WO1982001819A1 - Agent antipelliculaire - Google Patents

Agent antipelliculaire Download PDF

Info

Publication number
WO1982001819A1
WO1982001819A1 PCT/DE1981/000216 DE8100216W WO8201819A1 WO 1982001819 A1 WO1982001819 A1 WO 1982001819A1 DE 8100216 W DE8100216 W DE 8100216W WO 8201819 A1 WO8201819 A1 WO 8201819A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrochloride
imidazolylmethyl
sulfide
dichlorobenzyl
chloro
Prior art date
Application number
PCT/DE1981/000216
Other languages
German (de)
English (en)
Inventor
Ag Schering
Original Assignee
Strehlke Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803046391 external-priority patent/DE3046391A1/de
Priority claimed from DE19813104430 external-priority patent/DE3104430A1/de
Application filed by Strehlke Peter filed Critical Strehlke Peter
Publication of WO1982001819A1 publication Critical patent/WO1982001819A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Definitions

  • the present invention relates to agents with anti-dandruff action, which act as active ingredients (3,4-dichlorobenzyl) - [2- (1-imidazolylmethyl) phenyl] sulfide, hydrochloride and 4-chloro-2- (l-imidazolylmethyl) diphenyl sulfide, hydrochloride contain.
  • anti-dandruff agents such as zinc or magnesium pyridine thione or selenium disulfide
  • Their mechanism of action consists in normalizing the significantly increased cell division activity in the epidermis in dandruff [Plewig, Klig ⁇ an Areh. clin. exp. Derm. 256, 406 (1970)].
  • Effective anti-dandruff agents also have an anti-camthogenic effect, i.e. they lead to thinning of the epidermis.
  • a reduction in toxicity would also be important as a promotion that is constantly being placed on modern medicinal products.
  • the effectiveness against dandruff in the individual compositions must not deteriorate under the usual storage conditions of a bathroom.
  • the antidandruff agent should also be inert towards other constituents of the application agent. Other characteristics of the active ingredient, such as color and smell, must meet the requirements that are placed on a cosmetic product today.
  • the invention relates to an agent for inhibiting scaling of the scalp, characterized in that it has an effective dose (3,4-dichlorobenzyl) - [2- (1-imidazolylmethyl) phenyl] sulfide, hydrochloride or 4-chloro-2- ( Contains 1-imidasolylmethyl) diphenyl sulfide, hydrochloride.
  • the invention also relates to the use of (3,4-dichlorobenzyl) - [2- (1-imidazolylmethyl) phenyl] sulfide, hydrochloride or 4-chloro-2- (1-imidazolylmethyl) diphenyl sulfide, hydrochloride for prophylactic and therapeutic treatment of the scalp against dandruff.
  • (3,4-dichlorobenzyl) - [2- (1-imidazolylmethyl) phenyl] sulfide, hydrochloride and 4-chloro-2- (1-imidasolylmethyl) diphenyl sulfide, hydrochloride are formulated in a manner known per se by being mixed with 0.1-5% by weight in ethanol / water or isopropanol / water for hair lotions or in 1-5% by weight for Sharapoos (hairdressing gels or inlay agents) and customary auxiliaries and carriers.
  • hair treatment agents which contain fatty alcohol-folyalkylene oxide adducts in their preparations, preferably those of fatty alcohols of chain length with 10-20 carbon atoms with 5-40 mol ethylene oxide units.
  • Possible hair treatment agents with an anti-dandruff effect are: hair shampoo, hair tonic, hair fixative, hairdressing cream, hair conditioner, hair treatment, hair lotion etc.
  • the anti-dandruff active ingredients (3.4-dichlorobenzyl) - [2- (1-imidazolylmethyl) - phenyl] sulfide hydrochloride and 4-Chloro-2- (1-imidazolylmethyl) diphenyl sulfide, hydrochloride in shampoos, hair lotions, inlay agents and hairdressing gels.
  • the agents mentioned contain other carriers and components customary in hair treatment compositions in the usual proportions.
  • Surfactant components such as fatty alcohol sulfates and fatty alcohol ether sulfates are intended for this purpose.
  • Amphoteric surfactants can also be used for this (eg miranols). The best preparations can be achieved with the above-mentioned surfactant component fatty alcohol polyalkylene oxide adduct.
  • Other additives are emulsifiers (e.g. Na, K or alkanolamine salts of fatty acids), thickeners (e.g. NaCl, NH 4 Cl in combinations with alkyl ether sulfates), superfatting agents (e.g.
  • polyoxyethylated lanolin derivatives such as lecithin derivatives or alkylolamides
  • framework components such as paraffin, full-fat alcohols, Protein breakdown products, vitamin complexes, solubilizers such as vinyl pyrrolidone-vinyl acetate copolymeridates, plant extracts.
  • the active substances should be used in amounts between 0.001 and 0.1 g per patient and per day.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Agent antipelliculaire contenant, en tant que substances actives, le chlorhydrate du sulfure (3,4-ichlorobenzyle)-(2-(1-imidazolylmethyle)-phenyle) ainsi que le chlorhydrate du sulfure 4-chloro-2-(1-midazolylmethyle)-diphenyle.
PCT/DE1981/000216 1980-12-05 1981-12-04 Agent antipelliculaire WO1982001819A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3046391801205 1980-12-05
DE19803046391 DE3046391A1 (de) 1980-12-05 1980-12-05 Antischuppenmittel
DE3104430 1981-02-04
DE19813104430 DE3104430A1 (de) 1981-02-04 1981-02-04 Antischuppenmittel

Publications (1)

Publication Number Publication Date
WO1982001819A1 true WO1982001819A1 (fr) 1982-06-10

Family

ID=25789617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1981/000216 WO1982001819A1 (fr) 1980-12-05 1981-12-04 Agent antipelliculaire

Country Status (3)

Country Link
EP (1) EP0065974A1 (fr)
JP (1) JPS57502126A (fr)
WO (1) WO1982001819A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013033914A2 (pt) 2011-06-30 2016-11-22 Hansen Ab Gmbh agente para o controle de parasitas em animais e uso de um agente

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2430039A1 (de) * 1974-06-22 1976-01-08 Bayer Ag Azolantimykotika als kosmetische mittel
US4006243A (en) * 1974-04-11 1977-02-01 Schering Aktiengesellschaft Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles
GB2068228A (en) * 1980-01-24 1981-08-12 Janssen Pharmaceutica Nv Novel anti-microbial compositions for the topical treatment of acne vulgaris

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS571781B2 (fr) * 1973-01-18 1982-01-12
JPS5426197B2 (fr) * 1973-06-25 1979-09-03

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006243A (en) * 1974-04-11 1977-02-01 Schering Aktiengesellschaft Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles
DE2430039A1 (de) * 1974-06-22 1976-01-08 Bayer Ag Azolantimykotika als kosmetische mittel
GB2068228A (en) * 1980-01-24 1981-08-12 Janssen Pharmaceutica Nv Novel anti-microbial compositions for the topical treatment of acne vulgaris

Also Published As

Publication number Publication date
EP0065974A1 (fr) 1982-12-08
JPS57502126A (fr) 1982-12-02

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