US20150197389A1 - Heat insulation cold closet for medical supplies - Google Patents

Heat insulation cold closet for medical supplies Download PDF

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Publication number
US20150197389A1
US20150197389A1 US14/594,138 US201514594138A US2015197389A1 US 20150197389 A1 US20150197389 A1 US 20150197389A1 US 201514594138 A US201514594138 A US 201514594138A US 2015197389 A1 US2015197389 A1 US 2015197389A1
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United States
Prior art keywords
heat insulation
layer
closet
medical supplies
thickness
Prior art date
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Abandoned
Application number
US14/594,138
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English (en)
Inventor
Weiqiang BAO
Lei Zhang
Jianwu SUN
Wei Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUZHOU ANTEKPAC INDUSTRIAL Co Ltd
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SUZHOU ANTEKPAC INDUSTRIAL Co Ltd
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Publication date
Application filed by SUZHOU ANTEKPAC INDUSTRIAL Co Ltd filed Critical SUZHOU ANTEKPAC INDUSTRIAL Co Ltd
Assigned to SUZHOU ANTEKPAC INDUSTRIAL CO., LTD. reassignment SUZHOU ANTEKPAC INDUSTRIAL CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAO, Weiqiang, Sun, Jianwu, XU, WEI, ZHANG, LEI
Publication of US20150197389A1 publication Critical patent/US20150197389A1/en
Abandoned legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/38Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
    • B65D81/3813Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container
    • B65D81/3816Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container formed of foam material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/38Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
    • B65D81/3813Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container
    • B65D81/3823Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container formed of different materials, e.g. laminated or foam filling between walls
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00General constructional features
    • F25D23/06Walls
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2201/00Insulation
    • F25D2201/10Insulation with respect to heat
    • F25D2201/14Insulation with respect to heat using subatmospheric pressure

