US6770036B2 - Apparatus for measuring activity of autonomic nerve - Google Patents

Apparatus for measuring activity of autonomic nerve Download PDF

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Publication number
US6770036B2
US6770036B2 US10/136,400 US13640002A US6770036B2 US 6770036 B2 US6770036 B2 US 6770036B2 US 13640002 A US13640002 A US 13640002A US 6770036 B2 US6770036 B2 US 6770036B2
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activity
nerve
unit
person
measuring
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US10/136,400
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US20020169365A1 (en
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Masato Nakada
Toshiaki Sasaki
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Tanita Corp
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Tanita Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A61B5/6826—Finger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02444—Details of sensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041—Evaluating nerves condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6838—Clamps or clips

Definitions

  • the present invention relates to an apparatus for measuring an activity of autonomic nerve that is capable of evaluating the relation between psychosomatic conditions of a person based on the activity of autonomic nerve consisting of sympathetic nerve and parasympathetic nerve.
  • an object of the present invention is to eliminate the problems in the prior art, as described above, and to provide an improved apparatus for measuring an activity of autonomic nerve that is capable of multi-dimensionally evaluating the psychosomatic conditions of a person.
  • the present invention provides an apparatus for measuring an activity of autonomic nerve, comprising: a sympathetic nerve activity measuring unit; a parasympathetic nerve activity measuring unit; a memory unit; and an evaluation unit, whereby said sympathetic nerve activity measuring unit measures an activity of the sympathetic nerve, said parasympathetic nerve activity measuring unit measures an activity of the parasympathetic nerve antagonistically functioning with the sympathetic nerve, said memory unit stores reference data acting as the criterion for comparing with relation between psychosomatic conditions based on the activity of the sympathetic nerve and the activity of the parasympathetic nerve, and said evaluation unit compares measurement data representing the activity of the sympathetic nerve measured by said sympathetic nerve activity measuring unit and the activity of the parasympathetic nerve measured by said parasympathetic nerve activity measuring unit with said reference data stored in said memory unit for evaluating the relation between psychosomatic conditions.
  • the activity of the sympathetic nerve is measured by the sympathetic nerve activity measuring unit, and the activity of the parasympathetic nerve is measured by the parasympathetic nerve activity measuring unit. Then, the measurement data representing the activities of the sympathetic nerve and parasympathetic nerve is compared in the evaluation unit with the reference data stored in the memory unit for evaluating the relation between psychosomatic conditions. In other words, evaluation of the relation between psychosomatic conditions allows the multi-dimensional seizing of the psychosomatic conditions.
  • the apparatus further comprises a display unit on which the relation between psychosomatic conditions evaluated by said evaluation unit is displayed. Displaying the relation between psychosomatic conditions on the display unit makes possible to visually recognize and clearly understand the psychosomatic conditions.
  • the display unit multi-dimensionally displays the relation between psychosomatic conditions evaluated by said evaluation unit. Displaying multi-dimensionally the relation between psychosomatic conditions on the display unit also makes possible to visually recognize and clearly understand the psychosomatic conditions.
  • the display unit divides the relation between psychosomatic conditions into sections around the center point where said measurement data is matched with the reference data. Therefore, the relation between the psychosomatic conditions is displayed in each of the directions around the center point.
  • the direction or tendency of the psychosomatic condition as to whether it is in exasperation or in inhibitory can be understood.
  • the display unit classifies the relation between psychosomatic conditions by color. This can facilitate identification and understanding of the relation between psychosomatic conditions.
  • FIG. 1 is a schematic perspective view illustrating an apparatus for measuring an activity of autonomic nerve according to one embodiment of the present invention
  • FIG. 2 is a block diagram showing a configuration of the apparatus in FIG. 1;
  • FIG. 3 is a flow chart for explaining an operation of the apparatus
  • FIG. 4 is a view showing an example of a display on a display unit of the apparatus.
  • FIG. 5 is a view showing an additional example of the display in which FIG. 5A shows a case where the date and time are displayed; FIG. 5B shows a case where the time and pulse rate are displayed; and FIG. 5C shows a case where an activity of sympathetic nerve and an activity of parasympathetic nerve are shown together with the pulse rare.
  • FIG. 1 is a schematic perspective view illustrating an apparatus for measuring an activity of autonomic nerve according to one embodiment of the present invention
  • FIG. 2 is a block diagram showing a configuration of such apparatus.
  • the apparatus of the present invention comprises a body portion 1 , a band 2 connected to the body portion 1 and a fingerstall-like detector 3 connected to the body portion 1 via a lead wire 4 .
  • the band 2 is wrapped around a wrist of a person to be measured for holding the body portion 1 of the apparatus.
  • the detector 3 includes a pulse wave sensor 5 known in the art.
  • the body portion 1 of the apparatus includes an amplifier circuit 6 for amplifying a pulse wave signal detected by the pulse wave sensor 5 ; an A/D converter circuit 7 for converting an analogue signal output from the amplifier circuit 6 into a digital signal; a sympathetic nerve activity calculation unit 8 for calculating an activity of sympathetic nerve based on the digital signal from the A/D converter circuit 7 ; and a parasympathetic nerve activity calculation unit 9 for calculating an activity of parasympathetic nerve based on the digital signal from the A/D converter circuit 7 .
  • the amplifier circuit 6 , the A/D converter circuit 7 and the parasympathetic nerve activity calculation unit 9 within the body portion 1 , together with the pulse wave sensor 5 in the detector 3 form a parasympathetic nerve activity measuring unit 11 for measuring the activity of parasympathetic nerve antagonistically functioning with the sympathetic nerve.
  • the body portion 1 of the apparatus further includes a memory unit 12 and an evaluation unit 13 .
  • the memory unit 12 stores reference data acting as the criterion for comparing with relation between psychosomatic conditions based on the activity of the sympathetic nerve and the activity of the parasympathetic nerve.
  • the evaluation unit 13 compares measurement data representing the activity of the sympathetic nerve measured by the sympathetic nerve activity measuring unit 10 and the activity of the parasympathetic nerve measured by the parasympathetic nerve activity measuring unit 11 with the reference data stored in the memory unit 12 for evaluating the relation between psychosomatic conditions.
  • the sympathetic nerve activity calculation unit 8 , the parasympathetic nerve activity calculation unit 9 and the evaluation unit 13 within the body unit 1 are implemented by a CPU 14 .
  • a display unit 15 for displaying the relation between psychosomatic conditions and the like evaluated by the evaluation unit 13 is mounted on the body portion 1 at the outer side thereof.
  • the band 2 of the apparatus for measuring the activity of autonomic nerve according to the present invention is wrapped around the wrist of a person to be measured for holding the body portion 1 of the apparatus thereon. Then the fingerstall-like detector 3 is mounted on an index finger of the person to be measured.
  • the pulse wave sensor 5 included in the detector 3 detects the pulse wave of the person to produce the detected pulse wave signal, which is then amplified by the amplifier circuit 6 .
  • the amplified pulse wave signal is then converted in the A/D converter circuit 7 into the digital signal (Step S 1 ).
  • any change in pulse rate is derived based on “R—R” interval of the A/D converted pulse wave signal.
  • a power spectral analysis is performed using first Fourier transformation and the like (Step S 2 ).
  • the peak value “[HF]me” in strength of the signal within the power spectral analyzed high frequency band is specified to determine the activity of parasympathetic nerve.
  • the peak value “[HF]me” in strength of the signal within the power spectral analyzed high frequency band and the peak value “[LF]me” in strength of the signal within the low frequency band are specified for calculation of “[LF/HF]me” to determine the activity of sympathetic nerve (Step S 3 ).
  • the activity of the parasympathetic nerve is represented by a peak value in strength of the signal within the high frequency band
  • the activity of the sympathetic nerve is represented by a peak value in strength of the signal within the low frequency band divided by a peak value in strength of the signal within the high frequency band.
  • Such values are adopted because they are considered to properly reflect the parasympathetic nerve and the sympathetic nerve, based on an examination of results of various studies that have been published.
  • another kind of values may be adopted if they properly reflect the parasympathetic nerve and the sympathetic nerve.
  • the evaluation unit 13 the measurement data representing the activity of the parasympathetic nerve and the activity of the sympathetic nerve derived in Step S 3 ([HF]me and [LF/HF]me) is compared with the reference data ([HF]st and [LF/HF]st) stored in the memory unit 12 , and the evaluation of the relation between psychosomatic conditions is performed according to the result of comparison in the following manner:
  • Step S 4 If the result of comparison is [HF]me ⁇ [HF]st and [LF/HF]me>[LF/HF]st then there is a tendency of increased tension of the person and the tendency of vivacity of the person is evaluated as to whether it is higher or lower, based on the magnitude of difference between the values compared. If the result of comparison is [HF]me>[HF]st and [LF/HF]me ⁇ [LF/HF]st then there is a tendency of decreased tension and the tendency of vivacity is evaluated in the same manner (Step S 4 ).
  • psychosomatic condition means “psyche (or mind)” or “soma (or body)” condition or both of them.
