécystokinin pour le traitement des troubles psychiatriques
US5066828A (en) * 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
EP0617621A4 (fr) * 1991-12-20 1995-04-05 Merck Sharp & Dohme Antagonistes de la cholecystokinine centrale possedant une efficacite pharmaceutique.
GB9200420D0 (en) * 1992-01-09 1992-02-26 James Black Foundation The Lim Amino acid derivatives
US5716958A (en) 1994-10-27 1998-02-10 Tobishi Pharmaceutical Co., Ltd. Amino acid derivative having anti-CCK activity
EP1902014A2 (fr) * 2005-07-11 2008-03-26 Wyeth Inhibiteurs de glutamate aggrecanase
US7863330B2 (en) * 2006-06-14 2011-01-04 Rottapharm S.P.A. Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders
CN108912007B (zh) * 2018-06-20 2021-02-26 中国农业科学院兰州畜牧与兽药研究所 一种右氯谷胺的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803223A (en) * 1970-07-20 1974-04-09 Searle & Co 3-amino-n-substituted succinamic acids and intermediates thereto
GB2160869A (en) * 1984-06-25 1986-01-02 Rotta Research Lab Glutamic and aspartic acid derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1108819A (en) * 1964-07-31 1968-04-03 Rotta Research Lab Derivatives of 2-acylaminobicarboxylic acids and method for preparing same
US3465081A (en) * 1966-05-13 1969-09-02 Thompson Chem Co Hayward Method of controlling pestiferous organisms
AT293368B (de) * 1969-10-13 1971-10-11 Rotta Research Lab Verfahren zur Herstellung von N-Benzoyl-L-(D- oder DL)-glutaminsäure-l-amiden
US4243678A (en) * 1977-12-30 1981-01-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Acylhydrocarbylaminoalkanoic acids, compositions and uses
GB8704671D0 (en) * 1987-02-27 1987-04-01 Shell Int Research Glycine compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803223A (en) * 1970-07-20 1974-04-09 Searle & Co 3-amino-n-substituted succinamic acids and intermediates thereto
GB2160869A (en) * 1984-06-25 1986-01-02 Rotta Research Lab Glutamic and aspartic acid derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Chemical Society, Perkin Transactions 1, No. 19, 1975 (GB), R. BANKS et al., "Rearrangements and Cyclization of -Alkoxyalkyl- and -Phenoxyalkylcarbamoyl Chlorides", pages 1836-1840, see page 1837 *

Also Published As

Publication number Publication date
IT1215169B (it) 1990-01-31
JPS62181246A (ja) 1987-08-08
EP0286643B1 (fr) 1991-05-15
IT8568062A0 (it) 1985-12-17
PT83952A (en) 1987-01-01
JPH0543698B2 (fr) 1993-07-02
DK169666B1 (da) 1995-01-09
ES2081777A6 (es) 1996-03-01
GR862921B (en) 1987-04-27
ZA869460B (en) 1987-08-26
AU595858B2 (en) 1990-04-12
PT83952B (pt) 1989-06-30
US4769389A (en) 1988-09-06
WO1987003869A2 (fr) 1987-07-02
CA1269110A (fr) 1990-05-15
IE59534B1 (en) 1994-03-09
IE863233L (en) 1987-06-17
DK425487D0 (da) 1987-08-14
DK425487A (da) 1987-08-14
EP0286643A1 (fr) 1988-10-19
AU6949787A (en) 1987-07-15

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