US3713775A - Centrifuge clinical chemistry analysis system - Google Patents
Centrifuge clinical chemistry analysis system Download PDFInfo
- Publication number
- US3713775A US3713775A US00048386A US3713775DA US3713775A US 3713775 A US3713775 A US 3713775A US 00048386 A US00048386 A US 00048386A US 3713775D A US3713775D A US 3713775DA US 3713775 A US3713775 A US 3713775A
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- United States
- Prior art keywords
- cap
- container
- housing
- tip
- chassis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/54—Labware with identification means
- B01L3/545—Labware with identification means for laboratory containers
- B01L3/5453—Labware with identification means for laboratory containers for test tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
- B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
- B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
- B04B9/10—Control of the drive; Speed regulating
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/07—Centrifugal type cuvettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B7/00—Elements of centrifuges
- B04B7/02—Casings; Lids
- B04B2007/025—Lids for laboratory centrifuge rotors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/90—Collapsible wall structure
Definitions
- ABSTRACT Medical testing apparatus including a centrifuge with a series of cuvettes received therein.
- the cuvettes may be discrete units or arranged in groups which make up cassettes.
- Each of the cuvettes has a test chamber or reaction chamber into which reagents and specimen pass during the centrifuging operation.
- the reagents are contained prior to centrifuging in plastic bags which include intentionally weak seams designed to fail during centrifuging and to permit the reagents to flow into the reaction chamber.
- the specimen is contained within a pipette tip closed by a cap.
- the cap is also designed to fail or, in other words, be centrifuged off of the pipette tip in order to permit the blood serum or plasma in the pipette tip to flow past the cap and into the reaction chamber after the red blood cells have been packed down into the cap by thecentrifuging operation.
- the cuvettes can be removed from the centrifuge and placed into a photometer to determine the amount of light passed or the amount of light passed can be determined directly while the cuvettes are being spun or turned in the centrifuge by a photometer.
- One embodiment of this invention might include medical test apparatus comprising a housing having a test chamber within which a test reaction is carried out, means for centrifuging said housing, a reagent container received within said housing and carried by said housing in spaced relation to said test chamber, said reagent container having a closure of predetermined strength sufficiently weak to fail and open under the action of said centrifuging means to permit flow of reagent from said container into said test chamber.
- the embodiment may also include a pipette tip and a cap on said pipette tip. The centrifuging means is operated to cause the red blood cells to be spun down into the cap. The speed of the centrifuge is then increased causing procedures for facilitating the running of medical tests.
- the cap to fly off the pipette tip and the serum in the tip to pass into the test chamber.
- This invention also relates to a complete system for simultaneously and automatically processing a plurality of photometric chemical tests.
- Each unit test cell or cuvette is self contained with pre-packaged reagents.
- the general object of this invention is to overcome a major deficiency in the prior art by providing a means of processing whole blood directly, as an integral part of the test cycle.
- An advantage is that this invention-also provides a means of adapting most of the presently developed photometric clinical chemistry procedures which are designed for use with preprocessed serum or blood plasma, to whole blood procedures by a mechanical technique. This greatly reduces time required for testing, allows the use of extremely small amounts of blood (in the 25 micro-liter range) and significantly reduces the level of operator skill required.
- a second area of major improvement over the prior art is the pre-packaging of all reagents in separate cells of the reaction cuvette assembly. All of the critical dispensing of reagents is carried out in the production facility eliminating the need for the complex reagent dispensing and handling system presently built into automatic clinical analyzer systems in common use today. Because of this the cost and maintenance requirements of the instruments can be reduced and the ability to maintain accuracy improved.
- Objects of the invention are to provide an improved test system and apparatus; to provide medical test apparatus which does not require a highly trained operator; to provide medical test apparatus capable of preprocessing whole blood directly as an integral part of the test procedure; to provide medical test apparatus which simplifies maintenance in the field because no bulk reagents are dispensed; and to provide medical test apparatus making possible use of a form of doublebeam spectrophotometry technique to cut down error because of change in light source intensity.
- FIG. 1 is a perspective view of a cassette carrier
- FIG. 2 is a perspective view of a pipette and a sample tube
- FIG. 3 is a perspective view of the pipette and a cassette
- FIG. 4 is a perspective view of a centrifuge
- FIG. 5 is a longitudinal sectional view of an assembly including a curvette, a chassis, a pipette tip, a reagent containing bag, and a cap;
- FIG. 5A is a perspective fragmentary view of the structure of FIG. 5 but showing the cap thereof in a different operating position;
- FIG. 6 is a fragmentary perspective view of the cuvette, the cassette carrier, and a photocell arrangement
- FIG. 7 is an enlarged (as compared to FIG. 5) elevation of the chassis
- FIG. 8 is an end elevation of the structure illustrated in FIG. 7;
- FIG. 9 is a section taken along the line 9-9 of FIG.
- FIG. 10 is an enlarged top plan view of the cuvette
- FIG. 13 is, an enlarged side elevation of the pipette P
- FIG. 14 is an enlarged plan view of the reagent containing bag.
- FIG. 15 is a side elevation of the structure illustrated in FIG. 14.
- a sample tube 30 containing whole blood is illustrated and carries information on the label 31 concerning the contents and may be sealed or closed by a cap (not shown).
- a cassette 35 is illustrated which includes four cuvettes 36 connected together by plastic material 37. The top openings 38 in the cuvettes are sealed by a tear strip seal (not shown). Also the cassette is provided with a data card 33 carry ing information concerning the contents of the cassette.
- the plastic material 37 is bendable in the manner illustrated in FIG. 1 to permit the cassette 35 with its cuvettes 36 to be mounted or received within a cassette carrier 40 illustrated in FIG. 1.
- the cassette carrier 40 is shown in FIG.
- the flat bottom 42 of the carrier includes a central circular opening 47 with a keyway 50 therein which permits locking of the eassette carrier in place in a centrifuge for rotation of the carrier and centrifuging of the contents thereof.
- FIG. 2 there is shown a pipette 51 which includes a pipette pump 52 and a pipette tip or container 55.
- the pipette is disclosed in the co-pending application for U. S. Letters Pat, Ser. No. 864,280, of I-Iinchman, Sommerville and Schmitz, assigned to the same assignee as the present invention. It is sufficient for present purposes to state that the pipette pump 52 functions to always draw in and dispense an equal volume of blood or other substance by suitable operation of the plunger 54.
- FIG. 13 shows in detail the construction of the pipette tip 55 as including a hollow interior 56 which has a tapered portion 57 facilitating attachment of the pipette tip 55 to the pipette pump. As shown in FIG.
- the pipette pump 52 has an O-ring 60 mounted thereon which assists in effectively connecting the pipette tip 55 to the pump 52 in a leak proof manner.
- the O-ring seats in the cylindrical portion 58.
- the hollow interior 56 of the tip includes tapering portion 56' which tapers gradually from its larger end adjacent the cylindrical portion 58 down to the other smaller end 59 of the pipette tip 55.
