IT8568062A0 - Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione - Google Patents
Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazioneInfo
- Publication number
- IT8568062A0 IT8568062A0 IT8568062A IT6806285A IT8568062A0 IT 8568062 A0 IT8568062 A0 IT 8568062A0 IT 8568062 A IT8568062 A IT 8568062A IT 6806285 A IT6806285 A IT 6806285A IT 8568062 A0 IT8568062 A0 IT 8568062A0
- Authority
- IT
- Italy
- Prior art keywords
- glutammic
- procedure
- preparation
- antagonist activity
- aspartic acids
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 150000001510 aspartic acids Chemical class 0.000 title 1
- 230000000975 bioactive effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8568062A IT1215169B (it) | 1985-12-17 | 1985-12-17 | Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione |
AU69497/87A AU595858B2 (en) | 1985-12-17 | 1986-12-08 | Pharmaceutically active derivatives of glutamic and aspartic acids |
EP87901263A EP0286643B1 (en) | 1985-12-17 | 1986-12-08 | Pharmaceutically active derivatives of glutamic and aspartic acids |
PCT/EP1986/000724 WO1987003869A2 (en) | 1985-12-17 | 1986-12-08 | Pharmaceutically active derivatives of glutamic and aspartic acids |
AT87901263T ATE63539T1 (de) | 1985-12-17 | 1986-12-08 | Pharmazeutisch aktive derivate von glutaminund asparaginsaeuren. |
DE8787901263T DE3679333D1 (de) | 1985-12-17 | 1986-12-08 | Pharmazeutisch aktive derivate von glutamin- und asparaginsaeuren. |
IE323386A IE59534B1 (en) | 1985-12-17 | 1986-12-10 | New oxygenated-alkyl derivatives of glutamic and aspartic acids with antagonistic activity to bio-active polypeptides and a method for their preparation |
CA000525358A CA1269110A (en) | 1985-12-17 | 1986-12-15 | Oxygenated-alkyl derivatives of glutamic and aspartic acids with antagonistic activity to bio-active polypeptides and a method for their preparation |
JP61301132A JPS62181246A (ja) | 1985-12-17 | 1986-12-16 | 生体活性ポリペプチド類に対し拮抗活性を有するグルタミン酸類およびアスパラギン酸類の新規酸素化アルキル誘導体およびその製造法 |
ES08603651A ES2081777A6 (es) | 1985-12-17 | 1986-12-16 | Nuevos derivados de acido d,l-glutamico y acido d,l-aspartico |
US06/942,751 US4769389A (en) | 1985-12-17 | 1986-12-17 | Oxygenated-alkyl derivatives of glutamic and aspartic acids with antagonistic activity to bio-active polypeptides and a method for their preparation |
PT83952A PT83952B (pt) | 1985-12-17 | 1986-12-17 | Processo para a preparacao de novos derivados alquilicos oxigenados dos acidos glutamico e aspartico com accao antagonica a dos polipeptidos bioactivos |
ZA869460A ZA869460B (en) | 1985-12-17 | 1986-12-17 | Oxygenated-alkyl derivatives of glumatic and aspartic acids with antagonistic activity to bio-active polypeptides and a method for their preparation |
GR862921A GR862921B (en) | 1985-12-17 | 1986-12-17 | New oxygenated-alkyl derivatives of glutamic and aspartic acids with antagonistic activity to bio-active polypeptides and a method for their preparation |
DK425487A DK169666B1 (da) | 1985-12-17 | 1987-08-14 | Farmaceutisk aktive derivater af D,L-glutamin- og D,L-asparaginsyre, fremgangsmåde til deres fremstilling samt farmaceutisk sammensætning og sammensætning til anvendelse ved husdyrbrug indeholdende sådanne derivater |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8568062A IT1215169B (it) | 1985-12-17 | 1985-12-17 | Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8568062A0 true IT8568062A0 (it) | 1985-12-17 |
IT1215169B IT1215169B (it) | 1990-01-31 |
Family
ID=11307569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT8568062A IT1215169B (it) | 1985-12-17 | 1985-12-17 | Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione |
Country Status (13)
Country | Link |
---|---|
US (1) | US4769389A (it) |
EP (1) | EP0286643B1 (it) |
JP (1) | JPS62181246A (it) |
AU (1) | AU595858B2 (it) |
CA (1) | CA1269110A (it) |
DK (1) | DK169666B1 (it) |
ES (1) | ES2081777A6 (it) |
GR (1) | GR862921B (it) |
IE (1) | IE59534B1 (it) |
IT (1) | IT1215169B (it) |
PT (1) | PT83952B (it) |
WO (1) | WO1987003869A2 (it) |
ZA (1) | ZA869460B (it) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
US5089638A (en) * | 1986-06-16 | 1992-02-18 | Merck & Co., Inc. | Amino acid analogs as CCK-antagonists |