Definitions

  • the present invention relates to the technical field of the preservation of medical supplies, and more specifically to a heat insulation cold closet for medical supplies.
  • cold storage of drugs falls into two major categories: cold storage with the use of power and cold storage without the use of powder.
  • cold storage with the use of power power needs to be applied during the cold storage and accordingly the cold storage conditions are restrained more or less, and the cost is increased due to the cost of an uninterrupted power supply.
  • Cold storage without the use of powder relies on coolant and a heat insulation material.
  • coolant-filled bags are put around a drug to be refrigerated, and then the drug to be refrigerated and the coolant-filled bags are put into a container made of a heat insulation material to achieve the effect of preventing heat exchange and heat conduction.
  • the cold-storage cold closet in the prior art mainly consists of a cold closet and a coolant, and most of the current cold-storage cold closets are made of the heat-insulation and heat-preservation material—polyurethane foamed plastic.
  • polyurethane foam has good heat-preservation properties, in order to achieve the desired preservation effect, the thickness of polyurethane foam in the closet body of a cold closet is generally about 50 mm, thereby making the cold-storage closet heavy.
  • the closet body needs to have a large dimension in order to maintain the effective volume of the interior of the closet body, thus such cold closet is not practical.
  • the heat insulation cold closet for medical supplies according to the present invention not only has good cold-storage and heat-insulation effects, but also can significantly increase the effective volume of the closet body.
  • the heat insulation cold closet for medical supplies comprises a closet body with an opening, and a cover body sealed and meshed with the opening, characterized in that the closet body, from inside to outside, successively consists of a rigid polyurethane layer, a vacuum heat insulation panel layer, a foamed polyurethane panel layer and a housing.
  • the cover body from inside to outside, successively consists of a vacuum heat insulation panel layer, a foamed polyurethane panel layer and a housing.
  • the rigid polyurethane layer has a thickness of 2 to 5 mm
  • the vacuum heat insulation panel layer has a thickness of 8 to 15 mm
  • the foamed polyurethane panel layer has a thickness of 5 to 20 mm.
  • the material of the housing is polypropylene or polyethylene.
  • the heat insulation cold closet for medical supplies according to the present invention has the following beneficial effects:
  • the thickness of the heat insulation cold closet is reduced so that the effective volume of an incubator having the same shape can be greatly increased; furthermore, the coefficient of heat insulation of the heat insulation cold closet is smaller than or equal to 0.004 W/mK, heat radiation, heat conduction and heat convection between the interior of the closet body and the external environment can be effectively prevented, and the heat insulation closet can guarantee that the interior temperature is controlled at 2-8° C. for more than 120 hours.
  • the heat insulation cold closet according to the present invention is mainly used for cold storage and freezing of drugs, such as vaccines, insulin, blood products, biological products and reagents, during transportation and storage.
  • FIG. 1 is a structure diagram of the heat insulation cold closet for medical supplies according to the present invention.
  • the heat insulation cold closet for medical supplies comprises a closet body 10 with an opening, and a cover body 20 sealed and meshed with the opening; the closet body, from inside to outside, successively consists of a rigid polyurethane layer 12 , a vacuum heat insulation panel layer 14 , a foamed polyurethane panel layer 16 and a housing 18 ; the cover body, from inside to outside, successively consists of a vacuum heat insulation panel layer, a foamed polyurethane panel layer and a housing.
  • the thickness of the heat insulation cold closet is reduced so that the effective volume of an incubator having the same shape can be greatly increased.
  • refrigerated items such as vaccines, insulin, blood products, biological products, reagents and other drugs as well as a coolant, are first stacked in a certain ratio and a certain manner in the closet body 10 , the cover body 20 is closed to isolate the environment inside the closet body 10 from the environment outside the closet body 10 , and the cold energy emitted by the coolant ensures that the refrigerated items in the incubator are in certain cryogenic states.
  • the composite heat insulation structure formed from the polyurethane foamed plastic layer and the vacuum heat insulation panel layer, as described in the present invention, allows the heat insulation cold closet according to the present invention to have a coefficient of heat insulation of ⁇ 0.004 W/mK, so that heat radiation, heat conduction and heat convection between the interior of the closet body and the external environment can be effectively prevented. Furthermore, since the foamed polyurethane panel layer and the vacuum heat insulation panel layer are liable to deformation and breakage in case of collision due to an external force, a rigid polyurethane layer is further provided.
