US7451665B2 - Autoanalyzer and probe cleaning method - Google Patents

Autoanalyzer and probe cleaning method Download PDF

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Publication number
US7451665B2
US7451665B2 US11/668,246 US66824607A US7451665B2 US 7451665 B2 US7451665 B2 US 7451665B2 US 66824607 A US66824607 A US 66824607A US 7451665 B2 US7451665 B2 US 7451665B2
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sampling
probe
specimen
cleaning
amount
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US20070175284A1 (en
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Takehiko Oonuma
Hiroko TAKAYAMA
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Canon Medical Systems Corp
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Toshiba Corp
Toshiba Medical Systems Corp
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Assigned to TOSHIBA MEDICAL SYSTEMS CORPORATION reassignment TOSHIBA MEDICAL SYSTEMS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KABUSHIKI KAISHA TOSHIBA
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser

Definitions

  • the present invention relates to an improvement in an autoanalyzer that samples a specimen by using a probe to perform biochemical analysis and immunological analysis with respect to the specimen, and in a probe cleaning method of cleaning the probe used in the autoanalyzer.
  • An autoanalyzer is provided in, e.g., hospitals.
  • the autoanalyzer analyzes a specimen, e.g., blood or urine in accordance with each inspection item.
  • the autoanalyzer is constituted by coupling a biochemical analysis unit that performs biochemical analysis with respect to a specimen and an immunological analysis unit that carries out immunological analysis.
  • the autoanalyzer accommodates a specimen in a specimen container, and carries this specimen container between the biochemical analysis unit and the immunological analysis unit by using a carriage system.
  • a reaction tube is provided in each of the biochemical analysis unit and the immunological analysis unit.
  • the reaction tube is carried by the carriage system.
  • the specimen in the specimen container is divided and poured into the reaction tube in each of the biochemical analysis unit and the immunological analysis unit.
  • Divided pouring is carried out by each sampling mechanism provided in each of the biochemical analysis unit and the immunological analysis unit.
  • Each sampling mechanism is constituted by, e.g., providing a sampling probe to a sampling arm. The sampling mechanism immerses the sampling probe in the specimen in the specimen container by driving the sampling arm, sucks the specimen in the specimen container by the sampling probe, moves the sampling probe into the reaction tube, and discharges the specimen into the reaction tube from the sampling probe.
  • the autoanalyzer sequentially carries the plurality of specimen containers accommodating different specimens therein to the biochemical analysis unit and the immunological analysis unit to divide and pour the specimens into the respective reaction tubes. Therefore, as shown in FIG. 15 , the sampling probe is cleaned to avoid contamination between the previous specimen and the next specimen, i.e., carry-over. The sampling probe is cleaned after the specimen is sucked to be discharged into the reaction tube. As a result, in regard to an amount of a residue of the sampling probe, an amount Cb of the residue after cleaning is smaller than an amount Ca of the residue before cleaning as shown in FIG. 15 .
  • Jpn. Pat. Appln. KOKAI Publication No. 2004-251797 discloses forming an opening, from which a cleaning liquid is discharged, to include a region where the cleaning liquid discharged toward an outer wall of a sampling probe placed in a cleaned state is immersed in a specimen.
  • the biochemical analysis unit and the immunological analysis unit have a considerable difference in measurement sensitivity with respect to a specimen.
  • the sensitivity of the immunological analysis unit is higher than that of the biochemical analysis unit.
  • the biochemical analysis unit does not require high performance in relation to carry-over between specimens. Even if there is carry-over between the previous specimen and the next specimen, the biochemical analysis unit does not affect an analysis result.
  • the immunological analysis unit requires high performance concerning carry-over between specimens. Therefore, if there is carry-over between the previous specimen and the next specimen, an error in an analysis result occurs in the immunological analysis unit.
  • Carry-over between specimens is also dependent on a degree of contamination of a sampling probe, conditions under which a specimen is sampled, and others. Therefore, in the existing circumstances, it is difficult to keep the performance requiring the carry-out performance between specimens under all conditions.
  • the carry-over between specimens vary depending on sampling conditions due to the following tendency.
  • the carry-over between specimens is also increased.
  • An increase in the number of times of sampling and an increase in the carry-over do not necessarily have a proportionality relation.
  • the carry-over between specimens is increased in accordance with an integration amount of specimens to be sucked by a sampling probe.
  • the integration amount of specimens is a sum total of sampling amounts of all specimens including a dummy and sampling amounts of the first sampling to the nth sampling, for example.
  • a maximum number of times of sampling in the autoanalyzer exceeds 100 times because of specifications.
  • a sampling probe may suck and discharge a specimen having a sampling amount of, e.g., 35 ⁇ L because of its specifications. In such sampling, even if the number of times of sampling is the same as that of sampling having an average sampling amount, e.g., approximately 4 ⁇ L, the carry-over between specimens becomes large.
  • a value of the carry-over between specimens required under maximum conditions in specifications is, e.g., 0.1 ppm or below.
  • an autoanalyzer comprising: a probe that samples a specimen; an analysis unit that analyzes the specimen sampled by the probe; a cleaning mechanism that cleans the probe; and
  • a probe cleaning change section that changes at least one of the number of times of cleaning and a cleaning time of the probe by the cleaning mechanism based on at least one of the number of times of sampling of the specimen and a sampling amount of the specimen by the probe.
  • a probe cleaning method comprising: sequentially sampling a specimen by a probe; and changing at least one of the number of times of cleaning and a cleaning time when cleaning the probe based on at least one of the number of times of sampling of the specimen by the probe and a sampling amount of the specimen.
