UY23572A1 - Empleo de inhibidores de activadores de plasminógeno para el tratamiento de inflamaciones y heridas. - Google Patents

Empleo de inhibidores de activadores de plasminógeno para el tratamiento de inflamaciones y heridas.

Info

Publication number
UY23572A1
UY23572A1 UY23572A UY23572A UY23572A1 UY 23572 A1 UY23572 A1 UY 23572A1 UY 23572 A UY23572 A UY 23572A UY 23572 A UY23572 A UY 23572A UY 23572 A1 UY23572 A1 UY 23572A1
Authority
UY
Uruguay
Prior art keywords
treatment
inhibitors
pai
lesions
inflammatory
Prior art date
Application number
UY23572A
Other languages
English (en)
Inventor
Dickneite Gerhard
Schueler Eckhard
Roemisch Juergen
Eric-Paul Paques
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of UY23572A1 publication Critical patent/UY23572A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere al empleo de inhibidores de activadores de plasminógeno para la preparación de un medicamento para la terapia y/o profilaxis de inflamaciones de los ojos, de los oídos, de la piel, de los huesos, de las articulaciones, del intestino o de otros órganos internos y/o para el tratamiento intraoperativo y/o postoperativo y/o para el tratamiento de heridas abiertas. Los activadores del plasminógeno son uroquinasa y/o tPA. Los inhibidores son PAI-1 y/o PAI-2, preferiblemente fragmentos de PAI-2. Se utilizan en el tratamiento de úlcera córnea, uveítis, conjuntivitis, otitis media, agrietamiento de la membrana del tímpano con evolución inflamatoria, eritemas de la piel, eczema, dermatitis por contacto, osteoartritis, enfermedad inflamatoria del intestino, pancreatitis, acné, tratamiento de lesiones epiteliales, tratamiento de la cicatrización en el caso de lesiones de los ojos, entre otras lesiones inflamatorias.
UY23572A 1992-04-30 1993-04-27 Empleo de inhibidores de activadores de plasminógeno para el tratamiento de inflamaciones y heridas. UY23572A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4214215A DE4214215A1 (de) 1992-04-30 1992-04-30 Verwendung von inhibitoren von plasminogenaktivatoren zur behandlung von entzuendungen

Publications (1)

Publication Number Publication Date
UY23572A1 true UY23572A1 (es) 1993-05-04

Family

ID=6457814

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23572A UY23572A1 (es) 1992-04-30 1993-04-27 Empleo de inhibidores de activadores de plasminógeno para el tratamiento de inflamaciones y heridas.

Country Status (16)

Country Link
EP (1) EP0567816A1 (es)
JP (1) JPH069425A (es)
KR (1) KR930021179A (es)
CN (1) CN1080873A (es)
AU (1) AU3822993A (es)
CA (1) CA2095207A1 (es)
CZ (1) CZ76893A3 (es)
DE (1) DE4214215A1 (es)
HU (1) HUT65755A (es)
IL (1) IL105521A0 (es)
MX (1) MX9302519A (es)
NO (1) NO931561L (es)
PL (1) PL298748A1 (es)
SK (1) SK41593A3 (es)
UY (1) UY23572A1 (es)
ZA (1) ZA933023B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
GB2271507A (en) * 1992-09-04 1994-04-20 Summit Technology Ireland Bv Compositions containing plasmin activity inhibitors
NZ533467A (en) 1993-07-19 2006-02-24 Angiotech Pharm Inc Anti-angiogenic compositions and methods of use
US5994341A (en) * 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
US5939525A (en) * 1995-03-27 1999-08-17 Viron Therapeutics, Inc. Methods of treating inflammation and compositions therefor
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
CA2326438A1 (en) * 1998-04-01 1999-10-07 Biotech Australia Pty. Limited Use of protease inhibitors for treating skin wounds
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6120847A (en) * 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
AU4672300A (en) * 1999-04-29 2000-11-17 Ista Pharmaceuticals, Inc Biochemical methods that eliminate corneal scars, opacification and haze
US6156373A (en) * 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
JP3690720B2 (ja) 1999-09-14 2005-08-31 インターナショナル・ビジネス・マシーンズ・コーポレーション クライアントサーバーシステム、オブジェクトのプール方法および記憶媒体
AU1123001A (en) 1999-10-27 2001-05-08 Alexandra Lucas Compositions and methods for preventing and treating transplant rejection
JP2001247458A (ja) * 2000-03-08 2001-09-11 Hamari Chemicals Ltd トラネキサム酸亜鉛化合物を含む糖尿病治療剤
EP1365798B1 (en) 2000-09-29 2009-12-30 Viron Therapeutics, Inc. Use of serp-1 in combination with an immunosuppressant for treating arthritis
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
EP1498084B1 (en) 2000-10-16 2014-06-18 Innovational Holdings, LLC Expandable medical device for delivery of beneficial agent
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
AT500019B1 (de) * 2001-06-27 2007-06-15 Inst Gefaessbiologie Und Throm Verwendung in vitro des transkriptionsfaktors nak-1 oder von nak-1 regulierten genen zur diagnose von entzündlichen und malignen erkrankungen
GB0126389D0 (en) * 2001-11-02 2002-01-02 Pfizer Ltd Wafer
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US7285530B2 (en) 2004-10-21 2007-10-23 Viron Therapeutics, Inc. Use of SERP-1 as an antiplatelet agent
US20090202524A1 (en) * 2007-10-31 2009-08-13 Alcon Research, Ltd. Pai-1 expression and activity inhibitors for the treatment of ocular disorders
US20110130338A1 (en) * 2008-01-21 2011-06-02 Dermadis Sa Use of serine protease inhibitors in the treatment of skin diseases
TWI763960B (zh) * 2017-12-15 2022-05-11 大陸商深圳瑞健生命科學研究院有限公司 一種預防或治療骨關節炎的方法及藥物
CN118557734A (zh) * 2024-07-24 2024-08-30 中山大学中山眼科中心 Serpinb2抑制剂在制备用于治疗湿性年龄相关性黄斑变性药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3829523A1 (de) * 1988-08-31 1990-03-01 Behringwerke Ag Verwendung von plasminogen-aktivator-inhibitor (pai-2) zur immunsuppression
DK0458937T3 (da) * 1989-12-20 1998-02-23 Biotech Australia Pty Ltd Varianter af PAI-2
EP0451130A3 (en) * 1990-04-05 1992-08-05 Baltimore Biotech, Inc. Use of amiloride and other pyrazine derivatives for preventing or treating ocular neovascularization