- the pipette 51 is inserted into the cap 62 for attaching the cap to the reduced diameter cylindrical portion 63 and abutting the shoulder 61 of the pipette tip.
- the cap 62 is cylindrical and has a closed end 64' in addition to the open end 64.
- a cuvette 36 is illustrated in more detail as including a generally cylindrical portion 100 and a flat portion 101.
- the cylindrical portion 100 has a generally cylindrical hollow interior 102 into which the chassis 105 of FIGS. 7, 8 and 9 is projected in operation of the present apparatus as described in more detail below.
- the flattened portion 101 of the cuvette has formed therein a test or reaction chamber and a reference chamber 106 which are separated by a partition 107.
- the chassis has a hollowed-out interior 110 formed with a shoulder or tapered portion 111 which functions to prevent further movement rightwardly as viewed in FIGS. 7 and 9 of the cap 62.
- the cap 62 is so sized as to be easily slidable in the hollow interior 110 without being loosely received whereby the cap will always have its closed end 64' projected toward the flattened end of the cuvette as shown in FIGS. 5A and 5.
- the hollow interior 110 is also formed with inwardly opening grooves 112 which permit blood (serum) or plasma to run past the cap rightwardly out of the open end 115 of the hollow interior 110.
- the chassis 105 also includes outwardly projecting ribs 116 which function to engage and hold the flexible plastic container of FIG. 23 between the chassis and the cuvette. It will be noted that the grooves l12 lead into grooves 114 which open into the tapered portion 111.
- the test procedure of the present invention is illustrated as including the placing of the pipette tip 55 in the blood contained within the container 30 for the obtaining of a sample of blood.
- This blood sample is precisely measured by operation of the pipette 51.
- the pipette is so operated as to withdraw the blood contained within the pipette tip slightly away from the tip and then the end of the pipette tip is wiped off.
- the end of the pipette is then inserted in a cap 62 in such a manner that the shoulder 61 abuts the cap.
- the pipette tip 55 with its cap 62 thereon is then inserted into the cuvette 36 of the cassette in the manner shown in FIGS. 3 and 5A.
- FIGS. 5 and 5A show in addition a reference component bag or container 200 and a reagent bag or container 201. As shown in FIG.
- the reagent bags 201 and the reference component bag 200 are joined together as a part of the four bag group 202. These four bags are folded or cupped around the exterior of the chassis 105 so that the dividing areas 205 between the bags of the group contact the projections 116 illustrated in FIGS. 7, 8 and 9.
- the group 202 of bags is so constructed that one edge 206, 207, 208 and 209 of the group of bags 202 is weaker than all the other edges thereof so that under centrifugal action the edges 206, 207, 208 and 209 fail, permitting dispensing of the contents of the bag by centrifugal force into the reaction chamber and the reference chamber.
- the bags 201 and 200 are so located that all of the bags 201 empty into the reaction chamber and only the bags 200 empty into the reference chamber.
- the weakness of the edges 206, 207, 208 and 209 is also designed so as to fail at a certain speed of the centrifuge, in other words, upon a certain number of gs being exerted on an edge. If desired, the edges can be designed to fail at different weaknesses. In this manner, the various reagents or contents of the bags can be discharged in order so as to cause the test reaction to be in accordance with predetermined standard test procedures.
- the cassette with its four cuvettes and four pipette tips is then loaded into the centrifuge 300 as shown in FIG. 4 after the top 301 has been placed on the cassette carrier 40.
- the cassette carrier has apertures 302 in its base 42 as well as apertures 305 in its top.
- the apertures 302 and 305 are each aligned with a respective one of the flattened portions 101 of the cuvettes.
- the centrifuge 300 is capable of various speeds of rotation up to 10,000 rpm as desired by the operator.
- a lamp 306, photocell 307 and light shield 310 with slit 311 are built into and are a part of the centrifuge.
- Another embodiment of the invention might include a standard colorimeter separate from the centrifuge and usable only after the centrifuging operation has been carried out. In such an embodiment the centrifuge would not incorporate a colorimeter or photocell.
- the reference chamber 106 provides the advantage of double beam spectrophotometry by making possible with a single beam a comparison of the absorbancy of a reference solution and-a sample. This comparison is made over a time interval which is short relative to the rate of change in intensity oflight source thus providing the advantage of double beam spectrophotometry.
- the operator controls or may control the time at which various events occur.
- the first step in the process is the spinning down of the blood which may occur for example at l,800 rpm because of the small quantity of blood being spun down.
- the operator speeds up the centrifuge to the speed at which the cap 62 comes off of the centrifuge tip for example at 3,000 rpm. Further speeding up of the centrifuge to 8,000 rpm causes the first of the bags 200 and 201 to fail and all bags 200 and 201 have failed at 10,000 rpm.
- Various other bag failure speeds can be selected in order to accomplish the test procedure and timing desired.
- the centrifuge might be programmed to automatically reach the various speeds desired at various times desired so as to make the procedure entirely automatic.
- FIG. 5 shows the cuvette just after the speed has been reached at which the cap is forced off of the pipette tip. Also shown is the discharging of the reagent bags into the reaction chamber 105 and the reference chamber 106. As illustrated, the cap 62 moves leftwardly against the tapered surface 11]. Prior to the leftward (as illustrated) movement of the cap in the hollow interior of the chassis, the red blood cells 400 in the blood have substantially all moved into the cap 62 so that serum fills the rest of the cap and also extends into the pipette tip. When the cap comes off the pipette tip and moves the relatively short distance from the tip to the tapered surface 111, the hollow interior 110 (which is basically cylindrical where the cap is) guides the cap preventing any of its contents from spilling. The substantial g forces acting on the cap and its contents level off the top (or rightward as illustrated) surface of the liquid in the cap so that the total contents of the cap are precisely determined. Also the cap moves only a very short distance so that splashing does not occur.
- the cap might have a capacity of, for example, 0.0125 ml while the change of blood in the pipette tip and cap is, for example, 0.025 ml.
- the red blood cells occupy perhaps 0.0833 of volume at the bottom (or leftward end as illustrated) of the cap.
- serum occupies the remainder of the contents of the cap as well as extends up into the pipette tip. Therefore, the liquid which flows into the reaction chamber is serum from the tip.
- This serum moves out of the pipette tip and through the grooves 112 and 114 and through the open end 115 when the cap comes away from the tip.
- the serum that flows in this manner intothe reaction chamber is a precise .0125 ml of liquid because of the centrifugal force action.
- the photometer optics might be built into the centrifuge in such a manner that, after the reactions are completed, the centrifuge head is stopped and then rotated by hand so as to successively position each cuvette into the light beam for a reading.
- the blood specimen might be diluted prior to placing the specimen in the pipette tip so as to make possible use of existing test procedures instead of requiring the setting up of new test procedures.
- the quantities are scaled down in order to keep the balance and therefore the same chemistries can be used.
