US8687928B2 - Optical characteristic measuring probe - Google Patents

Optical characteristic measuring probe Download PDF

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Publication number
US8687928B2
US8687928B2 US13/318,998 US201013318998A US8687928B2 US 8687928 B2 US8687928 B2 US 8687928B2 US 201013318998 A US201013318998 A US 201013318998A US 8687928 B2 US8687928 B2 US 8687928B2
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Prior art keywords
light
measuring
guide body
optical characteristic
mark
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Expired - Fee Related, expires
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US13/318,998
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US20120057149A1 (en
Inventor
Soh Ohzawa
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Konica Minolta Opto Inc
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Konica Minolta Opto Inc
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Assigned to KONICA MINOLTA OPTO, INC. reassignment KONICA MINOLTA OPTO, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OHZAWA, SOH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147—Holding or positioning arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00177—Optical arrangements characterised by the viewing angles for 90 degrees side-viewing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/064—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8514—Probe photometers, i.e. with optical measuring part dipped into fluid sample with immersed mirror

Definitions

  • the present invention relates to an optical characteristic measuring probe which is suitable to, for example, an optical coherent tomography (OCT: Optical Coherent Tomography) device, and is provided for irradiating a subject to be measured with light and receiving light returning from a subject to be measured.
  • OCT optical coherent tomography
  • OCT optical Coherent Tomography
  • An optical coherent tomography device is a technology that low coherence light is divided into two beams, one of the beams is projected to a subject, back scattered light on which phase information of the subject has been given interferes with the other beam, the phase information of the subject is obtained based on intensity information of the inferring light, and an image of a measuring portion of the subject is formed (see Patent Literatures 1 and 2, for example).
  • Patent Literature 1 for the purpose of making a penetration catheter penetrate a proper position, a mark is provided on an area of an optical probe of an optical coherent tomography device and the image of the mark is observed, which enables to adjust the position and/or rotation direction of the leading end of the probe.
  • Patent Literature 2 provides an intraluminal image forming device which uses a probe for being inserted into a lumen to obtain a tomographic image, for observing the inside of the lumen and taking its image with moving the probe in a guide tube.
  • a mark is provided on the guide tube to determine a reference position of a tomographic image, and imaging process is performed without image displacement.
  • the position of the leading end of the probe is determined by arranging a mark for determining the position of the leading end of the probe and by detecting back light which has been generated when measurement light enters the mark and returns.
  • the reference mark is detected by using an actual measurement light, the mark appears in an observed image, which cause problems that shadow of the mark is generated therein, the observed image located behind the mark is shaded and missed, and contrast of the image is deteriorated.
  • An object of the present invention is to provide an optical characteristic measuring probe which can detect the position and the direction of the leading end of the probe without affecting an observed image.
  • the optical characteristic measuring probe is characterized by comprising: a light guide body for transmitting light from a light source and irradiating a subject to be measured with light; and a guide tube for holding the light guide body such that the light guide body freely rotates on an axis of the guide tube and is freely displaced in a direction of the axis, wherein the light guide body guides at least two types of light including measuring light for measuring an optical characteristic of the subject to be measured and position determining light for measuring a position of the light guide body, and a mark is arranged on a side surface of the guide tube, where the mark has a characteristic of transmitting the measuring light and returning only the position determining light to the light guide body.
  • the measuring light is near infrared light and the position determining light is visible light.
  • the measuring light is coherent light and the position determining light is incoherent light.
  • the optical characteristic measuring probe is a rotary scanning probe.
  • the light guide body transmits two types of light of measuring light and position determining light
  • a mark is arranged at a measuring position of the guide tube, where the mark has the characteristics of transmitting the measuring light and returning only the position determining light to the light guide body.
