US20090186090A1 - Oral Care Composition to Reduce or Eliminate Dental Sensitivity - Google Patents

Oral Care Composition to Reduce or Eliminate Dental Sensitivity Download PDF

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Publication number
US20090186090A1
US20090186090A1 US12/356,837 US35683709A US2009186090A1 US 20090186090 A1 US20090186090 A1 US 20090186090A1 US 35683709 A US35683709 A US 35683709A US 2009186090 A1 US2009186090 A1 US 2009186090A1
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United States
Prior art keywords
composition
oral care
care composition
silica
fluid flow
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Abandoned
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US12/356,837
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English (en)
Inventor
Lynette Zaidel
Suman K. Chopra
Michael Prencipe
Qin Wang
Constantina Christopoulou
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Colgate Palmolive Co
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Colgate Palmolive Co
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Publication date
Priority claimed from US11/742,039 external-priority patent/US20080268001A1/en
Priority claimed from US12/103,919 external-priority patent/US20080267891A1/en
Priority to US12/356,837 priority Critical patent/US20090186090A1/en
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Assigned to COLGATE-PALMOLIVE COMPANY reassignment COLGATE-PALMOLIVE COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WANG, QIN
Assigned to COLGATE-PALMOLIVE COMPANY reassignment COLGATE-PALMOLIVE COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CHOPRA, SUMAN K., PRENCIPE, MICHAEL, ZAIDEL, LYNETTE
Publication of US20090186090A1 publication Critical patent/US20090186090A1/en
Priority to CA2749189A priority patent/CA2749189C/en
Priority to BRPI1007053-2A priority patent/BRPI1007053B1/pt
Priority to JP2011548085A priority patent/JP5865081B2/ja
Priority to EP10701595A priority patent/EP2389228A2/en
Priority to AU2010210890A priority patent/AU2010210890B2/en
Priority to MYPI2011002993A priority patent/MY159576A/en
Priority to CN2010800054232A priority patent/CN102292125A/zh
Priority to MX2011007235A priority patent/MX2011007235A/es
Priority to SG2011046182A priority patent/SG172780A1/en
Priority to RU2011134912/15A priority patent/RU2011134912A/ru
Priority to TW099101691A priority patent/TWI558419B/zh
Priority to ARP100100134A priority patent/AR075043A1/es
Priority to PCT/US2010/021582 priority patent/WO2010090855A2/en
Priority to ZA2011/04856A priority patent/ZA201104856B/en
Priority to CO11084233A priority patent/CO6382144A2/es
Priority to JP2015150966A priority patent/JP2015232013A/ja
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • Dentin is a portion of the tooth internal to the enamel and cementum that has a radially striated appearance owing to a large number of fine canals or tubules known as the dentinal tubules.
  • Tubules run from the pulp cavity to the periphery of the dentin and are generally about two microns in diameter at their base and somewhat narrower at their periphery. Tubules are not usually exposed to the environment in the oral cavity, as they are usually covered by enamel or cementum. The cementum in turn is often covered by the gums.
  • the second approach involves the mechanical shield of the nerve by, e.g., blocking of the dentinal tubules wholly or partially with “tubule blocking agents.”
  • Agents that have been disclosed in the prior art include, e.g., cationic alumina, clays, water-soluble or water-swellable polyelectrolytes, oxalates, amorphous calcium phosphate, hydroxyapatite, maleic acid copolymers and polyethylene particles.
  • the invention includes an oral care composition comprising an adherent material and silica particles, wherein the oral care composition provides a fluid floss rate of no greater than about 45% of the fluid floss rate of etched dentin.
  • a composition comprises silica particles having a particle size distribution (PSD) of 3 ⁇ m to 5 ⁇ m.
  • a composition comprises silica particles having a median particle size of 3 ⁇ m to 5 ⁇ m.
  • the composition comprises silica particles having an average particle size of 3 ⁇ m to 5 ⁇ m.
  • a composition comprises silica particles having a particle size distribution (PSD) of 2 ⁇ m to 5 ⁇ m.
  • a composition comprises silica particles having a median particle size of 2 ⁇ m to 5 ⁇ m. In yet another aspect, the composition comprises silica particles having an average particle size of 2 ⁇ m to 5 ⁇ m. In another aspect, a composition comprises silica particles having an average particle size of 2.7 ⁇ m to 4.0 ⁇ m. In another aspect, a composition comprises a population of silica particles having a particle size selected from the group consisting of 2 ⁇ m, 2.5 ⁇ m, 3 ⁇ m, 3.5 ⁇ m, 4 ⁇ m, 4.5 ⁇ M, and 5 ⁇ m, wherein said population of silica particles comprise at least 20% of the total silica particles in said oral care composition.
  • a composition comprises silica particles having a median particle size of 3 ⁇ m to 5 ⁇ m, a d10 of 1.5 ⁇ m to 3 ⁇ m, and a d90 of 6 ⁇ m to 11 ⁇ m.
  • a composition comprises silica particles having a median particle size of 2 ⁇ m to 4 ⁇ m, a d10 of 0.5 ⁇ m to 2 ⁇ m, and a d90 of 5 ⁇ m to 10 ⁇ m.
