US8680154B2 - Injectable veterinary composition - Google Patents

Injectable veterinary composition Download PDF

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Publication number
US8680154B2
US8680154B2 US11/722,280 US72228005A US8680154B2 US 8680154 B2 US8680154 B2 US 8680154B2 US 72228005 A US72228005 A US 72228005A US 8680154 B2 US8680154 B2 US 8680154B2
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United States
Prior art keywords
pyrrolidone
florfenicol
composition
methyl
solvent
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US11/722,280
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English (en)
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US20090275662A1 (en
Inventor
Carole Barbot
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Intervet International BV
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Intervet International BV
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Priority to US11/722,280 priority Critical patent/US8680154B2/en
Assigned to INTERVET INTERNATIONAL B.V. reassignment INTERVET INTERNATIONAL B.V. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BARBOT, CAROLE
Publication of US20090275662A1 publication Critical patent/US20090275662A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • compositions of the present invention exhibit desirable properties which are useful characteristics for the administration of relatively high concentrations of florfenicol or other antibiotic compounds.
  • the compositions are physically and chemically stable.
  • the compositions have desirable viscosity characteristics which allows for good syringeability over a wide temperature range and ease of processing, such as good flow rate through sterilizing filter membranes.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
US11/722,280 2004-12-21 2005-12-20 Injectable veterinary composition Active 2029-12-19 US8680154B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/722,280 US8680154B2 (en) 2004-12-21 2005-12-20 Injectable veterinary composition

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63815404P 2004-12-21 2004-12-21
EP04106809 2004-12-21
EP04106809.9 2004-12-21
EP04106809 2004-12-21
PCT/EP2005/056950 WO2006067138A2 (en) 2004-12-21 2005-12-20 Injectable veterinary composition
US11/722,280 US8680154B2 (en) 2004-12-21 2005-12-20 Injectable veterinary composition

Publications (2)

Publication Number Publication Date
US20090275662A1 US20090275662A1 (en) 2009-11-05
US8680154B2 true US8680154B2 (en) 2014-03-25

Family

ID=36498916

Family Applications (1)

Application Number Title Priority Date Filing Date
US11/722,280 Active 2029-12-19 US8680154B2 (en) 2004-12-21 2005-12-20 Injectable veterinary composition

Country Status (17)

Country Link
US (1) US8680154B2 (pt)
EP (1) EP1830885B1 (pt)
JP (1) JP5017122B2 (pt)
AR (1) AR052827A1 (pt)
AT (1) ATE411046T1 (pt)
AU (1) AU2005318187B2 (pt)
BR (1) BRPI0519157B8 (pt)
CA (1) CA2591307C (pt)
DE (1) DE602005010479D1 (pt)
DK (1) DK1830885T3 (pt)
ES (1) ES2315942T3 (pt)
MX (1) MX2007007528A (pt)
NO (1) NO338532B1 (pt)
PL (1) PL1830885T3 (pt)
PT (1) PT1830885E (pt)
SI (1) SI1830885T1 (pt)
WO (1) WO2006067138A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR044437A1 (es) 2003-05-29 2005-09-14 Schering Plough Ltd Composiciones y metodo para el tratamiento de infecciones en ganado vacuno y porcino
CA2672795A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
FR2925335B1 (fr) * 2007-12-21 2010-03-19 Ceva Sante Animale Compositions orales liquides de florfenicol diluables dans l'eau de boisson
KR20110038723A (ko) * 2008-07-30 2011-04-14 인터벳 인터내셔널 비.브이. 플로르페니콜에 대한 중간체로서 유용한 옥사졸린-보호된 아미노디올 화합물의 제조 방법
BRPI1002021A2 (pt) 2010-01-21 2012-05-22 Nanocore Biotecnologia S A composições farmacêuticas para tratamento de infecções bacterianas
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
CN102973498A (zh) * 2012-12-13 2013-03-20 江苏恒丰强生物技术有限公司 一种氟苯尼考注射液及其制备方法
UA119324C2 (uk) 2013-04-02 2019-06-10 Теміс Медікер Лімітед Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні
CN108653213A (zh) * 2018-06-05 2018-10-16 王琴 一种氟苯尼考粉及其制备方法
CN108969486A (zh) * 2018-06-05 2018-12-11 王琴 一种氟苯尼考可溶性粉及其制备方法
CN108743541A (zh) * 2018-06-24 2018-11-06 王琴 水溶性兽药制剂及其制备方法

Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2000970A (en) 1977-07-15 1979-01-24 Abic Ltd Injectable chloramphenicol composition
US4235892A (en) 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
US4311857A (en) 1979-02-05 1982-01-19 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor
US4582918A (en) 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4743700A (en) 1984-02-03 1988-05-10 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds
US4876352A (en) 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US4912138A (en) 1986-09-15 1990-03-27 Zambon S.P.A. Pharmaceutical preparation containing thiamphenicol for veterinary use
US4973750A (en) 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
WO1992004016A1 (en) 1990-08-29 1992-03-19 Schering Corporation Pharmaceutical composition of florfenicol
US5105009A (en) 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
US5227494A (en) 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
EP0621033A1 (en) 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
US5382673A (en) 1990-10-25 1995-01-17 Schering Corporation Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
US5567844A (en) 1984-02-03 1996-10-22 Zambon S.P.A. Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols
US5663361A (en) 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
US20030220302A1 (en) 2002-05-20 2003-11-27 Schering-Plough Animal Health Corporation Compositions and method for treating infection in cattle and swine
WO2004014340A1 (en) 2002-08-13 2004-02-19 Dae Han New Pharm Co., Ltd. Injectable composition comprising florfenicol as an active ingredient
US20040242546A1 (en) 2003-05-29 2004-12-02 Schering-Plough Animal Health Corporation Compositions and method for treating infection in cattle and swine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040015624A (ko) * 2002-08-13 2004-02-19 대한뉴팜(주) 플로르페니콜을 활성성분으로 함유하는 경구투여용약제학적 조성물

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2000970A (en) 1977-07-15 1979-01-24 Abic Ltd Injectable chloramphenicol composition
US4235892A (en) 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
US4311857A (en) 1979-02-05 1982-01-19 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor
US5105009A (en) 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
US4743700A (en) 1984-02-03 1988-05-10 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds
US5567844A (en) 1984-02-03 1996-10-22 Zambon S.P.A. Process for preparing 1-phenyl-2-amino-3-fluoro-1-propanols
US4582918A (en) 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A (en) 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4912138A (en) 1986-09-15 1990-03-27 Zambon S.P.A. Pharmaceutical preparation containing thiamphenicol for veterinary use
US4876352A (en) 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US5227494A (en) 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
EP0546018A1 (en) 1990-08-29 1993-06-16 Schering Corp FLORFENICOL CONTAINING MEDICINAL PRODUCT.
WO1992004016A1 (en) 1990-08-29 1992-03-19 Schering Corporation Pharmaceutical composition of florfenicol
US5382673A (en) 1990-10-25 1995-01-17 Schering Corporation Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
EP0621033A1 (en) 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
US5663361A (en) 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
US20030220302A1 (en) 2002-05-20 2003-11-27 Schering-Plough Animal Health Corporation Compositions and method for treating infection in cattle and swine
WO2004014340A1 (en) 2002-08-13 2004-02-19 Dae Han New Pharm Co., Ltd. Injectable composition comprising florfenicol as an active ingredient
US20040242546A1 (en) 2003-05-29 2004-12-02 Schering-Plough Animal Health Corporation Compositions and method for treating infection in cattle and swine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Fiedler, Herbert P., Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik and angrenzende Gebiete, 3rd edition, 1989, p. 577. This paper is not in English. See second full paragraph of p. 4 of Applicant's specification for a discussion relating to this reference.
Handbook of Pharmaceutical Excipients, published by American Pharmaceutical Association/The Pharmaceutical Society of Great Britain, 1986, p. 127.
Schafer, Thomas W. et al., Novel Fluorine-Containing Analogs of Chloramphenicol and Thiamphenicol: Antibacterial and Biological Properties, in Current Chemotherapy and Infectious Disease Proceedings of the 11th ICC and the 19th ICAA American Society of Microbiology, 1980 pp. 444-446.

Also Published As

Publication number Publication date
BRPI0519157B8 (pt) 2020-06-02
EP1830885B1 (en) 2008-10-15
US20090275662A1 (en) 2009-11-05
JP2008524311A (ja) 2008-07-10
AR052827A1 (es) 2007-04-04
DK1830885T3 (da) 2009-01-05
AU2005318187B2 (en) 2010-12-16
WO2006067138A2 (en) 2006-06-29
EP1830885A2 (en) 2007-09-12
JP5017122B2 (ja) 2012-09-05
SI1830885T1 (sl) 2009-02-28
MX2007007528A (es) 2007-10-08
BRPI0519157A2 (pt) 2008-12-30
NO338532B1 (no) 2016-08-29
PT1830885E (pt) 2008-12-22
DE602005010479D1 (de) 2008-11-27
ES2315942T3 (es) 2009-04-01
ATE411046T1 (de) 2008-10-15
CA2591307C (en) 2012-12-04
AU2005318187A1 (en) 2006-06-29
WO2006067138A3 (en) 2006-09-21
PL1830885T3 (pl) 2009-04-30
BRPI0519157B1 (pt) 2020-05-19
CA2591307A1 (en) 2006-06-29
NO20072880L (no) 2007-07-19

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