  • FIG. 1 is a schematic structural view illustrating a concept of the present invention.
  • FIG. 2 is a structural view showing an example of an optical probe relating to the present invention.
  • FIGS. 3 a and 3 b is a sectional view showing various structures around the leading end of the optical probe.
  • FIG. 4 is a structural view showing an example that an optical probe relating to the present invention is applied to an optical tomography measurement device.
  • FIG. 1 shows a schematic structural view illustrating the concept of the present invention.
  • Optical probe P includes a light guide body such as an optical fiber therein, and optical scanning section OS is arranged on the leading end of the light guide body.
  • Optical scanning section OS irradiates a subject to be measured with light and takes light which has been reflected on the subject to be measured therein.
  • Light source for measurement SA supplies measuring light for measuring the optical characteristics of the subject to be measured.
  • Light source for position determination SB supplies position determining light for measuring the position of the light guide body. Measuring light and position determining light from light sources SA and SB are coupled together with coupler CA, and are supplied to optical probe P through coupler CB.
  • the measuring light is coherent light in the near-infrared area (for example, wavelength area from 800 nm to 1500 nm) and the position determining light is incoherent light in the visible area (for example, wavelength area from 380 nm to 750 nm). Since the position determining light is incoherent light such as LED light, signal change coming from interference caused when an optical path length changes, which is caused under the condition that the light is coherent light, can be reduced and the position can be measured more accurately.
  • OCT optical coherent tomography
  • Coupler CB is an optical element which transmits measuring light and position determining light from light sources SA and SB and separates light going back from optical probe P into measuring light and position determining light depending on wavelength.
  • Signal from photodetector for measuring light DA is used for measuring optical characteristics of the subject to be measured.
  • Signal from photodetector for position determining light DB is supplied to synchronizing signal generation circuit SY and is converted into synchronizing signal for optical scanning section OS.
  • a circulator, wavelength-selective filter (for example, dichroic filter) and WDM (wavelength division multiplexing) device can be used for couplers CA and CB.
  • FIG. 2 is a structural view showing an example of an optical probe relating to the present invention.
  • FIGS. 3 a and 3 b is a sectional view showing various structures around the leading end of the optical probe.
  • the optical probe is composed of guide tube 70 , light guide body 71 , light converging lens 72 and prism 72 , and is structured to be bendable as the total system.
  • Guide tube 70 has an sectional shape forming a circular cylinder, and is formed of an elastic material with high transmittance for measuring light, for example, fluoroethylene resin.
  • Light guide body 71 is formed of an elastic material with high transmittance for the measuring light and position determining light, for example, an optical fiber.
  • Light guide body 71 is housed inside guide tube 70 and is held such that the light guide body freely rotates on its axis and is freely displaced in the axis direction.
  • a rotating drive mechanism is arranged on the base of the light guide body 71 , and the light guide body 71 is structured such that light guide body 71 can rotate on the axis at a constant rotation speed, for example, 1200 rpm.
  • Light converging lens 72 is mounted on the leading end of light guide body 71 .
  • Prism 73 includes a reflection surface for reflecting the measuring light and position determining light, and is mounted on light converging lens 72 .
  • Light converging lens 72 and prism 73 rotate together with light guide body 71 as one body and emit the measuring light and position determining light in the radial direction to carry out rotation scanning of the subject to be measured throughout 360 degrees, where the subject is located outside guide tube 70 .
  • mark M is arranged on the side surface of guide tube 70 , where the mark M has the characteristics of transmitting the measuring light and returning only the position determining light to light guide body 71 . It is preferable that such the mark M exhibits the same optical characteristics as guide tube 70 with respect to the measuring light, and further exhibits the optical characteristics different from guide tube 70 with respect to the position determining light. For example, a material or coating whose light transmittance, light scattering characteristic and light reflectance change depending on wavelength is selected.
  • mark M can be formed to scatter only the position determining light.
