US20170197919A1 - 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives - Google Patents
3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives Download PDFInfo
- Publication number
- US20170197919A1 US20170197919A1 US15/405,482 US201715405482A US2017197919A1 US 20170197919 A1 US20170197919 A1 US 20170197919A1 US 201715405482 A US201715405482 A US 201715405482A US 2017197919 A1 US2017197919 A1 US 2017197919A1
- Authority
- US
- United States
- Prior art keywords
- diazaspiro
- decan
- phenyl
- methyl
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 [1*]N([2*])C1([3*])C([15*])([16*])C([13*])([14*])C2(N([4*])C(=O)N(C([9*])([10*])C([7*])([8*])C(=O)C[5*])C2([11*])[12*])C([17*])([18*])C1([19*])[20*] Chemical compound [1*]N([2*])C1([3*])C([15*])([16*])C([13*])([14*])C2(N([4*])C(=O)N(C([9*])([10*])C([7*])([8*])C(=O)C[5*])C2([11*])[12*])C([17*])([18*])C1([19*])[20*] 0.000 description 20
- FVAJWAPETUKQAY-UHFFFAOYSA-N CC(C)CC(C)(C)C(=O)NCC(N)=O.CC(C)CC(C)(C)C(N)=O.CC(C)CCC(=O)NC(C)(C)C(N)=O.CC(C)CCC(=O)NC1=CC=CC=N1.CC(C)CCC(=O)NCC(N)=O.CC(C)CCC(=O)NCCC(=O)N(C)C.CC(C)CCC(=O)NCCO.CC(C)CCC(=O)O.CC(C)CCC(N)=O.CCCCNC(=O)CCC(C)C.CNC(=O)CCC(C)C.COC1=CC=NC(NC(=O)CCC(C)C)=C1.COCCNC(=O)CCC(C)C Chemical compound CC(C)CC(C)(C)C(=O)NCC(N)=O.CC(C)CC(C)(C)C(N)=O.CC(C)CCC(=O)NC(C)(C)C(N)=O.CC(C)CCC(=O)NC1=CC=CC=N1.CC(C)CCC(=O)NCC(N)=O.CC(C)CCC(=O)NCCC(=O)N(C)C.CC(C)CCC(=O)NCCO.CC(C)CCC(=O)O.CC(C)CCC(N)=O.CCCCNC(=O)CCC(C)C.CNC(=O)CCC(C)C.COC1=CC=NC(NC(=O)CCC(C)C)=C1.COCCNC(=O)CCC(C)C FVAJWAPETUKQAY-UHFFFAOYSA-N 0.000 description 2
- YXPWRXBQNUTSHW-UHFFFAOYSA-N CC(C)CCC(=O)NC1=CC=CN=C1.CC(C)CCC(=O)NC1=CC=CN=N1.CC(C)CCC(=O)NC1=CC=NC=C1.CC(C)CCC(=O)NC1=NC=CC=N1.CCC1=CC=C(NC(=O)CCC(C)C)C=N1.CCC1=CC=C(NC(=O)CCC(C)C)N=C1.COC1=CC(NC(=O)CCC(C)C)=CC=N1.COC1=CC=C(NC(=O)CCC(C)C)C=N1.COC1=CC=C(NC(=O)CCC(C)C)N=C1.COC1=CC=C(NC(=O)CCC(C)C)N=N1.COC1=CN=CC=C1NC(=O)CCC(C)C Chemical compound CC(C)CCC(=O)NC1=CC=CN=C1.CC(C)CCC(=O)NC1=CC=CN=N1.CC(C)CCC(=O)NC1=CC=NC=C1.CC(C)CCC(=O)NC1=NC=CC=N1.CCC1=CC=C(NC(=O)CCC(C)C)C=N1.CCC1=CC=C(NC(=O)CCC(C)C)N=C1.COC1=CC(NC(=O)CCC(C)C)=CC=N1.COC1=CC=C(NC(=O)CCC(C)C)C=N1.COC1=CC=C(NC(=O)CCC(C)C)N=C1.COC1=CC=C(NC(=O)CCC(C)C)N=N1.COC1=CN=CC=C1NC(=O)CCC(C)C YXPWRXBQNUTSHW-UHFFFAOYSA-N 0.000 description 2
- YPKYWFDEWBDBAU-UHFFFAOYSA-N CC1=CC=C(C2(N(C)C)CCC(=O)CC2)S1 Chemical compound CC1=CC=C(C2(N(C)C)CCC(=O)CC2)S1 YPKYWFDEWBDBAU-UHFFFAOYSA-N 0.000 description 2
- RJEQPUXGNQSAOC-UHFFFAOYSA-N CCN(C)C1(C2=CC=CC=C2)CCC(=O)CC1 Chemical compound CCN(C)C1(C2=CC=CC=C2)CCC(=O)CC1 RJEQPUXGNQSAOC-UHFFFAOYSA-N 0.000 description 2
- UJTRPUVGYJPVMB-SZPZYZBQSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 UJTRPUVGYJPVMB-SZPZYZBQSA-N 0.000 description 2
- AOAHTPZABFAKKS-ISILISOKSA-N CN(C)C(=O)CCNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2CCC2)C1=O Chemical compound CN(C)C(=O)CCNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2CCC2)C1=O AOAHTPZABFAKKS-ISILISOKSA-N 0.000 description 2
- KZTKIQIFDRIQTC-QUPDYRNUSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1CCC(N)=O)N(CC2(CCC2)O)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1CCC(N)=O)N(CC2(CCC2)O)C1=O)c1ccccc1 KZTKIQIFDRIQTC-QUPDYRNUSA-N 0.000 description 2
- KZQGRHRNLMQAOT-JSEFLNQRSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1CCC(Nc2cnc(C#N)nc2)=O)N(CC2(CCC2)O)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1CCC(Nc2cnc(C#N)nc2)=O)N(CC2(CCC2)O)C1=O)c1ccccc1 KZQGRHRNLMQAOT-JSEFLNQRSA-N 0.000 description 2
- BUUKYLQCURTNKC-OGLKEZPNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1(O)CCC1 BUUKYLQCURTNKC-OGLKEZPNSA-N 0.000 description 2
- RRAYUCLILOLMLK-WMPKNSHKSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 RRAYUCLILOLMLK-WMPKNSHKSA-N 0.000 description 2
- URBNKOSKXPPQNF-LNFXKIIUSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1CCCC(O)C1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1CCCC(O)C1)C(=O)N2CC1CCC1 URBNKOSKXPPQNF-LNFXKIIUSA-N 0.000 description 2
- YJTJPSBCCBKTGA-GVXFMRKGSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=C(S(C)=O)N=C1)C(=O)N2CC1CCC1.O Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=C(S(C)=O)N=C1)C(=O)N2CC1CCC1.O YJTJPSBCCBKTGA-GVXFMRKGSA-N 0.000 description 2
- LDOXJVHORXFSID-JSEFLNQRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CN=CC=C1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CN=CC=C1)C(=O)N2CC1(O)CCC1 LDOXJVHORXFSID-JSEFLNQRSA-N 0.000 description 2
- GNBTVIHKUOETAB-ZRZAMGCNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1CC1 GNBTVIHKUOETAB-ZRZAMGCNSA-N 0.000 description 2
- YUXZRZGVSWLFPZ-OEANFSLJSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C)CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(C)CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C)CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(C)CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 YUXZRZGVSWLFPZ-OEANFSLJSA-N 0.000 description 2
- FXCXWTFQQJOMPJ-BGYRXZFFSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 FXCXWTFQQJOMPJ-BGYRXZFFSA-N 0.000 description 2
- TZNQWEYVUZTFJM-HDICACEKSA-N CN1C2=C(C=CC=C2)N=C1[C@]1(N(C)C)CC[C@@]2(CC1)CNC(=O)N2 Chemical compound CN1C2=C(C=CC=C2)N=C1[C@]1(N(C)C)CC[C@@]2(CC1)CNC(=O)N2 TZNQWEYVUZTFJM-HDICACEKSA-N 0.000 description 2
- YTTKPGSREXWQHK-ZRZAMGCNSA-N CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CCOC)C1=O Chemical compound CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CCOC)C1=O YTTKPGSREXWQHK-ZRZAMGCNSA-N 0.000 description 2
- BLXBEVLVKISWJI-GUOBSTCESA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCCO)C(=O)N2CC1(O)CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCCO)C(=O)N2CC1(O)CCC1 BLXBEVLVKISWJI-GUOBSTCESA-N 0.000 description 2
- YTIBEDIVGQBBTF-CALCHBBNSA-N COC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CNC(=O)N3)=CC=C1 Chemical compound COC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CNC(=O)N3)=CC=C1 YTIBEDIVGQBBTF-CALCHBBNSA-N 0.000 description 2
- ULXXDAIEQSPJSY-PSWAGMNNSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=C(F)C=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=C(F)C=C4)(N(C)C)CC3)NC2=O)C=C1 ULXXDAIEQSPJSY-PSWAGMNNSA-N 0.000 description 2
- CAXPTEWBXLCYRI-ISILISOKSA-N COC1=NN=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1 Chemical compound COC1=NN=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1 CAXPTEWBXLCYRI-ISILISOKSA-N 0.000 description 2
- AHHOCSMWLFKYIY-UHFFFAOYSA-N N#CC1(C2=NC=CN=C2)CCC(=O)CC1 Chemical compound N#CC1(C2=NC=CN=C2)CCC(=O)CC1 AHHOCSMWLFKYIY-UHFFFAOYSA-N 0.000 description 2
- BDLRVHCFSIUCST-IHKAGALWSA-N C1=CC=C(C2(CCC3CCOC3)CCC3(CC2)OCCO3)C=C1.CC(C)(C)S(=O)CC1(C2=CC=CC=C2)CCC2(CC1)OCCO2.CC(C)(C)S(=O)N=C1CCC2(CC1)OCCO2.CN(CC1CCOC1)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(CC1CCOC1)C1(C2=CC=CC=C2)CCC2(CC1)NC(=O)NC2=O.CN(CC1CCOC1)C1(C2=CC=CC=C2)CCC2(CC1)OCCO2.CN(CC1CCOC1)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NC2=O.CN(CC1CCOC1)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NO2.Cl.NC1(C2=CC=CC=C2)CCC2(CC1)OCCO2.O=C1CCC2(CC1)OCCO2 Chemical compound C1=CC=C(C2(CCC3CCOC3)CCC3(CC2)OCCO3)C=C1.CC(C)(C)S(=O)CC1(C2=CC=CC=C2)CCC2(CC1)OCCO2.CC(C)(C)S(=O)N=C1CCC2(CC1)OCCO2.CN(CC1CCOC1)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(CC1CCOC1)C1(C2=CC=CC=C2)CCC2(CC1)NC(=O)NC2=O.CN(CC1CCOC1)C1(C2=CC=CC=C2)CCC2(CC1)OCCO2.CN(CC1CCOC1)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NC2=O.CN(CC1CCOC1)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NO2.Cl.NC1(C2=CC=CC=C2)CCC2(CC1)OCCO2.O=C1CCC2(CC1)OCCO2 BDLRVHCFSIUCST-IHKAGALWSA-N 0.000 description 1