- Test apparatus comprising a pipette tip, a cap on said pipette tip, means for housing said pipette tip and cap, means for centrifuging said pipette tip and cap and housing means at a first speed until blood contained in said tip and cap is spun down into its red cell fraction and its serum or plasma fraction and for thenincreasing the speed of said centrifuging to a second speed sufficiently fast to cause said cap to fly off of said tip and at least a portion of said serum or plasma fraction to move past said cap, said cap gripping said pipette tip with sufficient force to remain thereon at said first speed but with insufficient force to remain thereon at said second speed.
- Test apparatus comprising a housing having a test chamber within which a test reaction is carried out, means for centrifuging said housing, a reagent container received within and carried by said housing, said reagent container having a closure of pretermined strength sufficiently weak to fail and open under the action of said centrifuging means to permit flow of reagent from said reagent container into said test chamber.
- Test apparatus as defined in claim 2 additionally comprising a chassis projecting into said housing and holding said reagent container against said housing, a pipette tip mounted-on said chassis and extending into said chassis, a cap on said pipette tip, said chassis having a hollow interior therein whithin which said cap is received and is movable from an on the tip position to an off the tip position, said means for centrifuging being operable at a first speed at which blood contained in said tip and cap is spun down into its red cell fraction and its serum or plasma fraction and at a second speed at which said cap comes off said tip and moves in said chassis to said off-the-tip position, said chassis having an open end into which said hollow interior opens and which leads into said test chamber, said chassis having grooves opening into said hollow interior and permitting flow of serum or plasma past said cap through said open end into said test chamber.
- test apparatus of claim 3 wherein said housing is a cuvette having a reference chamber alongside said test chamber, photocell means and light source means, said means for centrifuging being operable to rotate said cuvette repeatedly between said photocell means and said light source means in such a manner that said reference chamber and said test chamber are exposed in order.
- said reagent container is a flexible bag having a plurality of compartments therein, said bag having some of said compartments positioned to discharge into said test chamber and another of said compartments positioned to discharge into said reference chamber.
- Test apparatus comprising a housing having a test chamber adapted to receive a specimen and reagents, said housing being adapted to be received in a centrifuge for centrifuge action thereon, a chassis member received in said housing, a pipette tip received in said chassis member, a cap on said pipette tip, reagent bags held between said housing and chassis, said cap being sufficiently securely attached to said tip to hold onto said tip while a blood specimen in said cap and tip is spun down into red blood cells and serum or plasma, said cap being sufficiently loosely attached to allow said cap to come off said tip'under increased centrifuge action, said chassis member having a hollow interior therein within which said cap is movable from an on the tip position to an off the tip position, said chassis member having grooves opening into said hollow interior permitting flow of serum or plasma past said cap into said test chamber.
- Test apparatus comprising a cuvette having a test chamber withinwhich a test reaction is carried out, said cuvette also having a reference chamber positioned alongside said test chamber, means for centrifuging said cuvette, photocell means and light source means, said centrifuging means being arranged to rotate said cuvette repeatedly between said photocell means and said light source means in such a manner that said reference chamber and said test chamber are exposed in order.
- Test apparatus comprising a pipette tip, a cap on said pipette tip, means for housing said pipette tip and cap, means for centrifuging said pipette tip and cap and housing means until blood contained in said tip and cap is spun down into its red cell fraction and its serum or plasma fraction and for then increasing the speed of said centrifuging sufficiently to cause said cap to fly off of said tip and at least a portion of said serum or plasma fraction to move past said cap, said housing means including a chassis, said pipette tip being mounted on said chassis so as to extend into said chassis with said cap on the portion of said tip which projects into said chassis, said chassis having a hollow interior therein within which said cap is received and is movable from an on the tip position to an off the tip position, said chassis interior being formed with a shoulder which provides the limit of movement of said cap when said cap moves into said off the tip position, said shoulder being closely spaced to said tip to prevent splashing of blood during said cap movement, said chassis havinggrooves opening into said hollow interior and permitting flow of
- Test apparatus comprising a container, a cap on said container, means for housing said container and cap, means for centrifuging said container and cap and housing means at a first speed until a specimen contained in said container and cap is spun down into a first fraction and a second fraction and for then increasing the speed of said centrifuging to a second speed sufficiently fast to cause said cap to fly off said container and at least a portion of said second fraction to move past said cap, said cap gripping said container with sufficient force to remain thereon at said first speed but with insufficient force to remain thereon at said second speed.
- Test apparatus comprising a housing having a test chamber adapted to receive a specimen and reagents, said housing being adapted to be received in. a centrifuge for centrifuge action thereon, a chassis member received in said housing, a container in said chassis member, a cap on said container, reagent bags held between said housing and chassis, said cap being sufficiently securely attached to said container to hold onto said container while a specimen in said container and cap is centrifuged at a first speed and spun down into a first fraction and a second fraction, said cap being sufficiently loosely attached to allow said cap to come off said container under increased centrifuge action, said chassis member having a hollow interior therein within which said cap is movable from an on the container position to an off the container position, said chassis member having grooves opening into said hollow interior permitting flow of a portion of said specimen past said cap into said test chamber.
- test apparatus of claim 10 wherein said reagent bags have a closure of predetermined strength sufficiently strong to remain closed at said first speed but sufficiently weak to fail and open under said increased centrifuge action to permit flow of reagent from said reagent bags into said test chamber.
- Test apparatus for spinning down blood into a first red cell fraction and a second serum or plasma fraction and for moving at least a portion of said second fraction away from said first fraction which comprises a container, a cap on said container, a housing for said container and cap, said container being mounted on of and away from said container when said means for centrifuging increases speed to said second speed.
- test apparatus of claim 13 wherein said housing has a test chamber, said test apparatus further including means for retaining said cap and container between said axis and said test chamber when said means for centrifuging centrifuges said housing and container.
- Test apparatus comprising a housing having a test chamber adapted to receive a specimen and reagents, said housing being adapted to be received in a centrifuge for centrifuge action thereon, a chassis member received in said housing, a container in said chassis member, a cap on said container, said cap being sufficiently securely attached to said container to hold onto said container while a specimen in said container and cap is spun down into a first portion and a second fraction, said cap being sufficiently loosely attached to allow said cap to come off said container under increased centrifuge action, said chassis member having a hollow interior therein within which said cap is movable from an on-the-container position to an off-thecontainer position, said chassis member having a passage opening into said hollow interior permitting flow of a portion of said specimen past said cap into said test chamber.