Also Published As

Publication number Publication date
ZA933023B (en) 1994-10-31
AU3822993A (en) 1993-11-04
CZ76893A3 (en) 1994-01-19
DE4214215A1 (de) 1993-11-04
EP0567816A1 (de) 1993-11-03
NO931561L (no) 1993-11-01
SK41593A3 (en) 1993-11-10
IL105521A0 (en) 1993-08-18
NO931561D0 (no) 1993-04-29
JPH069425A (ja) 1994-01-18
CA2095207A1 (en) 1993-10-31
PL298748A1 (en) 1993-12-27
MX9302519A (es) 1993-10-01
HU9301272D0 (en) 1993-07-28
CN1080873A (zh) 1994-01-19
KR930021179A (ko) 1993-11-22
HUT65755A (en) 1994-07-28

Similar Documents

Publication Publication Date Title
UY23572A1 (es) Empleo de inhibidores de activadores de plasminógeno para el tratamiento de inflamaciones y heridas.
Wollina et al. Biosurgery in wound healing–the renaissance of maggot therapy
Lin et al. Management of ocular conditions in the burn unit: thermal and chemical burns and Stevens-Johnson syndrome/toxic epidermal necrolysis
CU23208A3 (es) Oxazolidinonas sustituidas y su uso en el campo de la coagulacion sanguinea
Reitberger et al. Argon cold plasma–a novel tool to treat therapy-resistant corneal infections
RU2008102249A (ru) Профилактический или терапевтичесский агент для корнеального /конъюнктивального заболевания
BR0316776A (pt) Formula para anti-infeccioso tópico
Rhody Bacterial infections of the skin
ES2758372T3 (es) Composición para su uso en el tratamiento de infecciones bacterianas
US5166132A (en) Healing composition employing an enzyme-modified casein
Virág et al. Surgical management of hidradenitis suppurativa with keystone perforator island flap
Datarkar et al. Management of soft tissue injuries in the maxillofacial region
Cannon et al. Rate of epithelial regeneration: a clinical method of measurement, and the effect of various agents recommended in the treatment of burns
US20110045072A1 (en) Pharmaceutical composition, dressing and method for treating skin lesion, intermediate composition and process for preparing said dressing, and use of cerium salt associated with a collagen matrix
ES2703530T3 (es) Composición cicatrizante y utilización
NO960525D0 (no) Terapeutisk preparat
Ürütük Current Approach to Hyperbaric Oxygen Therapy.
Santos et al. Bilateral pseudocyst of the auricle in an infant girl
Neto et al. Lateral sinus thrombosis and cervical abscess complicating cholesteatoma in children: case report and review
Walls et al. Negative pressure dressings for severe hidradenitis suppurativa (acne inversa): a case report
EP1663195B1 (en) Taurine bromamine for inhibiting pathogenic bacteria and fungi growth as well as in a microbicidal composition
Perry et al. Reconstruction of ear deformity from post-piercing perichondritis
Rattan et al. Management of ocular adnexal trauma
US20070010582A1 (en) Use of N-chlorotaurine for treatment of oozing tissue deficiencies
Novati et al. Treatment of a double-giant Rhinophyma with electrocautery and Versajet hydrosurgery system