BR112014011211A2 - métodos para inibir crescimento de tumor antagonizando receptor il-6 - Google Patents

métodos para inibir crescimento de tumor antagonizando receptor il-6

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Publication number
BR112014011211A2
BR112014011211A2 BR112014011211A BR112014011211A BR112014011211A2 BR 112014011211 A2 BR112014011211 A2 BR 112014011211A2 BR 112014011211 A BR112014011211 A BR 112014011211A BR 112014011211 A BR112014011211 A BR 112014011211A BR 112014011211 A2 BR112014011211 A2 BR 112014011211A2
Authority
BR
Brazil
Prior art keywords
methods
antagonist
tumor growth
antagonizing
receptor
Prior art date
Application number
BR112014011211A
Other languages
English (en)
Inventor
Zhang Li
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112014011211A2 publication Critical patent/BR112014011211A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

resumo patente de invenção: "métodos para inibir crescimento de tumor antagonizando receptor il-6". a presente invenção refere-se a métodos para inibir ou atenuar o crescimento do tumor em um indivíduo por administração de um antagonista de il-6 ao indivíduo. em certas modalidades, os métodos da invenção são utilizados para inibir o crescimento de um tumor resistente a anti-vegf em um indivíduo. o antagonista de il-6 pode ser, por exemplo, um anticorpo que se liga especificamente a sl-6r. o antagonista de il-6 pode ser administrado em combinação com um antagonista de vegf, e/ou um antagonista de egfr 1.
BR112014011211A 2011-11-10 2012-11-09 métodos para inibir crescimento de tumor antagonizando receptor il-6 BR112014011211A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161557939P 2011-11-10 2011-11-10
US201261609968P 2012-03-13 2012-03-13
US201261613538P 2012-03-21 2012-03-21
PCT/US2012/064311 WO2013071016A2 (en) 2011-11-10 2012-11-09 Methods of inhibiting tumor growth by antagonizing il-6 receptor

Publications (1)

Publication Number Publication Date
BR112014011211A2 true BR112014011211A2 (pt) 2017-04-25

Family

ID=47179020

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014011211A BR112014011211A2 (pt) 2011-11-10 2012-11-09 métodos para inibir crescimento de tumor antagonizando receptor il-6

Country Status (20)

Country Link
US (3) US20130122003A1 (pt)
EP (1) EP2776468B1 (pt)
JP (3) JP6144689B2 (pt)
KR (1) KR101718748B1 (pt)
CN (1) CN103930443B (pt)
AR (1) AR088671A1 (pt)
AU (2) AU2012335596B2 (pt)
BR (1) BR112014011211A2 (pt)
CA (1) CA2853836C (pt)
IL (2) IL231854A (pt)
IN (1) IN2014CN02923A (pt)
JO (1) JO3370B1 (pt)
MX (1) MX357837B (pt)
MY (1) MY163953A (pt)
RU (1) RU2648150C2 (pt)
SG (1) SG11201401286QA (pt)
TW (3) TWI604852B (pt)
UY (1) UY34444A (pt)
WO (1) WO2013071016A2 (pt)
ZA (1) ZA201402414B (pt)

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US9017678B1 (en) 2014-07-15 2015-04-28 Kymab Limited Method of treating rheumatoid arthritis using antibody to IL6R
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US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
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AU2016271138A1 (en) * 2015-05-29 2017-12-07 Merrimack Pharmaceuticals, Inc. Combination cancer therapies
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WO2018106959A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
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AU2019235782A1 (en) 2018-03-14 2020-10-08 Celledit Llc Modification of immune cells for reducing toxicity and uses thereof in adoptive cell therapy
CN108567981A (zh) * 2018-07-17 2018-09-25 漯河医学高等专科学校 白细胞介素-6的拮抗剂在制备抑制Notch-1蛋白表达、治疗胰腺癌的药物中的应用
WO2020106757A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
AU2020205951A1 (en) * 2019-01-07 2021-07-22 Hunan Siweikang Therapeutics Co. Ltd Modified immune cells co-expressing chimeric antigen receptor and il-6 antagonist for reducing toxicity and uses thereof in adoptive cell therapy
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Publication number Publication date
US9409990B2 (en) 2016-08-09
CN103930443B (zh) 2017-08-04
US20130122003A1 (en) 2013-05-16
TW201332569A (zh) 2013-08-16
TWI604852B (zh) 2017-11-11
TW201716776A (zh) 2017-05-16
SG11201401286QA (en) 2014-05-29
EP2776468B1 (en) 2018-01-24
WO2013071016A2 (en) 2013-05-16
CA2853836C (en) 2019-07-23
US20170022279A1 (en) 2017-01-26
US20140322215A1 (en) 2014-10-30
ZA201402414B (en) 2015-03-25
CN103930443A (zh) 2014-07-16
MY163953A (en) 2017-11-15
WO2013071016A3 (en) 2013-07-25
AU2012335596A1 (en) 2014-05-22
JP2017095489A (ja) 2017-06-01
KR101718748B1 (ko) 2017-03-22
IL231854A0 (en) 2014-05-28
RU2014118739A (ru) 2015-12-20
UY34444A (es) 2013-05-31
AU2018203666A1 (en) 2018-06-14
IL231854A (en) 2016-11-30
CA2853836A1 (en) 2013-05-16
JO3370B1 (ar) 2019-03-13
IL248620A0 (en) 2016-12-29
EP2776468A2 (en) 2014-09-17
JP6144689B2 (ja) 2017-06-07
TW201806620A (zh) 2018-03-01
MX357837B (es) 2018-07-26
KR20140095481A (ko) 2014-08-01
MX2014004886A (es) 2014-07-09
JP6283754B2 (ja) 2018-02-21
AU2012335596B2 (en) 2018-05-17
RU2648150C2 (ru) 2018-03-22
JP2014534237A (ja) 2014-12-18
AR088671A1 (es) 2014-06-25
JP2018083841A (ja) 2018-05-31
IN2014CN02923A (pt) 2015-07-03

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