US3718133A - Container unit for liquid samples - Google Patents

Container unit for liquid samples Download PDF

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Publication number
US3718133A
US3718133A US00105930A US3718133DA US3718133A US 3718133 A US3718133 A US 3718133A US 00105930 A US00105930 A US 00105930A US 3718133D A US3718133D A US 3718133DA US 3718133 A US3718133 A US 3718133A
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Prior art keywords
bulb
volume
bulb member
liquid
container
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Expired - Lifetime
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US00105930A
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English (en)
Inventor
W Perry
J Marten
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Damon Corp
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Damon Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150267—Modular design or construction, i.e. subunits are assembled separately before being joined together or the device comprises interchangeable or detachable modules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/15058—Joining techniques used for protective means
    • A61B5/150587—Joining techniques used for protective means by friction fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150763—Details with identification means
    • A61B5/150786—Optical identification systems, e.g. bar codes, colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150946—Means for varying, regulating, indicating or limiting the speed or time of blood collection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers

Definitions

  • This invention relates to a disposable container unit for liquid samples and is particularly useful for the collection of blood specimens. It includes an elongated compressible bulb member having an integral nozzle attached thereto. An elongated storage volume having a closed and an open end and a small cross sectional area is also provided, the open end being in communication with the bulb member. Preferably but not necessarily the longitudinal axis of the storage volume, the bulb and the nozzle are coaxial. If the container unit is held vertically upward, liquid in the bulb will not flow freely into the storage volume because of its small cross sectional area. Similarly, if the storage volume contains liquid and is turned upside down, the liquid will not flow from it into the bulb.
  • the container in which the blood is collected is not itself used to hold the blood sample for analysis. Rather, when analysis is to be done the blood is transferred to a receptacle used by the analysis machine and this blood is then analyzed. This transfer procedure presents opportunity for loss of sterility, spillage and possibly loss of patient identity because of clerical error.
  • Disposable sterile container units which can be used as the sample container in the analysis machine and are particularly useful in the collection of small blood samples have also been heretofore developed. Such containers are shown, for example in the following pending U.S. patent applications, assigned to the assignee of the present invention:
  • the containers described contemplated the dilution of the blood sample and possibly its dialysis in the container itself. It has been found that in some cases it is more desirable to ingest a precise measured volume of the sample into the analysis machine and thereafter to precisely dilute it. Separation of the blood serum, which is used in analysis, from the red blood cells may conveniently be accomplished by centrifugation rather than dialysis, thus simplifying container construction.
  • Another object of our invention is to provide a container unit of the type described in which the red blood cells and the blood serum may be separated in the field and then maintained in a separated condition during shipment to a central analysis location.
  • a further object of our invention is to provide a container unit of the type described which may be manufactured by either blow molding or injection molding techniques conventionally used for the manufacture of large quantities of plastic products in an inexpensive manner.
  • a still further object of our invention is to provide a container of the type described which is convenient for the user to handle and which also may be used by relatively unskilled personnel.
  • Yet a further object of our invention is to provide a container unit of the type described which is generally useful for the collection, storage and treatment of liquid samples.
  • Container units made in accordance with our invention include an elongated compressible bulb member at one end of which is formed a nozzle through which the liquid to be collected is ingested into the bulb.
  • the bore through the nozzle is preferably but not necessarily coaxial with the longitudinal axis of the bulb.
  • An elongated storage container is also attached to the bulb, preferably at the end of the bulb opposite to that of the nozzle.
  • the longitudinal axis of the storage volume is coaxial with that of the bulb.
  • the entire unit may be molded of a translucent or semi-transparent plastic such as low density polyethylene.
  • the cross sectional area of the storage volume i.e., its area measured in a plane normal to its longitudinal axis at the point of communication with the bulb, is sufficiently small so that the storage volume is not self-venting.
