US7094414B2 - Famotidine injections - Google Patents

Famotidine injections Download PDF

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US7094414B2
US7094414B2 US10/451,402 US45140203A US7094414B2 US 7094414 B2 US7094414 B2 US 7094414B2 US 45140203 A US45140203 A US 45140203A US 7094414 B2 US7094414 B2 US 7094414B2
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famotidine
acid
injection
injection solution
solution
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US20040067993A1 (en
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Katsunori Nakata
Hiroshi Yatabe
Tsukasa Nishikawahara
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Astellas Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Definitions

  • the present invention relates to an injection solution containing famotidine or its salt. More specifically, the invention relates to a famotidine injection solution containing famotidine or its salt in an amount of about 1 mg/ml to about 40 mg/ml in terms of the base, further containing a water-soluble acid amide in an amount of about 1 mg to about 30 mg per 1 mg of famotidine, and an acidic substance and having a pH of about 5.5 to about 7.5 and a kinematic viscosity at room temperature of about 0.9 centistokes or more to about 3 centistokes or less.
  • Famotidine is a pharmaceutical agent excellent in inhibitory action of gastric acid secretion based on a histamine H2-receptor antagonistic action and generally used in the form of an oral or injection preparation as an agent for treating gastric ulcer, duodenal ulcer, and other digestive diseases (cf. Merck Index thirteen edition, page 696 and so on).
  • famotidine injection preparations two kinds of preparations, i.e., a solution preparation and a freeze-dried preparation are present.
  • the solution preparation is commercially available in United States and Europe for intravenous administration
  • the freeze-dried preparation is commercially available in Japan as an administration system mainly for intravenous administration and is also used for intramuscular administration.
  • an injection solution capable of being preserved at room temperature and capable of being administered intramuscularly is not commercially available.
  • Famotidine is a basic compound having a pKa value of about 7.1, and it is soluble in water but exhibits a low stability at an acidic side while the solubility extremely decreases at a neutral range where the stability is high.
  • JP-B-63-65047 (or CA1184495) describes the following: a low water-solubility (solubility of 0.1 w/v % or lower) of famotidine makes development of its injection preparation difficult; selection of a substance capable of solubilizing famotidine in a high concentration is necessary for developing the injection preparation; although selection of an acid is considered, selection of an acid capable of not only solubilizing famotidine but also stabilizing is necessary since it is unstable in an acidic region; a stable injection preparation dissolving famotidine in a high concentration (10 mg/ml) can be first provided when a specific acid, L-aspartic acid is mixed; and so forth.
  • the famotidine injection preparation in clinical use at present is a freeze-dried preparation produced based on the patented invention and it main administration route is intravenous administration.
  • a freeze-dried preparation should be prepared before use employing a physiologically allowable dissolution liquid such as physiological saline, and thus it can be said that the preparation is a preparation accompanied by vexatious complication.
  • the pH of the solution obtained by dissolving the freeze-dried preparation in water for injection is about 5.2.
  • U.S. Pat. No. 5,650,421 discloses an injection preparation wherein the concentration of famotidine or it salt is from 0.1 mg/ml to 0.8 mg/ml, the pH is adjusted to from 5.7 to 6.4 by adding an acid such as L-aspartic acid, and the preparation is mixed with physiological saline in advance.
  • a preparation having a high concentration which is adjusted to a volume for intramuscular administration requiring a minimum volume i.e., it is necessary to be a preparation having a concentration of 6.67 mg/ml or higher (a concentration calculated based on the assumption that the liquid amount capable for intramuscular administration is about 3 ml or less and 20 mg of famotidine, which is a single dose thereof, is contained).
  • JP-A-11-193233 describes a famotidine injection preparation having a pH of about 5.5 to about 7.5 which contains famotidine or its salt in an amount of about 1 mg/ml to about 40 mg/ml in terms of famotidine, especially which comprises famotidine or its salt, an acidic substance, and a water-soluble non-aqueous solvent.
