US3759374A - Cuvette - Google Patents

Cuvette Download PDF

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Publication number
US3759374A
US3759374A US00051048A US3759374DA US3759374A US 3759374 A US3759374 A US 3759374A US 00051048 A US00051048 A US 00051048A US 3759374D A US3759374D A US 3759374DA US 3759374 A US3759374 A US 3759374A
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US
United States
Prior art keywords
foil
cuvette
cuvettes
sealed
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00051048A
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English (en)
Inventor
R Helger
W Baumer
A Hartel
A Stein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
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Publication of US3759374A publication Critical patent/US3759374A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions

Definitions

  • the reagent solution required for a single determination can be supplied in individual small bottles which are made available to the analyst ready for use.
  • the reagent mixtures can be supplied in individual, single use small bottles or plastic capsules, either by introducing the solid substances directly, or by metering the solution into the individual containers and then freeze-drying the. solution therein In the last-mentioned form, such finished reagents have found wide application.
  • cuvettes which can serve both as a storage vessel for the reagent as well as a container for measuring the analysis sampleshSu ch cuvettes can be manufactured in good quality at very low prices from transparent and dimensionally stable material, especially plastics, so that it is economically feasible to use them only once.
  • one-time usage offers the advantage that the cleaning and the drying (or the intermediate rinsing) of the cuvette after each measuring step arefeliminated. For these reasons, disposable single-use plastic cuvettes are presently employed in most of the discontinuousautomatic analyzers.
  • the plastic cuvette In the manual technique, the plastic cuvette has not received widespread acceptance heretofore, especially those which are adapted to serve both as the storage container for the reagents for a single determination and for the optical measurement or the visual evaluation of the analytical sample. The reason apparently is v the lack of a simple closure device. Because of the measuring techniques employed, rectangular or square internal cross sections or basal surfaces arepreferred.
  • the aperture cross section must not be smaller than the internal cross section, so that the inner surfaces of the cuvette form a truncated pyramid with an inclination of the side wall of -5. Consequently, rectangular or square apertures are produced which are difficult to seal.
  • glue to the normal square opening of the cuvette ahead portion of plastic having device.
  • thesealing of filled cuvette s having a rectangular or square aperture is accomplished in a simple and inexpensive manner by bonding, e.g., gluing, welding or sealing a film or foil to the upper edges of the side walls defining the aperture.
  • FIG. 1 is a perspective invention
  • FIG. 2 is a side elevation of a plurality of cuvettes of this invention joined together by the sealing means;*and FIG. 3'is a perspective view of a plurality of cuvettes shown'in FIG. 2 joined by a common sealing means.
  • each of the four side walls 2 of cuvette 10 have a recessed portion 4 of reduced thickness extending to the upper edge of the side wall and forming a shoulder in the outer surface of the side wall.
  • the indented portions 4 and shoulders 5 of adjacent cuvettes and the portion of the film or foil 3a above form a cavity 6 which facilitates separating the cuvettes by cutting the film or foil with a knife, pencil or other sharp or pointed utensil. Cutting of the common web 3a can be facilitated by optional score or printed guidelines 7.
  • the upper surface of the film or foil 3a is printed with indicia identifying the contents of the cuvette.
  • the cuvettes of this invention can be formed of glass, quartz, or, preferably, plastic and are transparent, at least in the zone of the beam path, in the wavelength range to be measured, e.g., 200-800 nanometersor a partial range thereof.
  • Preferred materials are plastics which can be formed into cuvettes by injection molding, for example, polystyrene or polymethacrylates and, in particular, polymethacrylates formed from lower-alkyl methacrylates, e.g., polymethyl, ethyl, propyl, isopropyl, n-butyl or tert.-butyl methacrylate, or mixed polymeric esters of methacrylic acid with various, especially lower, alcohols.
  • Polymethyl methacrylate and polyethyl methacrylate are especially suitable, since they have good transmissibility in the ultraviolet range and thus permit measurements in the UV range without large loss of energy.
  • the novel cuvette can also be formed from cellulose esters, such as for example, cellulose or butyrate, or mixed esters of cellulose with various, especially lower, carboxylic acids, especially cellulose acetates/butyrates, for example, those sold under the tradename Acetobutyrat.
  • cellulose esters such as for example, cellulose or butyrate, or mixed esters of cellulose with various, especially lower, carboxylic acids, especially cellulose acetates/butyrates, for example, those sold under the tradename Acetobutyrat.