- NFXOCAOYHFJZRF-DMRIWGJVSA-N CC(=O)NC1(C#N)CCC(C2=CC=CC=C2)(N(C)C)CC1.CCN1C(=O)NC[C@]12CC[C@@](C1=CC=CC=C1)(N(C)C)CC2.CCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.CCNC1(CN)CCC(C2=CC=CC=C2)(N(C)C)CC1.CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)C1(C2=CC=CC=C2)CCC(N)(C#N)CC1 Chemical compound CC(=O)NC1(C#N)CCC(C2=CC=CC=C2)(N(C)C)CC1.CCN1C(=O)NC[C@]12CC[C@@](C1=CC=CC=C1)(N(C)C)CC2.CCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.CCNC1(CN)CCC(C2=CC=CC=C2)(N(C)C)CC1.CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)C1(C2=CC=CC=C2)CCC(N)(C#N)CC1 NFXOCAOYHFJZRF-DMRIWGJVSA-N 0.000 description 1
- CVBVKDYNJYAYPU-UHFFFAOYSA-N CC(C)CC(C)(C)C(=O)NCCO.CC(C)CC1(C(N)=O)CC1.CC(C)CC1(C(N)=O)CCC1.CC(C)CC1(C(N)=O)CCOCC1.CC(C)CC1(C(N)=O)COC1.CC(C)CCC(=O)N1CC(O)C(O)C1.CC(C)CCC(=O)N1CCC(O)C(O)C1.CC(C)CCC(=O)N1CCCC(O)C1.CC(C)CCC(=O)N1CCN2N=CN=C2C1.CC(C)CCC(=O)N1CCNC(=O)C1.CC(C)CCC(=O)N1CCOCC1.CC(C)CCC(=O)NC1COC1.CCC(C)(C)C(=O)N1CCS(=O)(=O)CC1 Chemical compound CC(C)CC(C)(C)C(=O)NCCO.CC(C)CC1(C(N)=O)CC1.CC(C)CC1(C(N)=O)CCC1.CC(C)CC1(C(N)=O)CCOCC1.CC(C)CC1(C(N)=O)COC1.CC(C)CCC(=O)N1CC(O)C(O)C1.CC(C)CCC(=O)N1CCC(O)C(O)C1.CC(C)CCC(=O)N1CCCC(O)C1.CC(C)CCC(=O)N1CCN2N=CN=C2C1.CC(C)CCC(=O)N1CCNC(=O)C1.CC(C)CCC(=O)N1CCOCC1.CC(C)CCC(=O)NC1COC1.CCC(C)(C)C(=O)N1CCS(=O)(=O)CC1 CVBVKDYNJYAYPU-UHFFFAOYSA-N 0.000 description 1
- DESUNRXBQZGRGE-UHFFFAOYSA-N CC(C)CC(C)(C)C(=O)NCCO.CC(C)CC1(C(N)=O)CC1.CC(C)CC1(C(N)=O)CCC1.CC(C)CC1(C(N)=O)CCOCC1.CC(C)CC1(C(N)=O)COC1.CC(C)CCC(=O)N1CCC(O)C(O)C1.CC(C)CCC(=O)N1CCCC(O)C1.CC(C)CCC(=O)N1CCN2N=CN=C2C1.CC(C)CCC(=O)N1CCNC(=O)C1.CC(C)CCC(=O)N1CCOCC1.CC(C)CCC(=O)NC1COC1.CCC(C)(C)C(=O)N1CCS(=O)(=O)CC1 Chemical compound CC(C)CC(C)(C)C(=O)NCCO.CC(C)CC1(C(N)=O)CC1.CC(C)CC1(C(N)=O)CCC1.CC(C)CC1(C(N)=O)CCOCC1.CC(C)CC1(C(N)=O)COC1.CC(C)CCC(=O)N1CCC(O)C(O)C1.CC(C)CCC(=O)N1CCCC(O)C1.CC(C)CCC(=O)N1CCN2N=CN=C2C1.CC(C)CCC(=O)N1CCNC(=O)C1.CC(C)CCC(=O)N1CCOCC1.CC(C)CCC(=O)NC1COC1.CCC(C)(C)C(=O)N1CCS(=O)(=O)CC1 DESUNRXBQZGRGE-UHFFFAOYSA-N 0.000 description 1
- LWLYYTSIBMMJLS-UHFFFAOYSA-N CC(C)CCC(=O)N1CC(O)C(O)C1.CC(C)CCC(=O)N1CCCC1C(N)=O.CC(C)CCC(=O)NC1=CN=CN=C1.CC(C)CCC(=O)NC1=NC(O)=CC=N1.CC(C)CCC(=O)NCC1(O)CCC1.CC(C)CCC(=O)NCC1=CN=CO1.CC(C)CCC(=O)NCC1=NC=CO1.COC1=CC=NC(NC(=O)CCC(C)C)=N1.COC1=NC(NC(=O)CCC(C)C)=CN=C1.[C-]#[N+]C1=NC=C(NC(=O)CCC(C)C)C=N1 Chemical compound CC(C)CCC(=O)N1CC(O)C(O)C1.CC(C)CCC(=O)N1CCCC1C(N)=O.CC(C)CCC(=O)NC1=CN=CN=C1.CC(C)CCC(=O)NC1=NC(O)=CC=N1.CC(C)CCC(=O)NCC1(O)CCC1.CC(C)CCC(=O)NCC1=CN=CO1.CC(C)CCC(=O)NCC1=NC=CO1.COC1=CC=NC(NC(=O)CCC(C)C)=N1.COC1=NC(NC(=O)CCC(C)C)=CN=C1.[C-]#[N+]C1=NC=C(NC(=O)CCC(C)C)C=N1 LWLYYTSIBMMJLS-UHFFFAOYSA-N 0.000 description 1
- JRKGXBDSFKBRRO-UHFFFAOYSA-N CC(C)CCC(=O)N1CCCC1C(N)=O.CC(C)CCC(=O)NC1=CN=CN=C1.CC(C)CCC(=O)NC1=NC(O)=CC=N1.CC(C)CCC(=O)NCC1(O)CCC1.CC(C)CCC(=O)NCC1=CN=CO1.CC(C)CCC(=O)NCC1=NC=CO1.COC1=CC=NC(NC(=O)CCC(C)C)=N1.COC1=NC(NC(=O)CCC(C)C)=CN=C1.[C-]#[N+]C1=NC=C(NC(=O)CCC(C)C)C=N1 Chemical compound CC(C)CCC(=O)N1CCCC1C(N)=O.CC(C)CCC(=O)NC1=CN=CN=C1.CC(C)CCC(=O)NC1=NC(O)=CC=N1.CC(C)CCC(=O)NCC1(O)CCC1.CC(C)CCC(=O)NCC1=CN=CO1.CC(C)CCC(=O)NCC1=NC=CO1.COC1=CC=NC(NC(=O)CCC(C)C)=N1.COC1=NC(NC(=O)CCC(C)C)=CN=C1.[C-]#[N+]C1=NC=C(NC(=O)CCC(C)C)C=N1 JRKGXBDSFKBRRO-UHFFFAOYSA-N 0.000 description 1
- XXNYTOSRCAMJJW-MKPDMIMOSA-N CC(C)CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1CCC1.O=C(O)C(F)(F)F Chemical compound CC(C)CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1CCC1.O=C(O)C(F)(F)F XXNYTOSRCAMJJW-MKPDMIMOSA-N 0.000 description 1
- DJBAFQQHRFSGLU-BXFJNQSESA-N CC(C)CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.COC1=CC=C(CN2CC3(CCC(=O)CC3)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC(C#N)(N(C)CC(C)C)CC3)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC4(CC3)OCCO4)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC4(CC3)OCCO4)NC2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)CC(C)C)CC3)N(CC3CCC3)C2=O)C=C1 Chemical compound CC(C)CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.COC1=CC=C(CN2CC3(CCC(=O)CC3)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC(C#N)(N(C)CC(C)C)CC3)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC4(CC3)OCCO4)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC4(CC3)OCCO4)NC2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)CC(C)C)CC3)N(CC3CCC3)C2=O)C=C1 DJBAFQQHRFSGLU-BXFJNQSESA-N 0.000 description 1
- IFWPOYXGSFWZQQ-NNTVRFIESA-N CC(C)CN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC(C)C)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound CC(C)CN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC(C)C)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 IFWPOYXGSFWZQQ-NNTVRFIESA-N 0.000 description 1
- UKPBJXHAQIRHIP-CALCHBBNSA-N CC1=CC(F)=CC([C@]2(N(C)C)CC[C@@]3(CC2)CNC(=O)N3)=C1 Chemical compound CC1=CC(F)=CC([C@]2(N(C)C)CC[C@@]3(CC2)CNC(=O)N3)=C1 UKPBJXHAQIRHIP-CALCHBBNSA-N 0.000 description 1
- LBSGXGGZVASQBJ-WBMYFENBSA-N CC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC(C)(C)C#N)C(=O)N3CC2CC2)=CC=C1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 Chemical compound CC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC(C)(C)C#N)C(=O)N3CC2CC2)=CC=C1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 LBSGXGGZVASQBJ-WBMYFENBSA-N 0.000 description 1
- STCDCANXGQREKB-OKZTUQRJSA-N CC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CNC(=O)N3)=CC=C1.CN(C)C1(C#N)CCC2(CC1)CNC(=O)N2 Chemical compound CC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CNC(=O)N3)=CC=C1.CN(C)C1(C#N)CCC2(CC1)CNC(=O)N2 STCDCANXGQREKB-OKZTUQRJSA-N 0.000 description 1
- GHFWSINEVIVLSZ-ZRZAMGCNSA-N CCCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1 Chemical compound CCCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1 GHFWSINEVIVLSZ-ZRZAMGCNSA-N 0.000 description 1
- QDTIPJNVPRDSPB-KDURUIRLSA-N CCCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound CCCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 QDTIPJNVPRDSPB-KDURUIRLSA-N 0.000 description 1
- QYGSLACIQFZBSS-MKPDMIMOSA-N CCCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CCC1 Chemical compound CCCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CCC1 QYGSLACIQFZBSS-MKPDMIMOSA-N 0.000 description 1
- HDTPZWYGAVLHRK-CALCHBBNSA-N CCC[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2 Chemical compound CCC[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2 HDTPZWYGAVLHRK-CALCHBBNSA-N 0.000 description 1
- FCLNXUSXKVWEGG-XUGKJROYSA-N CCC[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NC2=O.CCC[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NC2=O.CCC[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2.CCC[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)NC(=O)NC2=O.CCN=C1CCC2(CC1)OCCO2.CCNC1(C2=CC=CC=C2)CCC(=O)CC1.CCNC1(C2=CC=CC=C2)CCC2(CC1)OCCO2.Cl.O=C1CCC2(CC1)OCCO2 Chemical compound CCC[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NC2=O.CCC[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)NC(=O)NC2=O.CCC[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2.CCC[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)NC(=O)NC2=O.CCN=C1CCC2(CC1)OCCO2.CCNC1(C2=CC=CC=C2)CCC(=O)CC1.CCNC1(C2=CC=CC=C2)CCC2(CC1)OCCO2.Cl.O=C1CCC2(CC1)OCCO2 FCLNXUSXKVWEGG-XUGKJROYSA-N 0.000 description 1
- ILJIPUJJYUSUTD-ZRZAMGCNSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2C Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2C ILJIPUJJYUSUTD-ZRZAMGCNSA-N 0.000 description 1