  • the above invention using a water-soluble non-aqueous solvent is an excellent technology which solves the above problem and especially achieves a drug concentration of about 6.67 mg/ml or higher enabling intramuscular administration and a long-term stability at room temperature, but owing to the characteristic property of the water-soluble non-aqueous solvent such as polyethylene glycol, propylene glycol, or glycerin, viscosity of the formulated drug solution increases and its absorption after intramuscular administration is delayed as compared with the conventional preparation because of the factors such as the viscosity, so that the improvement has been desired.
  • the characteristic property of the water-soluble non-aqueous solvent such as polyethylene glycol, propylene glycol, or glycerin
  • famotidine or its salt can be unexpectedly solubilized by an water-soluble acid amide such as nicotinic acid amide, isonicotinic acid amide, or N,N-dimethylacetamide, which is hitherto not used as a solubilizing agent for famotidine preparations, in the coexistence of an acid substance such as lactic acid, the purpose being not achieved by a common solubilizing agent.
  • an acid substance such as lactic acid
  • famotidine can be contained in a high concentration without using a large amount of organic solvent and the stability can be assured at room temperature over a long period of time.
  • the inventors have further found that upon the measurement of kinematic viscosity of the famotidine freeze-dried preparation containing L-aspartic acid, the famotidine injection preparation containing a water-soluble non-aqueous solvent, and the injection solution provided by the invention, no difference is observed visually but the injection solution provided by the invention has a low viscosity nearly equal to the viscosity of the freeze-dried preparation and in the famotidine injection solution, the formulation capable of avoiding absorption delay of famotidine without impairing the absorbability is enabled by controlling the kinematic viscosity of the preparation at room temperature to about 3 centistokes or less.
  • the inventors have found that the absorbability can be further increased by preparing an injection solution wherein a sugar alcohol such as mannitol or a sugar such as glucose is contained in famotidine or its salt, the water-soluble acid amide, and the acidic substance. Based on these findings, they have accomplished the invention.
  • a non-aqueous solvent for the purpose of solubilization and stabilization of famotidine is entirely not used or its amount to be used can be extremely limited, it is a noteworthy effect that a pain caused by the non-aqueous solvent is not concerned, necessity of adding a soothing agent including benzyl alcohol as a representative in a high concentration can be extruded, and also anxiety of absorption delay at the administration owing to a high concentration of the soothing agent, which is commonly known, can be dispelled.
  • the invention relates to (1) a famotidine injection solution containing famotidine or its salt in an amount of about 1 mg/ml to about 40 mg/ml in terms of the base, further containing a water-soluble acid amide in an amount of about 1 mg to about 30 mg per 1 mg of famotidine, and an acidic substance and having a pH of about 5.5 to about 7.5 and a kinematic viscosity at room temperature of about 0.9 centistokes or more to about 3 centistokes or less, (2) the famotidine injection solution, which further contains a sugar alcohol and/or sugar, (3) the famotidine injection solution, wherein a mixing amount of the sugar alcohol and/or sugar is from about 0.2 to about 16% by weight, (4) the famotidine injection solution, wherein the sugar alcohol and/or sugar is one or two or more compounds selected from the group consisting of mannitol, sorbitol, glucose, and mannose, (5) the famotidine injection solution
  • the invention relates to use of a water-soluble acid amide for the production of a stable famotidine injection solution. Furthermore, the invention relates to use of mannitol for the production of a stable famotidine injection solution wherein absorbability of famotidine is increased.
  • the “kinematic viscosity” herein is a value obtained by dividing viscosity of a liquid by its density and means a value measured using an Ubbelohde viscometer in accordance with Japanese Pharmacopoeia viscosity measuring method.
  • centistokes in CGS system is used as a unit.
  • the kinematic viscosity of the famotidine freeze-dried preparation containing L-aspartic acid is about 1 centistokes and the kinematic viscosity of the famotidine injection preparation containing a water-soluble non-aqueous solvent, which exhibits absorption delay, is about 5 centistokes.
  • a “high” viscosity in famotidine injection preparations or injection solutions means a viscosity exceeding about 3 centistokes and especially indicates about 5 centistokes which is observed in the famotidine injection preparation containing a water-soluble non-aqueous solvent
  • a “low” viscosity means a viscosity of about 0.9 centistokes or more to about 3 centistokes or less.
