Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/20—Pills, tablets, discs, rods
  • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
  • A61K9/2806—Coating materials
  • A61K9/282—Organic compounds, e.g. fats
  • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof

Definitions

• the subject of the invention is a hard coating process.
• Both the confectionery and the above pharmaceutical products can be of the traditional type, that is to say comprising sugars such as saccha- rose, dextrose, fructose or glu ⁇ cose syrups; they can also be of the “sugar-free” type, that is to say based in particular on polyols such as sorbitol, xylitol, mannitol or non-cariogenic hydrogenated hydrolyzate known under the brand LYCASIN _, and free of sucrose, dextrose, fructose, glucose syrups or equivalent products.
• sugars such as saccha- rose, dextrose, fructose or glu ⁇ cose syrups
• sugars such as saccha- rose, dextrose, fructose or glu ⁇ cose syrups
• they can also be of the “sugar-free” type, that is to say based in particular on polyols such as sorbitol, xylitol, mannitol or non
• the coating of the core is carried out in an inclined tank rotating around its axis and called dredger, inside which there are a plurality of nuclei forming a moving mass, on the surface of which is distributed to the liquid state the constituent material of the future envelope.
• This constituent material is traditionally sucrose.
• sucrose like other sugars such as dextrose or fructose, has undesirable biological effects, in particular from the point of view of dental caries. It is indeed very easily and very quickly acidifiable by bacteria from the mouth. In addition, the sweet taste of sucrose is often little appreciated, especially in the hot season, the consumer then seeking, in chewing gum and confectionery in general, a refreshing and less sweet flavor.
• xylitol envelopes the only one rapidly deteriorating over time as it cracks, their external surface, smooth at the start, becoming wrinkled and the internal structure of the envelope, which initially has a microcrystalline character, taking on a rough, unpleasant structure to the palate during chewing; in any case, we can no longer speak of a hard xylite coating, analogous to that carried out with sucrose.
• sorbitol As far as sorbitol is concerned, it is reputed to be completely inapplicable in a hard coating process.
• sorbitol can only be used as an ingredient of the nucleus and not of the shell, due to its hygroscopic nature.
• crystallization of sorbitol is much more difficult than that of xylitol and manni ⁇ tol and that this difficulty is aggravated by the fact that sorbitol can be obtained in several different crystalline forms, only the form gamma constituting a stable form.
• a known coating process does indeed use sor ⁇ bitol as a coating agent, but associated with an excess of xylitol and, on the other hand, the coating syrup does not consist of a concentrated aqueous solution of
• the sorbitol is used by adding, on a moving bed of cores to be coated, a syrup having a dry matter concentration of between 60 and 85% by weight, preferably between 62 and 80 % by weight and, more preferably still, between 65 and 77% by weight, the richness of the syrup in D-sorbitol being greater than 80%, preferably 95% and, more preferably still, 99% r - other apart, the temperature prevailing in the moving bed of cores to be coated is maintained at
• Q_ a value below 55 ° C, preferably between 50 and 10 ° C and, more preferably still, between 40 and 15 ° C, all of these conditions being chosen, within the limits indicated, so that when the sorbitol syrup comes into contact with the cores to be coated, that is to say at the temperature maintained in the moving bed, it is at a saturation level of between 0.65 and 1.25, preferably between 0.8 and 1.15.
• the temperature of the sorbitol syrup used is less than 100 ° C, preferably 90 ° C and, more preferably still, 70 ° C.
• saturation level is meant the ratio, for a given temperature, of the concentration of the syrup expressed in
• the sugar-coating products in accordance with the invention are characterized by the fact that the coating is based on sorbitol, crystallized on any the thickness of said coating.
• the sprayed sorbitol syrup used has a dry matter concentration of between 60 and 85% by weight, preferably between 62 and 80% by weight, and, more preferably still, between 65 and 77% by weight.
• the richness of this syrup in D-sorbitol is greater than 80%, preferably 95% and, more preferably still, 99%.
• the temperature prevailing in the bed of moving cores is maintained at a value below 55 ° C, preferably between 50 and 10 ° C and, more preferably still, between 40 and 15 ° C.
• the dry matter concentration of the sorbitol syrup, on the one hand, and the temperature of the bed of cores, on the other hand, are chosen within the limits indicated above so that, when the sorbitol syrup arrives in contact with the cores to be coated, it is at a saturation level of between 0.65 and 1.25, preferably between 0.8 and 1.15.
• the coating is done by successive cycles each comprising a first phase of addition of the sorbitol syrup to the bed of nuclei and a second phase during which the addition is stopped while maintaining the rotation of the tank and the temperature prevailing within the mass of nuclei ,, the casing with which the cores have been coated being dried and polished during this phase.
• the thickness of the envelope can be freely chosen depending in particular on the core to be coated or the desired effects.
• the means for maintaining the temperature within the mass of moving nuclei can be constituted by a device for blowing hot air of controlled temperature.