  • the rigid polyurethane material not only does not contaminate drugs or other products, but also has high hardness and strength and can provide the composite heat insulation structure with adequate protection.
  • the foamed polyurethane panel layer according to the present invention can be obtained by in-situ foaming, or a foamed polyurethane panel can be prepared, then an acrylic adhesive is applied, and the foamed polyurethane panel and a vacuum heat insulation panel layer are laminated to form a composite heat insulation structure.
  • the rigid polyurethane layer was obtained by casting or coating a polyurethane prepolymer prepared from 23.5 to 25.0 wt % of MDI, 18.0 to 20.0 wt % of PEG1000, 5.0 to 5.5 wt % of PTMG1000, 2.0 to 2.2 wt % of 1,4-butanediol, 1.2 to 1.5 wt % of ethoxylated bisphenol F diacrylate, 1.5 to 1.8 wt % of vinyltriethoxysilane, 0.20 to 0.25 wt % of dibutyltin dilaurate, 5.0 to 5.5 wt % of ethyl methyl carbonate, and ethyl acetate being the balance.
  • the thickness of the rigid polyurethane layer is 0.1 mm, it has a tensile strength of greater than 12 MPa and an elongation rate of 180 to 250%, and thus can provide the composite heat insulation structure with adequate protection.
  • the test was carried out by the following method: The polyurethane prepolymer was coated on the surface of release paper using a coater, and then heat treatment was performed at 50° C. for 15 minutes to obtain a rigid polyurethane layer having a thickness of 0.1 mm. Then, a 6 cm ⁇ 1 cm sample was obtained by cutting, the sample was elongated at a speed of 300 mm/min, and the tensile strength and the elongation rate thereof were determined.
  • a polyurethane layer was obtained by casting or coating a polyurethane prepolymer prepared from 25.0 wt % of MDI, 18.0 wt % of PEG1000, 5.5 wt % of PTMG1000, 2.2 wt % of 1,4-butanediol, 1.5 wt % of ethoxylated bisphenol F diacrylate, 0.20 wt % of dibutyltin dilaurate, 5.5 wt % of ethyl methyl carbonate, and ethyl acetate being the balance.
  • the preparation method is the same as that described in Example 1.
  • the thickness of the polyurethane layer is 0.1 mm, it has a tensile strength of greater than 5 to 6 MPa and an elongation rate of between 250 and 280%.
  • a polyurethane layer was obtained by casting or coating a polyurethane prepolymer prepared from 25.0 wt % of MDI, 18.0 wt % of PEG1000, 5.5 wt % of PTMG1000, 2.2 wt % of 1,4-butanediol, 1.8 wt % of vinyltriethoxysilane, 0.20 wt % of dibutyltin dilaurate, 5.5 wt % of ethyl methyl carbonate, and ethyl acetate being the balance.
  • the preparation method is the same as that described in Example 1.
  • the thickness of the polyurethane layer is 0.1 mm, it has a tensile strength of greater than 7 to 8 MPa and an elongation rate of between 120 and 150%.
  • a polyurethane layer was obtained by casting or coating a polyurethane prepolymer prepared from 25.0 wt % of MDI, 18.0 wt % of PEG1000, 5.5 wt % of PTMG1000, 2.2 wt % of 1,4-butanediol, 0.20 wt % of dibutyltin dilaurate, 5.5 wt % of ethyl methyl carbonate, and ethyl acetate being the balance.
  • the preparation method is the same as that described in Example 1.
  • the thickness of the polyurethane layer is 0.1 mm, it has a tensile strength of greater than 5 to 6 MPa and an elongation rate of between 200 and 250%.
  • the vacuum heat insulation panel comprises a core material and a sealing layer, the core material being a panel which is formed from glass fibers and a getter composition and the interior of which is kept in vacuum; the core material is sealed with the sealing layer, which is formed from a first aluminum foil layer and a second aluminum foil layer laminated on the upper and lower surfaces of a PET film; the PET film has a thickness of 100 to 120 ⁇ m, and both the first and second aluminum foil layers have a thickness of 20 to 25 ⁇ m; and the first and second aluminum foil layers are anodized such that an anodized aluminum film is formed on each of them.
  • the anodized aluminum film was prepared by the following method: First, an aluminum foil layer was washed (with the acidic cleaning agent AcidClean®UC, a product from Atotech Germany Ltd.), and then impregnated in an aqueous solution of 5 wt % sodium hydroxide at a liquid temperature of 30° C. for 2 minutes so that it was treated with sodium hydroxide; after washing with water, the aluminum foil layer was impregnated in a 5 wt % nitric acid bath at a liquid temperature of 10° C. for 1 minute (for the purpose of neutralization), and then anodized in an aqueous solution of citric acid.
  • the aqueous solution of citric acid contained 18 to 20 g/L of citric acid, 1.8 to 2.0 g/L of dihydroxyethylglycine, 0.8 to 1.0 g/L of hydrogen peroxide, and 2.5 to 3.0 g/L of triammonium citrate, wherein the liquid temperature was 10 to 12° C., the current density was 0.1 to 0.2 A/dm 2 , and electrolysis was carried out for 8 to 10 min.
  • the above-mentioned anodization made it possible to supply sufficient aluminum ions, to essentially eliminate a depolarization effect, and to obtain a compact anodized aluminum film. After the above treatment, the thickness of the anodized aluminum film was 1 to 2 ⁇ m.