IT1196849B (it) * | 1986-12-16 | 1988-11-25 | Rotta Research Lab | Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
IT1217123B (it) * | 1987-02-05 | 1990-03-14 | Rotta Research Lab | Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione |
US5105007A (en) * | 1987-10-19 | 1992-04-14 | Abbott Laboratories | Phenylacetylglutamine (PAG) analytical test |
EP0411668B2 (en) * | 1989-08-04 | 1998-11-11 | MERCK SHARP & DOHME LTD. | Central cholecystokinin antagonists for treatment of psychiatric disorders |
US5066828A (en) * | 1990-04-12 | 1991-11-19 | Merrell Dow Pharmaceuticals Inc. | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
EP0617621A4 (en) * | 1991-12-20 | 1995-04-05 | Merck Sharp & Dohme | CENTRAL CHOLECYSTOKININ ANTAGONISTS HAVING PHARMACEUTICAL EFFECTIVENESS. |
GB9200420D0 (en) * | 1992-01-09 | 1992-02-26 | James Black Foundation The Lim | Amino acid derivatives |
US5716958A (en) | 1994-10-27 | 1998-02-10 | Tobishi Pharmaceutical Co., Ltd. | Amino acid derivative having anti-CCK activity |
EP1902014A2 (en) * | 2005-07-11 | 2008-03-26 | Wyeth | Glutamate aggrecanase inhibitors |
US7863330B2 (en) * | 2006-06-14 | 2011-01-04 | Rottapharm S.P.A. | Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders |
CN108912007B (zh) * | 2018-06-20 | 2021-02-26 | 中国农业科学院兰州畜牧与兽药研究所 | 一种右氯谷胺的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1108819A (en) * | 1964-07-31 | 1968-04-03 | Rotta Research Lab | Derivatives of 2-acylaminobicarboxylic acids and method for preparing same |
US3465081A (en) * | 1966-05-13 | 1969-09-02 | Thompson Chem Co Hayward | Method of controlling pestiferous organisms |
AT293368B (de) * | 1969-10-13 | 1971-10-11 | Rotta Research Lab | Verfahren zur Herstellung von N-Benzoyl-L-(D- oder DL)-glutaminsäure-l-amiden |
US3803223A (en) * | 1970-07-20 | 1974-04-09 | Searle & Co | 3-amino-n-substituted succinamic acids and intermediates thereto |
US4243678A (en) * | 1977-12-30 | 1981-01-06 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Acylhydrocarbylaminoalkanoic acids, compositions and uses |
NZ212436A (en) * | 1984-06-25 | 1989-04-26 | Rotta Research Lab | D,l-glutamic and d,l-aspartic acid derivatives and pharmaceutical compositions |
GB8704671D0 (en) * | 1987-02-27 | 1987-04-01 | Shell Int Research | Glycine compounds |
-
1985
- 1985-12-17 IT IT8568062A patent/IT1215169B/it active
-
1986
- 1986-12-08 WO PCT/EP1986/000724 patent/WO1987003869A2/en active IP Right Grant
- 1986-12-08 AU AU69497/87A patent/AU595858B2/en not_active Ceased
- 1986-12-08 EP EP87901263A patent/EP0286643B1/en not_active Expired - Lifetime
- 1986-12-10 IE IE323386A patent/IE59534B1/en not_active IP Right Cessation
- 1986-12-15 CA CA000525358A patent/CA1269110A/en not_active Expired - Fee Related
- 1986-12-16 ES ES08603651A patent/ES2081777A6/es not_active Expired - Fee Related
- 1986-12-16 JP JP61301132A patent/JPS62181246A/ja active Granted
- 1986-12-17 ZA ZA869460A patent/ZA869460B/xx unknown
- 1986-12-17 GR GR862921A patent/GR862921B/el unknown
- 1986-12-17 PT PT83952A patent/PT83952B/pt not_active IP Right Cessation
- 1986-12-17 US US06/942,751 patent/US4769389A/en not_active Expired - Lifetime
-
1987
- 1987-08-14 DK DK425487A patent/DK169666B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT1215169B (it) | 1990-01-31 |
JPS62181246A (ja) | 1987-08-08 |
EP0286643B1 (en) | 1991-05-15 |
PT83952A (en) | 1987-01-01 |
JPH0543698B2 (it) | 1993-07-02 |
DK169666B1 (da) | 1995-01-09 |
ES2081777A6 (es) | 1996-03-01 |
GR862921B (en) | 1987-04-27 |
ZA869460B (en) | 1987-08-26 |
AU595858B2 (en) | 1990-04-12 |
WO1987003869A3 (en) | 1987-08-13 |
PT83952B (pt) | 1989-06-30 |
US4769389A (en) | 1988-09-06 |
WO1987003869A2 (en) | 1987-07-02 |
CA1269110A (en) | 1990-05-15 |
IE59534B1 (en) | 1994-03-09 |
IE863233L (en) | 1987-06-17 |
DK425487D0 (da) | 1987-08-14 |
DK425487A (da) | 1987-08-14 |
EP0286643A1 (en) | 1988-10-19 |
AU6949787A (en) | 1987-07-15 |
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Legal Events
Date | Code | Title | Description |
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TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971231 |