  • ionic carboxylgroup-containing ethylene copolymers which can optionally be cross-linked, for example, polymers of ethylene and other unsaturated monomers, e.g., acrylic acid derivatives, especially those polymers sold under the trademark Surlyn A.”
  • Polymeric carbonic acid esters of aromatic bisphenols e.g., those sold under the trademark Makrolon, can also be used.
  • the plan form of the cuvette i.e., its base cross section and aperture, is preferably square with an optical path length inner edge length of the plan form) of 10 mm.
  • the cuvette preferably has a height of 30-60 mm.
  • the outer walls of the cuvette are preferably plane-parallel. However, they can also beformed into other shapes suitable for optical measurement. For example, the outer surfaces of the side walls can form an angle with the vertical, for instance of the same order of magnitude as the inner surfaces thereof.
  • the wall thickness of the cuvette is preferably 0.3 10 mm., especially l 5 mm.
  • the dimensions of the square or rectangular aperture preferably corresponds to the entire inner cross section of the cuvette.
  • a metal or metal alloy foil preferably aluminum, or film (plastic or paper) can be employed.
  • the foil or film can be rigid, self-supporting or non-self-supporting and can be of a thickness of 5 1,000 n, preferably 20-50 lb.
  • Laminated foils and films (which term includes sheets of paper) can also be em- 4 ployed. If the film or foil is not self-bonding, it can be provided with a layer of adhesive on one face thereof, preferably adhesives of the hot glue type which, at
  • Suitable foils provided with a layer of hot glue are commercially available.
  • Especially tight bonds between aluminum foils and polymethacrylate cuvettes are obtained, for example, by applying the commercial adhesive V 274/6 (producer: Ardal-Klebstoffwerke, Mainz) to the foil, either in a molten condition or dissolved in a solvent.
  • V 274/6 producer: Ardal-Klebstoffwerke, Mainz
  • a uniform layer can be obtained by spreading the solution, applying it by a roller, or, best of all, by spraying. Thereafter, the solvent is allowed to evaporate, optionally at a higher temperature.
  • the opposite face of the foils can be subjected to a continuous printing process in accordance with the conventional methods, suitably in such a manner that, later on, each cuvette seal bears at least once the text describing the contents. It is also possible to apply the layer of adhesive to the upper edge of the sides of the cuvette which define the aperture, rather than to the foil, or to both.
  • the adhesive can be omitted.
  • the cuvette can be sealed by placing the surface of the film or foil coated with the adhesive layer in contact with the upper edges of the side walls 2 of the cuvette 10 and pressing it into place with a planar plate.
  • a hot glue is employed, the plate is heated to the temperature required to soften the glue, e.g., C.
  • a normal household iron can be used as the heated plate.
  • the sealing step is conducted analogously to the sealing of a single cuvette, viz., with a heatable metallic plate.
  • they are preferably disposed on a planar surface.
  • the cuvette is first provided with a temporary seal.
  • a temporary seal is of interest when the reagent in the cuvette is to be freeze-dried and must be sealed, for preservation reasons, under a nitrogen atmosphere in the lyophilizing chamber.
  • the film or foil can be attached to the plates disposed above the plates supporting the. cuvettes.
  • dry nitrogen is introduced into the chamber. Due to the sealing hydraulics, with the chamber closed, the foil is pressed so firmly against the cuvettes that a temporary seal is obtained.
  • the permanent or final seal is achieved with the aid of a heated metal plate in the manner described above after the chamber has been'opened.
  • the cuvette seals produced in this manner provide a very good seal. They can withstand an internal pressure of about 2 atmospheres gauge or more. Yet, later on, the'sealing foil or film can very easily be removed during use by tearing off the film or foil. Alternatively, it is also possible to simply penetrate the foil, to put the cuvette to use, using the tip of the measuring pippette used to introduce the liquid sample into the cuvette.
  • the cuvettes are expediently provided on the outer upper edge, with a recessed portion 4 which acts as a guide for a blade during the cutting process which separates the cuvettes joined by a common film or foil 3a.
  • the shoulder 5 advantageously has a width of about 0.2 1 mm. and the recessed portion 4 has a height of about 0.2 mm.
  • the width of this recessed portion-must be dimensioned so that the upper edges of the side walls 2 defining the aperture of the cuvette have a minimum thickness of about 0.2 mm, and preferably thickness of 0.8 1.2 mm. It is, of course, also possible to employ cuvettes having, in place of a recessed outer face, an outwardly beveled or an outwardly rounded upper edge to provide the cavity which guides the'cutting means.
  • Potassium phosphate monobasic; potassium phosphate, dibasic; DL-alanine; NADH,; and lactate dehydrogenase (for determining glutamatepyruvate transaminase); and t I c. Potassium phosphate, monobasic; potassium phosphate, dibasic; sodium-L-asparaginate; NADH,; and malate dehydrogenase (for the determination of glutamate-oxalacetate transaminase).
