ATE511506T1 - Thiopen-derivate als wirkstoffe gegen okulare hypotonie - Google Patents

Thiopen-derivate als wirkstoffe gegen okulare hypotonie

Info

Publication number
ATE511506T1
ATE511506T1 AT08713891T AT08713891T ATE511506T1 AT E511506 T1 ATE511506 T1 AT E511506T1 AT 08713891 T AT08713891 T AT 08713891T AT 08713891 T AT08713891 T AT 08713891T AT E511506 T1 ATE511506 T1 AT E511506T1
Authority
AT
Austria
Prior art keywords
thiopene
occular
hypotonia
derivatives
active ingredients
Prior art date
Application number
AT08713891T
Other languages
English (en)
Inventor
David Old
Vinh Ngo
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE511506T1 publication Critical patent/ATE511506T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AT08713891T 2007-01-22 2008-01-22 Thiopen-derivate als wirkstoffe gegen okulare hypotonie ATE511506T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88601307P 2007-01-22 2007-01-22
PCT/US2008/051650 WO2008091860A1 (en) 2007-01-22 2008-01-22 Thiophene derivatives useful as ocular hypotensive agents

Publications (1)

Publication Number Publication Date
ATE511506T1 true ATE511506T1 (de) 2011-06-15

Family

ID=39420781

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08713891T ATE511506T1 (de) 2007-01-22 2008-01-22 Thiopen-derivate als wirkstoffe gegen okulare hypotonie

Country Status (7)

Country Link
US (1) US8039496B2 (de)
EP (1) EP2114913B1 (de)
JP (1) JP5394933B2 (de)
AT (1) ATE511506T1 (de)
AU (1) AU2008207991B9 (de)
CA (1) CA2675981A1 (de)
WO (1) WO2008091860A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007272683B2 (en) * 2006-07-10 2012-08-23 Allergan, Inc. Substituted cyclopentane derivatives as therapeutic agents
WO2009132093A2 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
CA2722312C (en) 2008-04-24 2016-08-09 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
US9890146B2 (en) 2014-02-27 2018-02-13 Ono Pharmaceutical Co., Ltd. Compound having selective EP2 agonist activity
EP3327018B1 (de) 2015-07-23 2020-11-25 ONO Pharmaceutical Co., Ltd. 2-(octahydrocyclopenta[b]pyran-2-yl)1,3-thiazol-4-carbonsäure-derivate und ähnliche verbindungen als ep2 agonisten mit augeninnendruck-senkender wirkung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US6291522B1 (en) * 2000-09-27 2001-09-18 Allergan Sales, Inc. Cyclopentane heptan(ENE)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents
ES2246419T3 (es) * 2001-11-05 2006-02-16 Allergan, Inc. Analogos de omega-cicloalquil-17-heteroaril-prostaglandina e2 como agonistas del receptor ep-2.
US7183310B2 (en) * 2004-08-10 2007-02-27 Allergan, Inc. Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US7101904B2 (en) * 2004-08-10 2006-09-05 Allergan, Inc. Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US7091231B2 (en) 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
US7429669B2 (en) * 2006-06-20 2008-09-30 Allergan, Inc. Therapeutic compounds
US7507817B2 (en) * 2006-11-17 2009-03-24 Allergan, Inc. Prostaglandin prodrugs
WO2009132093A2 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
CA2722312C (en) * 2008-04-24 2016-08-09 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents

Also Published As

Publication number Publication date
EP2114913A1 (de) 2009-11-11
EP2114913B1 (de) 2011-06-01
AU2008207991B2 (en) 2014-01-16
WO2008091860A1 (en) 2008-07-31
CA2675981A1 (en) 2008-07-31
JP2010516779A (ja) 2010-05-20
US8039496B2 (en) 2011-10-18
AU2008207991A1 (en) 2008-07-31
JP5394933B2 (ja) 2014-01-22
US20100029735A1 (en) 2010-02-04
AU2008207991B9 (en) 2014-02-27

Similar Documents

Publication Publication Date Title
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
NO20084853L (no) Forbindelser som er agonister av muscarinreseptorer og som kan vaere effektive i behandling av smerte, Alzheimers sykdom og/eller schizofreni
MA30717B1 (fr) Derives de pyridin-3-yle en tant qu'agents immunomodulateurs
MA30718B1 (fr) Derives de pyridin-4-yle en tant qu'agents immunomodulateurs.
NO20062704L (no) Azabicykliske heterocykler som cannabinoide reseptormodulatorer
DE602004028150D1 (de) Aminopyrazolderivate als gsk-3-inhibitoren
ATE517882T1 (de) Chinolinderivate
EA200870193A1 (ru) Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение
ATE540932T1 (de) Hydantoin-derivate als antibakterielle wirkstoffe
NO20062689L (no) Azabisykliske heterosykler som modulatorer for kannabinoidreseptorer
NO20084872L (no) 2-pyridonderivater for behandling av sykdom eller tilstander der inhibering av neutrofil elastaseaktivitet er gunstig
ATE502633T1 (de) Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
SE0401971D0 (sv) Piperidne derivatives
EA201071040A1 (ru) Новые производные 1-бензил-3-гидроксиметилиндазола и их применение при лечении заболеваний, обусловленных экспрессией mcp-1, cx3cr1 и p40
ATE384058T1 (de) Thiazolderivate
EA200802223A1 (ru) 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90
MA30821B1 (fr) Derives de pyrazoline utiles comme antagonistes des recepteurs de mineralocorticoïdes
SE0401342D0 (sv) Therapeutic compounds
NO20071314L (no) Peptidiske vasopressinreseptoragonister
EA201071039A1 (ru) Новые производные 1-бензил-3-гидроксиметилиндазола и их применение для лечения заболеваний, основанных на экспрессии mcp-1, cx3cr1 и p40
NO20083058L (no) Cykloheksylsulfonamidderivater med H3 reseptor aktivitet
SE0402762D0 (sv) Indazole sulphonamide derivatives
EA201071043A1 (ru) Новые производные 1-бензил-3-гидроксиметилиндазола и их применение при лечении заболеваний, обусловленных экспрессией mcp-1 и cx3cr1
RU2011112684A (ru) АГЕНТ, СПОСОБСТВУЮЩИЙ РОСТУ ВОЛОС, СОДЕРЖАЩИЙ В КАЧЕСТВЕ АКТИВНОГО ИНГРЕДИЕНТА ПРОИЗВОДНОЕ 15,15-ДИФТОРПРОСТАГЛАНДИНА F2α
ATE511506T1 (de) Thiopen-derivate als wirkstoffe gegen okulare hypotonie

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties