US20110172593A1 - An inserter - Google Patents

An inserter Download PDF

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Publication number
US20110172593A1
US20110172593A1 US13/119,399 US200913119399A US2011172593A1 US 20110172593 A1 US20110172593 A1 US 20110172593A1 US 200913119399 A US200913119399 A US 200913119399A US 2011172593 A1 US2011172593 A1 US 2011172593A1
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US
United States
Prior art keywords
inserter
slider
plunger
insertion tube
intrauterine system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/119,399
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English (en)
Inventor
Heikki Lyyikäinen
Iikka Jutila
Calvo Alonson
Harri Jukarainen
Taina Tjäder
Andrew MacLeod
Michael Noble
David Whitaker
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Bayer Oy
Original Assignee
Bayer Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Bayer Oy filed Critical Bayer Oy
Assigned to BAYER OY reassignment BAYER OY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CALVO ALONSO, ULLA, JUTILA, ILKKA, JUKARAINEN, HARRI, LYYTIKAINEN, HEIKKI, TJADER, TAINA, WHITAKER, DAVID, MACLEOD, ANDREW, NOBLE, MICHAEL
Publication of US20110172593A1 publication Critical patent/US20110172593A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/18—Inserters or removers ; Apparatus for loading an intra-uterine device into an insertion tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142—Wirelike structures, e.g. loops, rings, spirals

Definitions

  • the present invention is related to an inserter for positioning an intrauterine device or an intrauterine system in the uterus.
  • IUDs mechanical and copper wire-containing intrauterine devices
  • IUSs drug containing cylinder
  • inserters are constructed for introducing the device into the uterus in a contracted state. These inserters usually comprise an insertion tube having a relatively narrow diameter and a rounded, blunt end which will pass through the cervical canal easily and will not damage or injure the fundus upon contact therewith, and a plunger inside the insertion tube. Prior to insertion the device, whether an IUD or an IUS, is usually retracted into the insertion tube either by means of string(s) attached to the device and intended for the removal of the device from the uterus, or by pushing the device into the insertion tube by a plunger with inserters having a special window to adapt the device in the expanded shape (see for example GB 1 403 393).
  • the insertion tube with the device therein is introduced through the cervical canal into the uterus.
  • the device is released either by pushing the plunger towards the uterus or by holding the plunger steady and by retracting the insertion tube outwards.
  • the device is supposed to resume its original expanded shape.
  • Simple rod-shaped inserters have been suggested for inserting relatively small or sufficiently flexible intrauterine devices in their original, expanded shape by using simple push-in technique. With these inserters the correct positioning and a secure attachment of an IUS or IUD on the inserter as well as a proper handling of the removal strings may be difficult. Therefore there is still need for an improved inserter.
  • European patent application EP1 691 740 relates to an inserter, with which the correct positioning and directional stiffness of the device in the inserter prior to and during insertion can be ensured, for instance, by shaping the forward end of the plunger such that the IUS assumes a specified constant configuration when drawn into the insertion tube. The IUS thus will not be twisted during insertion.
  • European patent EP 798 999 relates to an inserter, which allows the correct positioning of an IUS also in those cases in which the elongate member of a T-shaped device contains active material, which involves a diameter larger than that of an elongate member of a copper-wire IUD.
  • the inserter comprises a plunger, a handle attached to the plunger, a string for the removal of the IUS, a cleft on the end of the handle to lock the string(s) in such a way that the IUS remains immobile in relation to the plunger, and an insertion tube around the plunger.
  • the IUS is drawn into the insertion tube by pushing the tube over the device or by pulling on the removal threads where after the threads are manually locked in the cleft.
  • the relative movement of the plunger and the protective tube is restricted by a stop member or stop members to ascertain that the correct configuration of the IUS is achieved.
  • the stop members ensure that the front edge of the insertion tube is stopped in a configuration in which the hemispherical tips of the T-wings remain partly uncovered by the insertion tube but the wings nevertheless remain pressed against each other. These stop members are however fixed on the handle.
  • inserters described in these documents overcome many of the problems encountered with the conventional inserters, but the string(s) still need to be handled and manually locked. Further, the inserters are designed primarily for the insertion of the conventional devices which are to be inserted in a compressed configuration. Therefore there is still need for an improved inserter, which can be used to insert in original expanded configuration intrauterine devices and systems having frames of various shapes.