  • the novel cuvette can be provided with a partition separating the lower portion of the cuvette into two chambers.
  • the mutually incompatible auxiliary substances can be introduced in metered quantities into these chambers, e.g., in the form of solutions, with subsequent freeze-drying.
  • the reactants can be combined by shaking.
  • the cuvettes, or bundles of cuvettes are preferably packed into a metal container or in a metallic foil, op-. tionally in the form of packaged bundles, optionally with the addition of a drying agent.
  • a second, uncoated aluminum foil is placed thereover. Then, pressure and heat are applied to the upper face of the foil for about 15 seconds with a household iron adjusted to 150 C. (wool). Thereafter, the foil is cut in the channels formed by the indented portion (grooves) of the cuvettes with a nife.
  • EXAMPLE 2 One kg. of Ardal V274/6 contact cement is melted and mixed with ml. of chloroform. The solution is introduced into a foil spreading machine wherein the solution runs, without the use of rolls, directly onto the aluminum foil disposed underneath the storage tank.
  • the foil moves at a speed of cm./min. beneath the applicator blade, and is coated during this procedure with a thin film of adhesive. After passing a drying channel and cooling, the foil is again reeled up on a drum, suitably with the interposition of a separating paper (e.g., siliconized paper), to prevent the foil from sticking together.
  • a separating paper e.g., siliconized paper
  • the cuvettes are sealed as described in Examples 1(b) and 1(c).
  • a device having four temperature-controllable plates.
  • the uppermost plate serves as radiation protection, and the lower three plates serve as supporting plates.
  • the arrangement also contains a hydraulic unit with which the plates can later be pressed together.
  • the adhesive coated aluminum foil produced as described in Example 2, is attached to the undersides of the upper three plates so that the printed side is oriented upwardly and the side having the coating of hot glue is directed downwardly.
  • the three frames with the filled cuvettes are placed on the three lower plates, and a freeze-drying process is conducted in a conventional manner. After introducing a nitrogen atmosphere, but before opening the chamber, the plates and thus also the cuvettes positioned between the plates and the foil, are pressed one to the other with the aid of the hydrau-- lic unit for a short period of time. When the frames with the cuvettes are withdrawn from the chamber, the foil adheres to the cuvettes so tightly that the nitrogen cannot escape. Thereafter, a plate heated to 150 C.
  • the foil between the cuvettes is cut by guiding ablade along in the channels formed by the indented upper portion 4 of adjacent cuvettes. Not all of the cuvettes are separated from one another. Instead, the foil is cut so as to leave, e.g., 25 cuvettes together in a bundle. -After releasing the setscrews, the bundles of cuvettes, filled with reagent, sealed, and labeled, can be withdrawn from the frame and further packaged.
  • a single cuvette is separated from the bundle, simultaneously removing the foil closure.
  • Two ml. of water and 0.5 ml. of the serum to be examined are added thereto, the components are mixed, and the reduction of extinction (A E per minute) is measured at 366 nanometers (1 cm. layer thickness).
  • GOT concentration is calculated in accordance with the following-formula:
  • the solution contains 2 X 10 M of NADH in 0.02 M of bicarbonate buffer, pH 9.5.
  • the freeze-dried product is dissolved in a 6 X 10" M of pyruvate solution in 0.l M of phosphate buffer, pH 7.4, rather than in water.
  • EXAMPLE 4 A commercial hot melt film (silicon paper with a coating of hot glue) is pressed, with the aid of an iron, heated roll or other suitable heated device, for a few seconds onto printed paper at about C. After cooling, the silicon paper can be readily pulled from the printed paper, to which the hot glue adheres completely.
  • the printed paper, provided with a layer of this hot glue, is employed for sealing the cuvettes in accordance with Examples 1(b) and 1(0).
  • a sealed cuvette having a rectangular or square basal surface and side walls whose inner surfaces form a truncated pyramid having a side wall inclination of 0-5 and whose upper edges form a rectangular or square apparatusure corresponding in dimensions to the inner cross section of the cuvette and whose side walls have a recessed outer face at their upper end which forms a shoulder in said side walls extending to their upper edge, formed of a transparent and dimensionally stable plastic which is light-permeable in at least a portion of the wavelength range from 200-800 nanometers and adapted for string solids and liquids and for the optical measurement of analytical samples, said aperture being sealed by a foil or film bonded to said upper edge of said side walls.
  • a cuvette according toclaim 1 formed of polystyrene.
  • a cuvette according to claim 1 whose aperture is sealed with aluminum foil.
  • a cuvette according to claim 5 whose aperture is sealed with aluminum foil.
  • a plurality of cuvettes according to claim 1 whose film bears identifying indicia on its outer surface. side walls are in face-to-face contact and which are 9.
  • a cuvette according to claim 2 whose aperture is joined together by the film or foil sealing their aperture. sealed with aluminum foil.