- LMSSRWPVQJMNEG-MKPDMIMOSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CCC1 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CCC1 LMSSRWPVQJMNEG-MKPDMIMOSA-N 0.000 description 1
- WMPYFZMPLXAUKI-SZPZYZBQSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 WMPYFZMPLXAUKI-SZPZYZBQSA-N 0.000 description 1
- UBTGLYHAJPYFPU-ZRZAMGCNSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2C Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2C UBTGLYHAJPYFPU-ZRZAMGCNSA-N 0.000 description 1
- XEMGIQPBMSNWHD-LDNJAJMQSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 XEMGIQPBMSNWHD-LDNJAJMQSA-N 0.000 description 1
- HUAGLEFIEYQSFB-ZTJXZFIRSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)CC)CC2)N(CC2(O)CCC2)C1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)CC)CC2)NC1=O Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)CC)CC2)N(CC2(O)CCC2)C1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)CC)CC2)NC1=O HUAGLEFIEYQSFB-ZTJXZFIRSA-N 0.000 description 1
- JYISQYXXOIFAQU-MKPDMIMOSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 JYISQYXXOIFAQU-MKPDMIMOSA-N 0.000 description 1
- QOOLZRHJRVJBOG-DLJSHSNLSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1.CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1.CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1.CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1.CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1 QOOLZRHJRVJBOG-DLJSHSNLSA-N 0.000 description 1
- WPOZHHVGJUCWFL-IYARVYRRSA-N CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)C2 Chemical compound CCN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)C2 WPOZHHVGJUCWFL-IYARVYRRSA-N 0.000 description 1
- VTYCOLALETXHKD-HDICACEKSA-N CCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound CCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 VTYCOLALETXHKD-HDICACEKSA-N 0.000 description 1
- JJYDCXFYYCNDHU-OYRHEFFESA-N CCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 Chemical compound CCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 JJYDCXFYYCNDHU-OYRHEFFESA-N 0.000 description 1
- PKWYLMKJQPYABQ-OYRHEFFESA-N CCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 Chemical compound CCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 PKWYLMKJQPYABQ-OYRHEFFESA-N 0.000 description 1
- QGZULSXZLHNTIK-WMPKNSHKSA-N CCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 Chemical compound CCN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 QGZULSXZLHNTIK-WMPKNSHKSA-N 0.000 description 1
- KTUJDHIVGYUTGQ-UHFFFAOYSA-N CCOC(=O)C1CC(C#N)(C2=NC=CC=C2)CCC1=O.N#CC1(C2=NC=CC=C2)CCC(=O)CC1.N#CCC1=NC=CC=C1 Chemical compound CCOC(=O)C1CC(C#N)(C2=NC=CC=C2)CCC1=O.N#CC1(C2=NC=CC=C2)CCC(=O)CC1.N#CCC1=NC=CC=C1 KTUJDHIVGYUTGQ-UHFFFAOYSA-N 0.000 description 1
- CTQQNFCCLUITBF-PLQXJYEYSA-N CN(C)C(=O)CCN1C[C@]2(CC[C@](C3=CC(F)=CC=C3)(N(C)C)CC2)N(CC2CC2)C1=O Chemical compound CN(C)C(=O)CCN1C[C@]2(CC[C@](C3=CC(F)=CC=C3)(N(C)C)CC2)N(CC2CC2)C1=O CTQQNFCCLUITBF-PLQXJYEYSA-N 0.000 description 1
- GLFIIPIRIREFLU-ZARUUYCLSA-M CN(C)C(=O)CCN1C[C@]2(CC[C@](C3=CC=CC(F)=C3)(N(C)C)CC2)N(CC2CC2)C1=O.CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CN(CCC(=O)[Na]O)C(=O)N2CC1CC1.CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 Chemical compound CN(C)C(=O)CCN1C[C@]2(CC[C@](C3=CC=CC(F)=C3)(N(C)C)CC2)N(CC2CC2)C1=O.CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CN(CCC(=O)[Na]O)C(=O)N2CC1CC1.CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 GLFIIPIRIREFLU-ZARUUYCLSA-M 0.000 description 1
- JDYPYUQIRJOJOP-UHFFFAOYSA-N CN(C)C(CC1)(CCC1(CN1)NC1=O)C#N Chemical compound CN(C)C(CC1)(CCC1(CN1)NC1=O)C#N JDYPYUQIRJOJOP-UHFFFAOYSA-N 0.000 description 1
- OGSDLIAKYFZEGW-UHFFFAOYSA-N CN(C)C1(C#N)CCC2(CC1)CNC(=O)N2.O=C1CCC2(CC1)CNC(=O)N2.O=C1NC(=O)C2(CCC3(CC2)OCCO3)N1.O=C1NCC2(CCC3(CC2)OCCO3)N1 Chemical compound CN(C)C1(C#N)CCC2(CC1)CNC(=O)N2.O=C1CCC2(CC1)CNC(=O)N2.O=C1NC(=O)C2(CCC3(CC2)OCCO3)N1.O=C1NCC2(CCC3(CC2)OCCO3)N1 OGSDLIAKYFZEGW-UHFFFAOYSA-N 0.000 description 1
- BVQCYMYEGQJUCE-UHFFFAOYSA-N CN(C)C1(C#N)CCC2(CC1)OCCO2.CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)C1(C2=CC=CC=C2)CCC2(CC1)OCCO2.O=C1CCC2(CC1)OCCO2 Chemical compound CN(C)C1(C#N)CCC2(CC1)OCCO2.CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)C1(C2=CC=CC=C2)CCC2(CC1)OCCO2.O=C1CCC2(CC1)OCCO2 BVQCYMYEGQJUCE-UHFFFAOYSA-N 0.000 description 1
- FCNMFIASRXITOQ-YCOHQTMZSA-N CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)C1(C2=CC=CC=C2)CCC2(CC1)CNC(=O)N2.CN(C)C1(C2=CC=CC=C2)CCC2(CC1)NC(=O)NC2=O.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)C1(C2=CC=CC=C2)CCC2(CC1)CNC(=O)N2.CN(C)C1(C2=CC=CC=C2)CCC2(CC1)NC(=O)NC2=O.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 FCNMFIASRXITOQ-YCOHQTMZSA-N 0.000 description 1
- JEROXGFNMKTBEG-KACWVIIFSA-N CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)NC(=O)NC2=O Chemical compound CN(C)C1(C2=CC=CC=C2)CCC(=O)CC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)NC(=O)NC2=O JEROXGFNMKTBEG-KACWVIIFSA-N 0.000 description 1
- MWFVWRDGDVLNIJ-UHFFFAOYSA-N CN(C)C1(C2=CC=CS2)CCC(=O)CC1 Chemical compound CN(C)C1(C2=CC=CS2)CCC(=O)CC1 MWFVWRDGDVLNIJ-UHFFFAOYSA-N 0.000 description 1
- NRXBCVRFSOXKBZ-UHFFFAOYSA-N CN(C)C1(C2=NC=CC=C2)CCC(=O)CC1.COC(=O)NC1(C2=NC=CC=C2)CCC2(CC1)OCCO2.N#CC1(C2=NC=CC=C2)CCC(=O)CC1.N#CC1(C2=NC=CC=C2)CCC2(CC1)OCCO2.NC(=O)C1(C2=NC=CC=C2)CCC2(CC1)OCCO2.NC1(C2=NC=CC=C2)CCC2(CC1)OCCO2 Chemical compound CN(C)C1(C2=NC=CC=C2)CCC(=O)CC1.COC(=O)NC1(C2=NC=CC=C2)CCC2(CC1)OCCO2.N#CC1(C2=NC=CC=C2)CCC(=O)CC1.N#CC1(C2=NC=CC=C2)CCC2(CC1)OCCO2.NC(=O)C1(C2=NC=CC=C2)CCC2(CC1)OCCO2.NC1(C2=NC=CC=C2)CCC2(CC1)OCCO2 NRXBCVRFSOXKBZ-UHFFFAOYSA-N 0.000 description 1
- GOBRHSNCPYYXSB-UHFFFAOYSA-N CN(C)C1(C2=NC=CN=C2)CCC(=O)CC1 Chemical compound CN(C)C1(C2=NC=CN=C2)CCC(=O)CC1 GOBRHSNCPYYXSB-UHFFFAOYSA-N 0.000 description 1
- SOQQQHJQTOJEOW-UHFFFAOYSA-N CN(C)C1(CC2=CC=CC=C2)CCC(=O)CC1 Chemical compound CN(C)C1(CC2=CC=CC=C2)CCC(=O)CC1 SOQQQHJQTOJEOW-UHFFFAOYSA-N 0.000 description 1
- HGSIGDMRMZBEEU-OYRHEFFESA-N CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC2CCC2)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1)N(CC2CCC2)C1=O)c1ccccc1 HGSIGDMRMZBEEU-OYRHEFFESA-N 0.000 description 1
- UOJBBXGJZRHFCE-UETHYEEUSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1CCC(N2Cc3ncn[n]3CC2)=O)N(CC2CCC2)C1O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1CCC(N2Cc3ncn[n]3CC2)=O)N(CC2CCC2)C1O)c1ccccc1 UOJBBXGJZRHFCE-UETHYEEUSA-N 0.000 description 1
- LTWIXTDRAFZAPF-ISILISOKSA-N CN(C)[C@](CC1)(CC[C@@]1(CN1Cc(cc2)ccc2OC)N(CC2CCC2)C1=O)c1ccccc1 Chemical compound CN(C)[C@](CC1)(CC[C@@]1(CN1Cc(cc2)ccc2OC)N(CC2CCC2)C1=O)c1ccccc1 LTWIXTDRAFZAPF-ISILISOKSA-N 0.000 description 1
- TTXXMDGWIWSWFJ-PLQXJYEYSA-N CN(C)[C@]1(C2=CC(F)=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC(F)=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CC1 TTXXMDGWIWSWFJ-PLQXJYEYSA-N 0.000 description 1
- JJODJBUGAYAMHN-OKILXGFUSA-N CN(C)[C@]1(C2=CC=C(Cl)S2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=C(Cl)S2)CC[C@]2(CC1)CNC(=O)N2 JJODJBUGAYAMHN-OKILXGFUSA-N 0.000 description 1
- NODDPJDKVOQNJT-IYBDPMFKSA-N CN(C)[C@]1(C2=CC=C(F)C=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=C(F)C=C2)CC[C@]2(CC1)CNC(=O)N2 NODDPJDKVOQNJT-IYBDPMFKSA-N 0.000 description 1
- QKBKXSRRKYXSHF-IYBDPMFKSA-N CN(C)[C@]1(C2=CC=CC(C(F)(F)F)=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC(C(F)(F)F)=C2)CC[C@]2(CC1)CNC(=O)N2 QKBKXSRRKYXSHF-IYBDPMFKSA-N 0.000 description 1
- ZRBAFZXGNDDDBU-IYBDPMFKSA-N CN(C)[C@]1(C2=CC=CC(Cl)=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC(Cl)=C2)CC[C@]2(CC1)CNC(=O)N2 ZRBAFZXGNDDDBU-IYBDPMFKSA-N 0.000 description 1
