UY29349A1 - Inhibicion de los objetivos de la hipertensión ocular mediada por arni - Google Patents
Inhibicion de los objetivos de la hipertensión ocular mediada por arniInfo
- Publication number
- UY29349A1 UY29349A1 UY29349A UY29349A UY29349A1 UY 29349 A1 UY29349 A1 UY 29349A1 UY 29349 A UY29349 A UY 29349A UY 29349 A UY29349 A UY 29349A UY 29349 A1 UY29349 A1 UY 29349A1
- Authority
- UY
- Uruguay
- Prior art keywords
- ocular hypertension
- objectives
- arni
- inhibition
- beta
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01007—Acetylcholinesterase (3.1.1.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/03—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; catalysing transmembrane movement of substances (3.6.3)
- C12Y306/03009—Na+/K+-exchanging ATPase (3.6.3.9)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01001—Carbonate dehydratase (4.2.1.1), i.e. carbonic anhydrase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se presenta la interferencia del ARN inhibir la expresión del ARNm del objetivo de la hipertensión ocular a los efectos de reducir la presión intraocular elevada de los pacientes que sufren de glaucoma de ángulo abierto o hipertensión ocular. Los objetivos de la hipertensión ocular incluyen las anhidrasas carbónicasII, IV y XII, los receptores adrenérgicos B(Beta)1 y B(Beta)2, la acetilcolinesterasa, Na+/K+-ATPasa y el cotransportar Na-K-2C1. La hipertensión ocular se trata administrando los ARNi del presente invento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64892605P | 2005-02-01 | 2005-02-01 | |
US75336405P | 2005-12-22 | 2005-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY29349A1 true UY29349A1 (es) | 2006-05-31 |
Family
ID=36587258
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29348A UY29348A1 (es) | 2005-02-01 | 2006-01-26 | Inhibición de objetivos oculares mediada por arni |
UY29349A UY29349A1 (es) | 2005-02-01 | 2006-01-26 | Inhibicion de los objetivos de la hipertensión ocular mediada por arni |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29348A UY29348A1 (es) | 2005-02-01 | 2006-01-26 | Inhibición de objetivos oculares mediada por arni |
Country Status (14)
Country | Link |
---|---|
US (4) | US7592324B2 (es) |
EP (2) | EP1846557A2 (es) |
JP (2) | JP2008528632A (es) |
KR (2) | KR20070099048A (es) |
AR (2) | AR052103A1 (es) |
AU (2) | AU2006210846A1 (es) |
BR (2) | BRPI0606979A2 (es) |
CA (2) | CA2595678A1 (es) |
MX (2) | MX2007009194A (es) |
RU (2) | RU2007132848A (es) |
SA (1) | SA06260487B1 (es) |
TW (2) | TW200639253A (es) |
UY (2) | UY29348A1 (es) |
WO (2) | WO2006083945A2 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1781787T3 (pl) | 2004-08-23 | 2018-01-31 | Sylentis Sau | Leczenie zaburzeń oka charakteryzowanych przez podwyższone ciśnienie wewnątrzgałkowe przy użyciu siRNA |
AU2006223131A1 (en) | 2005-03-11 | 2006-09-21 | Alcon, Inc. | RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma |
GB0505081D0 (en) * | 2005-03-14 | 2005-04-20 | Genomica Sau | Downregulation of interleukin-12 expression by means of rnai technology |
GB0521351D0 (en) * | 2005-10-20 | 2005-11-30 | Genomica Sau | Modulation of TRPV expression levels |
GB0521716D0 (en) * | 2005-10-25 | 2005-11-30 | Genomica Sau | Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases |
ATE456053T1 (de) * | 2005-12-30 | 2010-02-15 | Ventana Med Syst Inc | Na+, k+-atpase-expression bei zervixdysplasie und krebs |
CA2659464A1 (en) * | 2006-08-24 | 2008-02-28 | Alcon Research, Ltd. | Rnai-mediated inhibition of gremlin for treatment of iop-related conditions |
WO2008092142A2 (en) * | 2007-01-26 | 2008-07-31 | Alcon Research, Ltd. | Rnai-mediated inhibition of aquaporin 1 for treatment of ocular neovascularization |
WO2008104978A2 (en) * | 2007-02-28 | 2008-09-04 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