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
US00051048A 1969-07-03 1970-06-30 Cuvette Expired - Lifetime US3759374A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691933689 DE1933689A1 (de) 1969-07-03 1969-07-03 Kuevette

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US3759374A true US3759374A (en) 1973-09-18

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US (1) US3759374A (en, 2012)
JP (1) JPS5015598B1 (en, 2012)
BE (1) BE752777A (en, 2012)
CH (1) CH512934A (en, 2012)
CS (1) CS164269B2 (en, 2012)
DE (1) DE1933689A1 (en, 2012)
FR (1) FR2050482B1 (en, 2012)
GB (1) GB1259059A (en, 2012)
IL (1) IL34427A (en, 2012)
NL (1) NL7006315A (en, 2012)
SE (1) SE377499B (en, 2012)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968876A (en) * 1975-03-19 1976-07-13 Brookfield Richard A Sealed container with a sterilized hypodermic needle within it and method for effecting the sealing thereof
DE2711853A1 (de) * 1977-03-18 1978-09-21 Eppendorf Geraetebau Netheler Gefaessverbund mit einer mehrzahl von kuevetten oder reaktionsgefaessen und haltevorrichtung fuer einen solchen verbund
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
US4198484A (en) * 1978-07-26 1980-04-15 Abbott Laboratories Cuvette ampule for use with automatic analyzer apparatus
USRE30391E (en) * 1976-02-23 1980-09-02 Abbott Laboratories Chemical analysis cuvette
US4249826A (en) * 1977-07-25 1981-02-10 Laboratoires Biotrol S.A. Method and device for analyzing and measuring out constituents of solid or liquid media
US4251159A (en) * 1979-01-15 1981-02-17 American Hospital Supply Corporation Disposable multi-chamber cuvette
US4472357A (en) * 1981-11-18 1984-09-18 Medical Laboratory Automation, Inc. Blood bank cuvette cassette and label therefor
US4751186A (en) * 1984-02-15 1988-06-14 Eppendorf Geratebau Netheler & Hinz Gmbh Process for performing sample analyses and rack for performing the process
USRE34133E (en) * 1976-07-23 1992-11-24 Dynatech Holdings, Ltd. Microtest plates
DE4217868A1 (de) * 1992-05-29 1993-12-02 Univ Schiller Jena Temperierbare Multiküvette
US5401465A (en) * 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
DE4405375A1 (de) * 1994-02-19 1995-08-24 Fritz Nerbe Nachfolger Juergen Mikrotiterplatte
US5514343A (en) * 1994-06-22 1996-05-07 Nunc, As Microtitration system
US5720924A (en) * 1993-04-23 1998-02-24 Boehringer Mannheim Gmbh Storage system for test elements
DE19736630A1 (de) * 1997-08-22 1999-03-11 Schott Glas Mikrotiterplatte
EP0843171A3 (en) * 1996-11-14 1999-06-23 Konelab Corporation Multicell cuvette package, method of loading multicell cuvettes into a measurement instrument and a dispensing device for loading cuvettes
US6333008B1 (en) * 1994-08-17 2001-12-25 Stratec Eletronik Gnbh Measuring system and method for performing luminometric series analyses as well as multiple cuvette for receiving liquid samples therefor
US20020009397A1 (en) * 2000-06-06 2002-01-24 Taisuke Hirono Cuvette stand and stand with cuvettes
EP1234614A1 (de) * 2001-02-27 2002-08-28 Pentapharm Gmbh Mit Stegen unterteiltes Messgefäss zur Aufnahme von Reagenzien, dessen Herstellung und Verwendung
US20040226984A1 (en) * 2003-05-13 2004-11-18 Smith Philip Russel James Tube for storing fluid
US20050019231A1 (en) * 2001-09-28 2005-01-27 Kahl Johan Valentin Flow chamber
US20050079622A1 (en) * 2003-10-14 2005-04-14 Davis Freeman Packaging of multiple fluid receptacles
EP1524036A3 (en) * 2003-10-14 2007-08-01 Ortho-Clinical Diagnostics, Inc. Packaging of multiple fluid receptacles
EP1550853A4 (en) * 2002-07-25 2007-11-07 Nippon Sheet Glass Co Ltd BIOCHEMICAL CONTAINER
US20110064543A1 (en) * 2008-05-28 2011-03-17 Thermo Fisher Scientific Oy Reaction vessel and method for the handling thereof
US20120292220A1 (en) * 2010-02-26 2012-11-22 Vesa Nuotio Handling package of cuvettes
USD766760S1 (en) * 2014-03-19 2016-09-20 Sony Corporation Container for measuring electrical characteristics
USD810959S1 (en) * 2015-09-29 2018-02-20 Bd Kiestra B.V. Cuvette tray
US20180224460A1 (en) * 2017-02-08 2018-08-09 Becton, Dickinson And Company Dried dye reagent devices and methods for making and using the same
USD839448S1 (en) 2015-09-29 2019-01-29 Bd Kiestra B.V. Cuvette
US11099121B2 (en) * 2019-02-05 2021-08-24 BacterioScan Inc. Cuvette device for determining antibacterial susceptibility
US11833005B2 (en) * 2019-07-22 2023-12-05 Ivoclar Vivadent Ag Container for producing a dental synthetic material composition
US11992844B2 (en) 2018-11-13 2024-05-28 Becton, Dickinson And Company Dried reagent strainers and methods for making and using the same