- JRCJVXKVCDKQGZ-IYBDPMFKSA-N CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2 JRCJVXKVCDKQGZ-IYBDPMFKSA-N 0.000 description 1
- XOBLTQWYFPJFPW-OEANFSLJSA-N CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C)CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(F)=C4)(N(C)C)CC3)N(CC3(C)CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(F)=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C)CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(F)=C4)(N(C)C)CC3)N(CC3(C)CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(F)=C4)(N(C)C)CC3)NC2=O)C=C1 XOBLTQWYFPJFPW-OEANFSLJSA-N 0.000 description 1
- UIJPVGKIXCWNMB-TYKWCNGQSA-N CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1(O)CCC1 UIJPVGKIXCWNMB-TYKWCNGQSA-N 0.000 description 1
- IDCFFWNUAWPGTH-BGYRXZFFSA-N CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC(F)=C2)CC[C@]2(CC1)CNC(=O)N2CC1CC1 IDCFFWNUAWPGTH-BGYRXZFFSA-N 0.000 description 1
- RXWLBWHJUMFRIW-IYBDPMFKSA-N CN(C)[C@]1(C2=CC=CC(OC(F)(F)F)=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC(OC(F)(F)F)=C2)CC[C@]2(CC1)CNC(=O)N2 RXWLBWHJUMFRIW-IYBDPMFKSA-N 0.000 description 1
- BRHFVBVCHLLBKF-SOAUALDESA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CC1 BRHFVBVCHLLBKF-SOAUALDESA-N 0.000 description 1
- DVIDJHWMPIJRPZ-MEMLXQNLSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 DVIDJHWMPIJRPZ-MEMLXQNLSA-N 0.000 description 1
- MSOGFJAJGAAARV-YOCNBXQISA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 MSOGFJAJGAAARV-YOCNBXQISA-N 0.000 description 1
- NXMMTORUUDSGTH-AYCAFKJYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)C2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)C2CC1CC1 NXMMTORUUDSGTH-AYCAFKJYSA-N 0.000 description 1
- ZWPXGMYPZDYTFI-ABXOJXOFSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2 ZWPXGMYPZDYTFI-ABXOJXOFSA-N 0.000 description 1
- HGSIGDMRMZBEEU-MEMLXQNLSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2CC1CCC1 HGSIGDMRMZBEEU-MEMLXQNLSA-N 0.000 description 1
- CYCVGAXNNKFRKC-OYRHEFFESA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 CYCVGAXNNKFRKC-OYRHEFFESA-N 0.000 description 1
- CSWOPIPZLPXWIC-FIBVIPKVSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)O)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)O)C(=O)N2CC1(O)CCC1 CSWOPIPZLPXWIC-FIBVIPKVSA-N 0.000 description 1
- BRHFVBVCHLLBKF-PLQXJYEYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CC1 BRHFVBVCHLLBKF-PLQXJYEYSA-N 0.000 description 1
- GFWFBBAARAWDFH-DNCSFDTKSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)O)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)O)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1 GFWFBBAARAWDFH-DNCSFDTKSA-N 0.000 description 1
- XAXFGHSYJWAJOA-KRKINAOUSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCOCC1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCOCC1)C(=O)N2CC1(O)CCC1 XAXFGHSYJWAJOA-KRKINAOUSA-N 0.000 description 1
- OTWMEMVARBDDOS-KRKINAOUSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCS(=O)(=O)CC1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCS(=O)(=O)CC1)C(=O)N2CC1(O)CCC1 OTWMEMVARBDDOS-KRKINAOUSA-N 0.000 description 1
- CAQGDJHSSCFMSM-IPPIPOLYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCS(=O)(=O)CC1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCSCC1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCS(=O)(=O)CC1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)N1CCSCC1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 CAQGDJHSSCFMSM-IPPIPOLYSA-N 0.000 description 1
- FJRVNIAFJKDOHQ-HNRBIFIRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC1CCC1 FJRVNIAFJKDOHQ-HNRBIFIRSA-N 0.000 description 1
- GUCJWVSKXSGYOM-XCQYSIBYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)O)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)O)C(=O)N2CC1CCC1 GUCJWVSKXSGYOM-XCQYSIBYSA-N 0.000 description 1
- DRMJYICTFBHWLA-DBAYTGFXSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCCO)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCCO)C(=O)N2CC1(O)CCC1 DRMJYICTFBHWLA-DBAYTGFXSA-N 0.000 description 1
- DVIDJHWMPIJRPZ-OYRHEFFESA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 DVIDJHWMPIJRPZ-OYRHEFFESA-N 0.000 description 1
- CJJNDFMHJQGFNW-MKPDMIMOSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(C#N)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(C#N)CCC1 CJJNDFMHJQGFNW-MKPDMIMOSA-N 0.000 description 1
- AIOVCAOMXWLQBG-PLQXJYEYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(F)CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(F)CC1 AIOVCAOMXWLQBG-PLQXJYEYSA-N 0.000 description 1
- MSOGFJAJGAAARV-OGLKEZPNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 MSOGFJAJGAAARV-OGLKEZPNSA-N 0.000 description 1
- NRUOPTKUUXVRSH-PLQXJYEYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CC1 NRUOPTKUUXVRSH-PLQXJYEYSA-N 0.000 description 1
- MRYOMMAJGAGKJH-PLQXJYEYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1COC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1COC1 MRYOMMAJGAGKJH-PLQXJYEYSA-N 0.000 description 1
- SNCGFVFZQOJFNH-PLQXJYEYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1(C(N)=O)CC1)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1(C(N)=O)CC1)C(=O)N2CC1CC1 SNCGFVFZQOJFNH-PLQXJYEYSA-N 0.000 description 1
- NHPAXJUXUACACI-PLQXJYEYSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1(C(N)=O)COC1)C(=O)N2CC1CC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1(C(N)=O)COC1)C(=O)N2CC1CC1 NHPAXJUXUACACI-PLQXJYEYSA-N 0.000 description 1
- UGMHTGXNTSNAJX-ZRZAMGCNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2 UGMHTGXNTSNAJX-ZRZAMGCNSA-N 0.000 description 1
- ROOGJRTXASWVHE-HNRBIFIRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC1=CC=CC=C1)C(=O)N2CC1CCC1 ROOGJRTXASWVHE-HNRBIFIRSA-N 0.000 description 1
- PCXXTRJTXRHCFM-ISILISOKSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1CCN3N=CN=C3C1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1CCN3N=CN=C3C1)C(=O)N2CC1CCC1 PCXXTRJTXRHCFM-ISILISOKSA-N 0.000 description 1
- BTBUCHFRHHXMNB-YFVZOPNBSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1CC[C@H](O)[C@@H](O)C1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1CC[C@H](O)[C@@H](O)C1)C(=O)N2CC1CCC1 BTBUCHFRHHXMNB-YFVZOPNBSA-N 0.000 description 1
- ZRAJKPPXGGEZII-NQPYUKKHSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1C[C@H](O)[C@@H](O)C1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1C[C@H](O)[C@@H](O)C1)C(=O)N2CC1CCC1 ZRAJKPPXGGEZII-NQPYUKKHSA-N 0.000 description 1
- ZRAJKPPXGGEZII-GQYOUUAKSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1C[C@H](O)[C@H](O)C1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)N1C[C@H](O)[C@H](O)C1)C(=O)N2CC1CCC1 ZRAJKPPXGGEZII-GQYOUUAKSA-N 0.000 description 1
- AIWJUCVNYRUQNX-GVXFMRKGSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=C(S(C)=O)C=N1)C(=O)N2CC1CCC1.O Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=C(S(C)=O)C=N1)C(=O)N2CC1CCC1.O AIWJUCVNYRUQNX-GVXFMRKGSA-N 0.000 description 1
- AHHGQHRZXVYIEN-DBAYTGFXSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=CN=N1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=CN=N1)C(=O)N2CC1(O)CCC1 AHHGQHRZXVYIEN-DBAYTGFXSA-N 0.000 description 1
- YKGHIJILEURQFN-JSEFLNQRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=NC=C1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=NC=C1)C(=O)N2CC1(O)CCC1 YKGHIJILEURQFN-JSEFLNQRSA-N 0.000 description 1