  • a composition comprises silica particles, wherein the composition has a cumulative particle size volume fraction ⁇ 3.95 ⁇ m (AUC 3.95) of at least 20%, and wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.
  • a composition comprises silica particles, wherein the silica particles comprise a population of starting material silica particles having a cumulative particle size volume fraction (AUC 3.95) of at least 40%, wherein the oral care composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin.
  • the silica particles of a composition have a porosity of less than 0.45 cc/g in pores of 600 Angstroms or smaller.
  • the adherent material in a composition is a polymer having a number average molecular weight between 100,000 and 2,500,000, inclusive.
  • the adherent material is selected from polymers of polyvinyl phosphonic acid, poly (l-phosphonopropene) sulfonic acid, poly(beta styrene phosphonic acid), alpha styrene phosphonic acid, synthetic anionic polymeric polycarboxylate, maleic anhydride, maleic acid, and methyl vinyl ether.
  • the adherent molecule is a polymer of methyl vinyl ether and maleic anhydride.
  • a composition is formulated into a form selected from a rinse, a paste, a gel, a gum, a dissolvable lozenge, and a film.
  • the composition is formulated into a form selected from a dissolvable film.
  • a composition comprises a non-silica desensitizing agent.
  • the desensitizing agent is selected from the group consisting of a nitrate salt, an arginine ester, a bicarbonate salt, potassium nitrate, potassium chloride, an arginine-bicarbonate-phytate complex, potassium citrate, and arginine.
  • a composition further comprises an antibacterial agent. In an aspect, a composition further comprises 2,4,4′-trichloro-2′-hydroxydiphenyl ether.
  • a composition further comprises an agent selected from a chemical whitening agent, an opaque whitening agent and an anticalculus agent.
  • a composition further comprises a surfactant system that comprises sodium lauryl sulfate and tauranol.
  • a surfactant system consists essentially of sodium laurel sulfate and tauranol in a ratio of 1:5 to 1:3.
  • a composition further comprises an agent selected from a stannous ion agent; a fluoride compound; sodium fluoride; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethyl pyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agent; copper ion agent; essential oils; furanones; bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn
  • the invention provides compositions and methods for reducing dental sensitivity.
  • a method of reducing dental sensitivity comprises applying to the surface of a mammalian tooth an oral care composition of provided for herein.
  • a method of reducing dental sensitivity comprises applying to the surface of a mammalian tooth an oral care composition of claim 1 , wherein the adherent material is selected from polymers of polyvinyl phosphonic acid, poly (l-phosphonopropene) sulfonic acid, poly(beta styrene phosphonic acid), alpha styrene phosphonic acid, synthetic anionic polymeric polycarboxylate, maleic anhydride, maleic acid, and methyl vinyl ether.
  • a method of reducing dental sensitivity comprises applying to the surface of a mammalian tooth an oral care composition as provided for herein, wherein the particles have a porosity of less than 0.45 cc/g in pores of 600 Angstroms or smaller.
  • a method for protecting dentin from acid-mediated degradation comprising applying to the surface of a mammalian tooth an oral care composition as provided for herein.
  • a method for maintaining or increasing the systemic health of a mammal comprising applying a composition to an oral surface of a mammal at least once a day for a duration of time, wherein the composition comprises an oral care composition as provided for herein, wherein the silica particles are present in the composition in an amount of 5% by weight or greater, and an agent selected from triclosan; triclosan monophosphate; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agent; copper ion agent; essential oils; furanones; bacterioc
  • a method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the tooth surface a composition comprising an adherent material and a silica particle having a median particle size of no greater than a dentin tubule.
  • a method of occluding a dentin tubule within the surface of a mammalian tooth comprises applying to the tooth surface a composition as provided for herein.
  • the method of application is a method other than brushing the tooth surface.
  • a method of desensitizing a tooth in less than one day is provided, the method comprising applying to the tooth surface a composition as provided for herein.
  • the invention includes a method of increasing the potassium flux of a tooth, the method comprising applying to the tooth surface a composition as provided for herein. Also included is a method of increasing the potassium flux of a conventional potassium-containing desensitizing dentifrice, the method comprising applying to the tooth surface a composition as provided for herein.
  • a method of increasing the potassium flux of a conventional potassium-containing desensitizing dentifrice comprises applying to the tooth surface the composition as provided for herein, wherein the composition is applied either prior to application of the conventional dentifrice to the tooth, concomitant with application of the conventional dentifrice to the tooth, concomitant with application of the conventional dentifrice to the tooth in a mixture with the conventional dentifrice, or bib way of any combination thereof.
  • FIG. 1 depicts a comparison of the occlusion incidence resulting from treating with an oral care composition of the invention versus two different conventional desensitizing dentifrices in an acid-treated mammalian tooth dentin substrate.
  • Standard silica-containing desensitizing dentifrices are shown in columns 1 and 3
  • a silica-containing dentifrice of the invention is shown in column 2 .
  • FIG. 2 depicts the reduction in hydraulic conductance (% occlusion) of dentin segments treated with an oral care composition of the invention versus those treated with a conventional dentifrice.