EP2192926A1 (en) * | 2007-10-01 | 2010-06-09 | Alcon Research, Ltd. | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
JP5646997B2 (ja) * | 2007-10-03 | 2014-12-24 | クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. | 新規siRNA構造 |
US7973019B1 (en) | 2007-10-03 | 2011-07-05 | Alcon Research, Ltd. | Transferrin/transferrin receptor-mediated siRNA delivery |
AR069328A1 (es) | 2007-11-15 | 2010-01-13 | Alcon Mfg Ltd | Liberacion de rna interferente corto o sirna, intermediada por receptor de lipoproteina de baja densidad |
AR069704A1 (es) * | 2007-12-18 | 2010-02-10 | Alcon Res Ltd | Sistema de administracion de rnai de interferencia y usos del mismo |
WO2009090639A2 (en) * | 2008-01-15 | 2009-07-23 | Quark Pharmaceuticals, Inc. | Sirna compounds and methods of use thereof |
CA2738957A1 (en) * | 2008-10-22 | 2010-04-29 | Quark Pharmaceuticals, Inc. | Methods for treating eye disorders |
WO2012161677A1 (en) | 2011-05-20 | 2012-11-29 | Alcon Research, Ltd. | TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY |
WO2013103467A1 (en) | 2012-01-06 | 2013-07-11 | Alcon Research, Ltd. | Interfering rna delivery system and uses thereof |
GB201215857D0 (en) | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
IN2015DN02699A (es) | 2012-09-05 | 2015-09-04 | Sylentis Sau | |
US10011837B2 (en) | 2014-03-04 | 2018-07-03 | Sylentis Sau | SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions |
EP3429567B1 (en) | 2016-03-16 | 2024-01-10 | The J. David Gladstone Institutes | Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents |
EP3388520A1 (en) * | 2017-04-11 | 2018-10-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for reducing the expression of nkcc1 in a subject in need thereof |
CN109557309B (zh) * | 2018-12-04 | 2021-09-10 | 九江学院附属医院 | 碳酸酐酶-2作为检测标记物在肾结石诊断方面的应用 |
KR102414025B1 (ko) * | 2019-06-27 | 2022-06-29 | 전북대학교 산학협력단 | 신규한 에이디피-라이보실 사이클라아제 및 이의 저해제 |
KR20240014109A (ko) * | 2021-05-27 | 2024-01-31 | 알닐람 파마슈티칼스 인코포레이티드 | 탄산 무수화효소 2 발현을 침묵화하기 위한 조성물 및 방법 |
WO2023239756A1 (en) | 2022-06-07 | 2023-12-14 | Generation Bio Co. | Lipid nanoparticle compositions and uses thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
CA2361201A1 (en) * | 1999-01-28 | 2000-08-03 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
US6326193B1 (en) * | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
US20050112118A1 (en) * | 1999-12-02 | 2005-05-26 | Myriad Genetics, Incorporated | Compositions and methods for treating inflammatory disorders |
US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
JP2003526367A (ja) * | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Rna干渉の方法とrna干渉組成物 |
KR20080023768A (ko) * | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
EP1305450A2 (en) * | 2000-07-28 | 2003-05-02 | Compugen Inc. | Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome |
CZ302719B6 (cs) * | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
AU2002366641A1 (en) * | 2001-12-11 | 2003-06-23 | Fibrogen, Inc. | Methods for inhibiting ocular processes |
WO2003087840A2 (en) * | 2002-04-11 | 2003-10-23 | Oxford Glycosciences (Uk) Ltd | Protein involved in cancer |
JP2006500910A (ja) * | 2002-04-18 | 2006-01-12 | アキュイティ ファーマシューティカルズ、インク. | Cnsと眼の標的遺伝子を特異的に調節するための手段と方法及びその同定法 |
WO2003093441A2 (en) * | 2002-05-03 | 2003-11-13 | Duke University | A method of regulating gene expression |
WO2004014933A1 (en) * | 2002-08-07 | 2004-02-19 | University Of Massachusetts | Compositions for rna interference and methods of use thereof |
EP1572957A4 (en) * | 2002-08-27 | 2007-10-10 | Bristol Myers Squibb Pharma Co | IDENTIFICATION OF POLYNUCLEOTIDES FOR PREDICTING THE ACTIVITY OF COMPOUNDS INTERACTING WITH AND / OR MODULATING TYROSINE KINASE PROTEINS AND / OR TYROSINE KINASE PROTEIN PATHWAYS IN MAMMARY CELLS |