- HWJLLSBMWQIRHE-HKIJYHEPSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CN=C(C#N)N=C1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CN=C(C#N)N=C1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1(O)CCC1 HWJLLSBMWQIRHE-HKIJYHEPSA-N 0.000 description 1
- LEVXXVNOJPJUGS-DBAYTGFXSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CN=CN=C1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CN=CN=C1)C(=O)N2CC1(O)CCC1 LEVXXVNOJPJUGS-DBAYTGFXSA-N 0.000 description 1
- HROWLTWBFIPELA-DBAYTGFXSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=NC(O)=CC=N1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=NC(O)=CC=N1)C(=O)N2CC1(O)CCC1 HROWLTWBFIPELA-DBAYTGFXSA-N 0.000 description 1
- FKJOOBSAOARFLR-DBAYTGFXSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=NC=CC=N1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=NC=CC=N1)C(=O)N2CC1(O)CCC1 FKJOOBSAOARFLR-DBAYTGFXSA-N 0.000 description 1
- YKRJBPXNVMBEOH-LDNJAJMQSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1 YKRJBPXNVMBEOH-LDNJAJMQSA-N 0.000 description 1
- HFMIBULIXRFPDB-GGXWNNGUSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1(O)CCC1 HFMIBULIXRFPDB-GGXWNNGUSA-N 0.000 description 1
- LKRYNLHCDBNCQT-WQHFNAMMSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1.CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1.CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1 LKRYNLHCDBNCQT-WQHFNAMMSA-N 0.000 description 1
- ONBDWRNVEZUWIA-JSEFLNQRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCC1(O)CCC1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCC1(O)CCC1)C(=O)N2CC1CCC1 ONBDWRNVEZUWIA-JSEFLNQRSA-N 0.000 description 1
- FFKWBIALZLNQJR-HNRBIFIRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCC1=CN=CO1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCC1=CN=CO1)C(=O)N2CC1CCC1 FFKWBIALZLNQJR-HNRBIFIRSA-N 0.000 description 1
- CVIYVJAIWBCRLD-HNRBIFIRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCC1=NC=CO1)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCC1=NC=CO1)C(=O)N2CC1CCC1 CVIYVJAIWBCRLD-HNRBIFIRSA-N 0.000 description 1
- FTUVSEPBRRWMFK-OGLKEZPNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCCO)C(=O)N2CC1(O)CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NCCO)C(=O)N2CC1(O)CCC1 FTUVSEPBRRWMFK-OGLKEZPNSA-N 0.000 description 1
- SIWQPRUYWWLXLY-SNUJQULESA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)OC(C)(C)C)C(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1(O)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)OC(C)(C)C)C(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 SIWQPRUYWWLXLY-SNUJQULESA-N 0.000 description 1
- SNXKVHHPFXBOPE-IQOLNJGKSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)OC(C)(C)C)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.O=C(O)C(F)(F)F Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)OC(C)(C)C)C(=O)N2CC1CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.O=C(O)C(F)(F)F SNXKVHHPFXBOPE-IQOLNJGKSA-N 0.000 description 1
- DSOPIPQTMVKCTD-KLLIIFEOSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1CCC1.COC1=CC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=CC=N1.O=C(O)C(F)(F)F Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)O)C(=O)N2CC1CCC1.COC1=CC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=CC=N1.O=C(O)C(F)(F)F DSOPIPQTMVKCTD-KLLIIFEOSA-N 0.000 description 1
- WZVUICBCXWPOIM-PSWAGMNNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1CCC1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1CCC1 WZVUICBCXWPOIM-PSWAGMNNSA-N 0.000 description 1
- ZWPXGMYPZDYTFI-IWDCYMRNSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 ZWPXGMYPZDYTFI-IWDCYMRNSA-N 0.000 description 1
- SXPDQRKVJXDRPL-FJZXDREZSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 SXPDQRKVJXDRPL-FJZXDREZSA-N 0.000 description 1
- DOCIVHZRSAVBEH-OHDIVAPBSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC(=O)O.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC(=O)OC(C)(C)C)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1.O=C(O)C(F)(F)F Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC(=O)O.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC(=O)OC(C)(C)C)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1.O=C(O)C(F)(F)F DOCIVHZRSAVBEH-OHDIVAPBSA-N 0.000 description 1
- PGQAECBTSNCFQC-PZZVVJTASA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C#N)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C(N)=O)CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(C#N)CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C#N)CCC1.CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(C(N)=O)CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(C#N)CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 PGQAECBTSNCFQC-PZZVVJTASA-N 0.000 description 1
- XTOFPDULVYSIOU-QLATVXGRSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(O)CCC1.COC1=C(OC)C=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(OCC4=CC=CC=C4)CCC3)C2=O)C=C1.COC1=C(OC)C=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1(O)CCC1.COC1=C(OC)C=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(OCC4=CC=CC=C4)CCC3)C2=O)C=C1.COC1=C(OC)C=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 XTOFPDULVYSIOU-QLATVXGRSA-N 0.000 description 1
- ZTMIIBCRCDMRSM-HFCHJGAVSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1 Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CC1CCC1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1 ZTMIIBCRCDMRSM-HFCHJGAVSA-N 0.000 description 1
- YQLJETOWZKVMJZ-HDICACEKSA-N CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CCC(F)(F)F Chemical compound CN(C)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2CCC(F)(F)F YQLJETOWZKVMJZ-HDICACEKSA-N 0.000 description 1
- LCLNQGFHMKVZDG-HDJSIYSDSA-N CN(C)[C@]1(C2=CC=CS2)CC[C@@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CS2)CC[C@@]2(CC1)CNC(=O)N2 LCLNQGFHMKVZDG-HDJSIYSDSA-N 0.000 description 1
- LCLNQGFHMKVZDG-OKILXGFUSA-N CN(C)[C@]1(C2=CC=CS2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(C2=CC=CS2)CC[C@]2(CC1)CNC(=O)N2 LCLNQGFHMKVZDG-OKILXGFUSA-N 0.000 description 1
- TVRKUNRXMWDNQB-QAQDUYKDSA-N CN(C)[C@]1(CC2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(CC2=CC=CC=C2)CC[C@@]2(CC1)CNC(=O)N2 TVRKUNRXMWDNQB-QAQDUYKDSA-N 0.000 description 1
- TVRKUNRXMWDNQB-CALCHBBNSA-N CN(C)[C@]1(CC2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(C)[C@]1(CC2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 TVRKUNRXMWDNQB-CALCHBBNSA-N 0.000 description 1
- WSVHWFZWBTYMNN-KDURUIRLSA-N CN(CC1COC1)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN(CC1COC1)[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CNC(=O)N2 WSVHWFZWBTYMNN-KDURUIRLSA-N 0.000 description 1
- UDKBWGQFDQVUGM-UHFFFAOYSA-N CN1C(C2(N(C)C)CCC(=O)CC2)=NC2=C1C=CC=C2 Chemical compound CN1C(C2(N(C)C)CCC(=O)CC2)=NC2=C1C=CC=C2 UDKBWGQFDQVUGM-UHFFFAOYSA-N 0.000 description 1
- TZNQWEYVUZTFJM-IYARVYRRSA-N CN1C2=C(C=CC=C2)N=C1[C@]1(N(C)C)CC[C@]2(CC1)CNC(=O)N2 Chemical compound CN1C2=C(C=CC=C2)N=C1[C@]1(N(C)C)CC[C@]2(CC1)CNC(=O)N2 TZNQWEYVUZTFJM-IYARVYRRSA-N 0.000 description 1
- CMRTVWARCMJAKN-UHFFFAOYSA-N CN1C=CC(C2(C#N)CCC(=O)CC2)=N1 Chemical compound CN1C=CC(C2(C#N)CCC(=O)CC2)=N1 CMRTVWARCMJAKN-UHFFFAOYSA-N 0.000 description 1
- XQMYRHKNNWRZEC-UHFFFAOYSA-N CN1C=CC(C2(N(C)C)CCC(=O)CC2)=N1 Chemical compound CN1C=CC(C2(N(C)C)CCC(=O)CC2)=N1 XQMYRHKNNWRZEC-UHFFFAOYSA-N 0.000 description 1
- PODLHIKHMUVXMR-QUPDYRNUSA-N CNC(=O)CCN1C[C@]2(CC[C@@](NC)(C3=CC=CC=C3)CC2)N(CC2(O)CCC2)C1=O Chemical compound CNC(=O)CCN1C[C@]2(CC[C@@](NC)(C3=CC=CC=C3)CC2)N(CC2(O)CCC2)C1=O PODLHIKHMUVXMR-QUPDYRNUSA-N 0.000 description 1