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- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US854281A US3050239A (en) | 1959-11-20 | 1959-11-20 | Centrifuge apparatus |
DEC34478A DE1256921B (en) | 1959-11-20 | 1964-11-25 | Process for density gradient centrifugation in an ultracentrifuge and centrifuge for carrying out the process |
US52577166A | 1966-02-07 | 1966-02-07 | |
US4838670A | 1970-06-22 | 1970-06-22 | |
GB1828471*[A GB1357231A (en) | 1959-11-20 | 1971-06-22 | Test apparatus for use in testing a liquid |
AU47751/72A AU468478B2 (en) | 1959-11-20 | 1972-10-13 | Centrifuge clinical chemistry analysis system |
Publications (1)
Publication Number | Publication Date |
---|---|
US3713775A true US3713775A (en) | 1973-01-30 |
Family
ID=27542729
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US854281A Expired - Lifetime US3050239A (en) | 1957-12-30 | 1959-11-20 | Centrifuge apparatus |
US509361A Expired - Lifetime US3402883A (en) | 1959-11-20 | 1965-11-23 | Method for operating an ultracentrifuge and a suitable centrifuge for said method |
US525771A Expired - Lifetime US3481712A (en) | 1959-11-20 | 1966-02-07 | Sediment container and cap and analysis technique |
US00048386A Expired - Lifetime US3713775A (en) | 1959-11-20 | 1970-06-22 | Centrifuge clinical chemistry analysis system |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US854281A Expired - Lifetime US3050239A (en) | 1957-12-30 | 1959-11-20 | Centrifuge apparatus |
US509361A Expired - Lifetime US3402883A (en) | 1959-11-20 | 1965-11-23 | Method for operating an ultracentrifuge and a suitable centrifuge for said method |
US525771A Expired - Lifetime US3481712A (en) | 1959-11-20 | 1966-02-07 | Sediment container and cap and analysis technique |
Country Status (7)
Country | Link |
---|---|
US (4) | US3050239A (en) |
AU (1) | AU468478B2 (en) |
CA (1) | CA940428A (en) |
DE (3) | DE1256921B (en) |
FR (1) | FR2096403B1 (en) |
GB (5) | GB889082A (en) |
NL (2) | NL109202C (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3814522A (en) * | 1973-02-28 | 1974-06-04 | American Hospital Supply Corp | Specimen tube for microscopic examination |
US3819271A (en) * | 1971-11-15 | 1974-06-25 | Max Planck Gesellschaft | Method and apparatus for measuring agglutination of cells in a carrier liquid |
US3858795A (en) * | 1973-02-08 | 1975-01-07 | Int Equipment Co | Method for washing blood cells |
US3905772A (en) * | 1965-05-17 | 1975-09-16 | Medical Laboratory Automation | Apparatus for performing blood typing tests |
US3999868A (en) * | 1974-11-29 | 1976-12-28 | Manuel Sanz | Unit for use in optical analysis |
US3999862A (en) * | 1974-11-29 | 1976-12-28 | Georges Revillet | Apparatus for optically analyzing a solution |
US4105415A (en) * | 1976-04-21 | 1978-08-08 | Lovett Wayne D | Multi-purpose test tube |
US4119407A (en) * | 1976-03-08 | 1978-10-10 | Bio-Dynamics, Inc. | Cuvette with reagent release means |
US4124965A (en) * | 1976-08-13 | 1978-11-14 | Bio-Dynamics Inc. | Method for production of centrifugal release bag |
US4135883A (en) * | 1977-08-29 | 1979-01-23 | Bio-Dynamics Inc. | Blood analyzer system |
USRE30276E (en) * | 1976-09-29 | 1980-05-20 | E. I. Du Pont De Nemours And Company | Apparatus for stopper removal |
US4347875A (en) * | 1980-07-14 | 1982-09-07 | Eastman Kodak Company | Self-cleaning nozzle construction for aspirators |
WO1982003459A1 (en) * | 1981-04-02 | 1982-10-14 | Baxter Travenol Lab | Centrifugal analyzer |
US4409820A (en) * | 1981-06-17 | 1983-10-18 | Irwin Nash | Apparatus and method for use in quantitative analysis of a fluid suspension |
US4456581A (en) * | 1980-11-25 | 1984-06-26 | Boehringer Mannheim Gmbh | Centrifugal analyzer rotor unit and insert elements |
WO1986003008A1 (en) * | 1984-11-13 | 1986-05-22 | Cedars-Sinai Medical Center | Portable blood typing apparatus and method |
US4683120A (en) * | 1983-10-28 | 1987-07-28 | Gamma Biologicals, Inc. | Biological fluid assay system |
US4837160A (en) * | 1983-10-28 | 1989-06-06 | Gamma Biologicals, Inc. | Biological fluid assay system and method |
US4857274A (en) * | 1986-06-26 | 1989-08-15 | Kis Photo Industrie | Device for analyzing a liquid sample |
DE4041554A1 (en) * | 1990-12-22 | 1991-05-02 | Komanns Aribert | Measuring sedimentation kinetics of blood cells, etc. - using centrifuge with continuous photometric recording system |
DE19542225A1 (en) * | 1995-11-01 | 1997-05-07 | Buero Fuer Biomedizinische Ing | Method and device for determining rheological and mechanical parameters |
WO1997048491A1 (en) * | 1996-06-20 | 1997-12-24 | Hamilton Bonaduz Ag | Method for achieving chemical, in particular biochemical reactions and pipette tip with reaction vessel and with optional additional receiving component for said pipette tip |
DE19631855A1 (en) * | 1996-08-07 | 1998-02-12 | Komanns Aribert | Method for the detection of surface antigens or structural features of cells, particles or macromolecules |
US5919419A (en) * | 1994-02-22 | 1999-07-06 | Orion-yhtyma Oy | Analyzer cuvette, method and diagnostic test kit for determination of analytes in whole blood samples |
WO2006020182A2 (en) * | 2004-07-16 | 2006-02-23 | Smart Medical Technologies, Llc | Centrifuge system |
US20070231214A1 (en) * | 2006-03-28 | 2007-10-04 | Fujifilm Corporation | Pipette tip, liquid receiving structure, liquid supply device |
US7879293B2 (en) * | 2001-09-28 | 2011-02-01 | Orasure Technologies, Inc. | Sample collector and test device |
US20150160119A1 (en) * | 2013-12-06 | 2015-06-11 | BacterioScan Inc. | Cuvette Assembly Having Chambers For Containing Samples To Be Evaluated Through Optical Measurement |
DE102014019526A1 (en) * | 2014-12-23 | 2016-06-23 | Testo Ag | Examination procedure, disk-shaped sample carrier and use of a sample carrier |
US10006857B2 (en) | 2015-01-26 | 2018-06-26 | Bacterioscan Ltd. | Laser-scatter measurement instrument having carousel-based fluid sample arrangement |
