UY30480A1 - Procedimiento para la fabricacion de analgesicos a base de fentanilo, para su administracion por via oral transmucosa bajo forma de un caramelo. - Google Patents
Procedimiento para la fabricacion de analgesicos a base de fentanilo, para su administracion por via oral transmucosa bajo forma de un caramelo.Info
- Publication number
- UY30480A1 UY30480A1 UY30480A UY30480A UY30480A1 UY 30480 A1 UY30480 A1 UY 30480A1 UY 30480 A UY30480 A UY 30480A UY 30480 A UY30480 A UY 30480A UY 30480 A1 UY30480 A1 UY 30480A1
- Authority
- UY
- Uruguay
- Prior art keywords
- weight
- caramel
- water
- mass
- transmuctive
- Prior art date
Links
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title 1
- 229960002428 fentanyl Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 5
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 abstract 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 2
- 229930006000 Sucrose Natural products 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 235000013736 caramel Nutrition 0.000 abstract 2
- 229960004207 fentanyl citrate Drugs 0.000 abstract 2
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000008213 purified water Substances 0.000 abstract 2
- 239000005720 sucrose Substances 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Disolver en agua purificada una cantidad apropiada de citrato de fentanilo. Disolver en agua purificada un colorante aceptado. Mezclar un azucar poli alcoholico en agua purificada con una razon de agua / azucar poli alcoholico entre 17% al 19,5% en peso hasta obtener una masa liquida homogénea e incorporar Sacarosa con una relacion de la solucion anterior respecto de la Sacarosa entre 65% al 67,5 en peso. Calentar la masa a ebullicion a una temperatura desde 128s-132sC a 148s-152sC, evaporando agua hasta una masa resultante con un peso entre el 88 al 90% en peso respecto del peso total inicial. Enfriar la masa resultante hasta un entorno de 130s C y agregar las soluciones del Citrato de Fentanilo, el colorante y saborizante, agitando enérgicamente mateniendo la temperatura. Volcar en un molde o matriz esta masa caliente, con eventual incorporacion de un asa en cada caramelo. Retirar del molde una vez enfriado y solidificado el caramelo, y envasar enseguida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP060102985A AR058431A1 (es) | 2006-07-12 | 2006-07-12 | Procedimiento para la fabricacion de analgesicos a base de fentanilo para su administracion por via oral transmucosa bajo forma de caramelo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY30480A1 true UY30480A1 (es) | 2008-10-31 |
Family
ID=38461813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY30480A UY30480A1 (es) | 2006-07-12 | 2007-07-11 | Procedimiento para la fabricacion de analgesicos a base de fentanilo, para su administracion por via oral transmucosa bajo forma de un caramelo. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100003309A1 (es) |
| AR (1) | AR058431A1 (es) |
| BR (1) | BRPI0715459A2 (es) |
| CA (1) | CA2657421A1 (es) |
| UY (1) | UY30480A1 (es) |
| WO (1) | WO2008007991A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9044035B2 (en) * | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| US20160014233A1 (en) * | 2014-07-08 | 2016-01-14 | Google Inc. | Computer-implemented agent transfer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4372942A (en) * | 1981-08-13 | 1983-02-08 | Beecham Inc. | Candy base and liquid center hard candy made therefrom |
| US4692339A (en) * | 1982-09-30 | 1987-09-08 | Stetson Charles G | Process for addition and stabilization of vitamin C in a hard candy-like comestible |
| US4671953A (en) * | 1985-05-01 | 1987-06-09 | University Of Utah Research Foundation | Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics |
| US6680071B1 (en) * | 1999-03-03 | 2004-01-20 | R. P. Scherer Technologies, Inc. | Opioid agonist in a fast dispersing dosage form |
| US20040253307A1 (en) * | 2003-02-04 | 2004-12-16 | Brian Hague | Sugar-free oral transmucosal solid dosage forms and uses thereof |
| US20040213828A1 (en) * | 2003-04-23 | 2004-10-28 | Smith David J. | Pain relief lollipop compositions and methods |
-
2006
- 2006-07-12 AR ARP060102985A patent/AR058431A1/es unknown
-
2007
- 2007-07-11 UY UY30480A patent/UY30480A1/es not_active Application Discontinuation
- 2007-07-11 CA CA002657421A patent/CA2657421A1/en not_active Abandoned
- 2007-07-11 US US12/373,195 patent/US20100003309A1/en not_active Abandoned
- 2007-07-11 BR BRPI0715459-3A patent/BRPI0715459A2/pt not_active IP Right Cessation
- 2007-07-11 WO PCT/PT2007/000030 patent/WO2008007991A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008007991A1 (en) | 2008-01-17 |
| US20100003309A1 (en) | 2010-01-07 |
| CA2657421A1 (en) | 2008-01-17 |
| BRPI0715459A2 (pt) | 2013-03-12 |
| AR058431A1 (es) | 2008-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RDES | Application refused |
Effective date: 20191220 |