  • the measuring light is infrared light and the position determining light is visible light
  • mixing microparticles with the size of wavelength of the position determining light therein can provide a structure that the position determining light is greatly scattered and infrared light whose wavelength is longer than the position determining light is not sufficiently scattered.
  • the wavelengths of the position determining light and the measuring light are required to be set to have sufficiently different values.
  • a film having a reflectance which changes depending on wavelength can be formed as the mark M, which can achieve the similar effect as the above structure, when it reflects light with wavelength of the position determining light and transmits light with wavelength of the measuring light.
  • Such the mark M can be formed with referring to a band-pass filter disclosed in Japanese Unexamined Patent Application Publication No. S58-31307, and a multi-layer mirror which reflects only light in the visible area and is disclosed in Japanese Unexamined Patent Application Publication No. S59-195205.
  • a reflective volume grating can be used.
  • the grating may have a pitch being half or less of the wavelength, for example, being a value in the range from 200 nm to 400 nm.
  • Such the grating can transmit infrared light and can reflect visible light.
  • Mark M may be formed by being replaced with a part of the wall surface of guide tube 70 , as shown in FIG. 3 a and FIG. 3 b , or may be formed as a coating film on the outer surface or inner surface of guide tube 70 .
  • FIG. 3 a shows an example that one mark M is formed in a scanning area of 360 degrees.
  • prism 73 rotates and light is projected toward an area of guide tube 70 where mark M does not exist, the measuring light passes through guide tube 70 as it is, and the position determining light is not reflected on guide tube 70 .
  • FIG. 3 b shows an example that two marks M are formed in a scanning area of 360 degrees.
  • the first and second marks M are arranged with an interval of 180 degrees.
  • the first mark M is larger than the second mark M in width in order to distinguish the marks.
  • first synchronizing signal is generated.
  • second synchronizing signal is generated.
  • two units of synchronizing signal are generated per one rotation of prism 73 .
  • N marks M are arranged at intervals of 360/N degrees
  • N units of synchronizing signal are generated per one rotation of prism 73 .
  • the probe relating to the present invention is suitable for a rotary scanning probe.
  • a scanning area is continuous and a mark is hardly set outside the scanning area Therefore, it has been difficult to avoid that an image lacks because of the mark in the prior art.
  • the probe is suitable for a method that a rotating drive is carried out at the base of the probe in a rotary scanning probe.
  • the present invention is suitable for that, because the rotation condition at the leading end section can be directly measured.
  • Plural marks M may be arranged along the longitudinal direction of guide tube 70 , as shown in FIG. 2 .
  • light guide body 71 moves along the longitudinal direction with guide tube 70 being fixed.
  • the position determining light is reflected by mark M and returns to light guide body 71 .
  • a unit of synchronizing signal is generated.
  • the total units of the synchronizing signal generated corresponding to the movement of light guide body 71 are counted, which enables to measure the displacement amount of light guide body 71 .
  • the rotation angle and/or displacement amount of light guide body 71 can be measured by using the position determining light without affecting an observed image which is observed by using the measuring light.
  • FIG. 4 is a structural view showing an example that an optical probe relating to the present invention is applied to an optical tomography measurement device.
  • the optical tomography measurement device is structured as a Michelson interferometer employing a low coherence light source.
  • the optical tomography measurement device is composed of measurement light source 10 , coupler 12 , circulators 22 , 32 , attenuator 33 , probe 50 , reference mirror 30 , coupler 40 , differential detectors 42 a , 42 b , plural optical paths 11 , 21 , 31 , 41 a , 41 b , and is additionally composed of light source for position determination 61 , photodetector for position determination 62 and coupler 63 in order to use the position determining light by introducing the position determining light into the same optical path for the measuring light.
  • Optical paths 11 , 21 , 31 , 41 a , 41 b include flexible single-mode optical fibers.
  • Light source for measurement 10 includes an element such as SLD (Super Luminescent Diode), and generates low-coherence light, for example, whose central wavelength is 1.3 ⁇ m and spectral width of oscillation is about 50 nm.
  • the measurement light from light source for measurement 10 passes through optical path 11 and reaches coupler 12 .
  • Coupler 12 includes an element such as an optical fiber coupler and beam splitter, and has a function as a light splitting means which splits light from optical path 11 into branches in the predetermined ratio for optical paths 21 and 31 .