US10048198B2 (en) | 2013-12-06 | 2018-08-14 | Bacterioscan Ltd. | Method and system for optical measurements of contained liquids having a free surface |
US10065184B2 (en) | 2014-12-30 | 2018-09-04 | Bacterioscan Ltd. | Pipette having integrated filtration assembly |
US10233481B2 (en) | 2014-12-05 | 2019-03-19 | Bacterioscan Ltd | Multi-sample laser-scatter measurement instrument with incubation feature and systems for using the same |
US20200316498A1 (en) * | 2019-04-04 | 2020-10-08 | Tai Diagnostics, Inc. | Materials and methods for processing blood samples |
US11099121B2 (en) | 2019-02-05 | 2021-08-24 | BacterioScan Inc. | Cuvette device for determining antibacterial susceptibility |
US12077805B2 (en) | 2014-12-05 | 2024-09-03 | Ip Specialists Ltd. | Laser-scatter measurement instrument for organism detection and related network |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL252802A (en) * | 1959-11-20 | |||
GB1189195A (en) * | 1967-06-19 | 1970-04-22 | Mse Holdings Ltd | Centrifuges |
US3742934A (en) * | 1971-08-12 | 1973-07-03 | Medical Dev Corp | Body fluid collection bottle for pediatric use |
US3994171A (en) * | 1973-01-02 | 1976-11-30 | Schwartz Henry D | Clinical testing apparatus |
US3942717A (en) * | 1973-02-09 | 1976-03-09 | Robison William O | Specimen container |
US3881627A (en) * | 1973-05-09 | 1975-05-06 | Ethyl Dev Corp | Vial container and closure |
US3906890A (en) * | 1973-05-24 | 1975-09-23 | Corning Glass Works | Blood smeared slide centrifuge |
US3982895A (en) * | 1973-05-24 | 1976-09-28 | Corning Glass Works | Blood smeared slide centrifuge |
US3902477A (en) * | 1973-09-26 | 1975-09-02 | Becton Dickinson Co | Blood specimen container |
US3891140A (en) * | 1974-02-27 | 1975-06-24 | Becton Dickinson Co | Centrifuge |
US4074824A (en) * | 1975-12-03 | 1978-02-21 | Kontes Glass Company | Container for storage and shipment of chemical standards, radioactive isotopes and the like |
US4140489A (en) * | 1977-02-07 | 1979-02-20 | Lee Sun Y | Test tube for easy enumeration and cultivation of anaerobic and facultatively anaerobic microorganisms |
DE2824045C2 (en) * | 1978-06-01 | 1983-03-24 | Heraeus-Christ Gmbh, 3360 Osterode | Circuit arrangement for braking a laboratory centrifuge |
US4335730A (en) * | 1979-08-30 | 1982-06-22 | Griffin Gladys B | Collector assembly and specimen tube therefor |
US4306676A (en) * | 1980-04-17 | 1981-12-22 | Beckman Instruments, Inc. | Tube holder for centrifuge rotor |
US4341342A (en) * | 1980-12-04 | 1982-07-27 | Kabushiki Kaisha Kubota Seisakusho | Centrifuge |
FR2496268A1 (en) * | 1980-12-15 | 1982-06-18 | Guigan Jean | AUTONOMOUS SIMULTANEOUS ANALYSIS DEVICE AND METHOD FOR IMPLEMENTING SAME |
US4375272A (en) * | 1981-07-01 | 1983-03-01 | Beckman Instruments, Inc. | Fixed angle tube carrier |
JPS58169048A (en) * | 1982-03-30 | 1983-10-05 | ホエール・サイエンティフィック・インコーポレーテッド | Sampling unit |
US4571238A (en) * | 1983-09-09 | 1986-02-18 | E. I. Du Pont De Nemours And Company | Centrifuge rotor having a retaining arrangement thereon |
US4484907A (en) * | 1983-10-20 | 1984-11-27 | E. I. Du Pont De Nemours And Company | Microtube adapter having a holding and uncapping apparatus |
FI72660C (en) * | 1984-01-11 | 1987-07-10 | Fluilogic Systems Oy | CENTRIFUGERINGSFOERFARANDE OCH CENTRIFUGER FOER TILLAEMPNING AV DETSAMMA. |
US4548596A (en) * | 1984-06-04 | 1985-10-22 | Beckman Instruments, Inc. | Centrifuge rotor and method of assembly |
US4692137A (en) * | 1985-04-03 | 1987-09-08 | Beckman Instruments, Inc. | Split tube centrifuge rotor adapter |
US4696666A (en) * | 1986-07-18 | 1987-09-29 | Rice Jr Richard D | Centrifuge machine and rotor |
US4917804A (en) * | 1986-10-31 | 1990-04-17 | Baxter International Inc. | Method and vessel for separation of cryoglobin |
JPH02501356A (en) * | 1986-10-31 | 1990-05-17 | バクスター、インターナショナル、インコーポレイテッド | Method and container for blood component separation |
US4915847A (en) * | 1987-08-04 | 1990-04-10 | Baxter International Inc. | Cryoglobulin separation |
US4968486A (en) * | 1989-07-14 | 1990-11-06 | Eastman Kodak Company | Device for absorbing shock to a container |
US5199937A (en) * | 1989-08-24 | 1993-04-06 | Kurashiki Boseki Kabushiki Kaisha | Centrifugal separator |
US5295943A (en) * | 1989-11-07 | 1994-03-22 | E. I. Du Pont De Nemours And Company | Adapter for holding a pair of centrifuge tubes |
SE9000410L (en) * | 1990-02-06 | 1991-08-07 | Duma Ab | CONTAINER DEVICE AND PROCEDURES FOR PREPARING THEREOF |
US6436349B1 (en) | 1991-03-04 | 2002-08-20 | Bayer Corporation | Fluid handling apparatus for an automated analyzer |
CA2067695C (en) * | 1991-06-06 | 1997-07-08 | James A. Burns | Blood microcollection tube assembly |
DE4243478A1 (en) * | 1992-03-25 | 1993-09-30 | Peter H Gundelsheimer | Laboratory tubes for dosing liquids |
US5725832A (en) * | 1992-03-25 | 1998-03-10 | Gundelsheimer; Peter | Laboratory test tubes for the dosing of liquids |
US5275723A (en) * | 1992-07-06 | 1994-01-04 | Sp Industries Ltd. Partnership | Mobile phase reservoir |
US5292484A (en) * | 1992-07-16 | 1994-03-08 | Spectrum Systems, Inc. | Cuvette and cuvette cartridge for a chemical analyzer |
US6423550B1 (en) * | 1995-03-30 | 2002-07-23 | Ortho Pharmaceutical Corporation | Home oral fluid sample collection device and package for mailing of such device |
USD388176S (en) * | 1996-06-24 | 1997-12-23 | Q.I.S., Inc. | Chromatography vial |
JPH1015436A (en) * | 1996-07-09 | 1998-01-20 | Tomy Seiko:Kk | Centrifugal separation method and centrifugal separator |
US6001310A (en) * | 1996-10-11 | 1999-12-14 | Shaffer; John V. | Pliable centrifuge tube array |
WO1999046047A2 (en) | 1998-03-10 | 1999-09-16 | Large Scale Proteomics Corporation | Detection and characterization of microorganisms |
US6217332B1 (en) * | 1998-07-13 | 2001-04-17 | Nobel Biocare Ab | Combination implant carrier and vial cap |
USD418607S (en) * | 1998-07-28 | 2000-01-04 | Comar, Inc. | Vial |
US6330388B1 (en) | 1999-01-27 | 2001-12-11 | Northstar Photonics, Inc. | Method and apparatus for waveguide optics and devices |