- SWSSWQUDIVGOJZ-GUOBSTCESA-N CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2(O)CCC2)C1=O Chemical compound CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2(O)CCC2)C1=O SWSSWQUDIVGOJZ-GUOBSTCESA-N 0.000 description 1
- SKGCOQWAHFXDAF-PLQXJYEYSA-N CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2CCC2)C1=O Chemical compound CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2CCC2)C1=O SKGCOQWAHFXDAF-PLQXJYEYSA-N 0.000 description 1
- ZEZDQSMRILMTLS-HNRBIFIRSA-N CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)CC(C)C)CC2)N(CC2CCC2)C1=O Chemical compound CNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)CC(C)C)CC2)N(CC2CCC2)C1=O ZEZDQSMRILMTLS-HNRBIFIRSA-N 0.000 description 1
- YMYPOVUFRKKUIR-BGYRXZFFSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C#N)C(=O)N2 YMYPOVUFRKKUIR-BGYRXZFFSA-N 0.000 description 1
- QLFNECQENPMPBT-MKPDMIMOSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC1CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(=O)NCC(N)=O)C(=O)N2CC1CCC1 QLFNECQENPMPBT-MKPDMIMOSA-N 0.000 description 1
- BDRAJENDQZJWOH-BGYRXZFFSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2 BDRAJENDQZJWOH-BGYRXZFFSA-N 0.000 description 1
- MNELUQLHZZBLAJ-GUOBSTCESA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1(O)CCC1 MNELUQLHZZBLAJ-GUOBSTCESA-N 0.000 description 1
- VQOBOLYOZYRPSA-PSWAGMNNSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CC1 VQOBOLYOZYRPSA-PSWAGMNNSA-N 0.000 description 1
- GUMMFZOOOHLHAS-PLQXJYEYSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CC(C)(C)C(N)=O)C(=O)N2CC1CCC1 GUMMFZOOOHLHAS-PLQXJYEYSA-N 0.000 description 1
- XGXYPECOPWANJS-LDNJAJMQSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=CN=N1)C(=O)N2CC1(O)CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=CC=CN=N1)C(=O)N2CC1(O)CCC1 XGXYPECOPWANJS-LDNJAJMQSA-N 0.000 description 1
- VRBZDUOLYNBYSE-DBAYTGFXSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=NC=CC=C1)C(=O)N2CC1(O)CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1=NC=CC=C1)C(=O)N2CC1(O)CCC1 VRBZDUOLYNBYSE-DBAYTGFXSA-N 0.000 description 1
- YCGCAMXDQJPJFZ-OGLKEZPNSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(=O)NC1COC1)C(=O)N2CC1(O)CCC1 YCGCAMXDQJPJFZ-OGLKEZPNSA-N 0.000 description 1
- LXIFJNDEWNTBPF-DKXQDJALSA-N CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1(O)CCC1 Chemical compound CN[C@]1(C2=CC=CC=C2)CC[C@]2(CC1)CN(CCC(N)=O)C(=O)N2CC1(O)CCC1 LXIFJNDEWNTBPF-DKXQDJALSA-N 0.000 description 1
- SRQHJAXVYLDQIH-RNPORBBMSA-N COC1=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=CN=C1 Chemical compound COC1=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=CN=C1 SRQHJAXVYLDQIH-RNPORBBMSA-N 0.000 description 1
- DIFSATBFVKGPKV-UHFFFAOYSA-N COC1=CC(C2(N(C)C)CCC(=O)CC2)=CC=C1 Chemical compound COC1=CC(C2(N(C)C)CCC(=O)CC2)=CC=C1 DIFSATBFVKGPKV-UHFFFAOYSA-N 0.000 description 1
- ZLHHKTICBVRBDR-RNPORBBMSA-N COC1=CC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=CC=N1 Chemical compound COC1=CC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=CC=N1 ZLHHKTICBVRBDR-RNPORBBMSA-N 0.000 description 1
- YNQNTDHIBFUDOR-UHFFFAOYSA-N COC1=CC=C(CN2C(=O)NC3(CCC4(CC3)OCCO4)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC(=O)CC3)NC2=O)C=C1.COC1=CC=C(CN2CC3(CCC4(CC3)OCCO4)NC2=O)C=C1.O=C1CCC2(CC1)OCCO2.O=C1NC(=O)C2(CCC3(CC2)OCCO3)N1 Chemical compound COC1=CC=C(CN2C(=O)NC3(CCC4(CC3)OCCO4)C2=O)C=C1.COC1=CC=C(CN2CC3(CCC(=O)CC3)NC2=O)C=C1.COC1=CC=C(CN2CC3(CCC4(CC3)OCCO4)NC2=O)C=C1.O=C1CCC2(CC1)OCCO2.O=C1NC(=O)C2(CCC3(CC2)OCCO3)N1 YNQNTDHIBFUDOR-UHFFFAOYSA-N 0.000 description 1
- PUYZUJPEPOWCBI-RMVGASQLSA-N COC1=CC=C(CN2CC3(CCC(=O)CC3)NC2=O)C=C1.COC1=CC=C(CN2CC3(CCC(C#N)(N(C)C)CC3)NC2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(F)=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound COC1=CC=C(CN2CC3(CCC(=O)CC3)NC2=O)C=C1.COC1=CC=C(CN2CC3(CCC(C#N)(N(C)C)CC3)NC2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(F)=C4)(N(C)C)CC3)NC2=O)C=C1 PUYZUJPEPOWCBI-RMVGASQLSA-N 0.000 description 1
- YSJKGOYGPSKNGB-ISILISOKSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=C(O)C=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1 Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=C(O)C=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1 YSJKGOYGPSKNGB-ISILISOKSA-N 0.000 description 1
- SXAGLSCQRQEMTA-PLQXJYEYSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=C(OC)C=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=C(OC)C=C4)(N(C)C)CC3)NC2=O)C=C1 SXAGLSCQRQEMTA-PLQXJYEYSA-N 0.000 description 1
- PSAKXDMCNQHWLB-ARMFMHIHSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(O)=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1.COCOC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC2=CC=C(OC)C=C2)C(=O)N3)=CC=C1.COCOC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC2=CC=C(OC)C=C2)C(=O)N3CC2CCC2)=CC=C1 Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(O)=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1.COCOC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC2=CC=C(OC)C=C2)C(=O)N3)=CC=C1.COCOC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC2=CC=C(OC)C=C2)C(=O)N3CC2CCC2)=CC=C1 PSAKXDMCNQHWLB-ARMFMHIHSA-N 0.000 description 1
- JESRFVWPARRVJH-PLQXJYEYSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(OC)=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC(OC)=C4)(N(C)C)CC3)NC2=O)C=C1 JESRFVWPARRVJH-PLQXJYEYSA-N 0.000 description 1
- OLCNWYAAMVWJTM-DIVCQZSQSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)CC2=O)C=C1OC Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)CC2=O)C=C1OC OLCNWYAAMVWJTM-DIVCQZSQSA-N 0.000 description 1
- VIHCJXKWCTXBQW-XRAMAGQNSA-N COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 Chemical compound COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=C1.COC1=CC=C(CN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)NC2=O)C=C1 VIHCJXKWCTXBQW-XRAMAGQNSA-N 0.000 description 1
- JYFCNVBRYWQGRO-RNPORBBMSA-N COC1=CC=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=N1 Chemical compound COC1=CC=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)C=N1 JYFCNVBRYWQGRO-RNPORBBMSA-N 0.000 description 1
- MTMUABNOJFBMIQ-RNPORBBMSA-N COC1=CC=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)N=C1 Chemical compound COC1=CC=C(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)N=C1 MTMUABNOJFBMIQ-RNPORBBMSA-N 0.000 description 1
- IHMAVEDYKGGXJW-JSEFLNQRSA-N COC1=CC=NC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(O)CCC3)C2=O)=N1 Chemical compound COC1=CC=NC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3(O)CCC3)C2=O)=N1 IHMAVEDYKGGXJW-JSEFLNQRSA-N 0.000 description 1
- BJEFFGUPZYOXJH-RNPORBBMSA-N COC1=CC=NC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=C1 Chemical compound COC1=CC=NC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=C1 BJEFFGUPZYOXJH-RNPORBBMSA-N 0.000 description 1
- UHAGPISESJHKSD-ISILISOKSA-N COC1=CN=CC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=N1 Chemical compound COC1=CN=CC(NC(=O)CCN2C[C@]3(CC[C@](C4=CC=CC=C4)(N(C)C)CC3)N(CC3CCC3)C2=O)=N1 UHAGPISESJHKSD-ISILISOKSA-N 0.000 description 1
- HZZRQQGEOJSDSR-PLQXJYEYSA-N COCCCN1C(=O)N(CC(C)(C)C#N)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CC(C)(C)C#N)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 HZZRQQGEOJSDSR-PLQXJYEYSA-N 0.000 description 1
- YZSNXWWRCUGBTG-XMUIDLTISA-N COCCCN1C(=O)N(CC(C)(C)C#N)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.COCCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CC(C)(C)C#N)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.COCCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 YZSNXWWRCUGBTG-XMUIDLTISA-N 0.000 description 1