  • the reference data acting as the criterion used in step S 4 for comparing with the measurement data is selected among those data including the predetermined data that have been derived from the various kinds of data, the data of a person to be measured while he is ordinarily in rest, the normal data derived by averaging the past measurement data of a person to be measured, and the like.
  • the balance between the sympathetic nerve and the parasympathetic nerve commonly changes according to the circadian rhythm, which may cause any shift of a reference point or an intersection between the reference data of the activity of the sympathetic nerve and that of the activity of the parasympathetic nerve.
  • the balance between the sympathetic nerve and the parasympathetic nerve changes in curvilinear according to the circadian rhythm.
  • it is only necessary that the circadian rhythm for the balance between the sympathetic nerve and the parasympathetic nerve of the person is measured, thereby providing the reference data whose reference point is shifted on the balance curve that changes in curvilinear according to the circadian rhythm.
  • Such balance curve may be produced in several ways, based on the average of the data measured for longer time period, the expected values produced by sampling several points within a day, and the like.
  • FIG. 4 that illustrates one example of a screen 16 of the display unit 15
  • the “vivacity” is plotted on the horizontal axis and the “tension” is plotted on the vertical axis.
  • the both horizontal and vertical axes intersect at a position that is defined as the center point where the measurement data is matched with the reference data.
  • the result of evaluation produced by the evaluation unit 13 representing the relation between psychosomatic conditions is displayed on the screen 16 with continuous lighting or flashing (Step S 5 ).
  • the result of evaluation produced by the evaluation unit 13 representing the relation between psychosomatic conditions is displayed in such manner that the activity of sympathetic nerve derived by the sympathetic nerve activity calculation unit 8 is represented by a parallel line drawn from a sympathetic nerve activity virtual axis 17 (actually not appeared on the screen) to a parasympathetic nerve activity virtual axis 18 (actually not appeared on the screen), while the activity of parasympathetic nerve derived by the parasympathetic nerve activity calculation unit 9 is represented by a parallel line drawn from the parasympathetic nerve activity virtual axis 18 (actually not appeared on the screen) to the sympathetic nerve activity virtual axis 17 (actually not appeared on the screen), and an intersection of those parallel lines is defined as a point corresponding to the result of evaluation.
  • the result of evaluation may be lighted or flashed with different color depending on the result of relation between psychosomatic conditions.
  • each of sections provided by intersection of two axes may have different color.
  • the apparatus for measuring an activity of autonomic nerve is operated in such manner that the sympathetic nerve activity measuring unit 10 measures the activity of sympathetic nerve and the parasympathetic nerve activity measuring unit 11 measures the activity of parasympathetic nerve. Then the evaluation unit 13 compares such measurement data with the reference data stored in the memory 12 for evaluating the relation between the psychosomatic conditions. As the result, the psychosomatic conditions can multi-dimensionally be seized.
  • the axes representing the psychosomatic conditions intersect at a position that is defined as the center point where the measurement data is matched with the reference data, and the relation between the psychosomatic conditions at the time of measurement is displayed in each of the directions around the center point. Therefore, the direction or tendency of the psychosomatic condition as to whether it is in exasperation or in inhibitory can be understood.
  • the result of evaluation can readily be understood because it may be lighted or flashed with different color depending on the result of relation between the psychosomatic conditions or each of sections provided by intersection of two axes may have different color.
  • the pulse rate (HR) calculated from the signal in step S 1 may be added to the display of the sympathetic nerve activity (SNSA) and the parasympathetic nerve activity (PNSA) with or without the date and time information. Furthermore, what item is displayed may be switched using some switch unit.
  • the sympathetic nerve activity measuring unit 10 and the parasympathetic nerve activity measuring unit 11 are not limited to those that have been described in the embodiment of the present invention.
  • the activity of sympathetic nerve or parasympathetic nerve may be measured on the basis of the blood pressure, electrocardiogram, electroencephalogram and the like.
  • the present invention compares the measurement data with the reference data for evaluating the relation between psychosomatic conditions by the evaluation unit so that the psychosomatic conditions can multi-dimensionally be seized.
  • the result of evaluation given by the evaluation unit is displayed on the display unit by classifying the relation between psychosomatic conditions with different colors, or by dividing the relation between psychosomatic conditions into sections around the center point where the measurement data is matched with the reference data. Therefore, it is possible to visually recognize the direction or tendency of the psychosomatic condition as to whether it is in exasperation or in inhibitory, which can assist multi-dimensional seizing of the psychosomatic conditions.

