CO4770959A1 - Nuevas sulfonamidas - Google Patents

Nuevas sulfonamidas

Info

Publication number
CO4770959A1
CO4770959A1 CO96054000A CO96054000A CO4770959A1 CO 4770959 A1 CO4770959 A1 CO 4770959A1 CO 96054000 A CO96054000 A CO 96054000A CO 96054000 A CO96054000 A CO 96054000A CO 4770959 A1 CO4770959 A1 CO 4770959A1
Authority
CO
Colombia
Prior art keywords
lower alkyl
heterocyclyl
hydrogen
radical
phenyl
Prior art date
Application number
CO96054000A
Other languages
English (en)
Inventor
Breu Volker
Jean Marie Cassal
Georges Hirth
Marcel Muller
Henri Ramuz
Burri Kaspar
Martine Clozel
Bernd-Michael Loffler
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4770959A1 publication Critical patent/CO4770959A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos de fórmula:en dondeR1 significa fenilo, fenilo substituido o heterocíclilo;R2 significa fenilo o fenilo substituido; R3 significa hidroxilo, alcoxilo inferior o un radical -NR4 R5 ; R4 significa hidrógeno o un radical -R6 y R5 significa hidrógeno o un radical -(CH2 )n R6 ó R4 y R5 juntamente con el átomo de N al cual están unidos, significan un radical N-heterocíclico; R6 significa fenilo, fenilo substituido, cicloalquilo, heterocíclilo, alquilo inferior, hidroxilo-alquilo inferior, amino-alquilo inferior, carboxilo-alquilo inferior o alcoxicarbonilo inferior-alquilo inferior; Ra significa hidrógeno, alquilo inferior o hidroxilo; Rb significa hidrógeno o alquilo inferior; X significa oxígeno o azufre; Y significa oxígeno o azufre; Z significa hidrógeno, alquilo inferior, arilo, arilo-alquilo inferior, heterocíclilo o heterocíclilo-alquilo inferior; m significa 0, 1 ó 2; y n significa 0, 1 ó 2; y las sales farmacéuticamente compatibles de los mismos.
CO96054000A 1995-10-12 1996-10-10 Nuevas sulfonamidas CO4770959A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH289395 1995-10-12

Publications (1)

Publication Number Publication Date
CO4770959A1 true CO4770959A1 (es) 1999-04-30

Family

ID=4243971

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96054000A CO4770959A1 (es) 1995-10-12 1996-10-10 Nuevas sulfonamidas

Country Status (28)

Country Link
US (1) US5856484A (es)
EP (1) EP0768304B1 (es)
JP (1) JP2723496B2 (es)
CN (1) CN1115339C (es)
AR (1) AR004215A1 (es)
AT (1) ATE217867T1 (es)
AU (1) AU706748B2 (es)
BR (1) BR9605046B1 (es)
CA (1) CA2187130C (es)
CO (1) CO4770959A1 (es)
CZ (1) CZ260596A3 (es)
DE (1) DE59609225D1 (es)
DK (1) DK0768304T3 (es)
ES (1) ES2175006T3 (es)
HU (1) HUP9602748A3 (es)
IL (1) IL119371A (es)
MA (1) MA23980A1 (es)
MX (1) MX9604762A (es)
NO (1) NO308000B1 (es)
NZ (1) NZ299519A (es)
PE (1) PE17098A1 (es)
PL (1) PL316486A1 (es)
PT (1) PT768304E (es)
SG (1) SG46753A1 (es)
TR (1) TR199600778A2 (es)
TW (1) TW438779B (es)
UY (1) UY24346A1 (es)
ZA (1) ZA968451B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ260596A3 (en) * 1995-10-12 1997-12-17 Hoffmann La Roche Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof
JP4058507B2 (ja) * 1997-07-10 2008-03-12 国立大学法人 東京医科歯科大学 ４，５−ジヒドロ−［１Ｈ］−ベンズ［ｇ］インダゾール−３−カルボン酸誘導体
US6191170B1 (en) 1998-01-13 2001-02-20 Tularik Inc. Benzenesulfonamides and benzamides as therapeutic agents
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
CA2315614C (en) * 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
CN1407973A (zh) * 1999-12-22 2003-04-02 埃科特莱茵药品有限公司 丁炔二醇衍生物
US6720322B2 (en) 1999-12-22 2004-04-13 Actelion Pharamceuticals Ltd. Butyne diol derivatives
AU2001265871A1 (en) * 2000-04-25 2001-11-07 Actelion Pharmaceuticals Ltd Substituted sulfonylaminopyrimidines
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
US8463964B2 (en) * 2009-05-29 2013-06-11 Invensys Systems, Inc. Methods and apparatus for control configuration with enhanced change-tracking

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270116B (es) * 1991-04-25 1996-02-11 Hoffmann La Roche
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW287160B (es) * 1992-12-10 1996-10-01 Hoffmann La Roche
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
CZ260596A3 (en) * 1995-10-12 1997-12-17 Hoffmann La Roche Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof

Also Published As

Publication number Publication date
IL119371A0 (en) 1997-01-10
HUP9602748A3 (en) 1998-04-28
CN1115339C (zh) 2003-07-23
DK0768304T3 (da) 2002-09-09
MA23980A1 (fr) 1997-07-01
PE17098A1 (es) 1998-04-15
US5856484A (en) 1999-01-05
JP2723496B2 (ja) 1998-03-09
TR199600778A2 (tr) 1997-04-22
NO308000B1 (no) 2000-07-03
UY24346A1 (es) 2001-03-16
AU706748B2 (en) 1999-06-24
EP0768304B1 (de) 2002-05-22
JPH09110840A (ja) 1997-04-28
DE59609225D1 (de) 2002-06-27
BR9605046A (pt) 1998-06-30
MX9604762A (es) 1997-04-30
ATE217867T1 (de) 2002-06-15
IL119371A (en) 2001-04-30
NZ299519A (en) 1998-02-26
CN1151400A (zh) 1997-06-11
BR9605046B1 (pt) 2010-08-10
ES2175006T3 (es) 2002-11-16
ZA968451B (en) 1997-04-14
AU6817296A (en) 1997-04-17
HUP9602748A2 (en) 1997-05-28
NO964334D0 (no) 1996-10-11
EP0768304A1 (de) 1997-04-16
NO964334L (no) 1997-04-14
CA2187130C (en) 2006-10-03
PL316486A1 (en) 1997-04-14
HU9602748D0 (en) 1996-11-28
TW438779B (en) 2001-06-07
PT768304E (pt) 2002-10-31
CA2187130A1 (en) 1997-04-13
AR004215A1 (es) 1998-11-04
CZ260596A3 (en) 1997-12-17
SG46753A1 (en) 1998-02-20

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