UY23996A1 - Procedimiento para la preparacion de estreptograminas - Google Patents

Procedimiento para la preparacion de estreptograminas

Info

Publication number
UY23996A1
UY23996A1 UY23996A UY23996A UY23996A1 UY 23996 A1 UY23996 A1 UY 23996A1 UY 23996 A UY23996 A UY 23996A UY 23996 A UY23996 A UY 23996A UY 23996 A1 UY23996 A1 UY 23996A1
Authority
UY
Uruguay
Prior art keywords
streptogramins
group
represented
procedure
pristinamycin
Prior art date
Application number
UY23996A
Other languages
English (en)
Inventor
Blanc Veronique
Thibaut Denis
Nathalie Bamas-Jacques
Blanche Francis
Crouzet Joel
Jean Claude Barrier
Debussche Laurent
Famechon Alain
Jean Marc Paris
Rosset Gilles Dutruct
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY23996(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of UY23996A1 publication Critical patent/UY23996A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de estreptograminas, caracterizado porque recurre una cepa de microorganismo reproductor de estreptograminas, que posee por lo menos una modificación genética que afecta la biosíntesis de un precursor de las de las estreptograminas del grupo B, porque dicha cepa mutante es cultivada en un medio de cultivo adecuado y complementada con por lo menos un precursor original diferente de aquel cuya biosíntesis ha sido alterada y porque se procede a recuperar dichas estreptograminas. El procedimiento descrito se caracteriza porque su composición está representado por un compuesto de fórmula general (I) representado en la figura 1, donde: R2 y R4 representan independientemente uno del otro, un átomo de hidrógeno o un grupo metilo; R3 representa un átomo de hidrógeno o un grupo hidroxilo; X representa un grupo CO, CHOH, o CH2; R1 es un grupo representado en la figura 2. Ejemplos no limitantes: 4-metiltio-de(4-dimetilamino)pristinamicina Ia; 5-hidroxi 4-metiltio-de(4-dimetilamino) pristinamicina IH. Las estreptograminas forman un grupo homogéneo de antibióticos.
UY23996A 1994-07-08 1995-07-07 Procedimiento para la preparacion de estreptograminas UY23996A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408478A FR2722210B1 (fr) 1994-07-08 1994-07-08 Nouvelles streptogramines et procede de preparation de streptogramines par mutasynthese

Publications (1)

Publication Number Publication Date
UY23996A1 true UY23996A1 (es) 1995-09-08

Family

ID=9465182

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23996A UY23996A1 (es) 1994-07-08 1995-07-07 Procedimiento para la preparacion de estreptograminas

Country Status (33)

Country Link
US (2) US6352839B1 (es)
EP (2) EP2248901A1 (es)
JP (1) JPH10502532A (es)
KR (2) KR100420238B1 (es)
CN (1) CN1152338A (es)
AP (1) AP562A (es)
AT (1) ATE480626T1 (es)
AU (1) AU712397B2 (es)
BR (1) BR9508714A (es)
CA (1) CA2193130C (es)
CO (1) CO4410252A1 (es)
CZ (1) CZ5297A3 (es)
DE (1) DE69536102D1 (es)
DK (1) DK0770132T3 (es)
DZ (1) DZ1910A1 (es)
ES (1) ES2352324T3 (es)
FR (1) FR2722210B1 (es)
HU (1) HU220964B1 (es)
IL (1) IL114489A0 (es)
MA (1) MA23610A1 (es)
MX (1) MX9700257A (es)
NO (1) NO970047L (es)
NZ (1) NZ289153A (es)
PE (1) PE28596A1 (es)
PL (1) PL318193A1 (es)
PT (1) PT770132E (es)
RU (1) RU2205183C2 (es)
SK (1) SK597A3 (es)
TN (1) TNSN95077A1 (es)
TR (1) TR199500830A2 (es)
UY (1) UY23996A1 (es)
WO (1) WO1996001901A1 (es)
ZA (1) ZA955688B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524812B1 (en) 1993-10-07 2003-02-25 Regents Of The University Of Minnesota Genes encoding resistance to DNA alkylating agents
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
WO1997022711A1 (en) 1995-12-19 1997-06-26 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
FR2775288B1 (fr) * 1998-02-26 2000-03-31 Rhone Poulenc Rorer Sa Derives de streptogramines, leur preparation et les compositons qui les contiennent
EP2261347A3 (en) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
DE60006130D1 (de) * 1999-07-27 2003-11-27 Aventis Pharma Sa Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
FR2796950B1 (fr) * 1999-07-27 2001-09-21 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
FR2796949B1 (fr) * 1999-07-27 2001-09-21 Aventis Pharma Sa Derives de streptogramines, leur preparation et les compositions qui les contiennent
KR100679759B1 (ko) 1999-09-29 2007-02-07 메이지 세이카 가부시키가이샤 관능기에 의해 수식된 이차 대사산물을 생산하는형질전환체 및 신규 생합성 유전자
JPWO2002077203A1 (ja) * 2001-03-22 2004-09-09 学校法人北里学園 ボーベリオライドｉ物質あるいはボーベリオライドｉｉｉ物質の選択培地およびそれらの選択製造法
FR2825717B1 (fr) 2001-06-08 2005-02-18 Rhodia Chimie Sa Preparation stereoselective de l-acides amines cycliques
FR2841563B1 (fr) * 2002-06-28 2006-09-01 Aventis Pharma Sa Nouveaux variants du polypeptide papm de bacteries du genre streptomyces
AU2006243052B2 (en) * 2005-05-04 2010-07-08 Tmo Renewables Limited Thermophilic microorganisms with inactivated lactate dehydrogenase gene (LDH) for ethanol production
TWI387603B (zh) * 2005-07-20 2013-03-01 Merck Sharp & Dohme Ｈｃｖ ｎｓ３蛋白酶抑制劑
KR101423898B1 (ko) * 2005-12-14 2014-07-28 암브룩스, 인코포레이티드 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도
WO2007092475A2 (en) 2006-02-06 2007-08-16 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
US7548705B2 (en) * 2007-04-03 2009-06-16 Xerox Corporation Systems and methods for marking test patches for calibrating and/or visually confirming color accuracy of a marking device
WO2015098774A1 (ja) * 2013-12-26 2015-07-02 株式会社カネカ 光学活性環状イミノ酸の製造方法
CN112442507B (zh) * 2019-09-05 2022-09-30 武汉合生科技有限公司 马度米星化合物的生物合成基因簇及其应用
CN112970782A (zh) * 2019-12-16 2021-06-18 德强生物股份有限公司 一种劳意德链霉菌发酵得到的农药制剂及其制备方法