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JP2001137572A JP2002330934A (ja) 2001-05-08 2001-05-08 自律神経活動測定装置

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US6885888B2 (en) * 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6540689B1 (en) * 2000-02-22 2003-04-01 Ntc Technology, Inc. Methods for accurately, substantially noninvasively determining pulmonary capillary blood flow, cardiac output, and mixed venous carbon dioxide content
US8412315B2 (en) * 2002-03-01 2013-04-02 Christine Ross Analysis of heart rate variability data in animals for health conditions assessment
US7738952B2 (en) * 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
KR100763233B1 (ko) 2003-08-11 2007-10-04 삼성전자주식회사 동잡음 제거된 혈류량 신호 검출 장치 및 방법, 그리고이를 이용한 스트레스 검사 장치
JP4527425B2 (ja) * 2004-03-19 2010-08-18 日本赤十字社 自律神経活動モニター装置、血液処理装置および採血装置
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JP2007044442A (ja) * 2005-08-12 2007-02-22 Nippon Sekijiyuujishiya 周波数解析装置および自律神経活動評価装置
JP4986826B2 (ja) * 2006-11-30 2012-07-25 財団法人 東京都医学総合研究所 精神状態測定方法および装置並びにプログラム
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
JP5167156B2 (ja) * 2009-01-19 2013-03-21 株式会社デンソー 生体状態評価装置、生体状態評価システム、プログラム、及び記録媒体
JP2013215334A (ja) * 2012-04-06 2013-10-24 Parama Tec:Kk 自律神経活動レベル表示装置
JP6035837B2 (ja) * 2012-04-18 2016-11-30 セイコーエプソン株式会社 画像生成装置、画像表示装置、画像生成方法、表示制御方法、画像生成プログラム及び表示制御プログラム
JP6463064B2 (ja) * 2014-10-07 2019-01-30 ファミリーイナダ株式会社 マッサージ機及び体調管理システム

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US5178235A (en) 1989-08-02 1993-01-12 The Montalvo Corporation Modular brakes and clutches
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040193063A1 (en) * 2003-02-28 2004-09-30 Teiyuu Kimura Method and apparatus for measuring biological condition
US7252639B2 (en) 2003-02-28 2007-08-07 Denso Corporation Method and apparatus for measuring biological condition

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US20020169365A1 (en) 2002-11-14
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