  • FIG. 1 is a structural view showing a first embodiment of an autoanalyzer according to the present invention
  • FIG. 2 is a structural view showing a cleaning mechanism in the autoanalyzer
  • FIG. 3 is a view showing another structure in the autoanalyzer
  • FIG. 4 is a block diagram showing a control system in the autoanalyzer
  • FIG. 5 is a timing chart showing a specimen sampling operation and a sampling probe cleaning operation in accordance with each sampling period in the autoanalyzer;
  • FIG. 6 is a view showing a sampling probe cleaning method in the autoanalyzer
  • FIG. 7 is a view showing an example of a timing of additional cleaning by the autoanalyzer
  • FIG. 8 is a cleaning flowchart in the autoanalyzer
  • FIG. 9 is a timing chart showing a specimen sampling operation and a sampling probe cleaning operation in accordance with each sampling period in a second embodiment of an autoanalyzer according to the present invention.
  • FIG. 10 is a view showing an example of a timing of additional cleaning by the autoanalyzer
  • FIG. 11 is a view showing weighting with respect to each specimen sampling amount in a third embodiment of an autoanalyzer according to the present invention.
  • FIG. 12 is a view showing another timing of additional cleaning by the autoanalyzer according to the present invention.
  • FIG. 13 is a view showing still another timing of additional cleaning by the autoanalyzer according to the present invention.
  • FIG. 14 is a view showing yet another timing of additional cleaning by the autoanalyzer according to the present invention.
  • FIG. 15 is a view showing a conventional sampling probe cleaning method.
  • FIG. 1 is a structural view of an autoanalyzer.
  • the autoanalyzer is constituted by coupling a biochemical analysis unit 1 with an immunological analysis unit 2 and providing a carriage unit 3 between the biochemical analysis unit 1 and the immunological analysis unit 2 .
  • the carriage unit 3 carries a plurality of specimen containers 5 accommodating each specimen 4 , e.g., a blood serum or urine therein from the biochemical analysis unit 1 to the immunological analysis unit 2 in a direction indicated by arrows A.
  • the respective specimens 4 accommodated in the respective specimen containers 5 are taken from different patients.
  • a sampling mechanism 6 a is provided in the biochemical analysis unit 1 .
  • the sampling mechanism 6 a divides and pours the specimen 4 accommodated in the specimen container 5 into the biochemical analysis unit 1 .
  • the sampling mechanism 6 a is constituted by providing a sampling probe 8 a at a distal end of a sampling arm 7 a .
  • a reaction container 9 a is provided in the biochemical analysis unit 1 .
  • the sampling mechanism 6 a moves the sampling arm 7 a to a position above the specimen container 5 , moves down the sampling probe 8 a to be immersed in the specimen 4 in the specimen container 5 , sucks the specimen 4 , moves up the sampling probe 8 a , moves the sampling probe 8 a to a position above the reaction container 9 a , and moves down the sampling probe 8 a to discharge the specimen 4 into the reaction container 9 a .
  • the biochemical analysis unit 1 performs biochemical analysis of the specimen 4 divided and poured into the reaction container 9 a.
  • a sampling mechanism 6 b is provided in the immunological analysis unit 2 .
  • the sampling mechanism 6 b divides and pours the specimen 4 accommodated in the specimen container 5 into the immunological analysis unit 4 .
  • the sampling mechanism 6 b is constituted by providing a sampling probe 8 b at a distal end of a sampling arm 7 b .
  • a reaction container 9 b is provided in the immunological analysis unit 2 .
  • the sampling mechanism 6 b moves the sampling arm 7 b to a position above the specimen container 5 , moves down the sampling probe 8 b to be immersed in the specimen 4 in the specimen container 5 , sucks the specimen 4 , moves up the sampling probe 8 b , moves the sampling probe 8 b to a position above the reaction container 9 b , and moves down the sampling probe 8 b to discharge the specimen 4 into the reaction container 9 b .
  • the immunological analysis unit 2 performs immunological analysis of the specimen 4 divided and poured into the reaction container 9 b.
  • the biochemical analysis unit 1 and the immunological analysis unit 2 have a difference corresponding to a measurement sensitivity with respect to the specimen 4 , and a sensitivity of the immunological analysis unit 2 is higher than that of the biochemical analysis unit 1 .
  • the biochemical analysis unit 1 and the immunological analysis unit 2 respectively have cleaning mechanisms 10 a and 10 b .
  • the respective cleaning mechanisms 10 a and 10 b clean the respective sampling probes 8 a and 8 b .
  • FIG. 2 is a structural view of each cleaning mechanism 10 a or 10 b .
  • Each cleaning mechanism 10 a or 10 b is constituted by providing a cleaning pump 12 to a cleaning tank 11 .
  • the cleaning mechanism 10 a drives the cleaning pump 12 with respect to the sampling probe 8 a or 8 b inserted into the cleaning tank 11 to inject a cleaning liquid 13 , thereby cleaning the sampling probe 8 a or 8 b.
  • a timing of cleaning each sampling probe 8 a or 8 b is as follows.
  • the sampling probe 8 a will be explained.
  • the sampling mechanism 6 a moves the sampling probe 8 a to, e.g., a position above the specimen container 5 from an installation position of the cleaning mechanism 10 a , moves down the sampling probe 8 a to be immersed in the specimen 4 in the specimen container 5 , sucks the specimen 4 , moves up the sampling probe 8 a , moves the sampling probe 8 a to a position above the reaction container 9 a , and moves down the sampling probe 8 a to discharge the specimen 4 into the reaction container 9 a.
  • the sampling mechanism 6 a moves the sampling arm 7 a to the installation position of the cleaning mechanism 10 a .
  • the cleaning mechanism 10 a cleans the sampling probe 8 a.
  • the sampling mechanism 6 a again moves the sampling arm 7 a to the position above the specimen container 5 , and immerses the sampling probe 8 a in the specimen 4 in the specimen container 5 to suck the specimen 4 .