  • the liquid to be sampled. may be aspirated into the bulb member and the unit then held vertically upward i.e., with the open end of the storage volume upward and its longitudinal axis vertical. Because the storage volume is not self-venting, no liquid flows into it.
  • a marker on the portion of the bulb immediately adjacent the storage volume indicates that fraction of the volume of the bulb which is just sufficient to fill the storage volume. If sufficient liquid to fill the storage volume has not been ingested, more can be aspirated. If sufr'icient liquid is in the bulb, the technician merely shakes down the liquid into the storage volume in the same manner as one "shakes down a clinical thermometer.
  • the storage volume When the storage volume is filled, it may be inverted but the liquid therein will not flow outwardly because the volume is not vented. Any excess liquid in the bulb beyond that required to fill the bulb may be expressed from the nozzle.
  • the volume of the bulb is substantial as compared to the volume of the storage volume, usually being at least three times the storage volume.
  • FIG. I is a perspective view of the container unit of my invention.
  • FIG. 2 is a side plan view, partially in section, of a first embodiment of my invention
  • FIG. 3 is a cross-section taken on the line 3-3 of FIG. 2;
  • FIG. d is a partial side plan view, partially broken away, showing the manner in which the liquid sample is contained in the bulb before being shaken down" into the storage volume;
  • FIG. 5 is a view, similar to FIG. 4 showing; the appearance of the storage volume after the sample has been shaken down;
  • FIG. :6 is a side plan view, partially broken away, showing the manner in which liquid is retained in the storage volume when in the inverted position;
  • FIG. 7 is a view similar to FIG. 5 showing the appearance of the storage volume after a blood sample collected therein has been separated into serum and red blood cells;
  • FIG. 8 is a view similar to FIG. 2 of an alternative embodiment of my invention specifically designed for molding by injection molding techniques.
  • FIG. 9 is a sectional view taken along the lines 9-9 of FIG. 8.
  • the container unit of our invention includes a relatively large bulb member lb having a nozzle generally indicated at 12 integrally formed therewith.
  • the storage volume, generally indicated at 14 is shown also preferably formed by a wall member which is integral with that which forms the bulb.
  • a separable cap 16 is also provided for reasons to be explained below.
  • FIGS. 2 and 3 The embodiment of our invention illustrated in FIGS. 2 and 3 is particularly adapted and designed to be blow molded of low-density polyethylene or similar semi-transparent plastic material which is also at least somewhat resilient.
  • the drawings of FIGS. 2 and 3 are scale drawings at twice the size of an actual device made in accordance with our invention.
  • the bulb member as shown in FIGS. 1 and 2 is an elongated cylinder with hemispherical ends, the length including the ends being about six times the internal diameter.
  • the walls of the bulb are relatively thin so that they may readily be compressed by finger pressure to reduce the internal volume of the bulb.
  • the bulb walls were about 0.015 inch thick.
  • the nozzle 12 includes a cylindrical portion 12a, immediately adjacent the bulb and a tapering portion 1212.
  • a bore of substantially uniform size extends through 1 both portions of the nozzle into the bulb interior. 7
  • the cap 16 has an internal bore 16:: whose surface engages the outer surface of the cylindrical portion 12a of the nozzle with a sliding frictional fit so that the cap may be readily removed, yet will remain in place when attached to the unit.
  • the storage volume chamber is formed by an elongated hollow cylindrical member attached to the bulb member at the end of the bulb opposite the nozzle end. As shown, the end of the storage volume secured to the bulb is open and the end farthest from the bulb is closed. It will be observed that the cross-section of the storage volume is quite small as compared to the diameter of the bulb. In the illustrated embodiment the internal diameter was approximately 0.131 inches, giving a cross-sectional area of 0.0l35 square inches. The storage volume length was about 1.81 inches, the closed end being hemispherical in shape. This volume is sufficient to contain approximately 400 microliters of liquid. By way of contrast, in the illustrated embodiment, the total volume of the bulb is about 2,550 microliters.
  • a flag or card 18 is integrally molded with the side walls which define the storage volume 14. This card is thicker than the side walls of the bulb and storage container. As illustrated it extends from just below the bottom of the storage volume part way up the bulb. In the embodiment illustrated, if the bulb chamber 10 is filled with an amount of liquid such that,
  • the card serves to stiffen the side walls of the storage volume and the bottom of the bulb so that they are comparatively rigid as compared to the upper portion of the bulb. It will also be observed that the card extends to the right of the container unit, as seen in FIGS. 2 and 3, a greater distance than to the left. This makes the unit relatively easy to handle and also permits the unit to be readily positioned in a tray or other unit provided with a suitable slot.
