UY36460A - Pirazolpiridinaminas - Google Patents

Pirazolpiridinaminas

Info

Publication number
UY36460A
UY36460A UY0001036460A UY36460A UY36460A UY 36460 A UY36460 A UY 36460A UY 0001036460 A UY0001036460 A UY 0001036460A UY 36460 A UY36460 A UY 36460A UY 36460 A UY36460 A UY 36460A
Authority
UY
Uruguay
Prior art keywords
compounds
preparing
disorder
inflammatory
pirazolpiridinaminas
Prior art date
Application number
UY0001036460A
Other languages
English (en)
Inventor
Dr Nicole Schmidt
Dr Julien Lefranc
Dr Goerg Kettschau
Dr Kristin Petersen
Dr Philip Lienau
Dr Anja Richter
Dr Ulrich Klar
Dr Detlev Sülzle
Dr Keith Graham
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY36460A publication Critical patent/UY36460A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de pirazolpiridinamina sustituida de fórmula general (I) según se los describe y define aquí, métodos para preparar dichos compuestos, compuestos intermediarios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden a dichos compuestos y el uso de dichos compuestos para elaborar una composición farmacéutica para el tratamiento o la profilaxis de una enfermedad, en particular de un trastorno hiperproliferativo y/o de angiogénesis, de un trastorno inflamatorio o asociado con dolor inflamatorio,como único agente o en combinación con otros ingredientes activos.
UY0001036460A 2014-12-19 2015-12-18 Pirazolpiridinaminas UY36460A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14199096 2014-12-19
EP15187501 2015-09-29

Publications (1)

Publication Number Publication Date
UY36460A true UY36460A (es) 2016-07-29

Family

ID=54884024

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036460A UY36460A (es) 2014-12-19 2015-12-18 Pirazolpiridinaminas

Country Status (27)

Country Link
US (1) US10487092B2 (es)
EP (1) EP3233866B1 (es)
JP (1) JP2018501250A (es)
KR (1) KR20170095985A (es)
CN (1) CN107250138A (es)
AU (1) AU2015366417A1 (es)
BR (1) BR112017013148A2 (es)
CA (1) CA2971242A1 (es)
CL (1) CL2017001615A1 (es)
CO (1) CO2017005968A2 (es)
CR (1) CR20170264A (es)
CU (1) CU20170086A7 (es)
DO (1) DOP2017000146A (es)
EA (1) EA201791363A1 (es)
EC (1) ECSP17038893A (es)
GT (1) GT201700138A (es)
IL (1) IL252686A0 (es)
MX (1) MX2017008161A (es)
NI (1) NI201700078A (es)
PE (1) PE20171104A1 (es)
PH (1) PH12017501133A1 (es)
SG (1) SG11201704916TA (es)
SV (1) SV2017005466A (es)
TN (1) TN2017000258A1 (es)
TW (1) TW201625648A (es)
UY (1) UY36460A (es)
WO (1) WO2016096721A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) * 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
WO2017081003A1 (en) * 2015-11-12 2017-05-18 Bayer Pharma Aktiengesellschaft Substituted pyrazolopyridinamines
WO2018152117A1 (en) 2017-02-14 2018-08-23 Effector Therapeutics, Inc. Piperidine-substituted mnk inhibitors and methods related thereto
AU2019366947A1 (en) 2018-10-24 2021-06-03 Effector Therapeutics, Inc. Crystalline forms of Mnk inhibitors
CN111803476A (zh) * 2020-08-14 2020-10-23 华中科技大学协和深圳医院 芬戈莫德用于抑制革兰阳性细菌活性的用途
EP4211171A2 (en) 2020-09-10 2023-07-19 Precirix N.V. Antibody fragment against fap
US20230000986A1 (en) * 2021-07-01 2023-01-05 Board Of Regents, The University Of Texas System Mnk inhibitors and eif4e phosphorylation modulation to treat inflammatory pain in the aged
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
ES2280040T3 (es) 2003-07-24 2007-09-01 Bayer Pharmaceuticals Corporation Compuestos de tetrahidrobenzotienopirimidinamina sustituidos utiles para tratar trastornos hiperproliferativos.
CA2577664A1 (en) 2004-08-20 2006-03-02 Bayer Pharmaceuticals Corporation Novel heterocycles
WO2012097013A1 (en) 2011-01-10 2012-07-19 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2013174735A1 (en) * 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted benzothienopyrimidines
EP2852596B1 (en) * 2012-05-21 2016-06-22 Bayer Pharma Aktiengesellschaft Thienopyrimidines
JP6215338B2 (ja) * 2012-11-08 2017-10-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼモジュレーターとして有用な二環式ヘテロ環置換ピリジル化合物
EP2951187A1 (en) 2013-02-01 2015-12-09 Bayer Pharma Aktiengesellschaft Substituted thienopyrimidines and pharmaceutical use thereof

Also Published As

Publication number Publication date
CA2971242A1 (en) 2016-06-23
TN2017000258A1 (en) 2018-10-19
CU20170086A7 (es) 2017-11-07
KR20170095985A (ko) 2017-08-23
CN107250138A (zh) 2017-10-13
CR20170264A (es) 2017-07-21
DOP2017000146A (es) 2017-07-31
NI201700078A (es) 2017-09-22
WO2016096721A1 (en) 2016-06-23
SG11201704916TA (en) 2017-07-28
AU2015366417A1 (en) 2017-06-29
US10487092B2 (en) 2019-11-26
GT201700138A (es) 2018-12-06
EP3233866A1 (en) 2017-10-25
US20180162877A1 (en) 2018-06-14
CL2017001615A1 (es) 2018-03-16
PH12017501133A1 (en) 2017-11-27
PE20171104A1 (es) 2017-08-07
ECSP17038893A (es) 2017-07-31
MX2017008161A (es) 2017-09-18
TW201625648A (zh) 2016-07-16
EP3233866B1 (en) 2021-04-21
CO2017005968A2 (es) 2017-10-20
IL252686A0 (en) 2017-08-31
BR112017013148A2 (pt) 2019-11-19
JP2018501250A (ja) 2018-01-18
SV2017005466A (es) 2018-10-02
EA201791363A1 (ru) 2018-01-31

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20220721