  • the sampling mechanism 6 a moves the sampling probe 8 a from, e.g., the installation position of the cleaning mechanism 10 a to an installation position of the specimen container 5 , immerses the sampling probe 8 a in the specimen 4 in the specimen container 5 , sucks the specimen 4 , discharges the sucked specimen 4 into the reaction container 9 a , and cleans the sampling arm 7 a in the cleaning mechanism 10 a .
  • This operation is determined as one cycle.
  • each of the biochemical analysis unit 1 and the immunological analysis unit 2 sucks the specimen 4 in the specimen container 5 carried by the carriage unit 3 by using each sampling mechanism 6 a or 6 b , and discharges the specimen 4 into each reaction container 9 a or 9 b .
  • the present invention is not restricted to this structure, and each of the biochemical analysis unit 1 and the immunological analysis unit 2 may have a structure shown in FIG. 3 .
  • the plurality of specimen containers 5 are provided in a disc sampler 20 .
  • This disc sampler 20 rotates in, e.g., a direction indicated by an arrow B.
  • the plurality of reaction containers 9 a are provided in a reaction disc 21 .
  • This reaction disc 21 rotates in, e.g., a direction indicated by an arrow C.
  • the sampling mechanism 6 a is provided between the disc sampler 20 and the reaction disc 21 .
  • the cleaning mechanism 10 a is provided in a movement path of the sampling probe 8 a between the disc sampler 20 and the reaction
  • sampling mechanism 6 a moves the sampling probe 8 a from, e.g., an installation position of the cleaning mechanism 10 a to a position above the specimen container 5 , moves down the sampling probe 8 a to be immersed in the specimen 4 in the specimen container 5 , sucks the specimen 4 , moves up the sampling probe 8 a , rotates and moves the sampling probe 8 a to a position above the reaction container 9 a , and moves down the sampling probe 8 a to discharge the specimen 4 into the reaction container 9 a.
  • the sampling mechanism 6 a moves the sampling arm 7 a to the installation position of the cleaning mechanism 10 a .
  • the cleaning mechanism 10 a cleans the sampling probe 8 a.
  • the sampling mechanism 6 a again moves the sampling arm 7 a to the position above the specimen container 5 , and immerses the sampling probe 8 a in the specimen 4 in the specimen container 5 to suck the specimen 4 .
  • the control system 30 is formed of a computer, and has a CPU, an RAM, an ROM, an input/output port, and others.
  • the computer executes an autoanalysis program stored in the ROM.
  • the control system 30 has a main control section 31 formed of the CPU.
  • the main control section 31 controls operations of an autoanalysis section 33 , a sampling drive section 34 , a cleaning drive section 35 , and a probe cleaning adding section 36 as a probe cleaning change section in accordance with sampling information set in a sampling information setting section 32 .
  • Information of each specimen 4 sequentially carried by the carriage unit 3 is preset in the sampling information setting section 32 .
  • Information of each specimen 4 is, e.g., a name of a patient from who the specimen 4 is taken, a type of the specimen 4 , e.g., a blood serum or urine, each inspection item of the specimen 4 in the biochemical analysis unit 1 and the immunological analysis unit 2 , the number of times of sampling for each of the various specimens 4 in the biochemical analysis unit 1 and the immunological analysis unit 2 , a sampling amount for one time, and others.
  • the autoanalysis section 33 operates the biochemical analysis unit 1 in accordance with each predetermined sampling period to perform biochemical analysis of the specimen 4 divided and poured into the reaction container 9 a and also carries out a regular analysis operation of operating the cleaning mechanism 9 a in the biochemical analysis unit 1 .
  • the autoanalysis section 33 operates the immunological analysis unit 2 in accordance with each predetermined sampling period to effect immunological analysis of the specimen 4 divided and poured into the reaction container 9 b.
  • the autoanalysis section 33 operates the biochemical analysis unit 1 as follows.
  • the autoanalysis section 33 issues each operation command to the sampling drive section 34 in accordance with each of the sampling periods T 1 to Tn to operate the sampling mechanism 6 a , thereby effecting each of sampling operations S 1 to Sn for the specimen 4 .
  • the autoanalysis section 33 issues each operation command to the cleaning drive section 35 in accordance with each of the sampling periods T 1 to Tn after each of the sampling operations S 1 to Sn for each specimen 4 , thus performing each of cleaning operations W 1 to Wn for the sampling probe 8 a.
  • Each of the sampling periods T 1 to Tn corresponds to an operation in one cycle of the sampling mechanism 6 a mentioned above. Therefore, the respective sampling periods T 1 to Tn correspond to operations of the sampling mechanism 6 a in n cycles.
  • the sampling drive section 34 operates and controls each of the sampling mechanisms 6 a and 6 b .
  • the sampling drive section 34 moves, e.g., the sampling arms 7 a and 7 b of the respective sampling mechanisms 6 a and 6 b .
  • the sampling drive section 34 performs a sucking operation and a discharge operation of the respective sampling probes 8 a and 8 b.
  • the cleaning drive section 35 operates the cleaning pump 12 to inject the cleaning liquid 13 into the cleaning tank 11 .
  • the probe cleaning adding section 36 judges, e.g., whether the number of times of sampling of the specimen 4 by the sampling mechanism 6 a exceeds a preset number of times of sampling. Further, the probe cleaning adding section 36 also judges whether a sampling integration amount of the specimen 4 exceeds a preset sampling integration amount. When the number of times of sampling exceeds the set number of times of sampling or when the sampling integration amount exceeds the set sampling integration amount as a result of the judgment, the probe cleaning adding section 36 adds cleaning of the sampling probe 8 a before the next sampling of the specimen 4 besides regular cleaning of the sampling probe 8 a .
  • the probe cleaning adding section 36 carries out cleaning, e.g., twice or more.
  • FIG. 7 shows an example of a timing of additional cleaning.
  • the respective cleaning operations W 1 to Wn are regular cleaning with respect to the sampling probe 8 a .