  • An object of the invention is to provide a simple, easy to use inserter for the positioning of an intrauterine system in the uterus by solving at least partially at least some of the problems mentioned above.
  • An object of the invention is particularly to provide an inserter having an improved system for securing the simple and correct positioning of the intrauterine system in the uterus.
  • a typical inserter for an intrauterine system according to the present invention comprises
  • FIG. 1 illustrates a general overview of an inserter according to an embodiment of the invention.
  • FIGS. 2A , 2 B, 2 C and 2 D illustrate an operating principle of an inserter according to an embodiment of the invention.
  • FIGS. 3A and 3B illustrate a locking means according to an embodiment of the invention.
  • FIGS. 4A and 4B illustrate a locking means according to another embodiment of the invention.
  • FIGS. 5A and 5B illustrate a locking means according to yet another embodiment of the invention.
  • FIGS. 6A and 6B illustrate a locking means according to a further embodiment of the invention.
  • FIGS. 7A and 7B illustrate a locking means according to still a further embodiment of the invention.
  • FIGS. 8A and 8B illustrate an intrauterine system and its positioning on the inserter according to an embodiment of the invention.
  • FIGS. 8C and 8D illustrate another intrauterine system and its positioning on the inserter according to an embodiment of the invention
  • FIGS. 9A and 9B illustrate some details of FIG. 8B .
  • a typical inserter for an intrauterine system according to the present invention comprises
  • the invention therefore provides an easy to use inserter, by which only few simple steps are needed to prepare for the insertion and to securely install and position an intrauterine system into the uterus.
  • the longitudinal opening on the handle can have be also quite narrow and does not need to be symmetrically positioned on the handle and with respect to the longitudinal axis
  • the inserter comprises a flange arranged on the insertion tube at its first end.
  • the aim of this flange is to keep the intrauterine system in a correct position and to protect it prior to insertion.
  • the flange also functions as part of the means regulating the movement of the insertion tube.
  • the inserter may further comprise means for holding and guiding the strings during the insertion so that no manual handling of said strings will be needed.
  • the inserter may also comprise locking means for reversibly locking the strings to immobilize the intrauterine system in relation to the plunger, said locking means being controllable by the slider and/or by the insertion tube.
  • the inserter according to the invention is suitable for the positioning of intrauterine devices and intrauterine systems having different sizes and shapes.
  • the inserter is especially suitable for installing intrauterine devices having a flexible frame with continuous curved shape, for example annular, circular, oval, spiral, toroidal, triangular, shield-like, almond-like, diamond-like, elliptical or polygonal shape.
  • first ends are typically meant the ends that are closer to the uterus during the insertion of the intrauterine system.
  • Second ends are the ends opposite to the first ends.
  • IUS or IUD and removal strings are used when describing the preferred embodiment of the present invention, but these are not to be construed as limiting the claims.
  • a part of the handle comprises an opening having a first end and a second end and running in the longitudinal direction of the plunger.
  • the handle also preferably has at its first end a channel in which the insertion tube can slide in the longitudinal direction.
  • the handle can have many shapes and is designed for easy handling of the inserter even by using only one hand.
  • the plunger attached to the handle is advantageously hollow or has a groove or bore running in the axial direction thus allowing the string(s) to slide freely in it, without any risk of them getting jammed between the plunger and the insertion tube.
  • the forward end of said plunger is shaped to the form of a a slot or an extension to adapt the reservoir of the intrauterine system.
  • the IUS will not drop or be twisted during insertion procedure and assumes a specified constant configuration when released.
  • the forward part (part directed towards the uterus) of the inserter is preferably made of a flexible material to avoid perforation of the uterus, and can be straight or curved so as to conform to the anatomy of the uterus.
  • the first end of the insertion tube comprises a flange and both are made of a relatively flexible material, but are preferably stiffer than the plunger.
  • the slider mechanism is preferably inside the handle and comprises at least one elongated element, which can be moved in the longitudinal direction of the insertion tube.
  • the slider comprises a means to move the slider, which preferably is a part of the slider.