GB2375976B (en) * | 1999-04-17 | 2003-04-30 | Genevac Ltd | Methods and apparatus for preventing sample loss |
US6561805B2 (en) | 1999-08-12 | 2003-05-13 | Nobel Biocare Ab | Universal implant delivery system |
US6190300B1 (en) * | 2000-03-10 | 2001-02-20 | Labnet International Inc. | Centrifuge rotor adapted for use with centrifuge tube strips |
WO2002042803A2 (en) * | 2000-11-27 | 2002-05-30 | Northstar Photonics, Inc. | Apparatus and method for integrated photonic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
AU2003202962A1 (en) * | 2002-01-11 | 2003-07-30 | Bullis, Grant | Dental implant delivery system |
US20030165409A1 (en) * | 2002-03-04 | 2003-09-04 | Polymicro Technologies, Llc | Device and method for manipulating or dispensing multiple filaments |
US6813405B1 (en) * | 2002-03-29 | 2004-11-02 | Teem Photonics | Compact apparatus and method for integrated photonic devices having folded directional couplers |
US20030185514A1 (en) * | 2002-03-29 | 2003-10-02 | Bendett Mark P. | Method and apparatus for tapping a waveguide on a substrate |
US20030196455A1 (en) * | 2002-04-17 | 2003-10-23 | Mccov Michael A. | Apparatus and method for photonic waveguide fabrication |
US6955258B2 (en) * | 2003-07-31 | 2005-10-18 | Nobel Biocare Ab | Dental implant packaging system |
JP4996248B2 (en) | 2003-07-31 | 2012-08-08 | ハンディーラブ インコーポレイテッド | Processing of particle-containing samples |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
DK3088083T3 (en) | 2006-03-24 | 2018-11-26 | Handylab Inc | Method of carrying out PCR down a multi-track cartridge |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
EP3741869A1 (en) | 2007-07-13 | 2020-11-25 | Handylab, Inc. | Polynucleotide capture materials and methods of using same |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
JP5833450B2 (en) | 2008-12-31 | 2015-12-16 | スリーエム イノベイティブ プロパティズ カンパニー | Detection method of living bioburden using microparticles |
BRPI0918693A2 (en) | 2008-12-31 | 2016-07-26 | 3M Innovative Properties Co | sampling devices and methods for the concentration of microorganisms |
EP2519355B1 (en) | 2009-12-30 | 2017-01-25 | 3M Innovative Properties Company | Live bioload detection using microparticles |
US8550273B2 (en) | 2010-08-31 | 2013-10-08 | Wheaton Industries, Inc. | Cryogenic vials |
RU2690374C2 (en) | 2011-04-15 | 2019-06-03 | Бектон, Дикинсон Энд Компани | Scanning in real time microfluid thermal cycler and methods of synchronized thermal cycling and scanning optical detection |
USD692162S1 (en) * | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
CA2849917C (en) | 2011-09-30 | 2020-03-31 | Becton, Dickinson And Company | Unitized reagent strip |
CN104040238B (en) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | Polynucleotides sample preparation apparatus |
DK2810080T3 (en) | 2012-02-03 | 2024-06-17 | Becton Dickinson Co | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
JP2013173288A (en) * | 2012-02-27 | 2013-09-05 | Seiko Epson Corp | Stirring kit and recording device |
US9873921B2 (en) | 2012-10-22 | 2018-01-23 | Qiagen Gaithersburg, Inc. | Ultrasonic biological sample analysis apparatus and methods |
US9180461B2 (en) | 2012-10-22 | 2015-11-10 | Qiagen Gaithersburg, Inc. | Condensation-reducing incubation cover |
USD735881S1 (en) | 2012-10-22 | 2015-08-04 | Qiagen Gaithersburg, Inc. | Tube strip holder for automated processing systems |
US9135515B2 (en) | 2012-10-22 | 2015-09-15 | Qiagen Gaithersburg, Inc. | Automated pelletized sample vision inspection apparatus and methods |
US9260763B2 (en) | 2012-10-22 | 2016-02-16 | Qiagen Gaithersburg, Inc. | Sample processing method using tube strips and tube strip holder |
US9310281B2 (en) | 2012-10-22 | 2016-04-12 | Qiagen Gaithersburg, Inc. | Automated pelletized sample blotting apparatus and methods |
US9435718B2 (en) | 2012-10-22 | 2016-09-06 | Qiagen Gaithersburg, Inc. | Automated pelletized sample decanting apparatus and methods |
US9212976B2 (en) | 2013-03-15 | 2015-12-15 | Qiagen Gaithersburg, Inc. | Vision-guided aspiration apparatus and methods |
AU2013206318B1 (en) * | 2013-06-13 | 2014-10-16 | Thomas Charles Stevens | Suspended sediment sampler |
CN113751095B (en) | 2015-12-11 | 2024-01-09 | 巴布森诊断公司 | Sample container and method for separating serum or plasma from whole blood |
GB201703383D0 (en) | 2017-03-02 | 2017-04-19 | Gargle Tech Ltd | Testing for particulates |
IL281102B2 (en) | 2018-09-05 | 2024-04-01 | Hero Scient Ltd | Testing for particulates |
CN109668968A (en) * | 2019-01-09 | 2019-04-23 | 郭拓 | A kind of chromatography lake water quality detection device and its application method |
US11155402B2 (en) * | 2019-01-22 | 2021-10-26 | Lerman Container Corporation | Cartridge tube |
WO2022149975A1 (en) * | 2021-01-05 | 2022-07-14 | Cheong Mun Shun | Apparatus and method for automatically preparing thin-layer slides |
WO2022149135A2 (en) | 2021-01-06 | 2022-07-14 | Hero Scientific Ltd. | Filtration sampling devices |
US12050052B1 (en) | 2021-08-06 | 2024-07-30 | Babson Diagnostics, Inc. | Refrigerated carrier device for biological samples |
CA214392S (en) * | 2022-01-18 | 2024-01-12 | Assure Tech Hangzhou Co Ltd | Tester for testing biological fluids |
US12025629B2 (en) | 2022-04-06 | 2024-07-02 | Babson Diagnostics, Inc. | Automated centrifuge loader |
USD1039170S1 (en) * | 2022-04-25 | 2024-08-13 | Amazon Technologies, Inc. | Sample collection tube |
USD1042880S1 (en) * | 2022-07-15 | 2024-09-17 | Illumina, Inc. | Vial assembly |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3009388A (en) * | 1957-12-30 | 1961-11-21 | American Optical Corp | Apparatus for determining fluid fractions and sedimentataion rates |
US3050239A (en) * | 1959-11-20 | 1962-08-21 | Beckman Instruments Inc | Centrifuge apparatus |
US3071316A (en) * | 1959-05-19 | 1963-01-01 | Lourdes Instr Corp | Bottle support and cap assembly for centrifuge |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US330779A (en) * | 1885-11-17 | Centrifugal machine for testing milk and creai | ||