  • the probe cleaning adding section 36 determines that the number of times of sampling the specimen 4 by the sampling mechanism 6 a exceeds the set number of times of sampling in, e.g., the sampling period T 2 , it performs additional cleaning W′ 2 in the next sampling period T 3 .
  • the probe cleaning adding section 36 cancels execution of sampling the specimen 4 and performs the additional cleaning operation W 2 ′ alone for the sampling probe 8 a.
  • the number of times of sampling the specimen 4 is, e.g., a count value of the number of times of sampling after replacing the sampling probes 8 a and 8 b . It is to be noted that the number of times of sampling the specimen 4 may be a count value of the number of times of sampling from, e.g., the sampling period T 4 following the sampling period Tn where the previous additional cleaning is effected, i.e., the sampling period T 3 where the additional cleaning operation W 2 ′ is performed as shown in FIG. 7 .
  • the sampling integration amount of the specimen 4 is, e.g., an integration value of an amount of sampling the specimen 4 after replacing the sampling probes 8 a and 8 b . It is to be noted that the sampling integration amount of the specimen 4 may be an integration value of sampling amounts of the specimen 4 sampled from, e.g., the sampling period T 4 following the sampling period Tn where previous additional cleaning is effected, i.e., the sampling period T 3 where the additional cleaning operation W 2 ′ is performed as shown in FIG. 7 .
  • the probe cleaning adding section 36 obtains the total number of times of sampling including the number of times of sampling the next specimen 4 that is sampled by, e.g., the sampling mechanism 6 a , and judges whether the total number of times of sampling exceeds a preset number of times of sampling. Furthermore, the probe cleaning adding section 36 obtains a total sampling integration amount including a sampling integration amount of the next specimen 4 to be sampled, and judges whether the total sampling integration amount exceeds a preset sampling integration amount.
  • the probe cleaning adding section 36 adds cleaning for the sampling probe 8 a before the next sampling of the specimen 4 besides regular cleaning for the sampling probe 8 a like the above example.
  • the probe cleaning adding section 36 obtains the total number of times of sampling including the sampling operation S 3 in the next sampling period T 3 , and judges whether the total number of times of sampling exceeds the set number of times of sampling. Moreover, as shown in FIG. 7 , when the sampling mechanism 6 a is used to perform the sampling operation S 2 and the cleaning operation W 2 for the sampling probe 8 a in the sampling period T 2 , the probe cleaning adding section 36 obtains the total number of times of sampling including the sampling operation S 3 in the next sampling period T 3 , and judges whether the total number of times of sampling exceeds the set number of times of sampling. Moreover, as shown in FIG.
  • the probe cleaning adding section 36 obtains a total sampling integration amount including a sampling integration amount of the specimen 4 in the next sampling period T 3 , and judges whether the total sampling integration amount exceeds a set sampling integration amount.
  • the probe cleaning adding section 36 adds cleaning for the sampling probe 8 a before the next sampling of the specimen 4 besides regular cleaning for the sampling probe 8 a like the above example.
  • the probe cleaning adding section 36 carries out the additional cleaning operation W 2 ′ alone for the sampling probe 8 b without executing sampling of the specimen 4 in the next sampling period T 3 .
  • the probe cleaning adding section 36 has a sampling number count section 37 , a sampling amount integrating section 38 , and an additional cleaning executing section 39 .
  • the sampling number count section 37 counts, e.g., the number of times of sampling after replacing the sampling probes 8 a and 8 b .
  • the sampling number count section 37 adds the number of times of sampling “1” to the number of times of sampling at the end of, e.g., the sampling period T 1 to obtain the total number of times of sampling including the number of times in the next sampling period T 2 .
  • the sampling number count section 37 may start counting the number of times of each sampling operation with respect to the specimen 4 by the sampling probe 8 a or 8 b from, e.g., the sampling period T 4 following the sampling period T 3 where the additional cleaning operation W 2 ′ shown in FIG. 7 is performed.
  • the sampling amount integrating section 38 sequentially integrates sampling amounts of the specimen 4 by the sampling probes 8 a and 8 b after, e.g., replacing the sampling probes 8 a and 8 b to obtain an integration amount of sampling of the specimen 4 .
  • the sampling amount integrating section 38 integrates a sampling amount in the next sampling period to a sampling integration amount after replacing the sampling probes 8 a and 8 b to obtain a total sampling integration amount including an amount in the next sampling period.
  • a sampling amount in the next sampling period T 2 information of a sampling amount set in the sampling information setting section 32 is used.
  • sampling amount integrating section 38 may sequentially integrate sampling amounts of the specimen 4 by the sampling probes 8 a and 8 b from the sampling period T 4 following the sampling period T 3 where the additional cleaning operation W 2 ′ is performed as shown in FIG. 7 to obtain a sampling integration amount of the specimen 4 , for example.
  • the additional cleaning executing section 39 receives the number of times of sampling the specimen 4 obtained by the sampling number count section 37 and the sampling integration amount of the specimen 4 acquired by the sampling amount integrating section 38 .
  • the additional cleaning executing section 39 judges whether the number of times of sampling of the specimen 4 exceeds the set number of times of sampling. Additionally, the additional cleaning executing section 39 judges whether the sampling integration amount of the specimen 4 exceeds the set sampling integration amount.
  • the additional cleaning executing section 39 performs additional cleaning for the sampling probe 8 a .
  • the additional cleaning executing section 39 likewise performs additional cleaning for the sampling probe 8 a.
  • the additional cleaning executing section 39 judges whether the total number of times of sampling including the number of times of sampling the next specimen 4 to be sampled exceeds the set number of times of sampling. Further, the additional cleaning executing section 39 judges whether the total sampling integration amount including a sampling integration amount of the next specimen 4 to be sampled exceeds the set sampling integration amount.
  • the additional cleaning executing section 39 carries out additional cleaning for the sampling probe 8 a .