  • the slider comprises at least two elements, preferably parallel, which are combined on at least one point by a transversal member.
  • the transversal member may form means, for example a knob or switch, by which the slider can be moved.
  • the handle can comprise one or more means to adapt the slider elements and to facilitate the movement of the slider, for example a support, a shoulder, a holder, a saddle, a groove or a slot.
  • the slider may also comprise at least one structural element, for example an extension, which is capable to generate the necessary operation of the possible locking means to keep the strings immobilized during storage or during preparatory steps before insertion and/or to release the string(s) when the slider is moved to the backward position.
  • an extension which is capable to generate the necessary operation of the possible locking means to keep the strings immobilized during storage or during preparatory steps before insertion and/or to release the string(s) when the slider is moved to the backward position.
  • the slider is adjusted to correspond to the depth at which intrauterine system will be inserted, said depth being beforehand determined by using a sound or a probe.
  • the slider comprising said means for locking it, which means are adjustable with respect to the opening of the handle can be for example a self-locking button slider and movable in a stepwise way controlled for example by an indentation, a cogwheel or a rack and pinion mechanism positioned inside the handle.
  • the outer side of the handle has clear depth markings to facilitate the adjustment of the slider.
  • the slider and/or the insertion tube may additionally comprise at least one structural element, for example an extension, which is capable to generate the necessary operation of the locking means to keep the strings immobilized during storage or during preparatory steps before insertion or to release the string(s) when the slider is moved to the backward position.
  • at least one structural element for example an extension, which is capable to generate the necessary operation of the locking means to keep the strings immobilized during storage or during preparatory steps before insertion or to release the string(s) when the slider is moved to the backward position.
  • a therapeutic component of the intrauterine system is connected to the frame in at least one point.
  • the intrauterine system can be connected to the inserter for example via at least one connection part.
  • the connection part is preferably designed such that it enhances the retention of the device on the inserter prior and during the insertion of the device.
  • connection part can be for example a hollow knob, adapted to receive a pin, one of these parts being arranged on the intrauterine system and the other on the inserter. Another option is to use a traditional ball joint. A person skilled in the art is readily able to find a suitable solution for this connection part.
  • the first end of the plunger comprises at least one connection slot for receiving the connection part of the intrauterine system.
  • the first end of the plunger may also comprise two diagonally symmetrical connection slots for receiving the connection part of the intrauterine system. It is naturally possible that there are more than two connection slots, such as three, four, five or six slots.
  • the connection part then preferably comprises suitable parts fitting to these connections slots.
  • the first end of the plunger comprises at least one frame slot for receiving the frame of the intrauterine system.
  • the first end of the plunger may also comprise two diagonally symmetrical frame slots for receiving the frame of the intrauterine system.
  • the number of frame slots can also be higher, such as three, four, five or six.
  • the frame slots can be parallel to the longitudinal axis of the plunger or non-parallel to it.
  • the frame slots can for example be straight or slightly curved with respect to the outer surface of the plunger, in order for allowing the frame to be released.
  • the frame slots are preferably narrow enough to prevent the therapeutic component from slipping out and long enough to allow the movement of the therapeutic component and the stretching/compression of the frame during the insertion step.
  • the plunger or at least the first end of the plunger is large enough for containing the therapeutic component.
  • the frame slot(s) together with connection parts and the flange assure that the intrauterine system will be securely fitted and in the correct configuration during the insertion.
  • the first end of the insertion tube comprises at least one frame slot for receiving the frame of the intrauterine system.
  • the first end of the insertion tube may also comprise two diagonally symmetrical frame slots for receiving the frame of the intrauterine system.
  • the number of frame slots can also be higher, such as three, four, five or six.
  • the frame slots can be parallel to the longitudinal axis of the insertion tube or non-parallel to it.
  • the frame slots can for example be straight or slightly curved with respect to the outer surface of the insertion tube, in order for allowing the frame to be released.
  • the frame slots are preferably narrow enough to prevent the therapeutic component from slipping out and long enough to allow the movement of the therapeutic component and the stretching/compression of the frame.
  • the inserter according to the present invention may also comprise locking means for reversibly locking the intrauterine system in relation to the plunger, said locking means being controllable by the slider and/or the insertion tube.