  • famotidine or its salt in a high concentration in terms of famotidine which is desirable in the invention means a content of famotidine of about 1 mg/ml or more, preferably about 5 mg/ml or more, most suitably about 6.67 mg/ml or more per a preparation unit.
  • an injection solution is stable at room temperature over a long period of time” which is desirable in the invention means that the residual rate of famotidine is an acceptable limit or more (about 94% or more) even when the solution is stored at 25° C. for 1 year or more, preferably 1.5 years or more.
  • salt of famotidine is not particularly limited as far as it is pharmaceutically allowable one and is a salt of famotidine capable of achieving the object of the invention in the injection solution of the invention like famotidine.
  • salts described in JP-B-60-56143 or U.S. Pat. No. 4,362,736) or salts formed with acidic substances described in JP-A-11-193233 may be mentioned. These salts can be easily obtained by subjecting famotidine and the acidic substances to a conventional salt forming reaction.
  • the concentration of famotidine or its salt is preferably from about 1 mg/ml to about 40 mg/ml, which enables administration of 20 mg of famotidine or in terms of famotidine in a volume of about 0.5 ml to about 20 ml.
  • the concentration of about 5 mg/ml or more the solution can be used for gentle and slow intravenous administration or intravenous infusion after dilution with a physiologically acceptable liquid such as physiological saline and, in addition, can be used for a topical administration such as intramuscular administration, subcutaneous administration, or the like.
  • the water-soluble acid amide for use in the invention is not particularly limited as far as it is a pharmaceutically allowable one capable of achieving the object of the invention and is a water-soluble acid amide having a group —CONH 2 in the molecule and an ability to solubilize famotidine or its salt.
  • nicotinic acid amide, isonicotinic acid amide, gentisic acid ethanolamide, urea, N,N-dimethylacetamide, and the like may be mentioned.
  • a suitable water-soluble acid amide is nicotinic acid amide which has an experience of being used as an additive for commercially available injection solution and which is reported to have no serious harmful action.
  • urea is a “carbamic acid amide” as described in Japanese Pharmacopoeia and has the same function as the other water-soluble acid amides have, as one ingredient achieving solubilization, stabilization, and decrease of viscosity of the injection solution of the invention.
  • water-soluble acid amides may be used singly or as a mixture of two or more of them.
  • water-soluble non-aqueous solvents shown in JP-A-11-193233 for example, those described in the following Table 1 may be used as auxiliary solubilizing means.
  • kinematic viscosity of the mixed solutions of these non-aqueous solvents and water at 25° C. are shown in Table 1.
  • auxiliary solubilizing agent such as a cyclodextrin, a surfactant, or the like may be added within a range exhibiting no absorption delay.
  • the amount of the above water-soluble acid amide to be added varies depending on the kind of the water-soluble acid amide and the amount of the other solubilizing auxiliary agent and is not sweepingly defined but is generally from about 1 mg to 30 mg, preferably from about 2 mg to 15 mg per 1 mg of famotidine or its salt.
  • the acidic substance for use in the invention is not particularly limited as far as it is a pharmaceutically allowable one capable of achieving the object of the invention and is an acidic substance having an ability to solubilize and stabilize famotidine or its salt through the formation of a salt or complex with famotidine or its salt.
  • hydrochloric acid, lactic acid, L-aspartic acid, L-glutamic acid, benzoic acid, citric acid, malic acid, ascorbic acid, erythorbic acid, gluconic acid, acetic acid, nicotinic acid, and the like may be mentioned.
  • lactic acid More preferred is lactic acid, L-aspartic acid, L-glutamic acid, or nicotinic acid, and further preferred is lactic acid, L-aspartic acid, or L-glutamic acid.
  • lactic acid More preferred is lactic acid.
  • These acidic substances may be used singly or as a mixture of two or more of them.
  • ascorbic acid or erythorbic acid may be added. These are selected as acidic substances but also function as antioxidants.