  • the additional cleaning executing section 39 likewise performs additional cleaning for the sampling probe 8 a.
  • the specimen 4 e.g., a blood serum or urine taken from, e.g., each different patient is accommodated in each specimen container 5 .
  • Each specimen container 5 is mounted on the carriage unit 3 .
  • the carriage unit 3 sequentially carries each specimen container 5 from the biochemical analysis unit 1 to the immunological analysis unit 2 .
  • the main control section 31 operates and controls the autoanalysis section 33 .
  • the autoanalysis section 33 issues each operation command to the sampling drive section 34 in accordance with each of the sampling periods T 1 to Tn as shown in FIG. 5 , for example. Consequently, the sampling mechanism 6 a performs each of the sampling operations S 1 to Sn in accordance with each of the sampling periods T 1 to Tn.
  • the cleaning mechanism 10 a carries out each of the cleaning operations W 1 to Wn for the sampling probe 8 a after each of the sampling operations S 1 to Sn in accordance with each of the sampling periods T 1 to Tn.
  • Divided pouring of each specimen 4 and the cleaning operation of the sampling probe 8 a in each of the sampling periods T 1 to Tn are as follows.
  • the sampling mechanism 6 a moves the sampling probe 8 a to, e.g., a position above the specimen container 5 from an installation position of the cleaning mechanism 10 a .
  • the sampling mechanism 6 a moves down the sampling probe 8 a to be immersed in the specimen 4 in the specimen container 5 , and sucks the specimen 4 .
  • sampling of the specimen 4 by the sampling probe 8 a is carried out in accordance with a sampling amount set n the sampling information setting section 32 .
  • the sampling mechanism 6 a elevates the sampling probe 8 a to be moved to a position above the reaction container 9 a . Then, the sampling mechanism 6 a moves down the sampling probe 8 a and discharges the specimen 4 into the reaction container 9 a in the biochemical analysis unit 1 .
  • the sampling mechanism 6 a moves the sampling arm 7 a to an installation position of the cleaning mechanism 10 a .
  • the cleaning mechanism 10 a cleans the sampling probe 8 a . That is, the autoanalysis section 33 issues each operation command to the sampling drive section 34 every time each of the sampling operations S 1 to Sn ends. As a result, the sampling mechanism 6 a inserts the sampling ram 7 a into the cleaning tank 11 . Then, the autoanalysis section 33 issues an operation command to the cleaning drive section 35 .
  • the cleaning pump 12 injects the cleaning liquid 13 into the cleaning tank 11 . As a result, each of the cleaning operations W 1 , W 2 , . . . , Wn for the sampling arm 8 a is carried out every time each of the sampling operations S 1 to Sn ends.
  • the sampling mechanism 6 a again moves the sampling arm 7 a to the position above the specimen container 5 .
  • the biochemical analysis unit 1 sequentially performs biochemical analysis with respect to each specimen 4 divided and poured into each reaction container.
  • the sampling number count section 37 counts the number of times of sampling after, e.g., replacing the sampling probes 8 a and 8 b . It is to be noted that the sampling number count section 37 counts the number of times of the respective sampling operations with respect to the specimen 4 by the sampling probes 8 a and 8 b from the sampling period T 4 following the sampling period T 3 where the additional cleaning operation W 2 ′ shown in FIG. 7 is effected, for example.
  • the sampling amount integrating section 38 sequentially integrates sampling amounts of the specimen 4 realized by the sampling probes 8 a and 8 b after, e.g., replacing the sampling probes 8 a and 8 b to obtain a sampling integration amount of the specimen 4 . It is to be noted that the sampling amount integrating section 38 sequentially integrates sampling amounts of the specimen 4 realized by the sampling probes 8 a and 8 b from the sampling period T 4 following the sampling period T 3 where the additional cleaning operation W 2 ′ shown in FIG. 7 is effected, thereby obtaining a sampling integration amount of the specimen 4 , for example.
  • the main control section 31 operates the additional cleaning executing section 39 every time each of the sampling periods T 1 to Tn shown in FIG. 5 ends in, e.g., the biochemical analysis unit 1 at a step # 1 (a sampling and regular cleaning period).
  • the additional cleaning executing section 39 receives the number of times of sampling operations with respect to the specimen 4 carried out by the sampling probe 8 a from the sampling number count section 37 in accordance with each of the sampling periods T 1 to Tn.
  • the additional cleaning executing section 39 receives the number of times of sampling until the end of the previous sampling period, i.e., the sampling period T 2 from the sampling number count section 37 . Furthermore, when the sampling period T 2 ends, the additional cleaning executing section 39 receives a sampling integration amount until the end of the sampling period T 2 from the sampling amount integrating section 38 .
  • the additional cleaning executing section 39 receives a total number of times of sampling obtained by adding the number of times of sampling in the next sampling period T 3 from the sampling number count section 37 . Additionally, when the sampling period T 2 ends, the additional cleaning executing section 39 receives a total sampling integration amount obtained by integrating sampling amounts in the next sampling period T 3 from the sampling number count section 37 .
  • the additional cleaning executing section 39 judges whether the number of times of sampling of the specimen 4 until the end of the sampling period T 2 exceeds the set number of times of sampling. Further, the additional cleaning executing section 39 judges whether the sampling integration amount of the specimen 4 until the end of the sampling period T 2 exceeds the set sampling integration amount.
  • the additional cleaning executing section 39 judges whether the total number of times of sampling including the number of times of sampling in the next sampling period T 3 exceeds the set number of times of sampling when the sampling period T 2 ends. Furthermore, the additional cleaning executing section 39 judges whether the total sampling integration amount including the sampling integration amount in the next sampling period T 3 exceeds the set sampling integration amount when the sampling period T 2 ends.
  • the main control section 31 advances to a step # 3 to issue a command for regular cleaning of the probe, i.e., with no additional cleaning due to the additional cleaning executing section 39 .