EP1534832A2 (en) | 2002-09-04 | 2005-06-01 | Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Compositions and methods for tissue specific or inducible inhibition of gene expression |
WO2004022750A1 (en) | 2002-09-05 | 2004-03-18 | Garvan Institute Of Medical Research | Novel diagnostic and therapeutic methods and reagents therefor |
US7521431B2 (en) * | 2002-11-01 | 2009-04-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for siRNA inhibition of HIF-1 alpha |
ATE517992T1 (de) * | 2002-11-14 | 2011-08-15 | Dharmacon Inc | Funktionelle und hyperfunktionelle sirna |
US20040175732A1 (en) * | 2002-11-15 | 2004-09-09 | Rana Tariq M. | Identification of micrornas and their targets |
WO2004072261A2 (en) * | 2003-02-11 | 2004-08-26 | Immusol Incorporated | Sirna libraries optimized for predetermined protein families |
WO2005090606A2 (en) * | 2004-01-23 | 2005-09-29 | Dharmacon, Inc. | Identification of toxic nucleotide sequences |
GB0403600D0 (en) | 2004-02-18 | 2004-03-24 | Trinity College Dublin | Methods and reagents for treating disease |
KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
CA2576233C (en) * | 2004-08-10 | 2016-03-15 | Alnylam Pharmaceuticals, Inc. | Conjugate comprising an antagomir and a ligand |
PL1781787T3 (pl) * | 2004-08-23 | 2018-01-31 | Sylentis Sau | Leczenie zaburzeń oka charakteryzowanych przez podwyższone ciśnienie wewnątrzgałkowe przy użyciu siRNA |
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2006
- 2006-01-09 TW TW095100740A patent/TW200639253A/zh unknown
- 2006-01-09 TW TW095100739A patent/TW200639252A/zh unknown
- 2006-01-20 AR ARP060100333A patent/AR052103A1/es not_active Application Discontinuation
- 2006-01-26 UY UY29348A patent/UY29348A1/es not_active Application Discontinuation
- 2006-01-26 UY UY29349A patent/UY29349A1/es not_active Application Discontinuation
- 2006-01-30 AR ARP060100332A patent/AR052102A1/es unknown
- 2006-01-30 SA SA6260487A patent/SA06260487B1/ar unknown
- 2006-02-01 WO PCT/US2006/003515 patent/WO2006083945A2/en active Application Filing
- 2006-02-01 US US11/345,361 patent/US7592324B2/en not_active Expired - Fee Related
- 2006-02-01 JP JP2007553373A patent/JP2008528632A/ja not_active Withdrawn
- 2006-02-01 MX MX2007009194A patent/MX2007009194A/es active IP Right Grant
- 2006-02-01 BR BRPI0606979-7A patent/BRPI0606979A2/pt not_active Application Discontinuation
- 2006-02-01 AU AU2006210846A patent/AU2006210846A1/en not_active Abandoned
- 2006-02-01 JP JP2007553390A patent/JP2008528637A/ja not_active Withdrawn
- 2006-02-01 KR KR1020077019714A patent/KR20070099048A/ko not_active Application Discontinuation
- 2006-02-01 RU RU2007132848/15A patent/RU2007132848A/ru unknown
- 2006-02-01 CA CA002595678A patent/CA2595678A1/en not_active Abandoned
- 2006-02-01 RU RU2007132874/13A patent/RU2007132874A/ru not_active Application Discontinuation
- 2006-02-01 BR BRPI0607096-5A patent/BRPI0607096A2/pt active Search and Examination
- 2006-02-01 MX MX2007009200A patent/MX2007009200A/es not_active Application Discontinuation
- 2006-02-01 EP EP06720051A patent/EP1846557A2/en not_active Withdrawn
- 2006-02-01 EP EP06734380A patent/EP1848803A2/en not_active Ceased
- 2006-02-01 US US11/344,702 patent/US20060172963A1/en not_active Abandoned
- 2006-02-01 KR KR1020077019895A patent/KR20070099673A/ko not_active Application Discontinuation
- 2006-02-01 CA CA002595790A patent/CA2595790A1/en not_active Abandoned
- 2006-02-01 WO PCT/US2006/004018 patent/WO2006084217A2/en active Application Filing
- 2006-02-01 AU AU2006210451A patent/AU2006210451B2/en not_active Ceased
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2009
- 2009-08-06 US US12/536,698 patent/US20090326044A1/en not_active Abandoned
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2010
- 2010-12-14 US US12/967,121 patent/US20110124708A1/en not_active Abandoned
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