US486390A (en) * | 1892-11-15 | Centrifugal cream-tester | ||
US330780A (en) * | 1885-11-17 | And petee | ||
US998529A (en) * | 1906-07-12 | 1911-07-18 | Cassius M Ketcham | Centrifugal cream-separator. |
US1839944A (en) * | 1928-07-21 | 1932-01-05 | Charles F Barthels | Thermometer shaker |
US2110308A (en) * | 1936-02-11 | 1938-03-08 | Ralph W Nelson | Device for treating thermometers in hospitals |
GB617718A (en) * | 1945-03-01 | 1949-02-10 | Separator Ab | Improvements in butyrometer centrifuges |
DK75348C (en) * | 1948-06-15 | 1953-01-26 | Licentiat Karl Os Silverstolpe | Device for centrifuges for separating particles suspended in sample liquids or similar items. |
US2817970A (en) * | 1953-01-02 | 1957-12-31 | Pillsbury Mills Inc | Apparatus for determining the particle size distribution of finely divided materials |
US2720711A (en) * | 1954-03-15 | 1955-10-18 | John D Gray | Fountain pen cleaner |
US2854189A (en) * | 1956-05-25 | 1958-09-30 | Gilbert J Garrett | Centrifuge heating attachment |
US3080964A (en) * | 1959-05-01 | 1963-03-12 | Buckeye Molding Co | Container |
US3115460A (en) * | 1960-04-28 | 1963-12-24 | Lab Tek Plastics Co | Centrifuge container |
GB978743A (en) * | 1960-05-25 | 1964-12-23 | Nat Res Dev | Process for the preparation of an eosinophil-containing material and extracts thereof from blood |
US3107905A (en) * | 1960-10-19 | 1963-10-22 | Charles D Lucas | Belleville spring elastic suspension |
US3190731A (en) * | 1961-03-08 | 1965-06-22 | Technicon Instr | Sample-supply cups for analysis apparatus |
US3202348A (en) * | 1962-12-05 | 1965-08-24 | Martin Christ | Centrifuge having an improved centrifuge cell |
US3243105A (en) * | 1963-11-15 | 1966-03-29 | Norman G Anderson | System for separating particulate substances by reorienting gradients |
-
0
- NL NL252802D patent/NL252802A/xx unknown
- NL NL109202D patent/NL109202C/xx active
-
1959
- 1959-11-20 US US854281A patent/US3050239A/en not_active Expired - Lifetime
-
1960
- 1960-06-01 GB GB19315/60A patent/GB889082A/en not_active Expired
-
1964
- 1964-11-25 DE DEC34478A patent/DE1256921B/en active Pending
-
1965
- 1965-11-23 US US509361A patent/US3402883A/en not_active Expired - Lifetime
- 1965-11-25 GB GB50115/65A patent/GB1119420A/en not_active Expired
-
1966
- 1966-02-07 US US525771A patent/US3481712A/en not_active Expired - Lifetime
- 1966-10-31 GB GB48757/66A patent/GB1115297A/en not_active Expired
-
1967
- 1967-02-01 DE DE19671598301 patent/DE1598301A1/en active Pending
-
1970
- 1970-06-22 US US00048386A patent/US3713775A/en not_active Expired - Lifetime
-
1971
- 1971-01-27 DE DE2103841A patent/DE2103841C3/en not_active Expired
- 1971-06-01 CA CA114,539A patent/CA940428A/en not_active Expired
- 1971-06-01 GB GB2833172A patent/GB1357232A/en not_active Expired
- 1971-06-21 FR FR7122476A patent/FR2096403B1/fr not_active Expired
- 1971-06-22 GB GB1828471*[A patent/GB1357231A/en not_active Expired
-
1972
- 1972-10-13 AU AU47751/72A patent/AU468478B2/en not_active Expired
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3009388A (en) * | 1957-12-30 | 1961-11-21 | American Optical Corp | Apparatus for determining fluid fractions and sedimentataion rates |
US3071316A (en) * | 1959-05-19 | 1963-01-01 | Lourdes Instr Corp | Bottle support and cap assembly for centrifuge |
US3050239A (en) * | 1959-11-20 | 1962-08-21 | Beckman Instruments Inc | Centrifuge apparatus |
US3402883A (en) * | 1959-11-20 | 1968-09-24 | Firm Martin Christ | Method for operating an ultracentrifuge and a suitable centrifuge for said method |
US3481712A (en) * | 1959-11-20 | 1969-12-02 | Clay Adams Inc | Sediment container and cap and analysis technique |
Cited By (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3905772A (en) * | 1965-05-17 | 1975-09-16 | Medical Laboratory Automation | Apparatus for performing blood typing tests |
US3819271A (en) * | 1971-11-15 | 1974-06-25 | Max Planck Gesellschaft | Method and apparatus for measuring agglutination of cells in a carrier liquid |
US3858795A (en) * | 1973-02-08 | 1975-01-07 | Int Equipment Co | Method for washing blood cells |
US3814522A (en) * | 1973-02-28 | 1974-06-04 | American Hospital Supply Corp | Specimen tube for microscopic examination |
US3999868A (en) * | 1974-11-29 | 1976-12-28 | Manuel Sanz | Unit for use in optical analysis |
US3999862A (en) * | 1974-11-29 | 1976-12-28 | Georges Revillet | Apparatus for optically analyzing a solution |
US4119407A (en) * | 1976-03-08 | 1978-10-10 | Bio-Dynamics, Inc. | Cuvette with reagent release means |
US4105415A (en) * | 1976-04-21 | 1978-08-08 | Lovett Wayne D | Multi-purpose test tube |
US4124965A (en) * | 1976-08-13 | 1978-11-14 | Bio-Dynamics Inc. | Method for production of centrifugal release bag |
USRE30276E (en) * | 1976-09-29 | 1980-05-20 | E. I. Du Pont De Nemours And Company | Apparatus for stopper removal |
US4135883A (en) * | 1977-08-29 | 1979-01-23 | Bio-Dynamics Inc. | Blood analyzer system |
US4347875A (en) * | 1980-07-14 | 1982-09-07 | Eastman Kodak Company | Self-cleaning nozzle construction for aspirators |
EP0052770B1 (en) * | 1980-11-25 | 1985-08-07 | Roche Diagnostics GmbH | Rotor unit with removable segments for a centrifugal analyzer |
US4456581A (en) * | 1980-11-25 | 1984-06-26 | Boehringer Mannheim Gmbh | Centrifugal analyzer rotor unit and insert elements |
US4814144A (en) * | 1980-11-25 | 1989-03-21 | Boehringer Mannheim Gmbh | Centrifugal analyzer rotor unit and insert elements |
US4360360A (en) * | 1981-04-02 | 1982-11-23 | Baxter Travenol Laboratories, Inc. | Centrifugal analyzer |
WO1982003459A1 (en) * | 1981-04-02 | 1982-10-14 | Baxter Travenol Lab | Centrifugal analyzer |
US4409820A (en) * | 1981-06-17 | 1983-10-18 | Irwin Nash | Apparatus and method for use in quantitative analysis of a fluid suspension |
US4683120A (en) * | 1983-10-28 | 1987-07-28 | Gamma Biologicals, Inc. | Biological fluid assay system |
US4837160A (en) * | 1983-10-28 | 1989-06-06 | Gamma Biologicals, Inc. | Biological fluid assay system and method |