  • the sampling period T 3 the sampling operation S 3 with respect to the specimen 4 and the regular cleaning operation W 3 for the sampling probe 8 a are effected as usual.
  • the main control section 31 advances to the step # 3 to issue a command for regular cleaning of the probe, i.e., with no additional cleaning due to the additional cleaning executing section 39 .
  • the sampling operation S 3 with respect to the specimen 4 and the regular cleaning operation W 3 for the sampling probe 8 a are carried out as usual.
  • step # 5 allows the additional cleaning executing section 39 to execute additional cleaning after regular cleaning.
  • step # 5 allowing the additional cleaning executing section 39 to execute additional cleaning after regular cleaning also occurs when the sampling integration amount of the specimen 4 exceeds the set sampling integration amount.
  • the main control section 31 also advances to step # 5 and allows the additional cleaning executing section 39 to execute additional cleaning after regular cleaning.
  • step # 5 when the total number of times of sampling including the number of times of the sampling operation S 3 in the next sampling period T 3 exceeds the set number of times of sampling the main control section 31 advances to step # 5 as noted above and allows the additional cleaning executing section 39 to execute the above-noted additional cleaning.
  • this advancement to step # 5 allowing the additional cleaning executing section 39 to execute additional cleaning after regular cleaning also occurs when the total sampling integration amount in the sampling period T 3 exceeds the set sampling integration amount.
  • the main control section 31 also advances to step # 5 and allows the additional cleaning executing section 39 to execute additional cleaning after regular cleaning.
  • the additional cleaning executing section 39 adds cleaning of the sampling probe 8 a before the next sampling operation S 3 besides regular cleaning of the sampling probe 8 a to execute cleaning, e.g., twice or more.
  • the probe cleaning adding section 36 performs the sampling operation S 2 and the cleaning operation W 2 for the sampling probe 8 a in the sampling period T 2 with respect to the sampling mechanism 6 a as shown in FIG. 7 , and then carries out the additional cleaning operation W 2 ′ alone for the sampling probe 8 a in the next sampling period T 3 without effecting the sampling operation S 3 with respect to the specimen 4 .
  • the main control section 31 returns to a normal state, and performs the sampling operation S 3 with respect to the specimen 4 and the cleaning operation W 3 for the sampling probe 8 a in the sampling period T 4 as shown in FIG. 7 .
  • the main control section 31 advances to the step # 5 and allows the additional cleaning executing section 39 to execute additional cleaning.
  • the main control section 31 advances to the step # 5 and allows the additional cleaning executing section 39 to execute additional cleaning like the above example.
  • the additional cleaning operation alone for the sampling probe 8 a or 8 b is carried out in the next sampling period without executing the sampling operation with respect to the specimen 4 .
  • the sampling probe 8 a or 8 b can be assuredly cleaned.
  • An amount of contamination of the sampling probe 8 a or 8 b can be reduced as compared with that in conventional cleaning. Even if the number of times of sampling of the specimen 4 or the sampling integration amount is increased, performance requiring carry-over between the specimens 4 can be assured.
  • the additional cleaning operation is carried out.
  • the sampling probe 8 a or 8 b can be cleaned before performance requiring carry-over between the specimens 4 cannot be assured due to contamination of the sampling probe 8 a or 8 b , thus securing the performance requiring carry-over between the specimens 4 .
  • the biochemical analysis unit 1 and the immunological analysis unit having measurement sensitivity considerably higher than that of the biochemical analysis unit 1 can perform analysis of each specimen 4 with a high inspection accuracy.
  • Contamination of the sampling probe 8 a or 8 b is checked, e.g., once a week, once a month, or on a periodical base.
  • the contamination check is carried out when a contamination degree of the sampling probe 8 a or 8 b is measured and a measurement results shows a high contamination level.
  • this apparatus since additional cleaning is carried out, performance required in carry-over between the sampling probes 8 a and 8 b can be assured for a long time. A burden of checking contamination of each of the sampling probes 8 a and 8 b can be alleviated.
  • Additional cleaning of each of the sampling probes 8 a and 8 b is performed based on an amount, an injection power, an injection time, and others of the cleaning liquid 13 which are the same as those in regular cleaning.
  • the additional cleaning operation can be performed without changing settings of, e.g., an amount, an injection power, an injection time, and others of the cleaning liquid 13 in the cleaning mechanism 9 .
  • FIGS. 1 to 4 A second embodiment according to the present invention will now be explained. It is to be noted that an apparatus structure according to this embodiment is the same as that shown in FIGS. 1 to 4 , and hence different parts will be explained.
  • the same specimen 4 is divided and poured into a plurality of reaction containers 9 a from one specimen container 5 , for example.
  • a sampling mechanism 6 a moves a sampling probe 8 a to, e.g., a position above the specimen container 5 from an installation position of a cleaning mechanism 10 a , moves down the sampling probe 8 a to be immersed in the specimen 4 in the specimen container 5 , sucks the specimen 4 , moves up the sampling probe 8 a , moves the sampling probe 8 a to a position above the reaction container 9 a , and moves down the sampling probe 8 a to discharge the specimen 4 into the reaction container 9 a.
  • the sampling mechanism 6 a moves up a sampling arm 7 a , again moves the sampling arm 7 a to the position above the specimen container 5 that is the same as the above-described specimen container 5 , immerses the sampling probe 8 a in the specimen 4 in the specimen container 5 , sucks the specimen 4 , moves up the sampling probe 8 a , moves the sampling probe 8 a to, e.g., a position above a reaction container 9 a that is different from the above-explained reaction container 9 a , and moves down the sampling probe 8 a to discharge the specimen 4 into the reaction container 9 a.
  • the sampling mechanism 6 a moves the sampling probe 8 a to, e.g., an installation position of the specimen container 5 from the installation position of the cleaning mechanism 10 a to be immersed in the specimen 4 in the specimen container 5 , sucks the specimen 4 , and discharges the sucked specimen 4 into the reaction container 9 a .