  • the amount of the above acidic substance to be added varies depending on the kinds thereof, the kind of the water-soluble acid amide, adoption of the antioxidant, adoption of a buffer system, and the like, and is not sweepingly defined but is generally from about 0.2 to 20 mol, preferably from about 0.3 to 15 mol per 1 mol of famotidine or its salt.
  • the pH of the injection solution of the invention is preferably about 5.5 to about 7.5, more preferably from about 5.5 to about 7.0. It is preferable to mix an acidic substance so that the pH of the injection solution of the invention is finally adjusted to the above range or to adjust the pH to the above range with a basic substance such as sodium hydroxide after mixing an excess of the acidic substance.
  • the kinematic viscosity of the injection solution of the invention at room temperature is preferably from about 0.9 centistokes or more to about 3 centistokes or less, more preferably from about 0.9 centistokes or more to about 2 centistokes or less, most suitably from about 0.9 centistokes or more to about 1 centistokes or less.
  • a sugar alcohol or sugar in addition to the water-soluble acid amide and the acidic substance, can be added.
  • the sugar alcohol or sugar is preferably mannitol, sorbitol, glucose, or mannose, and more preferably mannitol. These sugar alcohol and sugar may be used in combination.
  • the mixing amount in the case that the sugar alcohol or sugar is added varies depending on the kind of the other ingredients and their mixing amounts, but is preferably from about 0.2 to about 16% by weight, more preferably from about 1 to about 10% by weight.
  • additives including a soothing agent such as benzyl alcohol, mepivacaine hydrochloride, or xylocaine hydrochloride, an antiseptic such as methyl parabenzoate, propyl parabenzoate, thimerosal, or chlorobutanol, and the like, can be added if necessary.
  • a hydrophilic low-molecular-weight additive such as sodium chloride can be added, if necessary.
  • the injection solution of the invention is excellent in mixing ability with a sodium chloride injection solution such as physiological saline, a sugar infusion solution, an electrolyte infusion solution, and the other infusion solutions, and thus can be used in combination with these infusion solutions.
  • a sodium chloride injection solution such as physiological saline, a sugar infusion solution, an electrolyte infusion solution, and the other infusion solutions, and thus can be used in combination with these infusion solutions.
  • water for injection is added to famotidine or its salt and a water-soluble acid amide, and further an acidic substance is added thereto to dissolve famotidine or its salt.
  • the water-soluble acid amide, and the acidic substance, mannitol and the other additives are added at a suitable step of the above production process and dissolved. Then, the thus obtained injection solution is sterilized and dispensed into containers for injection including ampoules and others, and the containers are sealed and packaged.
  • the injection solution of the invention can be sterilized by any of known methods, but in order to reduce the decrease of content of famotidine during the preparation as far as possible, it is preferable to produce the solution by a known aseptic manipulation other than sterilization by heating, for example, sterile filtration described in Examples or the like. Furthermore, the product may be treated so that it does not come into contact with oxygen by blowing nitrogen gas into a prepared solution or filling a headspace of an ampoule with nitrogen gas. Moreover, for the purpose of preventing photodecomposition of the drug during the production, the operation may be carried out in a dark place.
  • FIG. 1 is a graph illustrating a concentration change of Comparative Formulation 2 and Comparative Formulation 1 in blood plasma.
  • FIG. 2 is a graph illustrating a concentration change of Example 9 and Comparative Formulation 1 in blood plasma.
  • FIG. 3 is a graph illustrating a concentration change of Example 10 and Comparative Formulation 1 in blood plasma.
  • FIG. 4 is a graph illustrating a concentration change of Example 11 and Comparative Formulation 1 in blood plasma.
  • FIG. 5 is a graph illustrating a concentration change of Example 12 and Comparative Formulation 1 in blood plasma.
  • FIG. 6 is a graph illustrating a concentration change of Example 13 and Comparative Formulation 1 in blood plasma.