  • a slit llSa is provided in the card about mid-way between the two ends of the storage volume. The purpose of this slit will be hereinafter described.
  • container units of my invention When container units of my invention are to be used for blood sample collection, they are sterilized in any convenient manner and a solution of conventional anticoagulant and anti-foaming materials in a volatile vehicle such as distilled water is placed in the bulb. The vehicle containing these materials is evaporated, leaving the walls of the bulb coated with crystals of anticoagulant and anti-foaming material.
  • a volatile vehicle such as distilled water
  • the container unit of our invention may be used as in FIGS. 4 through 7. If blood is to be collected for example, the skin is incised as previously described and blood is allowed to well to the surface. The cap is then removed from a sterile container unit and the middle and upper bulb portion is squeezed between the finger and thumb to reduce the bulb volume. With the bulb in this condition, the nozzle is placed in the blood droplet and the pressure removed from the bulb. As it returns to normal volume it sucks in blood. The unit is then held vertically. If the sample collected is sufficient to fill the bottom of the bulb to the top of the card 18 (or such other marker as is provided) collection may cease. If it is not, additional blood is collected until the required volume has been obtained. It will be noted that in this process, none of the collected blood goes into the storage volume. When a sufficient sample of blood has been collected, the bottom portion of the container unit will appear as in FIG. 4.
  • the blood is shaken down into the storage olume by holding the container unit by the bulb portion and snapping the wrist in the same manner as one shakes down the mercury column in a clinical thermometer prior to use.
  • the bottom portion of the container unit then appears as in FIG. 5.
  • the unit may be inverted and, as shown in FIG. 6, the excess blood will flow to the portion of the bulb immediately adjacent the nozzle, where it may be expressed to waste simply by squeezing the bulb. It will be noted however that the blood in the storage volume remains in place, even when inverted and does not flow into the bottom of the bulb 10.
  • a blood sample of known volume has thus been collected for analysis and the container may then be capped and sent to the analysis location.
  • the sample may be centrifuged to separate the serum from the red blood cells while in the container. After centrifugation the blood sample will appear as shown in FIG. 7 with the less dense serum portion in the upper portion of the storage volume as indicated by 19a and the denser red blood cells in the lower portion as indicated by 1%.
  • the storage container may be folded by folding the card 18 about the line 18b extending across the card from the slit 10a. Such folding collapses the side walls of the storage volume thus insuring a seal. between the red blood cells and the serum.
  • the two portions of the folded card may be clipped together by a suitable clip and this may be removed at the analysis machine and the card unfolded.
  • the upper portion of the bulb may be simply cut off immediately above the top of the card 18 and the container unit placed in a suitable sample tray.
  • the container unit of our invention has been designed particularly for use with the automatic analysis apparatus disclosed in the commonly assigned co-pending U.S. patent application of D. l. Kozowsky, A. Ferrari and C. R. Hurtig entitled Constituents Measuring Chemical Analyzer Having Multiple Concurrently Operated Aliquot Processing Conveyors, said application having Ser. No. 105,805 and having been filed on the same date as the present application.
  • Sampling apparatus particularly designed for use with the container units of our invention is disclosed in the commonly-assigned co-pending U.S. patent application of J. Bannister, M. Jordan and J. Peters entitled "Liquids Sampler With Probe Bathing Chamber, said application having Ser. No. 105,803 and having been filed on the same date as this application.
  • FIGS. 8 and 9 we have illustrated another embodiment of a container unit of our invention. As mentioned above, this design is particularly designed for manufacture by injection molding. FIGS. 8 and 9 are also scale drawings of an actual unit and are twice actual size.
  • the unit of FIGS. 8 and 9 is made in two parts and these are fitted together to form the complete unit.
  • the upper part generally indicated at 20 includes a nozzle portion 22, the upper portion of the bulb member 24, a cap 25 and an integral attaching strap 25a to permanently attach the cap 25 to the unit.
  • the lower part, generally indicated at 26 includes the lower portion of the bulb member 23, the storage volume 30 and the flag or card 32.
  • the storage volume 30 and the lower portion of the bulb 28 are formed with walls of substantially greater thickness (about 0.030 inches) than the walls of the upper part of the bulb on part 20.