  • This operation is determined as one cycle, and this cycle is repeated more than once.
  • the sampling mechanism 6 a moves the sampling arm 7 a to the installation position of the cleaning mechanism 10 a .
  • the cleaning mechanism 10 a cleans the sampling probe 8 a.
  • a probe cleaning change section 36 judges whether additional cleaning is carried out like the first embodiment. When it is determined that additional cleaning is performed as a result of the judgment, the probe cleaning change section 36 repeats the cycle for the preset number of times, then executes a regular cleaning state, and performs cleaning of the sampling probe 8 a alone without executing sampling of the specimen 4 in the next cycle.
  • an autoanalysis section 33 issues each operation command to a sampling drive section 34 in accordance with, e.g., each of sampling periods T 1 to Tm as shown in FIG. 9 .
  • the sampling mechanism 6 a carries out each of sampling operations S 1 to Sm in accordance with each of the sampling periods T 1 to Tm.
  • the respective sampling operations S 1 to Sm are as follows.
  • the sampling mechanism 6 a moves the sampling probe 8 a to, e.g., the position above the specimen container 5 from the installation position of the cleaning mechanism 10 a , and moves down the sampling probe 8 a .
  • the sampling mechanism 6 a immerses the sampling probe 8 a in the specimen 4 in the specimen container 5 , and sucks the specimen 4 .
  • the sampling mechanism 6 a elevates the sampling probe 8 a , and moves the sampling probe 8 a to the position above the reaction container 9 a .
  • the sampling mechanism 6 a moves down the sampling probe 8 a to discharge the specimen 4 into the reaction container 9 a .
  • the sampling mechanism 6 a moves up the sampling arm 7 a , and again moves the sampling arm 7 a to the position above the specimen container 5 that is the same as the above-described specimen container 5 .
  • the sampling mechanism 6 a moves the sampling arm 7 a to the installation position of the cleaning mechanism 10 a .
  • the cleaning mechanism 10 a performs a cleaning operation W 1 with respect to the sampling probe 8 a.
  • sampling mechanism 6 a repeats sampling the specimen 4 .
  • an additional cleaning executing section 39 judges whether the number of times of sampling with respect to the same specimen 4 until end of the sampling period Tm exceeds a set number of times of sampling. Further, the additional cleaning executing section 39 judges whether a sampling integration amount of the same specimen 4 until end of the sampling period T 2 exceeds a set sampling integration amount.
  • the additional cleaning executing section 39 judges whether the total number of times of sampling including the number of times of sampling in the next sampling period T 1 exceeds the set number of times of sampling when, e.g., the sampling period Tm ends. Furthermore, the additional cleaning executing section 39 judges whether a total sampling integration amount including a sampling integration amount in the next sampling period T 1 exceeds the set sampling integration amount when the sampling period Tm ends.
  • a main control section 31 advances to step # 3 , and issues a command of performing regular cleaning (as at W 1 in period Tm of FIG. 10 ) and additional cleaning W′ (as in period Tm′ of FIG. 10 ) with respect to the additional cleaning executing section 39 . Consequently, as shown in FIG. 10 , in a sampling period Tm′, a cleaning operation W 1 ′ for the sampling probe 8 a is performed after regular cleaning W 1 . In contrast, if it is determined in step # 2 that the preset value of the number of times of sampling or the weighted sampling amount (sampling integration amount) is not exceeded, no additional cleaning is performed after the regular cleaning is completed.
  • a sampling mechanism 7 b on an immunological analysis unit 2 side likewise, when it is determined that the number of times of sampling of the specimen 4 exceeds a set number of times of sampling or that a sampling integration amount of the specimen 4 exceeds a set sampling integration amount, the main control section 31 advances to a step # 5 and allows the additional cleaning executing section 39 to execute additional cleaning like the above example. Likewise, when it is determined that the number of times of sampling with respect to the next specimen 4 to be sampled exceeds the set number of times of sampling or that a total sampling integration amount including a sampling amount in the next sampling period exceeds the set sampling integration amount, the main control section 31 advances to the step # 5 and allows the additional cleaning executing section 39 to execute additional cleaning.
  • the sampling probes 8 a and 8 b can be assuredly cleaned like the first embodiment.
  • An amount of contamination of each sampling probe 8 a or 8 b can be reduced as compared with conventional cleaning. Even if the number of times of sampling or the sampling integration amount of the specimen 4 is increased, performance requiring carry-over between the specimens 4 can be assured.
  • FIGS. 1 to 4 A third embodiment according to the present invention will now explained.
  • An apparatus structure according to this embodiment is the same as that shown in FIGS. 1 to 4 , and hence different parts will be described.
  • a sampling amount of a specimen 4 for each inspection item is weighted, that is it is subject to weighing.
  • a preset contamination amount can be set at a value (e.g., “10” as noted below) and when the sampling amount is at or above this set value it is multiplied by a first weighting factor (e.g., “2” as noted below).
  • a second weighting factor e.g., “1” as noted below.
  • the specimen 4 accommodated in a specimen container 5 is divided and poured into a plurality of reaction containers 9 a .
  • a divided pouring amount (a sampling amount) to each reaction container 9 a is, e.g., “10”, “7”, “5” or “8”.
  • a sampling amount integrating section 38 weights a sampling amount that increases adhesion of contamination to a sampling probe 8 a .
  • the sampling amount integrating section 38 has a preset contamination amount, and judges whether a sampling amount for each reaction container 9 a exceeds the set contamination amount for that container. When the sampling amount for a particular reaction container 9 a exceeds the set contamination amount for that particular container 9 a as a result of the judgment, the sampling amount integrating section 38 weights the sampling amount for that particular container 9 a reaction container 9 a , and uses the weighted sampling amount to obtain an integration amount of sampling of the specimen 4 .
