UY25841A1 - Cicloheptenos sustituidos y su procedimiento de obtencion - Google Patents

Cicloheptenos sustituidos y su procedimiento de obtencion

Info

Publication number
UY25841A1
UY25841A1 UY25841A UY25841A UY25841A1 UY 25841 A1 UY25841 A1 UY 25841A1 UY 25841 A UY25841 A UY 25841A UY 25841 A UY25841 A UY 25841A UY 25841 A1 UY25841 A1 UY 25841A1
Authority
UY
Uruguay
Prior art keywords
aryl
alkyl
heterocyclyl
agonists
coo
Prior art date
Application number
UY25841A
Other languages
English (en)
Inventor
Babette-Yvonne Koegel
Werner Guenter Englberg
Wolfgang Werner A Strassburger
Oswald Zimmer
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of UY25841A1 publication Critical patent/UY25841A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/16—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring
    • C07C13/18—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring with a cyclohexane ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención se refiere a cicloheptenos sustituidos de la fórmula general (I), un procedimiento para su preparación y su uso como medicamento, en la cual: R1 representa OH, O-alquilo, O-cicloalquilo, O-arilo, alquil-COO, aril-COO; R2 representa alquilo, CH2-arilo, alquenilen-arilo; y R3 representa CH2-cicloalquilo, CH2-arilo, heterociclilo, alquil-heterociclilo, o que se encuentran como racematos o en forma de enantiómeros puros, en forma de base o como sal con un ácido farmacéuticamente aplicable. Por ejemplo: Clorhidrato de 3-(6-(4-cloro-fenil)-2-dimetilaminometil-ciclohepten-1-enil)-fenol. Los compuestos de fórmula (I) sos sustancias de efecto analgésico cuya eficacia biológica puede ser producida parcial o principalmente a través de gamma-agonistas receptores de opiatos. Pueden utilizarse potencialmente todos estos compuestos como analgésicos y, en general, para todos los estados patológicos que generalmente pueden tratarse con gamma-agonistas de receptores de opiato.
UY25841A 1998-12-14 1999-12-09 Cicloheptenos sustituidos y su procedimiento de obtencion UY25841A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19857475A DE19857475A1 (de) 1998-12-14 1998-12-14 Substituierte Cycloheptene, deren Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
UY25841A1 true UY25841A1 (es) 2000-09-29

Family

ID=7890934

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25841A UY25841A1 (es) 1998-12-14 1999-12-09 Cicloheptenos sustituidos y su procedimiento de obtencion

Country Status (27)

Country Link
US (1) US6323369B1 (es)
EP (1) EP1010689B1 (es)
JP (1) JP4440398B2 (es)
KR (1) KR20000048101A (es)
CN (1) CN1231457C (es)
AR (1) AR021616A1 (es)
AT (1) ATE231119T1 (es)
AU (1) AU767102B2 (es)
BR (1) BR9907340A (es)
CA (1) CA2292017C (es)
CZ (1) CZ296788B6 (es)
DE (2) DE19857475A1 (es)
DK (1) DK1010689T3 (es)
ES (1) ES2190632T3 (es)
HK (1) HK1028595A1 (es)
HU (1) HU224313B1 (es)
IL (1) IL133481A (es)
NO (1) NO313826B1 (es)
NZ (1) NZ501651A (es)
PE (1) PE20001328A1 (es)
PL (1) PL199875B1 (es)
PT (1) PT1010689E (es)
RU (1) RU2233268C2 (es)
SI (1) SI1010689T1 (es)
SK (1) SK284186B6 (es)
UY (1) UY25841A1 (es)
ZA (1) ZA997637B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10000312A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
DE10261091A1 (de) 2002-12-20 2004-07-01 Grünenthal GmbH Gesättigte und ungesättigte Heteroarylcycloalkylmethyl-Amine
DE10326097A1 (de) * 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
DE102004034619A1 (de) * 2004-07-16 2006-02-23 Grünenthal GmbH Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer
CN103965059B (zh) * 2013-02-06 2017-12-22 上海科胜药物研发有限公司 一种制备(1r,2s)‑2‑(3,4‑二氟苯基)环丙胺的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3830934A (en) * 1967-07-27 1974-08-20 Gruenenthal Chemie Analgesic and antitussive compositions and methods

Also Published As

Publication number Publication date
DE19857475A1 (de) 2000-06-15
CN1231457C (zh) 2005-12-14
CA2292017C (en) 2009-09-08
PT1010689E (pt) 2003-06-30
PE20001328A1 (es) 2000-12-23
SK174299A3 (en) 2000-07-11
AU767102B2 (en) 2003-10-30
PL199875B1 (pl) 2008-11-28
IL133481A (en) 2004-05-12
IL133481A0 (en) 2001-04-30
HU9904564D0 (en) 2000-02-28
JP4440398B2 (ja) 2010-03-24
EP1010689A1 (de) 2000-06-21
SK284186B6 (sk) 2004-10-05
CZ451499A3 (cs) 2000-07-12
NO996156D0 (no) 1999-12-13
ATE231119T1 (de) 2003-02-15
DK1010689T3 (da) 2003-02-10
HUP9904564A2 (hu) 2000-12-28
AR021616A1 (es) 2002-07-31
NO313826B1 (no) 2002-12-09
NO996156L (no) 2000-06-15
JP2000178238A (ja) 2000-06-27
CA2292017A1 (en) 2000-06-14
NZ501651A (en) 2000-12-22
US6323369B1 (en) 2001-11-27
CN1266053A (zh) 2000-09-13
EP1010689B1 (de) 2003-01-15
BR9907340A (pt) 2001-01-16
DE59904035D1 (de) 2003-02-20
PL337154A1 (en) 2000-06-19
HK1028595A1 (en) 2001-02-23
HU224313B1 (hu) 2005-07-28
SI1010689T1 (en) 2003-06-30
KR20000048101A (ko) 2000-07-25
ZA997637B (en) 2000-06-14
HUP9904564A3 (en) 2001-01-29
RU2233268C2 (ru) 2004-07-27
AU6440699A (en) 2000-06-15
ES2190632T3 (es) 2003-08-01
CZ296788B6 (cs) 2006-06-14

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Legal Events

Date Code Title Description
RDES Application refused

Effective date: 20081222