  • a famotidine injection solution containing famotidine or its salt in an amount of about 1 mg/ml to about 40 mg/ml in terms of the base and having a pH of about 5.5 to about 7.5 and a kinematic viscosity at room temperature of about 0.9 centistokes or more to about 3 centistokes or less or by preparing an injection solution containing famotidine or its salt, a water-soluble acid amide, and an acidic substance, the invention exhibits a remarkable effect of enabling provision of a low-viscosity famotidine stabilized injection solution containing famotidine at a high concentration, being stable over a long period of time at room temperature, and never deteriorating the absorption of famotidine which can be hardly provided so far.
  • famotidine stabilized injection solution mixed with a sugar alcohol or sugar in addition to famotidine or its salt, the water-soluble acid amide, and the acidic substance is useful since it enables further increase of the absorbability to a level equal to that of a freeze-dried injection preparation.
  • the preparation was prepared by reconstituting a commercially available famotidine injection preparation (freeze-dried preparation) with water for injection so that the concentration of famotidine becomes 10 mg/ml.
  • Example 1 of JP-A-11-193233 an injection solution having formulation of pH 6.4 containing 10 mg/ml of famotidine, 370 mg/ml of polyethylene glycol 400, 20 mg/ml of benzyl alcohol, and 1.8 mg/ml of lactic acid was prepared.
  • the kinematic viscosity of the commercial famotidine injection preparation (freeze-dried preparation) [Comparative Formulation 1] and that of the famotidine injection preparation containing a water-soluble non-aqueous solvent [Comparative Formulation 2] were about 1 centistokes and about 5 centistokes, respectively.
  • Comparative Formulation 2 i.e., a famotidine injection preparation mixed with a water-soluble non-aqueous solvent was extremely higher than that of Comparative Formulation 1, i.e., a freeze-dried injection preparation.
  • C max was 1 ⁇ 2 or less
  • T max was 4 times
  • MRT was extended as compared with the case of the commercially available freeze-dried injection preparation, and hence the absorption was considered to be drastically delayed.
  • Each of the injection solutions of Examples 3, 4, 6, 9, 10 to 13, and 19 and the injection solution of Comparative Formulation 1 were intramuscularly administered to a hind limb part of the same rabbits. Also, each of the injection solutions of Examples 17 and 18 and the injection solution of Example 19 were intramuscularly administered to a hind limb part of the same rabbits. Blood was collected with time and the drug concentration in blood plasma was measured by HPLC/UV method.
  • the residual rates of famotidine were measured after storage under a condition of 50° C. for 1 month and/or under a condition of 40° C. for 3 months.
  • the residual rates of famotidine after storage of the preparation of Example 1 under a condition of 50° C. for 1 month and under a condition of 40° C. for 3 months were 96.7% and 96.3%, respectively.
  • the residual rates of famotidine after storage of the preparation of Example 2 under a condition of 50° C. for 1 month and under a condition of 40° C. for 3 months were 96.3% and 96.1%, respectively.
  • the residual rate of famotidine after storage of the preparation of Example 4 under a condition of 50° C. for 1 month was 96.1%.
  • the residual rate of famotidine after storage of the preparation of Example 9 under a condition of 40° C. for 3 months was 96.0%.
  • the residual rate of famotidine after storage of the preparation of Example 10 under a condition of 40° C. for 3 months was 97.2%.
  • the residual rate of famotidine after storage of the preparation of Example 11 under a condition of 40° C. for 3 months was 96.4%.
  • the residual rate of famotidine after storage of the preparation of Example 12 under a condition of 40° C. for 3 months was 95.7%.
  • the residual rate of famotidine after storage of the preparation of Example 13 under a condition of 40° C. for 3 months was 95.2%.
  • the residual rate of famotidine after storage of the preparation of Example 14 under a condition of 50° C. for 1 month was 94.7%.
  • the residual rate of famotidine after storage of the preparation of Example 15 under a condition of 50° C. for 1 month was 95.9%.
