UY24346A1 - Nuevas sulfonamidas - Google Patents

Nuevas sulfonamidas

Info

Publication number
UY24346A1
UY24346A1 UY24346A UY24346A UY24346A1 UY 24346 A1 UY24346 A1 UY 24346A1 UY 24346 A UY24346 A UY 24346A UY 24346 A UY24346 A UY 24346A UY 24346 A1 UY24346 A1 UY 24346A1
Authority
UY
Uruguay
Prior art keywords
phenyl
formula
hydroxyl
compounds
treatment
Prior art date
Application number
UY24346A
Other languages
English (en)
Inventor
Werner Neidhart
Bernd-Michael Loffler
Martine Clozel
Kaspar Burri
Henri Ramuz
Marcel Muller
Georges Hirth
Jean-Marie Cassal
Volker Breu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY24346A1 publication Critical patent/UY24346A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de la fórmula general l (como por ejemplo: Acido 6-(4-terc.butil-fenilsulfonilamino)-4-(2-hidroxi-etoxi)-5-(3-metoxi-fenoxi)-pirimidin-2-carboxilico) en donde R1significa fenilo, fenilo sustituido o heterociclilo; R2 se selecciona entre fenilo o fenilo sustituido; R3 puede ser hidroxilo, alcoxilo inferior o un radical NR4R5; Ra significa H, alquilo inferior o hidroxilo; Rb es H, o alquilo inferior; X e Y se selecciona entre O o S, n representan0, 1 o 2 y sales farmacéuticamente compatibles de las mismos, que pueden usarse como medicamentos, en especial para el tratamiento de trastornos asociados con las actividades de la endotelina. Una preparación farmacéutica, que contiene al compuesto de fórmula l, y materiales de soporte y adyuvantes. El empleo de compuestos de fórmula l como ingredientes activos para la preparación de medicamentos para el tratamiento de trastornos asociados con las actividades de la endotelina, especialmente trastornos circulatorios tales como la hipertensión, isquemia, vasospasmos y angina pectoris.
UY24346A 1995-10-12 1996-10-10 Nuevas sulfonamidas UY24346A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH289395 1995-10-12

Publications (1)

Publication Number Publication Date
UY24346A1 true UY24346A1 (es) 2001-03-16

Family

ID=4243971

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24346A UY24346A1 (es) 1995-10-12 1996-10-10 Nuevas sulfonamidas

Country Status (28)

Country Link
US (1) US5856484A (es)
EP (1) EP0768304B1 (es)
JP (1) JP2723496B2 (es)
CN (1) CN1115339C (es)
AR (1) AR004215A1 (es)
AT (1) ATE217867T1 (es)
AU (1) AU706748B2 (es)
BR (1) BR9605046B1 (es)
CA (1) CA2187130C (es)
CO (1) CO4770959A1 (es)
CZ (1) CZ260596A3 (es)
DE (1) DE59609225D1 (es)
DK (1) DK0768304T3 (es)
ES (1) ES2175006T3 (es)
HU (1) HUP9602748A3 (es)
IL (1) IL119371A (es)
MA (1) MA23980A1 (es)
MX (1) MX9604762A (es)
NO (1) NO308000B1 (es)
NZ (1) NZ299519A (es)
PE (1) PE17098A1 (es)
PL (1) PL316486A1 (es)
PT (1) PT768304E (es)
SG (1) SG46753A1 (es)
TR (1) TR199600778A2 (es)
TW (1) TW438779B (es)
UY (1) UY24346A1 (es)
ZA (1) ZA968451B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ260596A3 (en) * 1995-10-12 1997-12-17 Hoffmann La Roche Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof
JP4058507B2 (ja) * 1997-07-10 2008-03-12 国立大学法人 東京医科歯科大学 ４，５−ジヒドロ−［１Ｈ］−ベンズ［ｇ］インダゾール−３−カルボン酸誘導体
US6191170B1 (en) * 1998-01-13 2001-02-20 Tularik Inc. Benzenesulfonamides and benzamides as therapeutic agents
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
CA2315614C (en) * 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
US6720322B2 (en) 1999-12-22 2004-04-13 Actelion Pharamceuticals Ltd. Butyne diol derivatives
IL149529A0 (en) * 1999-12-22 2002-11-10 Actelion Pharmaceuticals Ltd Butyne diol derivatives
AU2001265871A1 (en) * 2000-04-25 2001-11-07 Actelion Pharmaceuticals Ltd Substituted sulfonylaminopyrimidines
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
US8463964B2 (en) * 2009-05-29 2013-06-11 Invensys Systems, Inc. Methods and apparatus for control configuration with enhanced change-tracking

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270116B (es) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (es) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
CZ260596A3 (en) * 1995-10-12 1997-12-17 Hoffmann La Roche Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof

Also Published As

Publication number Publication date
HUP9602748A2 (en) 1997-05-28
JP2723496B2 (ja) 1998-03-09
TW438779B (en) 2001-06-07
HUP9602748A3 (en) 1998-04-28
AU706748B2 (en) 1999-06-24
MA23980A1 (fr) 1997-07-01
ES2175006T3 (es) 2002-11-16
NO964334L (no) 1997-04-14
EP0768304A1 (de) 1997-04-16
MX9604762A (es) 1997-04-30
SG46753A1 (en) 1998-02-20
NO964334D0 (no) 1996-10-11
CO4770959A1 (es) 1999-04-30
BR9605046B1 (pt) 2010-08-10
BR9605046A (pt) 1998-06-30
IL119371A (en) 2001-04-30
DK0768304T3 (da) 2002-09-09
NZ299519A (en) 1998-02-26
CN1115339C (zh) 2003-07-23
CA2187130A1 (en) 1997-04-13
HU9602748D0 (en) 1996-11-28
PL316486A1 (en) 1997-04-14
ATE217867T1 (de) 2002-06-15
TR199600778A2 (tr) 1997-04-22
DE59609225D1 (de) 2002-06-27
PT768304E (pt) 2002-10-31
JPH09110840A (ja) 1997-04-28
ZA968451B (en) 1997-04-14
CA2187130C (en) 2006-10-03
EP0768304B1 (de) 2002-05-22
CZ260596A3 (en) 1997-12-17
PE17098A1 (es) 1998-04-15
IL119371A0 (en) 1997-01-10
AR004215A1 (es) 1998-11-04
AU6817296A (en) 1997-04-17
CN1151400A (zh) 1997-06-11
US5856484A (en) 1999-01-05
NO308000B1 (no) 2000-07-03

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Legal Events

Date Code Title Description
ABAN Application deemed to be withdrawn (no publication fee paid)

Effective date: 20050126