  • the measuring light split by coupler 12 passes through optical path 21 , circulator 22 and coupler 63 and reaches probe 50 .
  • Probe 50 irradiates the subject to be measured with the measuring light.
  • the back measuring light which has been reflected corresponding to the internal structure of the subject to be measured enters probe 50 again, goes back through optical path 21 , and reaches coupler 40 through circulator 22 .
  • the reference light split by coupler 12 passes through optical path 31 , circulator 32 and attenuator 33 and reaches reference mirror 30 .
  • the back reference light which has been reflected by reference mirror 30 goes back through optical path 31 , passes through attenuator 33 and circulator 32 , and reaches coupler 40 .
  • Coupler 40 includes an element such as an optical fiber coupler and a beam splitter and has a function as light interfering means which causes interference of light going back the optical paths 21 and 31 .
  • the interfering light passes through optical paths 41 a and 41 b and reaches differential detectors 42 a and 42 b , respectively.
  • Differential detectors 42 a and 42 b output the difference of two interfering signals.
  • the signal is stored in a signal processing device such as a personal computer.
  • the signal processing device constructs an optical tomographic image from the stored data, according to the method of optical tomography measurement which will be described later.
  • the method of the optical tomography measurement is roughly categorized into a time-domain OCT (TD-OCT) and a Fourier-domain OCT (FD-OCT), and the Fourier-domain OCT is further categorized into a swept-source OCT (SS-OCT) and a spectral-domain OCT (SD-OCT).
  • TD-OCT time-domain OCT
  • FD-OCT Fourier-domain OCT
  • SD-OCT spectral-domain OCT
  • the time-domain OCT one or more of optical phase modulators are arranged on one or both of optical path 21 and optical path 31 , to modulate the phase of light corresponding to scanning signal.
  • the swept source OCT a wavelength-variable light source is employed as light source 10 and wavelength of light is modulated corresponding to scanning signal.
  • spectral-domain OCT interfering light of the back measuring light and back reference light is separated into its spectral components with a grating and the resulting optical spectrum is measured with a linear image sensor
  • the present invention can be applied to any one of the above methods, but the swept-source OCT and the spectral-domain OCT are preferable because no structure which changes the optical path length in terms of time is required in the optical path for the reference light.
  • the signal intensity is enlarged by the differential detection, because the signal obtained after light from the optical path for the measuring light and light from the optical path for the reference light interfere with each other becomes signal with the opposite phase.
  • the interfering signal caused by ghost generated on the optical surface of a prism arranged in the optical path for the measuring light is just divided in coupler 40 and has the same phase. Therefore, noise signal can be reduced by the differential detection, which allows obtaining an excellent tomographic image.
  • the measuring light and the reference light are delivered by separate optical fibers, which enables to insert attenuator 33 only in the optical path 31 for the reference light. Thereby, the control of light amount of the back reference light can be realized easily and the light-mount adjustment suitable for the interference is performed. Further, because the measuring light and reference light pass through separate optical paths, ghost light which is caused in the optical path for the measuring light can be eliminated.
  • the position determining light from light source for position determination 61 is introduced through coupler 63 into optical path 21 .
  • the position determining light is reflected by mark M, enters probe 50 again, passes through coupler 63 and is detected by photodetector for position determination 62 as shown in FIG. 2 and FIGS. 3 a and 3 b .
  • synchronizing signal is generated.
  • the rotation angle and/or displacement amount of probe 50 can be measured.
  • mark M is transparent with respect to the measuring light, an image which is observed by using the measuring light does not lack and tomographic images can be obtain throughout the rotary scanning angle of 360 degrees
  • the light guide body rotates on the axis
  • the present invention can be applied to a scanning system wherein a MEMS mirror is arranged on the leading end of the probe and a system wherein a fiber itself is oscillated for scanning.
  • the scanning position on the leading end of the probe can be determined without attenuation of the measuring light, which allows obtaining an excellent OCT image.
  • the present invention is extremely useful industrially in the point that an optical characteristic measuring probe which can detect the position and direction of the leading end of the probe without affecting the observed image can be provided.