  • the set contamination amount is set to, e.g., “10”.
  • a weighting value is set to, e.g., “multiplying by 2” when the set contamination amount “10” is exceeded.
  • the weighting value is set to, e.g., “multiplying by 1” when the set contamination amount is not greater than “10”.
  • An additional cleaning executing section 39 receives the sampling integration amount from the sampling amount integrating section 38 .
  • the additional cleaning executing section 39 judges whether the sampling integration amount exceeds a preset sampling integration amount, e.g., whether the sampling integration amount exceeds a preset sampling integration amount “80”. When the sampling integration amount exceeds the set sampling integration amount, the additional cleaning executing section 39 executes additional cleaning.
  • the sampling probe 8 a divides and pours the specimen 4 accommodated in the specimen container 5 into the plurality of reaction containers 9 a .
  • Each sampling amount with respect to each reaction container 9 a is, e.g., “10”, “7”, “5”, or “8”.
  • the sampling amount integrating section 38 judges whether each sampling amount “10”, “7”, “5”, or “8” with respect to each reaction container 9 a exceeds a set contamination amount “10”. As a result of the judgment, since the sampling amount “10” with respect to the reaction container 9 a exceeds the set contamination amount, the sampling amount integrating section 38 multiplies the sampling amount “10” with respect to the reaction container 9 a by “2” to perform weighting. The sampling amount integrating section 38 multiplies each sampling amount “7”, “5”, or “8” with respect to each reaction container 9 a by “1” to perform weighting. The sampling amount integrating section 38 calculates 10 ⁇ 2+7 ⁇ 1+5 ⁇ 1+8 ⁇ 1 to obtain a sampling integration amount “40”.
  • the additional cleaning executing section 39 receives the sampling integration amount “40” from the sampling amount integrating section 38 .
  • the additional cleaning executing section 39 judges whether the sampling integration amount “40” exceeds a preset sampling integration amount, e.g., a preset sampling integration amount “80”. When the sampling integration amount exceeds the set sampling integration amount, the additional cleaning executing section 39 executes additional cleaning.
  • the sampling amount with respect to the specimen 4 is weighted.
  • a sampling amount that increases an amount of adhesion of contamination to the sampling probe 8 a is subjected to weighting using a large value, e.g., weighting of multiplying by “2”, thereby obtaining a sampling integration amount.
  • additional cleaning of the sampling probe 8 a can be performed on an earlier stage. It is possible to securely assure performance required in carry-over between the specimens 4 .
  • a probe cleaning adding section 36 may perform additional cleaning for the sampling probes 8 a and 8 b based on the following probe cleaning method.
  • a probe cleaning adding section 7 may add cleaning of the sampling probes 8 a and 8 b before the next sampling of the specimen 4 besides regular cleaning of the sampling probes 8 a and 8 b.
  • the probe cleaning adding section 7 may add cleaning of the sampling probes 8 a and 8 b before the next sampling of the specimen 4 besides regular cleaning of the sampling probes 8 a and 8 b.
  • the probe cleaning adding section 7 may add cleaning of the sampling probes 8 a and 8 b before the next sampling of the specimen 4 .
  • the probe cleaning adding section 7 may add cleaning of the sampling probes 8 a and 8 b before the next sampling of the specimen 4 .
  • the probe cleaning adding section 7 may add cleaning of the sampling probes 8 a and 8 b before the next sampling of the specimen 4 .
  • the probe cleaning adding section 7 may increase the number of times of additional cleaning for the sampling probes 8 a and 8 b .
  • additional cleaning an additional cleaning operation W 2 ′ alone may be performed in a sampling period T 4 after the additional cleaning operation W 2 ′ in a sampling period T 3 .
  • additional cleaning is continuously performed for two cycles in the respective sampling periods T 3 and T 4 .
  • the probe cleaning adding section 7 can move a timing of additional cleaning for the sampling probes 8 a and 8 b in, e.g., the sampling period T 3 .
  • the additional cleaning operation W 2 ′ may be performed in the middle of the sampling period T 3 .
  • the additional cleaning operation W 2 ′ may be carried out in the first half of the sampling period T 3 .
  • the probe cleaning adding section 7 may prolong a time required for additional cleaning of the sampling probes 8 a and 8 b .
  • a time of the additional cleaning operation W 2 ′ may be set to an entire time in the sampling period T 3 .
  • a time of the additional cleaning operation W 2 ′ may be set to an entire time of the respective sampling periods T 3 and T 4 that are continuous for two cycles.
  • the probe cleaning adding section 7 may perform the additional cleaning operation.

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JP5208675B2 (ja) * 2008-10-30 2013-06-12 シスメックス株式会社 検体処理装置
CN102435760A (zh) * 2011-12-16 2012-05-02 上海依达医疗器械有限公司 冰点渗透压测定仪探头的自动洁净装置
US9891240B2 (en) * 2012-08-02 2018-02-13 Hitachi High-Technologies Corporation Automatic analyzer
US9977041B2 (en) * 2012-12-05 2018-05-22 Hitachi High-Technologies Corporation Automatic analysis device
CN107643410B (zh) * 2016-07-21 2021-04-02 深圳迈瑞生物医疗电子股份有限公司 样本分析仪及样本分析仪的清洗控制方法
WO2020230451A1 (ja) * 2019-05-13 2020-11-19 株式会社日立ハイテク 自動分析装置、及びその洗浄方法
CN112444467B (zh) * 2019-09-05 2024-08-13 深圳迈瑞动物医疗科技股份有限公司 一种清洗方法、血液细胞分析仪及存储介质
CN115524504A (zh) * 2021-06-25 2022-12-27 深圳市帝迈生物技术有限公司 一种样本分析装置及其清洗方法、计算机可读存储介质

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EP1813950A1 (en) 2007-08-01

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