- RDNDOROHEDXCDD-PLQXJYEYSA-N COCCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 RDNDOROHEDXCDD-PLQXJYEYSA-N 0.000 description 1
- ALDCVMUHAYSEME-YGQVVATNSA-N COCCCN1C(=O)N(CCC(=O)N2CCCC2C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CCC(=O)N2CCCC2C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 ALDCVMUHAYSEME-YGQVVATNSA-N 0.000 description 1
- QFUQTOQNRCNUSM-MKPDMIMOSA-N COCCCN1C(=O)N(CCC(=O)N2CCNC(=O)C2)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CCC(=O)N2CCNC(=O)C2)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 QFUQTOQNRCNUSM-MKPDMIMOSA-N 0.000 description 1
- SHICPBZCHUDZKM-MKPDMIMOSA-N COCCCN1C(=O)N(CCC(=O)NC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CCC(=O)NC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 SHICPBZCHUDZKM-MKPDMIMOSA-N 0.000 description 1
- RQVJFABWBLBKOD-PLQXJYEYSA-N COCCCN1C(=O)N(CCC(=O)NCC(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CCC(=O)NCC(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 RQVJFABWBLBKOD-PLQXJYEYSA-N 0.000 description 1
- ZQXBRDROAFOOML-PLQXJYEYSA-N COCCCN1C(=O)N(CCC(=O)NCCO)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)N(CCC(=O)NCCO)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 ZQXBRDROAFOOML-PLQXJYEYSA-N 0.000 description 1
- PNMUKKTVKAFDTI-MZOQLALFSA-N COCCCN1C(=O)N(CCC(=O)NCCS(C)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O Chemical compound COCCCN1C(=O)N(CCC(=O)NCCS(C)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O PNMUKKTVKAFDTI-MZOQLALFSA-N 0.000 description 1
- UGOKRSGZFHZXMB-ZRZAMGCNSA-N COCCCN1C(=O)N(CCC(=O)O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O=C(O)C(F)(F)F Chemical compound COCCCN1C(=O)N(CCC(=O)O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O=C(O)C(F)(F)F UGOKRSGZFHZXMB-ZRZAMGCNSA-N 0.000 description 1
- UMNBKYXXMOXLCV-BGYRXZFFSA-N COCCCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 UMNBKYXXMOXLCV-BGYRXZFFSA-N 0.000 description 1
- YORZABKEBRCBTH-SZPZYZBQSA-N COCCC[C@]1(N(C)C)CC[C@@]2(CC1)CN(CC1=CC=C(OC)C=C1)C(=O)N2 Chemical compound COCCC[C@]1(N(C)C)CC[C@@]2(CC1)CN(CC1=CC=C(OC)C=C1)C(=O)N2 YORZABKEBRCBTH-SZPZYZBQSA-N 0.000 description 1
- SQYHWXDENAMAHS-PSWAGMNNSA-N COCCN1C(=O)N(CC(C)(C)C#N)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCN1C(=O)N(CC(C)(C)C#N)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 SQYHWXDENAMAHS-PSWAGMNNSA-N 0.000 description 1
- FFAQBUUGOIIEFJ-PSWAGMNNSA-N COCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCN1C(=O)N(CC(C)(C)C(N)=O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 FFAQBUUGOIIEFJ-PSWAGMNNSA-N 0.000 description 1
- LCWWNRNXFIRAFT-WMPKNSHKSA-N COCCN1C(=O)N(CCC(=O)NC2=CN=CN=C2)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCN1C(=O)N(CCC(=O)NC2=CN=CN=C2)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 LCWWNRNXFIRAFT-WMPKNSHKSA-N 0.000 description 1
- QMPRWIDOMJJAAF-PSWAGMNNSA-N COCCN1C(=O)N(CCC(=O)NCCO)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCN1C(=O)N(CCC(=O)NCCO)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 QMPRWIDOMJJAAF-PSWAGMNNSA-N 0.000 description 1
- DXZWFLYARKAIEH-RKTHSGCWSA-N COCCN1C(=O)N(CCC(=O)NCCO)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.COCCN1C(=O)N(CCC(=O)O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O=C(O)C(F)(F)F Chemical compound COCCN1C(=O)N(CCC(=O)NCCO)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.COCCN1C(=O)N(CCC(=O)O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O=C(O)C(F)(F)F DXZWFLYARKAIEH-RKTHSGCWSA-N 0.000 description 1
- BLSNRSBZENDUED-SZPZYZBQSA-N COCCN1C(=O)N(CCC(=O)O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O=C(O)C(F)(F)F Chemical compound COCCN1C(=O)N(CCC(=O)O)C[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2.O=C(O)C(F)(F)F BLSNRSBZENDUED-SZPZYZBQSA-N 0.000 description 1
- LNFLMKXVPAZCEG-KDURUIRLSA-N COCCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 Chemical compound COCCN1C(=O)NC[C@]12CC[C@](C1=CC=CC=C1)(N(C)C)CC2 LNFLMKXVPAZCEG-KDURUIRLSA-N 0.000 description 1
- OCGDWBULAHAXCS-LDNJAJMQSA-N COCCNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2(O)CCC2)C1=O Chemical compound COCCNC(=O)CCN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(CC2(O)CCC2)C1=O OCGDWBULAHAXCS-LDNJAJMQSA-N 0.000 description 1
- LCNXBSPBMIKNDQ-WMPKNSHKSA-N COCOC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC2=CC=C(OC)C=C2)C(=O)N3)=CC=C1 Chemical compound COCOC1=CC([C@]2(N(C)C)CC[C@@]3(CC2)CN(CC2=CC=C(OC)C=C2)C(=O)N3)=CC=C1 LCNXBSPBMIKNDQ-WMPKNSHKSA-N 0.000 description 1
- POBZXYYGFIWEJE-MCZWQBSQSA-N COCOC1=CC=C([C@]2(N(C)C)CC[C@]3(CC2)CC(=O)N(CC2=CC=C(OC)C=C2)C3)C=C1 Chemical compound COCOC1=CC=C([C@]2(N(C)C)CC[C@]3(CC2)CC(=O)N(CC2=CC=C(OC)C=C2)C3)C=C1 POBZXYYGFIWEJE-MCZWQBSQSA-N 0.000 description 1
- APBLAQTUWHYWTM-CALCHBBNSA-N Cc1cc([C@](CC2)(CC[C@]2(CN2)NC2=O)N(C)C)ccc1 Chemical compound Cc1cc([C@](CC2)(CC[C@]2(CN2)NC2=O)N(C)C)ccc1 APBLAQTUWHYWTM-CALCHBBNSA-N 0.000 description 1
- RIPTVOMHKXFRNF-SHQXZAHRSA-N [C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@@](CC)(C3=CC=CC=C3)CC2)N(COC)C1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@@](CC)(C3=CC=CC=C3)CC2)NC1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(COC)C1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)NC1=O Chemical compound [C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@@](CC)(C3=CC=CC=C3)CC2)N(COC)C1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@@](CC)(C3=CC=CC=C3)CC2)NC1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)N(COC)C1=O.[C-]#[N+]C(C)(C)CN1C[C@]2(CC[C@](C3=CC=CC=C3)(N(C)C)CC2)NC1=O RIPTVOMHKXFRNF-SHQXZAHRSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/979,932 US20180273491A1 (en) | 2016-01-13 | 2018-05-15 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US16/207,676 US20190100497A1 (en) | 2016-01-13 | 2018-12-03 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US16/450,406 US10793528B2 (en) | 2016-01-13 | 2019-06-24 | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US17/007,374 US20200399226A1 (en) | 2016-01-13 | 2020-08-31 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US17/188,802 US20210214315A1 (en) | 2016-01-13 | 2021-03-01 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US18/102,983 US20230183184A1 (en) | 2016-01-13 | 2023-01-30 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151011 | 2016-01-13 | ||
| EP16151011.0 | 2016-01-13 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US15/979,932 Continuation US20180273491A1 (en) | 2016-01-13 | 2018-05-15 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20170197919A1 true US20170197919A1 (en) | 2017-07-13 |
Family
ID=55129632