  • the walls of the upper part of the bulb are about 0.015 inches thick in one embodiment and these are readily compressible when molded of low density polyethylene.
  • the storage volume is not a right cylinder but tapers. This taper facilitates the withdrawal of the injection molded part from the mold.
  • the mean diameter is substantially equal to the mean diameter of the blow-molded unit shown in FIGS. 2 and 3.
  • a cylindrical collar 34 for receiving the lower portion of the part 20 is formed on the upper portion of the part 26.
  • Several small hemispherical protruberances 36 are provided on the collar to facilitate the attachment of an identification device during processing if desired.
  • the inner diameter of the collar 36 and the outer diameter of the lower portion of the bulb 24 forming a portion of part 20 are selected to form a close interference fit so that the two parts, when assembled as shown are sealed against leakage.
  • the bulb member is provided with an integral shoulder 38 which engages the upper surface of the collar 36 to limit downward motion of the upper part when the two parts 20 and 26 are assembled.
  • FIGS. 8 and 9 will function in the same manner as that illustrated in FIGS. 2 and 3. It does have the advantage that the top need not be cut off when it is desired to use the lower portion of the bulb and the storage volume as a sample container. Rather the top portion 20 may be simply pulled out of engagement with the collar 34.
  • the storage volume of units made according to our invention is not self-venting as is a conventional water glass for example.
  • this largest diameter is of the order of 0.150 inches for water, blood etc. or the cross-sectional area is about 0.0177 square inches. If the diameter is larger than about this value, the storage volume may fill as the liquid is aspirated by the bulb and thus there will be no opportunity for determining when the desired volume has been obtained. Further there will be no assurance that the liquid, once in the storage volume will not flow out as the container unit is placed in various positions during shipment. If the storage volume is made smaller than about 0.040 inches in diameter, it is difficult to shake the liquid in the bulb into the storage volume.
  • the storage volume of our device might include a vent opening at its lower end which is normally closed by a valve.
  • this valve could be opened and the liquid would flow into the vented storage volume. Thereafter the valve could be closed to seal the vent and the liquid would not thereafter freely flow from the storage volume.
  • the plastic tubing forming the storage volume might be heat sealed or a valve located about mid-way between the ends of the storagevolu'me might be closed to achieve separation.
  • the storage volume of the container unit of this invention can be termed as being provided by a compartment. Further, it will now be apparent that this compartment provides a chamber that provides both a storage function and a measurement function.
  • a low-cost container in which a known small volume of liquid may be collected, treated (as by centrifuging) and stored and which will retain the liquid once stored therein despite container unit orientation.
  • the lower portion With the upper portion of the unit removed, the lower portion may serve as a sample cup in connection with machine analysis of the sample.
  • the sample once taken need never be removed from the sterile container in which it was collected. Because of the container units simple construction with resultant low cost, the entire unit may be disposed of once it has been used.
  • a container for the collection and storage of a liquid comprising in combination 1. a bulb member having collapsible and resiliently restoring walls so as to be pumpable, and normally resiliently maintaining a first storage volume therein and normally having a minimal internal cross-section larger than a first area,
  • a nozzle affixed to said bulb member and having a liquid passage communicating through the wall of said bulb member with the interior thereof, and
  • a measurement and storage compartment having a second volume therein smaller than said first volume and affixed to said bulb member, the interior of said compartment communicating with the interior of said bulb member through an aperture of lesser cross-section than said first area and being fluid-tight except for said aperture, said aperture being sufficiently small to block the gravitational flow of liquid between said bulb member and said compartment.
  • Container apparatus for the collection of liquid volume thereof from said bulb member for material and for the storage thereof, said apparatus passing said liquid material from said bulb comprising member into said compartment,
  • a collapsible and resiliently restoring pumpable C- fOrming With Sa d bu b me ber a normallyaspirating bulb member normally having a first closed vesselopen y at Said nolllefimi storage volume and having a nozzle for aspirating having the liquid-Passing cross-Section of Said said liquid material thereinto, and open end sufficiently small to preclude the free 2.
  • a measurement and storage compartment flow under at least gravitational force of liquid a. having a known second storage volume less than material between Said compartment and Said said first volume, bulb memberb. having an open end feeding into said storage