  • This means that the locking means can also be controlled by a part of the slider and/or of the insertion tube, such as an extension of either or both of them.
  • the locking means is any arrangement which, induced by the movement of the slider, of the means to move the slider or of the insertion tube, can immobilize the removal string(s) to held IUS in stable position and again unlock the string(s) after insertion to release the IUS.
  • the invention relates to a locking means which comprises an object capable of reversibly preventing the movement of the string(s) by at least partly moving or pivoting from the original position, for example rotating around a shaft or an axle, and vertically or horizontally attached to the handle.
  • the object may have several shapes and may be for example round or rod-shaped, wedge, polygonal or rectangular with rounded or sharp corners.
  • the surface of the object preferably comprises one or more extensions having variable size and shape, for example a knob, a rib or a switch.
  • the object has a slot or pinhole through which the string(s) run.
  • the locking means may also comprise at least one counterpart against which the string(s) are pressed by the object and thus reversibly immobilized in the locking position.
  • the counterpart has a suitable shape adapted to fit at least some part of the surface of the object.
  • An extension, or extensions of the object can be used to keep the object and the counterpart in a fixed configuration until the IUS is released.
  • the counterpart preferably has a suitable design to keep the string(s) in proper direction, for example a slot or pinhole through which the string(s) run.
  • the object and said at least one counterpart have preferably a suitable length and diameter to fit inside the handle.
  • the outer surface of the insertion tube or the handle can have means to hold the strings until the intrauterine system has been inserted.
  • the locking means thus comprises
  • the main part comprises an opening or a slot in a diagonal direction through essentially the whole diameter of the main part, adapted to receive at least one removal string of the intrauterine system.
  • the locking means comprises
  • the main part has essentially the shape of a cylinder, or it is of triangular shape, or of any other suitable shape.
  • the insertion tube comprises an extension adapted to abut on the abutment surface of the first extension of the main part of the locking means.
  • the locking means comprises a main part comprising a first extension and a second extension arranged, in their initial position, to be essentially in contact with each other to from a blocking, wherein a part of the slider, the insertion tube or a part of the insertion tube is arranged to protrude into the main part of the locking means so as to separate the first and second extensions from each other.
  • the locking means could also be welding, gluing, cutting, knot or adhesion.
  • the strings could thus be for example attached to the body of the inserter by welding (for example by heating), gluing with glue or attaching with an adhesive agent (such as sticker).
  • the insertion tube would then release the attachment when contacting the slider.
  • Other options could be a knot or other mechanical hindrance, when the slot provided for the strings is larger in the releasing position.
  • the insertion tube could also comprise a blade that cuts the strings away from the inserter.
  • the locking means can be of any other kind than those specifically listed above as well as a combination thereof.
  • the invention further relates to a kit comprising an intrauterine system and an inserter according to the present invention.
  • the intrauterine system can be any intrauterine system known in the art. Any details and embodiments listed above naturally apply mutatis mutandis to the kit according to the invention.
  • the present invention also relates to a method for positioning an intrauterine system in a uterus of a patient, wherein the method uses an inserter according to the present invention.
  • the method comprises the steps of
  • the IUS is in a correct configuration relative to the inserter and there is no need to align the intrauterine system or for example to rearrange or correct the frame.
  • the IUS is positioned at the forward end of the plunger with the reservoir of the intrauterine system protected by the extension of the plunger and the frame locating outside the plunger in the expanded configuration, secured and protected by the flange.
  • the removal string(s) attached to the intrauterine system are preferably immobilized by the locking means, by the means on the surface of the insertion tube, or by both, to keep the IUS at a steady and correct position until it is released in the uterus.
  • the removal strings do however not necessarily need to be immobilized.
  • the depth of the uterus Prior to the insertion procedure the depth of the uterus is measured by sounding.
  • the slider mechanism or the means to move the slider is moved to correspond to the correct sounding depth.
  • the slider In the simplest form the slider is equipped with a self-locking press down and slide back button to adjust the correct sounding depth.
  • the handle is hold tightly and the inserter is introduced into the uterus until the flange touches the cervical opening.
  • the insertion tube starts moving backwards and the flexible plunger with the intrauterine system will go forwards into the uterus.