• the coating conditions in accordance with the invention there is at no point in the process either a melting or an irregular enlargement of the sorbitol crystals being formed, which leads at the end of the operation to a smooth, hard and shiny surface, without "orange peel” phenomenon or other surface irregularities.
• These conditions also maintain a visco ⁇ sity of the sorbitol syrup such that an excellent distribution of the liquid phase is achieved over the nuclei undergoing magnification and therefore rapid crystallization of the sorbitol.
• These conditions associated with the blowing of hot air, allow obtaining very fine crystals and excellent coating.
• Binding agents such as vegetable gums and gelatin or fatty substances such as mono- and diglycerides can also be provided. It is also possible to add other sugars such as xylitol or mannitol to sorbitol.
• the coating obtained in accordance with the invention a particular men ⁇ tion to "sugar-free" products and, among these, to non-cariogenic candies based on hydrogenated glucose syrups of the brand LYCASIN ⁇ -A Lorscjue, on the contrary, the core to be coated contains a fermentable sugar, the coating obtained in accordance with the invention attenuates the cariogenic character of the whole and in any case gives it the qualities inherent in crystallized sorbitol of stable form, in particular the feeling of freshness.
• the invention therefore has a general scope for all pharmaceutical products and candy confectionery.
• the coating products in accordance with the invention have a smooth and shiny surface, essentially free of imperfections and crystalline over the entire thickness of the envelope, that they are stable, even in atmospheres with high humidity and that they also present a very pleasant feeling of freshness at the time of consumption, due to the high heat of dissolution of sorbitol as well as its high solubility at 37 ° C.
• A. DRAGEIFICATION OF A CHEWING GUM OF THE "SUGAR-FREE” TYPE, Chewing gums "sugar-free” are prepared according to the method and composition described in French patent No. 79 15479 of June 15, 1979.
• composition selected was as follows:
• the liquid coloring phase the solid phase added gradually in small quantities.
• the dough was washed and cut into platelets of conventional shape. It is these platelets that we coated.
• 500 g of the above-mentioned wafers were placed in a laboratory dredger of the "LILLIPUT" type from the manufacturer FROGERAIS, equipped with a regulated air blower to keep the temperature of the wafer bed constant, and a probe thermometer placed in this bed.
• Dredger rotation speed 25-30 revolutions per minute.
• the coating product consisting of a sorbitol syrup was maintained at constant temperature using a thermoregulated water bath.
• the coating syrup is added by successive charges (cycles) of 20 g of syrup, the introduction of these charges being done in a few seconds every ten minutes, the time between the end of an introduction of the following introduction being necessary to obtain the crystallization of the sorbitol and the evaporation of the water thus released.
• the total quantity of syrup to be added depends, in particular, on the thickness desired for the envelope.
• the sorbitol used for the coating is made up of a hydrogenated glucose syrup known under the brand NE0S0RB ⁇ 70/02, the purity of which on dry matter is 99%. EXAMPLE 1.
• the concentration of the coating syrup is 83% dry matter.
• the cores to be coated were prepared on a rotary FROGERAIS compression machine with 16 punches of the MR 2 type, operating by direct compression.
• the product used is NEOSORB® 20/60 brand sorbitol powder flavored with mint and comprising 0.3% of lubricant consisting of magnesium stearate.
• the sugar coating was carried out by means of the equipment described in connection with the sugar coating of "sugar-free" chewing gum.
• the temperature of the coating bed could be raised to 70 ° C., since the melting temperature of the NEOSORB® is greater than 95 ° C.
• the coating syrup additions were 20 g every 10 minutes.
• EXAMPLE 4 Using nine tests, the influence of the temperature of the bed during coating and the temperature of a coating syrup, the concentration of which is 70% dry matter, was studied. .
• Example 4 Eight tests were carried out as indicated in Example 4, the syrup concentration being 80%. The conditions and results are collated in Table IV.
• test 17 the temperature prevailing in the bed, that is to say 70 ° C., is too high.
• the temperature of the moving bed has been kept at a value less than or at most equal to 30 ° C., this value is imposed by the material constituting the core. All the coating were carried out on 500 g of nuclei.
• This coating improves the resistance to storage of LYCASIN U candies and gives them a pleasant instant freshness.

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• Health & Medical Sciences (AREA)
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Citations (8)

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• 1980
  • 1980-10-16 WO PCT/FR1980/000151 patent/WO1981001100A1/fr active IP Right Grant
  • 1980-10-16 DE DE8080901943T patent/DE3066710D1/de not_active Expired
  • 1980-10-16 JP JP55502352A patent/JPH0126661B2/ja not_active Expired
  • 1980-10-16 CA CA000362521A patent/CA1168082A/en not_active Expired
  • 1980-10-16 US US06/276,361 patent/US4423086A/en not_active Expired - Lifetime
  • 1980-10-17 IT IT25431/80A patent/IT1133715B/it active
  • 1980-10-17 IE IE2159/80A patent/IE50168B1/en not_active IP Right Cessation
  • 1980-10-17 ES ES496044A patent/ES496044A0/es active Granted
• 1981
  • 1981-05-04 EP EP80901943A patent/EP0037407B1/fr not_active Expired
  • 1981-06-12 FI FI811850A patent/FI68763C/fi not_active IP Right Cessation
  • 1981-06-15 DK DK262181A patent/DK154470C/da not_active IP Right Cessation

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