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US00105930A 1971-01-12 1971-01-12 Container unit for liquid samples Expired - Lifetime US3718133A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10593071A 1971-01-12 1971-01-12
US19194971A 1971-10-22 1971-10-22

Publications (1)

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US3718133A true US3718133A (en) 1973-02-27

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US00105930A Expired - Lifetime US3718133A (en) 1971-01-12 1971-01-12 Container unit for liquid samples
US00333003A Expired - Lifetime US3809068A (en) 1971-01-12 1973-02-16 Container unit for liquid sample

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US (2) US3718133A (pt)
AU (1) AU459419B2 (pt)
BE (1) BE777919A (pt)
BR (1) BR7200177D0 (pt)
CH (1) CH557027A (pt)
DE (2) DE2201141A1 (pt)
FR (1) FR2122187A5 (pt)
GB (1) GB1361941A (pt)
IT (1) IT948836B (pt)
NL (1) NL7200210A (pt)
ZA (1) ZA72194B (pt)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3902477A (en) * 1973-09-26 1975-09-02 Becton Dickinson Co Blood specimen container
US3910103A (en) * 1973-05-23 1975-10-07 Ewald Rose Medical apparatus for measuring blood sedimentation
US4250893A (en) * 1979-02-21 1981-02-17 American Hospital Supply Corporation Sample collection device
US4314570A (en) * 1977-11-18 1982-02-09 Sarstedt W Capillary receptacle
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US3910103A (en) * 1973-05-23 1975-10-07 Ewald Rose Medical apparatus for measuring blood sedimentation
US3902477A (en) * 1973-09-26 1975-09-02 Becton Dickinson Co Blood specimen container
US4314570A (en) * 1977-11-18 1982-02-09 Sarstedt W Capillary receptacle
US4250893A (en) * 1979-02-21 1981-02-17 American Hospital Supply Corporation Sample collection device
US4378333A (en) * 1980-12-11 1983-03-29 Laipply Thomas C Device for preparing blood smears on glass slides and method therefor
WO1983000281A1 (en) * 1981-07-27 1983-02-03 American Hospital Supply Corp Ventable sample collection device
US4411163A (en) * 1981-07-27 1983-10-25 American Hospital Supply Corporation Ventable sample collection device
US4610171A (en) * 1985-04-26 1986-09-09 Nason Frederic L Urinanalysis vial
US4779768A (en) * 1987-07-24 1988-10-25 St. Amand Manufacturing Co., Inc. Volumetric dispensing pipette
US5338689A (en) * 1987-08-24 1994-08-16 Stiftung Fur Diagnostische Forschung Method and card for detecting antigens and/or antibodies
US5460940A (en) * 1987-08-24 1995-10-24 Stiftung Fur Diagnostische Forschung Method for detecting antigens and/or antibodies
US6114179A (en) * 1987-08-24 2000-09-05 Stiftung Fur Diagnostische Forschung Method and test kit for detecting antigens and/or antibodies
US5030421A (en) * 1988-08-31 1991-07-09 Davstar Industries, Inc. Integral centrifuge tube and specimen slide
US7745205B2 (en) 1990-06-04 2010-06-29 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US20050064582A1 (en) * 1990-06-04 2005-03-24 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
EP1493826A1 (en) * 1996-06-04 2005-01-05 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US5804744A (en) * 1996-09-30 1998-09-08 Chemtrace Apparatus for obtaining, storing and transporting liquid samples and methods for making and using same
US7674221B2 (en) 2005-06-22 2010-03-09 Caridianbct, Inc. Apparatus for separating discrete volumes of a composite liquid with balancing elements
US7438679B2 (en) 2005-06-22 2008-10-21 Caridianbct Biotechnologies, Llc Apparatus and method for separating volumes of a composite liquid with a balancing assembly