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Publication number Priority date Publication date Assignee Title
US4156734A (en) 1976-02-13 1979-05-29 Merck & Co., Inc. Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
DE3322402A1 (de) 1983-06-22 1985-01-03 Jagenberg Ag Vorrichtung zum falten und verschliessen des kopfes einer von einer innenseitig mit einer thermoplastischen kunststoffschicht ueberzogenen kartonbahn bzw. einer aus einem zuschnitt gebildeten faltschachtel in einer falt- und schweissstation
FR2549062B1 (fr) * 1983-07-13 1985-10-25 Rhone Poulenc Sante Nouveaux derives de synergistines, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2689518B1 (fr) * 1992-04-01 1995-04-07 Rhone Poulenc Rorer Sa Microorganismes, procédé de préparation et utilisation.
FR2696189B1 (fr) * 1992-09-25 1994-11-10 Rhone Poulenc Rorer Sa Polypeptides impliqués dans la biosynthèse des streptogramines, séquences nucléotidiques codant pour ces polypeptides et leur utilisation.

Also Published As

Publication number Publication date
US6352839B1 (en) 2002-03-05
IL114489A0 (en) 1995-11-27
KR100379100B1 (ko) 2003-10-08
SK597A3 (en) 1997-08-06
CO4410252A1 (es) 1997-01-09
PL318193A1 (en) 1997-05-26
NZ289153A (en) 1999-02-25
MX9700257A (es) 1997-05-31
ES2352324T3 (es) 2011-02-17
DE69536102D1 (de) 2010-10-21
JPH10502532A (ja) 1998-03-10
ATE480626T1 (de) 2010-09-15
CZ5297A3 (en) 1997-05-14
TR199500830A2 (tr) 1996-06-21
RU2205183C2 (ru) 2003-05-27
DZ1910A1 (fr) 2002-02-17
AU2891295A (en) 1996-02-09
NO970047D0 (no) 1997-01-07
AP562A (en) 1996-11-20
HUT77341A (hu) 1998-03-30
WO1996001901A1 (fr) 1996-01-25
CA2193130C (fr) 2010-10-19
CN1152338A (zh) 1997-06-18
KR100420238B1 (ko) 2004-02-26
NO970047L (no) 1997-01-07
AU712397B2 (en) 1999-11-04
TNSN95077A1 (fr) 1996-02-06
FR2722210B1 (fr) 1996-08-14
US20020142947A1 (en) 2002-10-03
ZA955688B (en) 1996-02-26
HU220964B1 (hu) 2002-07-29
AP9500752A0 (en) 1995-07-31
EP2248901A1 (fr) 2010-11-10
BR9508714A (pt) 1998-06-02
EP0770132A1 (fr) 1997-05-02
CA2193130A1 (fr) 1996-01-25
US6833382B2 (en) 2004-12-21
PT770132E (pt) 2010-12-09
PE28596A1 (es) 1996-07-06
MA23610A1 (fr) 1996-04-01
FR2722210A1 (fr) 1996-01-12
DK0770132T3 (da) 2011-01-10
EP0770132B1 (fr) 2010-09-08

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