UY34444A - Métodos para inhibir el crecimiento tumoral antagonizando el receptor de il-6 - Google Patents
Métodos para inhibir el crecimiento tumoral antagonizando el receptor de il-6Info
- Publication number
- UY34444A UY34444A UY0001034444A UY34444A UY34444A UY 34444 A UY34444 A UY 34444A UY 0001034444 A UY0001034444 A UY 0001034444A UY 34444 A UY34444 A UY 34444A UY 34444 A UY34444 A UY 34444A
- Authority
- UY
- Uruguay
- Prior art keywords
- antagonizing
- receiver
- methods
- tumor growth
- inhibit tumor
- Prior art date
Links
- 108090001005 Interleukin-6 Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 230000004614 tumor growth Effects 0.000 title 1
- 241000950314 Figura Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención proporciona métodos para inhibir o atenuar el crecimiento tumoral en un sujeto por la administración de un antagonista de IL-6 al sujeto. En determinadas realizaciones, los métodos de la invención se usan para inhibir el crecimiento de un tumor resistente a anti-VEGF en un sujeto. El antagonista de IL-6 puede ser, por ejemplo, un anticuerpo que se une específicamente a IL-6R. El antagonista de IL-6 puede administrarse en combinación con un antagonista de VEGF y/o un antagonista de EGFR y/o un antagonista de ErbB3.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161557939P | 2011-11-10 | 2011-11-10 | |
| US201261609968P | 2012-03-13 | 2012-03-13 | |
| US201261613538P | 2012-03-21 | 2012-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY34444A true UY34444A (es) | 2013-05-31 |
Family
ID=47179020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001034444A UY34444A (es) | 2011-11-10 | 2012-11-09 | Métodos para inhibir el crecimiento tumoral antagonizando el receptor de il-6 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20130122003A1 (es) |
| EP (1) | EP2776468B1 (es) |
| JP (3) | JP6144689B2 (es) |
| KR (1) | KR101718748B1 (es) |
| CN (1) | CN103930443B (es) |
| AR (1) | AR088671A1 (es) |
| AU (2) | AU2012335596B2 (es) |
| BR (1) | BR112014011211A2 (es) |
| CA (1) | CA2853836C (es) |
| IL (2) | IL231854A (es) |
| IN (1) | IN2014CN02923A (es) |
| JO (1) | JO3370B1 (es) |
| MX (1) | MX357837B (es) |
| MY (1) | MY163953A (es) |
| RU (1) | RU2648150C2 (es) |
| SG (1) | SG11201401286QA (es) |
| TW (3) | TWI604852B (es) |
| UY (1) | UY34444A (es) |
| WO (1) | WO2013071016A2 (es) |
| ZA (1) | ZA201402414B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3370B1 (ar) * | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
| WO2015000181A1 (zh) * | 2013-07-05 | 2015-01-08 | 华博生物医药技术（上海）有限公司 | 新型重组融合蛋白及其制法和用途 |
| US9017678B1 (en) | 2014-07-15 | 2015-04-28 | Kymab Limited | Method of treating rheumatoid arthritis using antibody to IL6R |
| DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CA2953698A1 (en) * | 2014-06-28 | 2015-12-30 | Kodiak Sciences Inc. | Dual pdgf/vegf antagonists |
| AU2016271138A1 (en) * | 2015-05-29 | 2017-12-07 | Merrimack Pharmaceuticals, Inc. | Combination cancer therapies |
| KR20180104635A (ko) | 2015-12-30 | 2018-09-21 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| WO2018106959A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| JP2021514656A (ja) * | 2018-03-02 | 2021-06-17 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | Ｉｌ−６抗体ならびにその融合構築物およびコンジュゲート |
| AU2019235782A1 (en) | 2018-03-14 | 2020-10-08 | Celledit Llc | Modification of immune cells for reducing toxicity and uses thereof in adoptive cell therapy |
| CN108567981A (zh) * | 2018-07-17 | 2018-09-25 | 漯河医学高等专科学校 | 白细胞介素-6的拮抗剂在制备抑制Notch-1蛋白表达、治疗胰腺癌的药物中的应用 |
| WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| AU2020205951A1 (en) * | 2019-01-07 | 2021-07-22 | Hunan Siweikang Therapeutics Co. Ltd | Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341152C (en) | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
| US5670373A (en) | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| WO1992019759A1 (en) | 1991-04-25 | 1992-11-12 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