WO1986003008A1 (en) * | 1984-11-13 | 1986-05-22 | Cedars-Sinai Medical Center | Portable blood typing apparatus and method |
US4857274A (en) * | 1986-06-26 | 1989-08-15 | Kis Photo Industrie | Device for analyzing a liquid sample |
DE4041554A1 (en) * | 1990-12-22 | 1991-05-02 | Komanns Aribert | Measuring sedimentation kinetics of blood cells, etc. - using centrifuge with continuous photometric recording system |
US5919419A (en) * | 1994-02-22 | 1999-07-06 | Orion-yhtyma Oy | Analyzer cuvette, method and diagnostic test kit for determination of analytes in whole blood samples |
DE19542225A1 (en) * | 1995-11-01 | 1997-05-07 | Buero Fuer Biomedizinische Ing | Method and device for determining rheological and mechanical parameters |
DE19542225B4 (en) * | 1995-11-01 | 2011-05-26 | L.U.M. Gmbh | Method and device for determining rheological and mechanical substance characteristics |
WO1997048491A1 (en) * | 1996-06-20 | 1997-12-24 | Hamilton Bonaduz Ag | Method for achieving chemical, in particular biochemical reactions and pipette tip with reaction vessel and with optional additional receiving component for said pipette tip |
DE19631855A1 (en) * | 1996-08-07 | 1998-02-12 | Komanns Aribert | Method for the detection of surface antigens or structural features of cells, particles or macromolecules |
DE19631855C2 (en) * | 1996-08-07 | 1998-10-15 | Komanns Aribert | Method and device for the detection of surface antigens or structural features of cells, particles or macromolecules |
US7879293B2 (en) * | 2001-09-28 | 2011-02-01 | Orasure Technologies, Inc. | Sample collector and test device |
US8673239B2 (en) | 2001-09-28 | 2014-03-18 | Orasure Technologies, Inc. | Sample collector and test device |
US20110120236A1 (en) * | 2001-09-28 | 2011-05-26 | Orasure Technologies, Inc. | Sample collector and test device |
WO2006020182A2 (en) * | 2004-07-16 | 2006-02-23 | Smart Medical Technologies, Llc | Centrifuge system |
US20060116270A1 (en) * | 2004-07-16 | 2006-06-01 | Mehdi Hatamian | Centrifuge system |
WO2006020182A3 (en) * | 2004-07-16 | 2006-04-06 | Smart Medical Technologies Llc | Centrifuge system |
US7867449B2 (en) * | 2006-03-28 | 2011-01-11 | Fujifilm Corporation | Pipette tip, liquid receiving structure, liquid supply device |
US20070231214A1 (en) * | 2006-03-28 | 2007-10-04 | Fujifilm Corporation | Pipette tip, liquid receiving structure, liquid supply device |
US10040065B2 (en) | 2013-12-06 | 2018-08-07 | Bacterioscan Ltd. | Cuvette assembly having chambers for containing samples to be evaluated through optical measurement |
WO2015085066A1 (en) * | 2013-12-06 | 2015-06-11 | BacterioScan Inc. | Optical measurement cuvette having sample chambers |
US20150160119A1 (en) * | 2013-12-06 | 2015-06-11 | BacterioScan Inc. | Cuvette Assembly Having Chambers For Containing Samples To Be Evaluated Through Optical Measurement |
CN106062531A (en) * | 2013-12-06 | 2016-10-26 | 百克特瑞欧扫描有限责任公司 | Optical measurement cuvette having sample chambers |
JP2016540998A (en) * | 2013-12-06 | 2016-12-28 | バクテリオスキャン エルティーディー | Optical measurement cuvette with sample chamber |
US9579648B2 (en) * | 2013-12-06 | 2017-02-28 | Bacterioscan Ltd | Cuvette assembly having chambers for containing samples to be evaluated through optical measurement |
US11801507B2 (en) | 2013-12-06 | 2023-10-31 | Ip Specialists Ltd. | Cuvette assembly having chambers for containing samples to be evaluated through optical measurement |
US10048198B2 (en) | 2013-12-06 | 2018-08-14 | Bacterioscan Ltd. | Method and system for optical measurements of contained liquids having a free surface |
JP2019090829A (en) * | 2013-12-06 | 2019-06-13 | バクテリオスキャン エルティーディー | Optical measurement cuvette having sample chambers |
CN106062531B (en) * | 2013-12-06 | 2019-03-08 | 百克特瑞欧扫描有限责任公司 | The test tube component of optical measurement is carried out for the characteristic to particle in fluid sample |
US12077805B2 (en) | 2014-12-05 | 2024-09-03 | Ip Specialists Ltd. | Laser-scatter measurement instrument for organism detection and related network |
US10233481B2 (en) | 2014-12-05 | 2019-03-19 | Bacterioscan Ltd | Multi-sample laser-scatter measurement instrument with incubation feature and systems for using the same |
DE102014019526A1 (en) * | 2014-12-23 | 2016-06-23 | Testo Ag | Examination procedure, disk-shaped sample carrier and use of a sample carrier |
DE102014019526B4 (en) * | 2014-12-23 | 2016-10-27 | Testo Ag | Examination procedure, disk-shaped sample carrier and use of a sample carrier |
US10065184B2 (en) | 2014-12-30 | 2018-09-04 | Bacterioscan Ltd. | Pipette having integrated filtration assembly |
US11268903B2 (en) | 2015-01-26 | 2022-03-08 | Ip Specialists Ltd. | Laser-scatter measurement instrument having carousel-based fluid sample arrangement |
US10006857B2 (en) | 2015-01-26 | 2018-06-26 | Bacterioscan Ltd. | Laser-scatter measurement instrument having carousel-based fluid sample arrangement |
US11099121B2 (en) | 2019-02-05 | 2021-08-24 | BacterioScan Inc. | Cuvette device for determining antibacterial susceptibility |
US20200316498A1 (en) * | 2019-04-04 | 2020-10-08 | Tai Diagnostics, Inc. | Materials and methods for processing blood samples |
US11931674B2 (en) * | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
Also Published As
Publication number | Publication date |
---|---|
US3050239A (en) | 1962-08-21 |
US3402883A (en) | 1968-09-24 |
FR2096403A1 (en) | 1972-02-18 |
DE2103841C3 (en) | 1974-01-17 |
GB1357232A (en) | 1974-06-19 |
DE1256921B (en) | 1967-12-21 |
FR2096403B1 (en) | 1977-01-21 |
GB1115297A (en) | 1968-05-29 |
NL252802A (en) | |
GB1119420A (en) | 1968-07-10 |
CA940428A (en) | 1974-01-22 |
DE2103841A1 (en) | 1972-02-10 |
US3481712A (en) | 1969-12-02 |
GB1357231A (en) | 1974-06-19 |
AU468478B2 (en) | 1976-01-15 |
DE2103841B2 (en) | 1973-06-20 |
DE1598301A1 (en) | 1970-12-10 |
AU4775172A (en) | 1974-04-26 |
GB889082A (en) | 1962-02-07 |
NL109202C (en) |
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