  • kinematic viscosity is desirably set at about 0.9 centistokes or more to about 3 centistokes or less, preferably about 0.9 centistokes or more to about 2 centistokes or less, most suitably about 0.9 centistokes or more to about 1 centistokes or less in order to exhibit absorbability similar to that of the commercially available freeze-dried injection preparation,
  • famotidine To 10 g of famotidine and 100 g of nicotinic acid amide were added about 800 ml of water for injection and 19 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, 9 g of benzyl alcohol was added thereto and water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.4 and a kinematic viscosity at room temperature of 1.09 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine and 50 g of nicotinic acid amide were added about 800 ml of water for injection and 22 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, 9 g of benzyl alcohol was added thereto and water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 1.00 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 1 g of famotidine and 10 g of nicotinic acid amide were added about 40 ml of water for injection and 20 ml of a 10 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.4 and a kinematic viscosity at room temperature of 1.12 centistokes was obtained.
  • famotidine To 5 g of famotidine, 1.478 g of L-aspartic acid, and 50 g of nicotinic acid amide was added water for injection to make the volume about 450 ml, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 500 ml, whereby an injection solution having a pH of 6.4 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 1 g of famotidine and 5 g of nicotinic acid amide were added about 80 ml of water for injection and 1.90 ml of a 100 mg/ml aqueous lactic acid solution, and 5 g of propylene glycol and 2 g of benzyl alcohol were further added thereto, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.4 and a kinematic viscosity at room temperature of 1.17 centistokes was obtained.
  • famotidine To 5 g of famotidine and 25 g of nicotinic acid amide were added about 420 ml of water for injection and 11.0 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 500 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 1.01 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, and 20 g of mannitol were added about 800 ml of water for injection and 22 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.1 and a kinematic viscosity at room temperature of 1.07 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, and 20 g of mannitol were added about 800 ml of water for injection and 17 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, 1 g of ascorbic acid was added and dissolved under blowing nitrogen gas into the drug solution and water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 1.08 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, and 20 g of mannitol were added about 800 ml of water for injection and 20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, 1 g of ascorbic acid was added and dissolved under blowing nitrogen gas into the drug solution and water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 5.8 and a kinematic viscosity at room temperature of 1.07 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, and 20 g of mannitol were added about 750 ml of water for injection, 61 ml of a 100 mg/ml aqueous lactic acid solution, and 30 ml of a 1N sodium hydroxide solution, followed by stirring to dissolve them. After complete dissolution of famotidine, 1 g of ascorbic acid was added and dissolved under blowing nitrogen gas into the drug solution and a suitable amount of a 1N sodium hydroxide solution was added to make the pH 6.1. Water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 1.09 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, and 20 g of mannitol were added about 750 ml of water for injection, 70 ml of a 100 mg/ml aqueous lactic acid solution, and 30 ml of a 1N sodium hydroxide solution, followed by stirring to dissolve them. After complete dissolution of famotidine, 1 g of ascorbic acid was added and dissolved under blowing nitrogen gas into the drug solution and a suitable amount of a 1N sodium hydroxide solution was added to make the pH 5.8. Water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 5.8 and a kinematic viscosity at room temperature of 1.09 centistokes was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, 2.07 g of citric acid monohydrate, and 20 g of mannitol was added about 800 ml of water for injection, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.1 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 10 g of famotidine, 50 g of nicotinic acid amide, 1.60 g of citric acid monohydrate, and 20 g of mannitol was added about 800 ml of water for injection, followed by stirring to dissolve them. After complete dissolution of famotidine, 1 g of ascorbic acid was added and dissolved under blowing nitrogen gas into the drug solution and water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.1 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 2 g of famotidine, 10 g of nicotinic acid amide, and 4 g of mannitol were added about 150 ml of water for injection and 22 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. Then, a suitable amount of a 1N sodium hydroxide solution was added to make the pH 6.2. After complete dissolution of famotidine, 0.2 g of erythorbic acid was added and dissolved and water for injection was further added to make the total volume 1000 ml, whereby an injection solution having a pH of 6.2 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • the resulting profile of the decomposed product was equal to the profile of the decomposed product of the preparation wherein ascorbic acid was added instead of erythorbic acid as a reference.