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
NL7706292A (nl) * 1976-06-09 1977-12-13 Electro Nucleonics Kommenreeks.
IT1115523B (it) * 1977-05-09 1986-02-03 Sclavo Inst Sieroterapeut Apparecchiatura adatta all'analisi di componenti di fluidi
DE3024835A1 (de) * 1980-07-01 1982-01-28 Bayer Ag, 5090 Leverkusen Reagenz fuer die haemoglobinbestimmung
FR2570189B1 (fr) * 1984-09-13 1986-09-26 Immunotech Sa Procede de dosage immunoenzymologique et moyens pour sa mise en oeuvre

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US2018005A (en) * 1933-11-17 1935-10-22 Owens Illinois Glass Co Sealing means for empty containers
US2138241A (en) * 1935-08-09 1938-11-29 Koch Herman Sealed package
US2258073A (en) * 1939-01-12 1941-10-07 Daniel S Stevens Disposable colorimeter cell
US2549574A (en) * 1948-07-08 1951-04-17 Archer Daniels Midland Co Apparatus for making fluorophotometric measurements
US2783908A (en) * 1953-02-13 1957-03-05 Glaxo Lab Ltd Closures for bottles, vials and the like
US2949710A (en) * 1958-09-16 1960-08-23 Airkem Inc Gel packaging method and resulting package
GB1004176A (en) * 1962-11-29 1965-09-08 Unilever Ltd Packaging containers
US3503493A (en) * 1968-01-08 1970-03-31 Hoffmann La Roche Medicament packaging device
US3579306A (en) * 1969-01-22 1971-05-18 Organon Diagnostic test device
US3673302A (en) * 1967-01-09 1972-06-27 Globe Union Inc Method for fabricating battery cases

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FR1151435A (fr) * 1956-06-14 1958-01-30 Bret Oil Bidon pour huile de graissage
FR1538610A (fr) * 1967-07-27 1968-09-06 Dispositif de gaufrage d'une bande complexe destinée à l'obturation de récipients de produits divers