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US15/405,482 Abandoned US20170197919A1 (en) | 2016-01-13 | 2017-01-13 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US15/979,932 Abandoned US20180273491A1 (en) | 2016-01-13 | 2018-05-15 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US16/207,676 Abandoned US20190100497A1 (en) | 2016-01-13 | 2018-12-03 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US16/450,406 Active US10793528B2 (en) | 2016-01-13 | 2019-06-24 | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US17/007,374 Abandoned US20200399226A1 (en) | 2016-01-13 | 2020-08-31 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US17/188,802 Abandoned US20210214315A1 (en) | 2016-01-13 | 2021-03-01 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US18/102,983 Pending US20230183184A1 (en) | 2016-01-13 | 2023-01-30 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US15/979,932 Abandoned US20180273491A1 (en) | 2016-01-13 | 2018-05-15 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US16/207,676 Abandoned US20190100497A1 (en) | 2016-01-13 | 2018-12-03 | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US16/450,406 Active US10793528B2 (en) | 2016-01-13 | 2019-06-24 | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US17/007,374 Abandoned US20200399226A1 (en) | 2016-01-13 | 2020-08-31 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US17/188,802 Abandoned US20210214315A1 (en) | 2016-01-13 | 2021-03-01 | 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| US18/102,983 Pending US20230183184A1 (en) | 2016-01-13 | 2023-01-30 | 3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US20170197919A1 (es) |
| EP (2) | EP3402783B1 (es) |
| JP (2) | JP6862457B2 (es) |
| KR (1) | KR20180100592A (es) |
| CN (1) | CN108699005B (es) |
| AR (1) | AR107361A1 (es) |
| AU (1) | AU2017207467B2 (es) |
| BR (1) | BR112018014302B1 (es) |
| CA (1) | CA3011175C (es) |
| CL (1) | CL2018001913A1 (es) |
| CO (1) | CO2018008445A2 (es) |
| CY (1) | CY1122882T1 (es) |
| DK (1) | DK3402783T3 (es) |
| EA (1) | EA037649B1 (es) |
| EC (1) | ECSP18060820A (es) |
| ES (1) | ES2803354T3 (es) |
| HR (1) | HRP20200656T1 (es) |
| HU (1) | HUE049374T2 (es) |
| IL (1) | IL260495B (es) |
| LT (1) | LT3402783T (es) |
| MX (1) | MX2018008640A (es) |
| NZ (1) | NZ745187A (es) |
| PL (1) | PL3402783T3 (es) |
| PT (1) | PT3402783T (es) |
| RS (1) | RS60223B1 (es) |
| SI (1) | SI3402783T1 (es) |
| TW (1) | TWI635081B (es) |
| WO (1) | WO2017121646A1 (es) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10793528B2 (en) | 2016-01-13 | 2020-10-06 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10793556B2 (en) | 2016-01-13 | 2020-10-06 | Gruenenthal Gmbh | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10807989B2 (en) | 2016-01-13 | 2020-10-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10807988B2 (en) | 2016-01-13 | 2020-10-20 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10829480B2 (en) | 2016-01-13 | 2020-11-10 | Gruenenthal Gmbh | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| MXPA03009602A (es) | 2001-04-18 | 2004-04-02 | Euro Celtique Sa | Analogos de nociceptina. |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP1628978A2 (en) | 2003-05-23 | 2006-03-01 | Zealand Pharma A/S | Triaza-spiro compounds as nociceptin analogues and uses thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| MX2009003939A (es) | 2006-10-19 | 2009-05-11 | Hoffmann La Roche | Derivados de imidazolona e imidazolidinona como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 para diabetes. |
| US8741916B2 (en) | 2007-04-09 | 2014-06-03 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the ORL-1 receptor |
| ES2663398T3 (es) * | 2008-03-27 | 2018-04-12 | Grünenthal GmbH | Derivados de 4-aminociclohexano sustituidos |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| US9884844B2 (en) * | 2012-12-31 | 2018-02-06 | Sunovion Pharmaceuticals, Inc. | Heterocyclic compounds and methods of use thereof |
| JP2017521488A (ja) | 2014-06-13 | 2017-08-03 | パーデュー、ファーマ、リミテッド、パートナーシップ | 複素環式モルフィナン誘導体及びその使用 |
| JP6854823B2 (ja) | 2016-01-13 | 2021-04-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（カルボキシメチル）−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
| TWI654181B (zh) | 2016-01-13 | 2019-03-21 | 歌林達有限公司 | ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物 |
| AU2017207467B2 (en) * | 2016-01-13 | 2020-07-16 | Grünenthal GmbH | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| ES2797904T3 (es) | 2016-01-13 | 2020-12-04 | Gruenenthal Gmbh | Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano |
-
2017
- 2017-01-13 AU AU2017207467A patent/AU2017207467B2/en active Active
- 2017-01-13 ES ES17700474T patent/ES2803354T3/es active Active
- 2017-01-13 DK DK17700474.4T patent/DK3402783T3/da active
- 2017-01-13 WO PCT/EP2017/025004 patent/WO2017121646A1/en active Application Filing
- 2017-01-13 TW TW106101123A patent/TWI635081B/zh active
- 2017-01-13 CN CN201780006500.8A patent/CN108699005B/zh active Active
- 2017-01-13 RS RS20200519A patent/RS60223B1/sr unknown
- 2017-01-13 EP EP17700474.4A patent/EP3402783B1/en active Active
- 2017-01-13 HU HUE17700474A patent/HUE049374T2/hu unknown
- 2017-01-13 EP EP20155667.7A patent/EP3722283A1/en active Pending
- 2017-01-13 PT PT177004744T patent/PT3402783T/pt unknown
- 2017-01-13 JP JP2018536433A patent/JP6862457B2/ja active Active
- 2017-01-13 CA CA3011175A patent/CA3011175C/en active Active
- 2017-01-13 KR KR1020187021561A patent/KR20180100592A/ko active Search and Examination
- 2017-01-13 BR BR112018014302-2A patent/BR112018014302B1/pt active IP Right Grant
- 2017-01-13 LT LTEP17700474.4T patent/LT3402783T/lt unknown
- 2017-01-13 AR ARP170100096A patent/AR107361A1/es unknown
- 2017-01-13 SI SI201730241T patent/SI3402783T1/sl unknown
- 2017-01-13 US US15/405,482 patent/US20170197919A1/en not_active Abandoned
- 2017-01-13 PL PL17700474T patent/PL3402783T3/pl unknown
- 2017-01-13 NZ NZ745187A patent/NZ745187A/en unknown
- 2017-01-13 EA EA201891610A patent/EA037649B1/ru unknown
- 2017-01-13 MX MX2018008640A patent/MX2018008640A/es unknown
-
2018
- 2018-05-15 US US15/979,932 patent/US20180273491A1/en not_active Abandoned
- 2018-07-09 IL IL260495A patent/IL260495B/en unknown
- 2018-07-13 CL CL2018001913A patent/CL2018001913A1/es unknown
- 2018-08-13 CO CONC2018/0008445A patent/CO2018008445A2/es unknown
- 2018-08-13 EC ECSENADI201860820A patent/ECSP18060820A/es unknown
- 2018-12-03 US US16/207,676 patent/US20190100497A1/en not_active Abandoned
-
2019
- 2019-06-24 US US16/450,406 patent/US10793528B2/en active Active
-
2020
- 2020-04-23 HR HRP20200656TT patent/HRP20200656T1/hr unknown
- 2020-05-06 CY CY20201100416T patent/CY1122882T1/el unknown
- 2020-08-31 US US17/007,374 patent/US20200399226A1/en not_active Abandoned
-
2021
- 2021-03-01 US US17/188,802 patent/US20210214315A1/en not_active Abandoned
- 2021-03-30 JP JP2021056938A patent/JP7148665B2/ja active Active
-
2023
- 2023-01-30 US US18/102,983 patent/US20230183184A1/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10793528B2 (en) | 2016-01-13 | 2020-10-06 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10793556B2 (en) | 2016-01-13 | 2020-10-06 | Gruenenthal Gmbh | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10807989B2 (en) | 2016-01-13 | 2020-10-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10807988B2 (en) | 2016-01-13 | 2020-10-20 | Grünenthal GmbH | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US10829480B2 (en) | 2016-01-13 | 2020-11-10 | Gruenenthal Gmbh | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10793528B2 (en) | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | |
| US10793556B2 (en) | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | |
| US10829480B2 (en) | 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives | |
| US10807989B2 (en) | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | |
| AU2017206908B2 (en) | 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Assignment |
Owner name: GRUENENTHAL GMBH, GERMANY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KUEHNERT, SVEN;KOENIGS, RENE MICHAEL;JAKOB, FLORIAN;AND OTHERS;SIGNING DATES FROM 20170309 TO 20170502;REEL/FRAME:042613/0388 |
|
| STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |