UY24374A1 - Procedimiento de produccion de acido clavulanico y/o sus sales - Google Patents
Procedimiento de produccion de acido clavulanico y/o sus salesInfo
- Publication number
- UY24374A1 UY24374A1 UY24374A UY24374A UY24374A1 UY 24374 A1 UY24374 A1 UY 24374A1 UY 24374 A UY24374 A UY 24374A UY 24374 A UY24374 A UY 24374A UY 24374 A1 UY24374 A1 UY 24374A1
- Authority
- UY
- Uruguay
- Prior art keywords
- fermentation
- soluble phosphate
- salts
- production
- throughout
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe un procedimiento para la producción de ácido clavulánico y/o sus sales. La misma se realiza mediante cultivo de "Streptomyces clavuligerus" ATCC 27064 o de mutantes obtenidos del mismo, en fermentación sumergida con aireación y agitación, en cultivo en lotes, semi-continuo o continuo, en el que las concentraciones de fosfato soluble se fijan al inicio y/o mantienen a lo largo de la fermentación, dentro de unos determinados valores. Las concentraciones de fosfato soluble presentes en el medio de cultivo se fijan al inicio y/o se mantienen a lo largo de la fermentación mediante precipitación de dicho fosfato soluble, se éste excede de los límites deseados. Dicho fosfato soluble se precipita mediante la adición de un compuesto de calcio al medio de cultivo. Se emplea una fuente de carbono que consiste en uno o más triglicéridos, naturales o sintéticos, que son añadidos al comienzo de la fermentación y/o a lo largo de la misma. La fermentación se lleva a cabo a una temperatura de 20-40ºC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09502300A ES2101658B1 (es) | 1995-11-23 | 1995-11-23 | Nuevo procedimiento de produccion de acido clavulanico y sus sales. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY24374A1 true UY24374A1 (es) | 1996-11-28 |
Family
ID=8292259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY24374A UY24374A1 (es) | 1995-11-23 | 1996-11-21 | Procedimiento de produccion de acido clavulanico y/o sus sales |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6100052A (es) |
| EP (1) | EP0811689B1 (es) |
| JP (1) | JP3313730B2 (es) |
| KR (1) | KR19980701615A (es) |
| CN (1) | CN1113965C (es) |
| AR (1) | AR004342A1 (es) |
| AT (1) | ATE219145T1 (es) |
| AU (1) | AU729094B2 (es) |
| BG (1) | BG101788A (es) |
| BR (1) | BR9606930A (es) |
| CA (1) | CA2211207A1 (es) |
| CO (1) | CO4700346A1 (es) |
| CZ (1) | CZ231797A3 (es) |
| DE (1) | DE69621780T2 (es) |
| DK (1) | DK0811689T3 (es) |
| ES (2) | ES2101658B1 (es) |
| HU (1) | HUP9800343A3 (es) |
| MX (1) | MX9705555A (es) |
| PL (1) | PL321456A1 (es) |
| PT (1) | PT811689E (es) |
| RU (1) | RU2187556C2 (es) |
| SI (1) | SI0811689T1 (es) |
| SK (1) | SK97997A3 (es) |
| TR (1) | TR199700679T1 (es) |
| UY (1) | UY24374A1 (es) |
| WO (1) | WO1997019187A1 (es) |
| ZA (1) | ZA969734B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
| SI9500265A1 (en) | 1995-08-28 | 1997-02-28 | Lek Tovarna Farmacevtskih | Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration |
| AR015825A1 (es) * | 1997-05-28 | 2001-05-30 | Gist Brocades Bv | Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato |
| PT102181A (pt) * | 1998-07-20 | 2000-01-31 | Dsm Nv | Processo melhorado para a producao de acido clavulanico |
| EP1026236A1 (en) * | 1999-02-04 | 2000-08-09 | Dsm N.V. | Auxotrophic strains for secondary metabolite biosynthesis |
| CN100355895C (zh) * | 2004-12-17 | 2007-12-19 | 天津科技大学 | 棒状链霉菌lat基因缺失的质粒、衍生物及其构建方法 |
| CN1872854B (zh) * | 2005-05-31 | 2010-04-07 | 西北农林科技大学农药研究所 | 一种内酰胺类抗生素及其制备方法 |
| WO2006128342A1 (fr) * | 2005-05-31 | 2006-12-07 | Northwest Sci-Tech University Of Agriculture & Forestry | Antibiotique de type lactame, champignon le produisant et utilisation |
| EP2589663A1 (en) | 2011-11-04 | 2013-05-08 | LEK Pharmaceuticals d.d. | Process for production of clavulanic acid |
| CA2984762C (en) * | 2015-05-05 | 2023-09-19 | Logos Technologies Llc | A semi-continuous process for the production of rhamnolipids at high yield and titer |
| CN109913392A (zh) * | 2019-03-30 | 2019-06-21 | 山东睿智医药科技有限公司 | 高产克拉维酸的棒状链霉菌菌株、其胁迫选育方法及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
| US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
| IT1152277B (it) * | 1982-06-30 | 1986-12-31 | Istituto Biochimico Italiano | Procedimento per la produzione di acido clavulanico |
| AR245221A1 (es) * | 1984-10-27 | 1993-12-30 | Beecham Group Plc | Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus |
| ES8602943A1 (es) * | 1984-10-27 | 1985-12-16 | Antibioticos Sa | Procedimiento para la mejora de la fermentacion de acido clavulanico y sus sales |
| AT400846B (de) * | 1994-02-25 | 1996-03-25 | Fermic S A De C V | Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure |
| SI9600120A (en) * | 1996-04-12 | 1997-12-31 | Lek Tovarna Farmacevtskih | New and improved fermentative procedure for the production of clavulanic acid and its salts |
-
1995
- 1995-11-23 ES ES09502300A patent/ES2101658B1/es not_active Expired - Fee Related
-
1996
- 1996-11-15 US US08/875,189 patent/US6100052A/en not_active Expired - Fee Related
- 1996-11-15 MX MX9705555A patent/MX9705555A/es unknown
- 1996-11-15 RU RU97114101/13A patent/RU2187556C2/ru not_active IP Right Cessation
- 1996-11-15 TR TR97/00679T patent/TR199700679T1/xx unknown
- 1996-11-15 CO CO96060301A patent/CO4700346A1/es unknown
- 1996-11-15 SI SI9630508T patent/SI0811689T1/xx unknown
- 1996-11-15 EP EP96938223A patent/EP0811689B1/en not_active Expired - Lifetime
- 1996-11-15 PT PT96938223T patent/PT811689E/pt unknown
- 1996-11-15 AU AU26122/97A patent/AU729094B2/en not_active Ceased
- 1996-11-15 DK DK96938223T patent/DK0811689T3/da active
- 1996-11-15 BR BR9606930A patent/BR9606930A/pt not_active Application Discontinuation
- 1996-11-15 ES ES96938223T patent/ES2178721T3/es not_active Expired - Lifetime
- 1996-11-15 HU HU9800343A patent/HUP9800343A3/hu unknown
- 1996-11-15 CN CN96192509A patent/CN1113965C/zh not_active Expired - Fee Related
- 1996-11-15 AT AT96938223T patent/ATE219145T1/de not_active IP Right Cessation
- 1996-11-15 CZ CZ972317A patent/CZ231797A3/cs unknown
- 1996-11-15 JP JP51941397A patent/JP3313730B2/ja not_active Expired - Fee Related
- 1996-11-15 PL PL96321456A patent/PL321456A1/xx unknown
- 1996-11-15 CA CA002211207A patent/CA2211207A1/en not_active Abandoned
- 1996-11-15 SK SK979-97A patent/SK97997A3/sk unknown
- 1996-11-15 DE DE69621780T patent/DE69621780T2/de not_active Expired - Fee Related
- 1996-11-15 WO PCT/ES1996/000215 patent/WO1997019187A1/es active IP Right Grant
- 1996-11-20 ZA ZA969734A patent/ZA969734B/xx unknown
- 1996-11-21 UY UY24374A patent/UY24374A1/es not_active IP Right Cessation
- 1996-11-22 AR ARP960105302A patent/AR004342A1/es unknown
- 1996-11-23 KR KR1019970705008A patent/KR19980701615A/ko not_active Application Discontinuation
-
1997
- 1997-07-25 BG BG101788A patent/BG101788A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2612297A (en) | 1997-06-11 |
| US6100052A (en) | 2000-08-08 |
| AR004342A1 (es) | 1998-11-04 |
| SI0811689T1 (en) | 2003-04-30 |
| RU2187556C2 (ru) | 2002-08-20 |
| ES2101658A1 (es) | 1997-07-01 |
| CA2211207A1 (en) | 1997-05-29 |
| CN1178556A (zh) | 1998-04-08 |
| PT811689E (pt) | 2002-11-29 |
| JP3313730B2 (ja) | 2002-08-12 |
| MX9705555A (es) | 1998-02-28 |
| ATE219145T1 (de) | 2002-06-15 |
| KR19980701615A (ko) | 1998-06-25 |
| HUP9800343A2 (hu) | 1998-05-28 |
| ES2178721T3 (es) | 2003-01-01 |
| AU729094B2 (en) | 2001-01-25 |
| CZ231797A3 (en) | 1997-12-17 |
| HUP9800343A3 (en) | 1999-04-28 |
| CN1113965C (zh) | 2003-07-09 |
| EP0811689B1 (en) | 2002-06-12 |
| DK0811689T3 (da) | 2003-01-27 |
| ES2101658B1 (es) | 1998-03-01 |
| TR199700679T1 (xx) | 1997-11-21 |
| DE69621780T2 (de) | 2003-02-06 |
| CO4700346A1 (es) | 1998-12-29 |
| BG101788A (en) | 1998-07-31 |
| BR9606930A (pt) | 1997-11-11 |
| EP0811689A1 (en) | 1997-12-10 |
| DE69621780D1 (de) | 2002-07-18 |
| JPH11501822A (ja) | 1999-02-16 |
| WO1997019187A1 (es) | 1997-05-29 |
| SK97997A3 (en) | 1998-05-06 |
| PL321456A1 (en) | 1997-12-08 |
| ZA969734B (en) | 1997-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VENC | Patent expired |
Effective date: 20161121 |