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US13/318,998 2009-05-07 2010-03-03 Optical characteristic measuring probe Expired - Fee Related US8687928B2 (en)

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JP2009112486 2009-05-07
JP2009-112486 2009-05-07
PCT/JP2010/053412 WO2010128605A1 (fr) 2009-05-07 2010-03-03 Sonde de mesure de caractéristique optique

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US8687928B2 true US8687928B2 (en) 2014-04-01

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EP (1) EP2428154A4 (fr)
JP (1) JP5304892B2 (fr)
CN (1) CN102413754A (fr)
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EP2667762A1 (fr) * 2011-01-28 2013-12-04 Koninklijke Philips N.V. Détection optique pour le suivi relatif d'endoscopes
WO2012115983A1 (fr) * 2011-02-21 2012-08-30 Parmar Jaywant Philip Cathéter optique de type endoluminal pour imagerie microscopique en champ lointain
CN102846302A (zh) * 2012-09-04 2013-01-02 无锡微奥科技有限公司 一种oct内窥镜成像装置
WO2017024145A1 (fr) * 2015-08-05 2017-02-09 Canon U.S.A., Inc. Endoscope à champ angulaire et vers l'avant
DE112016003116T5 (de) * 2016-03-30 2018-04-26 Hitachi, Ltd. Vorrichtung zur Messung einer dreidimensionalen Form und Sonde zur Messung einer dreidimensionalen Form
US10564042B1 (en) * 2016-04-18 2020-02-18 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Advantages of spatial demodulation in interferometric optical sensing applications
CN113545735B (zh) * 2021-09-18 2021-12-14 广州永士达医疗科技有限责任公司 Oct图像显示调整的方法及装置

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JPS59195205A (ja) 1983-04-19 1984-11-06 Minolta Camera Co Ltd 多層膜ミラ−
US4696544A (en) * 1985-11-18 1987-09-29 Olympus Corporation Fiberscopic device for inspection of internal sections of construction, and method for using same
JP2006520244A (ja) 2003-03-13 2006-09-07 メドトロニック バスキュラー インコーポレイテッド 光誘導貫通カテーテルおよびその使用方法
JP2008089349A (ja) 2006-09-29 2008-04-17 Fujifilm Corp 光断層画像化装置
JP2008177697A (ja) 2007-01-16 2008-07-31 Audio Technica Corp コンデンサマイクロホンユニット、及びコンデンサマイクロホン
JP2008191021A (ja) 2007-02-06 2008-08-21 Hoya Corp Ｏｃｔシステム

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JPS5831307A (ja) 1981-08-20 1983-02-24 Tokyo Optical Co Ltd 干渉フイルタ−
DE102005030647B3 (de) 2005-06-30 2007-03-22 Siemens Ag Vorrichtung und Verfahren zur intraluminalen Bildgebung für die Rekonstruktion von 3D-Bilddatensätzen
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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
JPS59195205A (ja) 1983-04-19 1984-11-06 Minolta Camera Co Ltd 多層膜ミラ−
US4696544A (en) * 1985-11-18 1987-09-29 Olympus Corporation Fiberscopic device for inspection of internal sections of construction, and method for using same
JP2006520244A (ja) 2003-03-13 2006-09-07 メドトロニック バスキュラー インコーポレイテッド 光誘導貫通カテーテルおよびその使用方法
JP2008089349A (ja) 2006-09-29 2008-04-17 Fujifilm Corp 光断層画像化装置
JP2008177697A (ja) 2007-01-16 2008-07-31 Audio Technica Corp コンデンサマイクロホンユニット、及びコンデンサマイクロホン
JP2008191021A (ja) 2007-02-06 2008-08-21 Hoya Corp Ｏｃｔシステム

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JP5304892B2 (ja) 2013-10-02
WO2010128605A1 (fr) 2010-11-11
JPWO2010128605A1 (ja) 2012-11-01
EP2428154A1 (fr) 2012-03-14
CN102413754A (zh) 2012-04-11
EP2428154A4 (fr) 2012-12-26
US20120057149A1 (en) 2012-03-08

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