  • the insertion is continued until the insertion tube meets the slider, when also the removal string(s), if locked, are released by the locking means or by the means on the insertion tube.
  • IUS is in the correct location, as determined beforehand by using a sound as described above.
  • the inserter thus allows easy and secure positioning of an IUS.
  • the use of the slider mechanism is straightforward and the locking means to hold the string(s) and the IUS immobile long enough as well as the predetermined distances the insertion tubes can be moved in each step guarantee an accurate positioning of the IUS during insertion and its accurate release.
  • slider and the corresponding reference number are used to designate both the slider itself and the means to move the slider attached to the slider.
  • the term slider is used for convenience of reading.
  • FIG. 1 illustrates a general overview of an inserter according to the invention.
  • the inserter comprises a handle 3 , a plunger 2 attached to the handle, a slider having means to move the slider 5 , an insertion tube 6 around the plunger, an IUS and the string or strings (not shown here) for the removal of the IUS, means for reversibly locking the string(s) (not shown) in such a way that the IUS remains immobile in relation to the plunger during the necessary steps prior to and during insertion, and again for releasing the string(s) and the IUS after it has been inserted, an opening 8 , a channel 9 in which the insertion tube slides in the longitudinal direction, and depth markings 19 on the handle which are used to adjust the slider to correspond the depth of the uterus.
  • the forward part of the handle 3 forms an opening 8 , having the first end 8 a and the second end 8 b , which opening runs in the direction of the plunger 2 and has at the first end a channel 9 in which the insertion tube 6 slides in the longitudinal direction.
  • the front surface of the means to move the slider 5 a is set on the depth marking corresponding the depth of the uterus, i.e. the insertion depth, as determined before hand by using a sound or a probe.
  • FIGS. 2A , 2 B, 2 C and 2 D illustrate an operating principle of the inserter.
  • FIG. 2A shows an inserter and in this case an almond-shaped IUS 1 in a configuration as they are in the sterilized package.
  • the IUS is placed in the front end (entry into the uterus) of the inserter so that the elongate member of the intrauterine system or the elongated member with a drug containing reservoir is inside the head of the plunger and the frame of the intrauterine system is in the expanded configuration and partly covered by the flange 4 .
  • the means to move the slider 5 is on the basic position.
  • the removal string(s) are inside the inserter, tightened and locked by the locking means (not shown in the Figure) or outside under the insertion tube hold by suitable means or extensions.
  • FIG. 2B illustrates the first step of insertion procedure. After the insertion depth has been determined by sounding, the slider is moved backwards until surface 5 a is on a correct depth marking of the handle 3 .
  • FIG. 2C illustrates the procedure to insert the IUS.
  • the intrauterine system in the configuration according to FIG. 2B is gently introduced into the uterus until the flange abuts the cervical opening.
  • the frame of the IUS will compress against the head of the plunger.
  • FIG. 2D illustrates the final step of insertion procedure. Insertion is continued from the step of FIG. 2C .
  • the flange pressed against the cervical opening will cause the insertion tube to move backwards, and only the plunger with the intrauterine system will move towards the uterus.
  • the insertion tube will move until the rear end of the tube meets the slider and at this point the intrauterine system is correctly positioned in the uterus.
  • the inserter is retracted out of the uterus.
  • the strings and the intrauterine system are automatically released when the insertion tube meets the slider or when the inserter is drawn out. The distance the insertion tube can move has been selected to indicate clearly the moment at which the IUS has completely been positioned.
  • FIGS. 3A and 3B illustrate a locking means according to an embodiment of the invention.
  • the locking means are arranged preferably at the inside of the handle 3 , on any of the inside surfaces of the handle.
  • the locking means are used to immobilise and release the string(s) of the IUS.
  • FIG. 3A illustrates a locking means according to an embodiment of the invention comprising a main part 10 having essentially the shape of a cylinder and comprising an opening 12 there through in a diagonal direction.
  • the string(s) 7 of the IUS pass through the opening 12 .
  • the main part 10 is rotatably mounted on the handle, on a shaft or an axle (not shown).
  • the locking means also comprises a counterpart 11 , such that in the locking position the string(s) are immobilized between the counterpart and the main part.