US8070665B2 (en) 2005-06-22 2011-12-06 CaridianBCT, Inc Method for separating discrete volumes of a composite liquid
US20090317305A1 (en) * 2005-06-22 2009-12-24 Caridianbct, Inc. Bag Set for Separating Discrete Volumes of A Composite Liquid
US20080096749A1 (en) * 2005-06-22 2008-04-24 Navigant Biotechnologies, Llc Apparatus and Method for Separating Discrete Volumes of A Composite Liquid
US20080087613A1 (en) * 2005-06-22 2008-04-17 Gambro Bct, Inc. Apparatus and Method for Separating Discrete Volumes of A Composite Liquid
US7766809B2 (en) 2005-06-22 2010-08-03 Caridianbct, Inc. Apparatus for separating discrete volumes of a composite liquid
US20100273627A1 (en) * 2005-06-22 2010-10-28 Caridianbct, Inc. Method for Separating Discrete Volumes of A Composite Liquid
US20080096750A1 (en) * 2006-10-20 2008-04-24 Navigant Biotechnologies, Llc Methods for Washing a Red Blood Cell Component and for Removing Prions Therefrom
US8016736B2 (en) 2006-10-20 2011-09-13 Caridianbct Biotechnologies, Llc Methods for washing a red blood cell component and for removing prions therefrom
US20080312576A1 (en) * 2007-06-15 2008-12-18 Mckinnon Robert J Plunger-less syringe for controlling blood flow
WO2009097188A1 (en) * 2008-01-30 2009-08-06 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test cards having indicating indicia
US8058073B2 (en) 2008-01-30 2011-11-15 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test cards having indicating indicia
US20090191641A1 (en) * 2008-01-30 2009-07-30 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test cards having indicating indicia
US8211365B2 (en) 2008-01-30 2012-07-03 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test cards having indicating indicia
CN101980785B (zh) * 2008-01-30 2013-10-16 奥索临床诊断有限公司 具有指示标记的免疫诊断试验卡
CN101980785A (zh) * 2008-01-30 2011-02-23 奥索临床诊断有限公司 具有指示标记的免疫诊断试验卡
US20110003675A1 (en) * 2009-07-06 2011-01-06 Caridianbct, Inc. Apparatus and Method for Automatically Loading Washing Solution In A Multi-Unit Blood Processor
US10226567B2 (en) 2010-05-27 2019-03-12 Terumo Bct, Inc. Multi-unit blood processor with temperature sensing
US8840535B2 (en) 2010-05-27 2014-09-23 Terumo Bct, Inc. Multi-unit blood processor with temperature sensing
US9687598B2 (en) 2010-05-27 2017-06-27 Terumo Bct, Inc. Multi-unit blood processor with temperature sensing
US9028388B2 (en) 2010-06-07 2015-05-12 Terumo Bct, Inc. Multi-unit blood processor with volume prediction
US9849222B2 (en) 2010-06-07 2017-12-26 Terumo Bct, Inc. Multi-unit blood processor with volume prediction
US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
WO2017091540A1 (en) * 2015-11-25 2017-06-01 Corning Incorporated Unitary serological pipette and methods of producing the same
US11065612B2 (en) 2015-11-25 2021-07-20 Corning Incorporated Unitary serological pipette and methods of producing the same
US20180161018A1 (en) * 2016-12-12 2018-06-14 Neoteryx, Llc Fluid sampling device
US11607203B2 (en) * 2016-12-12 2023-03-21 Neoteryx, Llc Fluid sampling device
US11400634B2 (en) 2017-05-25 2022-08-02 Corning Incorporated Methods of forming unitary serological pipettes

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BR7200177D0 (pt) 1973-05-17
DE2349484A1 (de) 1974-08-22
US3809068A (en) 1974-05-07
DE2201141A1 (de) 1972-08-10
ZA72194B (en) 1972-09-27
AU459419B2 (en) 1975-03-27
CH557027A (de) 1974-12-13
IT948836B (it) 1973-06-11
AU3784872A (en) 1973-07-19
NL7200210A (pt) 1972-07-14
BE777919A (fr) 1972-07-11
FR2122187A5 (pt) 1972-08-25
GB1361941A (en) 1974-07-30

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