  • the vacuum heat insulation panel of this example only differs from the vacuum heat insulation panel of Example 2 in that the method for the preparation of an anodized aluminum film is different.
  • the anodized aluminum film was generated by electrolysis in an oxalic acid solution.
  • an aluminum foil layer was washed (with the acidic cleaning agent AcidClean®UC, a product from Atotech Germany Ltd.), and then impregnated in an aqueous solution of 5 wt % sodium hydroxide at a liquid temperature of 30° C. for 2 minutes so that it was treated with sodium hydroxide; after washing with water, the aluminum foil layer was impregnated in a 5 wt % nitric acid bath at a liquid temperature of 10° C.
  • the aqueous solution of oxalic acid contained 20 g/L of oxalic acid, 1.8 g/L of EDTA, and 3.0 g/L of ammonium oxalate, wherein the liquid temperature was 10 ⁇ 12° C., the current density was 0.2 A/dm 2 , and electrolysis was carried out for 8 min.
  • the thickness of the anodized aluminum film was about 2 ⁇ m.
  • the vacuum heat insulation panel of this example only differs from the vacuum heat insulation panel of Example 2 in that the method for the preparation of an anodized aluminum film is different.
  • the anodized aluminum film was generated by electrolysis in a sulfuric acid solution.
  • an aluminum foil layer was washed (with the acidic cleaning agent AcidClean®UC, a product from Atotech Germany Ltd.), and then impregnated in an aqueous solution of 5 wt % sodium hydroxide at a liquid temperature of 30° C. for 2 minutes so that it was treated with sodium hydroxide; after washing with water, the aluminum foil layer was impregnated in a 5 wt % nitric acid bath at a liquid temperature of 10° C.
  • the aqueous solution of sulfuric acid contained 20 g/L of sulfuric acid, 1.8 g/L of EDTA, and 3.0 g/L of ammonium sulfate, wherein the liquid temperature was 10 ⁇ 12° C., the current density was 0.2 A/dm 2 , and electrolysis was carried out for 8 min.
  • the thickness of the anodized aluminum film was about 2 ⁇ m.
  • the vacuum heat insulation panel of this example only differs from the vacuum heat insulation panel of Example 2 in that an anodized aluminum film is not formed.
  • the vacuum heat insulation panel of Example 2 and the vacuum heat insulation panels of Comparative Examples 4 to 6 have substantially the same coefficient of heat insulation. Then, the vacuum heat insulation panel of Example 2 and the vacuum heat insulation panels of Comparative Examples 4 to 6 were kept in an accelerated penetration environment at 80° C. and 95RH for 48 h; their respective coefficients of heat insulation were measured at room temperature, wherein the coefficients of heat insulation in Comparative Examples 4 to 5 reached 0.031 W/mK and 0.035 W/mK respectively, the coefficient of heat insulation in Comparative Example 6 reached 0.05 W/mK or more, but the coefficient of heat insulation of the vacuum heat insulation panel of Example 2 was surprisingly maintained at 0.01 W/mK or less. It can be determined from the above comparison that the vacuum heat insulation panel of Example 2 is capable of stably maintaining the vacuum degree of the interior.
  • the heat insulation cold closet according to the present invention is mainly used for cold storage and freezing of drugs, such as vaccines, insulin, blood products, biological products and reagents, during transportation and storage; and, of course, it can also be applied to the preservation of items that need be refrigerated, such as food or electronic products.
  • drugs such as vaccines, insulin, blood products, biological products and reagents, during transportation and storage; and, of course, it can also be applied to the preservation of items that need be refrigerated, such as food or electronic products.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Laminated Bodies (AREA)
US14/594,138 2014-01-11 2015-01-11 Heat insulation cold closet for medical supplies Abandoned US20150197389A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410012203.2 2014-01-11
CN201410012203.2A CN103723379B (zh) 2014-01-11 2014-01-11 医疗药品用绝热冷藏箱

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US20150197389A1 true US20150197389A1 (en) 2015-07-16

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US (1) US20150197389A1 (zh)
EP (1) EP2894113B1 (zh)
CN (1) CN103723379B (zh)
SG (1) SG10201500133RA (zh)

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EP3808684A1 (de) * 2019-10-07 2021-04-21 va-Q-tec AG Wärmeisolationsbehälter für den transport
US20220281671A1 (en) * 2018-06-15 2022-09-08 Cold Chain Technologies, Llc Shipping system for storing and/or transporting temperature-sensitive materials
US11472942B2 (en) 2017-10-25 2022-10-18 Dow Global Technologies Llc Flexible wrapping material for preserving food freshness
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JP2019137458A (ja) * 2018-02-15 2019-08-22 株式会社カネカ 断熱容器、及び断熱容器を用いた運搬方法
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CN103723379A (zh) 2014-04-16
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EP2894113A1 (en) 2015-07-15
EP2894113B1 (en) 2017-03-08

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