  • famotidine To 2 g of famotidine, 10 g of nicotinic acid amide, and 4 g of glucose were added about 160 ml of water for injection and 4.4 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was further added to make the total volume 200 ml, whereby an injection solution having a pH of 6.1 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 2 g of famotidine, 10 g of nicotinic acid amide, and 4 g of mannose were added about 160 ml of water for injection and 4.4 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was further added to make the total volume 200 ml, whereby an injection solution having a pH of 6.1 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • famotidine To 2 g of famotidine, 10 g of nicotinic acid amide, and 10 g of sorbitol were added about 160 ml of water for injection and 4.4 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was further added to make the total volume 200 ml, whereby an injection solution having a pH of 6.1 was obtained.
  • the solution was charged into an ampoule and after the headspace was replaced with nitrogen, the ampoule was sealed with melting to prepare an injectable product.
  • a famotidine injection solution containing famotidine or its salt in an amount of about 1 mg/ml to about 40 mg/ml in terms of the base and having a pH of about 5.5 to about 7.5 and a kinematic viscosity at room temperature of about 0.9 centistokes or more to about 3 centistokes or less or by preparing an injection solution containing famotidine or its salt, a water-soluble acid amide and an acidic substance, the invention exhibits a remarkable effect of enabling provision of a low-viscosity famotidine injection solution containing famotidine at a high concentration, being stable over a long period of time at room temperature, and never deteriorating the absorption of famotidine, which can be hardly provided so far.
  • famotidine injection solution mixed with a sugar alcohol or sugar in addition to famotidine or its salt, the water-soluble acid amide, and the acidic substance is useful since it enables further increase of the absorbability to the extent equal to that of a freeze-dried injection preparation.

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JP2000-389887 2000-12-22
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US20100130573A1 (en) * 2008-11-25 2010-05-27 Richard Tokunaga Treatment and prevention of deleterious effects associated with alcohol consumption

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US20040185119A1 (en) * 2003-02-26 2004-09-23 Theuer Richard C. Method and compositions for treating gastric hyperacidity while diminishing the likelihood of producing vitamin deficiency
US20100105638A1 (en) * 2007-03-12 2010-04-29 Kerstin Den-Braven Cosmetic compositions
US8962039B2 (en) * 2009-09-04 2015-02-24 Munisekhar Medasani Method of treatment of neurodegenerative or neuro-muscular degenerative diseases and therapeutic agent to treat the same
CN101972248B (zh) * 2010-10-09 2012-02-01 江苏奥赛康药业股份有限公司 一种供注射用的法莫替丁组合物及其制备方法
CN103446048A (zh) * 2013-09-12 2013-12-18 南京正宽医药科技有限公司 一种法莫替丁注射液及其制备方法
CN103877579B (zh) * 2014-03-24 2015-08-26 海南双成药业股份有限公司 一种含有法莫替丁的药物组合物及其制剂
WO2017091166A1 (en) 2015-11-26 2017-06-01 Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. Stable pharmaceutical compositions and process for their preparation
JP7090845B2 (ja) * 2018-08-03 2022-06-27 高田製薬株式会社 パロノセトロン含有液体組成物
CN111904936B (zh) * 2020-08-28 2022-07-19 开封康诺药业有限公司 一种法莫替丁冻干粉针剂
CN113197869A (zh) * 2021-04-13 2021-08-03 河北智同生物制药股份有限公司 一种注射用法莫替丁冻干粉针剂及制备方法
WO2024062287A1 (en) * 2022-09-21 2024-03-28 Maiva Pharma Private Limited A premixed room temperature stable composition of famotidine for intravenous bolus injection and method thereof
CN115737548A (zh) * 2022-11-21 2023-03-07 四川汇宇制药股份有限公司 一种法莫替丁注射液的制备方法

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Publication number Priority date Publication date Assignee Title
US20100130573A1 (en) * 2008-11-25 2010-05-27 Richard Tokunaga Treatment and prevention of deleterious effects associated with alcohol consumption
US8058296B2 (en) 2008-11-25 2011-11-15 Richard Tokunaga Treatment and prevention of deleterious effects associated with alcohol consumption

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CA2432037A1 (en) 2002-07-04
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