  • the counterpart thus has a suitable shape adapted to fit to a part of the surface of the main part.
  • FIGS. 4A and 4B illustrate a locking means according to another embodiment of the invention.
  • FIG. 4A illustrates an object similar to the one presented in FIG. 3A , but having a different construction of the extension 10 a.
  • FIGS. 5A and 5B illustrate a locking means according to yet another embodiment of the invention.
  • This is a side view of a cylindrically shaped locking means, having a main part 13 which comprises two extensions 13 a and 13 b .
  • the locking means can rotate around a shaft or an axle 14 and is preferably attached to a shorter side of the inner surface of the handle.
  • the locking means also comprises a counterpart 15 such that the string(s) 7 are immobilised between the counterpart 15 and the extension 13 b .
  • the counterpart 15 has a suitable shape adapted to fit to a part of the surface of the extension 13 b .
  • the handle can also comprise a groove in which the string(s) run (not shown).
  • FIGS. 6A and 6B illustrate a locking means according to an embodiment of the invention.
  • the locking means 16 comprises two extensions 16 a and 16 b to immobilize the strings as shown in FIG. 6A .
  • the slider 5 and the insertion tube 6 move backwards the slider and/or the insertion tube protrudes into the locking means at least partly to expand the means enough to separate the extensions and to release the strings, as shown in FIG. 6B .
  • FIGS. 7A and 7B illustrate a locking means according to a further embodiment of the invention.
  • the locking means comprises two parts 17 a and 17 b to immobilize the strings as shown in FIG. 7A , said parts being able to move or turn from the original position.
  • the slider 5 has two extensions 18 a and 18 b . When the slider 5 and the insertion tube 6 move backwards the slider extensions turn the locking parts 17 a and 17 b apart from each other enough to release the strings, as shown in FIG. 7B .
  • FIGS. 8A and 8B illustrate an intrauterine system and its positioning on the inserter according to an embodiment of the invention.
  • the intrauterine system has a frame 1 a and a therapeutic component 1 b and it is positioned in the plunger or in an extension of the plunger 2 .
  • the intrauterine system is connected to the inserter via one connection part 19 .
  • the first end of the plunger 2 comprises one connection slot 20 for receiving the connection part 19 .
  • the therapeutic component is essentially completely and the frame essentially only partly positioned in a frame slot 21 .
  • FIGS. 8C and 8D illustrate another intrauterine system and its positioning on the inserter according to an embodiment of the invention, which has the same parts 1 a , 1 b , 2 , 19 and 20 as in FIGS. 8A and 8B .
  • the therapeutic component is essentially completely positioned inside the plunger and the frame is essentially completely outside the plunger.
  • FIGS. 9A and 9B illustrate some details of FIG. 8B , namely the first end of the plunger 2 and the connection of the intrauterine system on the plunger.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
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US13/119,399 2008-09-17 2009-09-11 An inserter Abandoned US20110172593A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20080524A FI20080524A0 (sv) 2008-09-17 2008-09-17 En inserter
FI20080524 2008-09-17
PCT/FI2009/050733 WO2010031899A1 (en) 2008-09-17 2009-09-11 An inserter

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2009/050733 A-371-Of-International WO2010031899A1 (en) 2008-09-17 2009-09-11 An inserter

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/857,134 Continuation US20130220338A1 (en) 2008-09-17 2013-04-04 Inserter
US13/857,134 Division US20130220338A1 (en) 2008-09-17 2013-04-04 Inserter

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US20110172593A1 true US20110172593A1 (en) 2011-07-14

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US13/119,399 Abandoned US20110172593A1 (en) 2008-09-17 2009-09-11 An inserter
US13/857,134 Abandoned US20130220338A1 (en) 2008-09-17 2013-04-04 Inserter
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US9707123B2 (en) 2017-07-18
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KR20110083599A (ko) 2011-07-20
EP2352469A1 (en) 2011-08-10
PT2352469E (pt) 2013-01-22
FI20080524A0 (sv) 2008-09-17
CN102159161B (zh) 2013-07-10
WO2010031899A1 (en) 2010-03-25
US20130220338A1 (en) 2013-08-29
EP2352469B1 (en) 2012-11-14
CA2735933A1 (en) 2010-03-25

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