| US5888510A (en) | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| DE69525971T3 (de) | 1994-12-29 | 2013-01-10 | Chugai Seiyaku K.K. | Verwendung eines pm-1 antikörpers oder eines mh 166 antikörpers zur verstärkung des anti-tumor-effektes von cisplatin oder carboplatin |
| US5795695A (en) | 1996-09-30 | 1998-08-18 | Xerox Corporation | Recording and backing sheets containing linear and cross-linked polyester resins |
| US7396664B2 (en) * | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| UA74146C2 (uk) * | 1999-06-08 | 2005-11-15 | Редженерон Фармасьютікалс, Інк. | Модифікований хімеричний поліпептид з покращеними фармакокінетичними властивостями |
| AU7824900A (en) | 1999-10-07 | 2001-04-23 | Eli Lilly And Company | Compounds and methods for inhibiting mrp1 |
| AU2000279624A1 (en) | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient |
| US7595378B2 (en) * | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| KR20060079180A (ko) * | 2003-07-02 | 2006-07-05 | 노보 노르디스크 에이/에스 | Ｎｋ 세포 활성을 조절하기 위한 조성물 및 방법 |
| BRPI0415505A (pt) | 2003-10-17 | 2006-12-12 | Chugai Pharmaceutical Co Ltd | agente terapêutico para mesotelioma |
| AR057941A1 (es) | 2005-11-25 | 2007-12-26 | Univ Keio | Agentes terapeuticos para el cancer de prostata |
| US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
| RS52643B (en) | 2006-06-02 | 2013-06-28 | Regeneron Pharmaceuticals Inc. | HIGH AFINITY ANTIBODIES TO THE HUMAN IL-6 RECEPTOR |
| WO2008154927A1 (en) * | 2007-06-21 | 2008-12-24 | Genmab A/S | Novel methods for treating egfr-associated tumors |
| MX2011005408A (es) * | 2008-11-25 | 2011-06-16 | Alder Biopharmaceuticals Inc | Antagonistas de il-6 para prevenir o tratar la trombosis. |
| US8323649B2 (en) * | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| JO3417B1 (ar) * | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| JO3370B1 (ar) * | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
-
2012
- 2012-11-04 JO JOP/2012/0332A patent/JO3370B1/ar active
- 2012-11-06 AR ARP120104169A patent/AR088671A1/es not_active Application Discontinuation
- 2012-11-09 CA CA2853836A patent/CA2853836C/en active Active
- 2012-11-09 EP EP12787338.8A patent/EP2776468B1/en active Active
- 2012-11-09 US US13/672,923 patent/US20130122003A1/en not_active Abandoned
- 2012-11-09 MY MYPI2014000968A patent/MY163953A/en unknown
- 2012-11-09 UY UY0001034444A patent/UY34444A/es unknown
- 2012-11-09 SG SG11201401286QA patent/SG11201401286QA/en unknown
- 2012-11-09 TW TW101141702A patent/TWI604852B/zh active
- 2012-11-09 TW TW105142150A patent/TW201716776A/zh unknown
- 2012-11-09 JP JP2014541298A patent/JP6144689B2/ja active Active
- 2012-11-09 BR BR112014011211A patent/BR112014011211A2/pt not_active Application Discontinuation
- 2012-11-09 AU AU2012335596A patent/AU2012335596B2/en active Active
- 2012-11-09 TW TW106138384A patent/TW201806620A/zh unknown
- 2012-11-09 WO PCT/US2012/064311 patent/WO2013071016A2/en active Application Filing
- 2012-11-09 KR KR1020147012146A patent/KR101718748B1/ko active IP Right Grant
- 2012-11-09 CN CN201280055109.4A patent/CN103930443B/zh active Active
- 2012-11-09 RU RU2014118739A patent/RU2648150C2/ru active
- 2012-11-09 MX MX2014004886A patent/MX357837B/es active IP Right Grant
-
2014
- 2014-04-01 IL IL231854A patent/IL231854A/en active IP Right Grant
- 2014-04-02 ZA ZA2014/02414A patent/ZA201402414B/en unknown
- 2014-04-17 IN IN2923CHN2014 patent/IN2014CN02923A/en unknown
- 2014-07-11 US US14/329,565 patent/US9409990B2/en active Active
-
2016
- 2016-07-07 US US15/204,639 patent/US20170022279A1/en not_active Abandoned
- 2016-10-30 IL IL248620A patent/IL248620A0/en unknown
-
2017
- 2017-01-06 JP JP2017000818A patent/JP6283754B2/ja active Active
-
2018
- 2018-01-26 JP JP2018011135A patent/JP2018083841A/ja not_active Withdrawn
- 2018-05-24 AU AU2018203666A patent/AU2018203666A1/en not_active Abandoned
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