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US2018005A (en) * 1933-11-17 1935-10-22 Owens Illinois Glass Co Sealing means for empty containers
US2138241A (en) * 1935-08-09 1938-11-29 Koch Herman Sealed package
US2258073A (en) * 1939-01-12 1941-10-07 Daniel S Stevens Disposable colorimeter cell
US2549574A (en) * 1948-07-08 1951-04-17 Archer Daniels Midland Co Apparatus for making fluorophotometric measurements
US2783908A (en) * 1953-02-13 1957-03-05 Glaxo Lab Ltd Closures for bottles, vials and the like
US2949710A (en) * 1958-09-16 1960-08-23 Airkem Inc Gel packaging method and resulting package
GB1004176A (en) * 1962-11-29 1965-09-08 Unilever Ltd Packaging containers
US3673302A (en) * 1967-01-09 1972-06-27 Globe Union Inc Method for fabricating battery cases
US3503493A (en) * 1968-01-08 1970-03-31 Hoffmann La Roche Medicament packaging device
US3579306A (en) * 1969-01-22 1971-05-18 Organon Diagnostic test device

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968876A (en) * 1975-03-19 1976-07-13 Brookfield Richard A Sealed container with a sterilized hypodermic needle within it and method for effecting the sealing thereof
USRE30391E (en) * 1976-02-23 1980-09-02 Abbott Laboratories Chemical analysis cuvette
USRE34133E (en) * 1976-07-23 1992-11-24 Dynatech Holdings, Ltd. Microtest plates
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
DE2711853A1 (de) * 1977-03-18 1978-09-21 Eppendorf Geraetebau Netheler Gefaessverbund mit einer mehrzahl von kuevetten oder reaktionsgefaessen und haltevorrichtung fuer einen solchen verbund
US4249826A (en) * 1977-07-25 1981-02-10 Laboratoires Biotrol S.A. Method and device for analyzing and measuring out constituents of solid or liquid media
US4198484A (en) * 1978-07-26 1980-04-15 Abbott Laboratories Cuvette ampule for use with automatic analyzer apparatus
US4251159A (en) * 1979-01-15 1981-02-17 American Hospital Supply Corporation Disposable multi-chamber cuvette
US4472357A (en) * 1981-11-18 1984-09-18 Medical Laboratory Automation, Inc. Blood bank cuvette cassette and label therefor
US4751186A (en) * 1984-02-15 1988-06-14 Eppendorf Geratebau Netheler & Hinz Gmbh Process for performing sample analyses and rack for performing the process
US5401465A (en) * 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
US5716583A (en) * 1992-05-05 1998-02-10 Smethers; Rick T. Luminometer with reduced sample crosstalk
DE4217868A1 (de) * 1992-05-29 1993-12-02 Univ Schiller Jena Temperierbare Multiküvette
US5720924A (en) * 1993-04-23 1998-02-24 Boehringer Mannheim Gmbh Storage system for test elements
US5863800A (en) * 1993-04-23 1999-01-26 Boehringer Mannheim Gmbh Storage system for test elements
DE4405375A1 (de) * 1994-02-19 1995-08-24 Fritz Nerbe Nachfolger Juergen Mikrotiterplatte
US5514343A (en) * 1994-06-22 1996-05-07 Nunc, As Microtitration system
US6333008B1 (en) * 1994-08-17 2001-12-25 Stratec Eletronik Gnbh Measuring system and method for performing luminometric series analyses as well as multiple cuvette for receiving liquid samples therefor
EP0843171A3 (en) * 1996-11-14 1999-06-23 Konelab Corporation Multicell cuvette package, method of loading multicell cuvettes into a measurement instrument and a dispensing device for loading cuvettes
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Also Published As

Publication number Publication date
CS164269B2 (en, 2012) 1975-11-07
GB1259059A (en, 2012) 1972-01-05
CH512934A (de) 1971-09-30
IL34427A0 (en) 1970-06-17
DE1933689A1 (de) 1971-01-21
FR2050482A1 (en, 2012) 1971-04-02
FR2050482B1 (en, 2012) 1975-01-10
IL34427A (en) 1973-10-25
JPS5015598B1 (en, 2012) 1975-06-06
SE377499B (en, 2012) 1975-07-07
NL7006315A (en, 2012) 1971-01-05
BE752777A (fr) 1970-12-30

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