  • FIG. 3 is a schematic depicting the potassium flux experiment of Example 3.
  • FIG. 4 depicts the difference in measured potassium flux with an oral care composition of the invention versus a conventional dentifrice.
  • FIG. 6 depicts the change in potassium flux upon change of pulpal pressure from 0 cm H 2 0 to 20 cm H 2 0.
  • the invention described herein includes an oral care composition that contains at least (a) an adherent material and (b) a silica particle.
  • the silica particle may have an average particle size of no greater than a dentin tubule, or alternatively it may have a median particle size of 8 microns or less.
  • the particles may be present in an amount of 5% by weight or greater.
  • the compositions may contain additional therapeutic and non-therapeutic components, and may also be utilized in the practice of various methods, all of which are included within the scope of the invention.
  • the composition and methods within the scope of the invention may be useful in, for example, reducing or eliminating tooth sensitivity of a mammal, improving/maintaining systemic health, and/or occluding dentin tubules.
  • Particle size distribution is measured using a Malvern Particle Size Analyzer, Model Mastersizer 2000 (or comparable model) (Malvern Instruments, Inc., Southborough, Mass.), wherein a helium-neon gas laser beam is projected through a transparent cell which contains silica, such as, for example, silica hydrogel particles suspended in an aqueous solution. Light rays which strike the particles are scattered through angles which are inversely proportional to the particle size. The photodetector arrant measures the quantity of light at several predetermined angles.
  • silica particles for oral compositions of the invention include silica particles with, for example, a particle size distribution of 3 to 4 microns, or alternatively, a particle size distribution of 5 to 7 microns, alternatively, a particle size distribution of 3 to 5 microns, alternatively, a particle size distribution of 2 to 5 microns, or alternatively, a particle size distribution of 2 to 4 microns.
  • the oral compositions within the scope of the invention also include particles that have a median particle size that is no greater than the average diameter of a mammalian dentin tubule, such that one or more particles is/are capable of becoming lodged within the tubule, thereby effecting a reduction or elimination of perceived tooth sensitivity.
  • suitable silica particles may have, for example, a median particle size of 8 microns or less, alternatively, a median particle size of 3 to 4 microns, alternatively, a median particle size of 5 to 7 microns, alternatively, a median particle size of 3 to 5 microns, alternatively, a median particle size of 2 to 5 microns, or alternatively, a median particle size of 2 to 4 microns.
  • a silica particle has a particle size of 2.0 microns. In another embodiment, a silica particle has a particle size of 2.5 microns. In another embodiment, a silica particle has a particle size of 3.0 microns. In another embodiment, a silica particle has a particle size of 3.5 nm microns. In another embodiment, a silica particle has a particle size of 4.0 microns. In another embodiment, a silica particle has a particle size of 4.5 microns. In another embodiment, a silica particle has a particle size of 5.0 microns. In an aspect of the invention, the silica particle size is a median particle size.
  • the silica particle size is an average (mean) particle size.
  • the silica particle comprises at least 5%, at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, or at least 40% of the total silica particles in a silica particle-containing composition.
  • a silica has a particle size characterized by the parameters of a median particle size of about 2 ⁇ m to about 4 ⁇ m, a d 10 of about 0.5 ⁇ m to about 2 ⁇ m, and a d 90 of about 5 ⁇ m to about 10 ⁇ m.
  • d 10 refers to particles having a diameter that is 10% of the threshold of the sampled population (i.e., 10% of the population is equal to or smaller than the d 10 value)
  • d 90 refers to particles having a diameter that is 90% of the threshold of the sampled population (i.e., 90% of the population is equal to or smaller than the d90 value).
  • At least a portion of the silica in a silica-containing dentifrice has a d 50 of 3.95 ⁇ m (i.e., 50% of the population of silica particles is equal to or smaller than the d 50 value).
  • Sorbosil AC43 silica has a d 50 of 3.95 ⁇ m.
  • the d 50 is measured using particle size measuring techniques as set forth elsewhere herein (e.g., MALVERN MASTERSIZER).
  • a silica-containing dentifrice has a population of particles at and below 3.95 ⁇ m as determined by the area under the curve (AUC) obtained in a particle size measurement.
  • AUC 3.95 refers to the cumulative volume fraction of particles ⁇ 3.95 ⁇ m.
  • a composition having 20% of its particles ⁇ 3.95 ⁇ m is said to have a cumulative particle size volume fraction (AUC 3.95) of 20%.
  • a silica-containing dentifrice of the invention has an AUC 3.95 value of least 18%. In another embodiment, a silica-containing dentifrice of the invention comprises has an AUC 3.95 value of least 26%. In another embodiment, a silica-containing dentifrice of the invention comprises has an AUC 3.95 value of least 22%. In another embodiment, a silica-containing dentifrice of the invention has an AUC 3.95 value of least 24%. In another embodiment, a silica-containing dentifrice of the invention has an AUC 3.95 value of least 26%. In another embodiment, a silica-containing dentifrice of the invention has an AUC 3.95 value of least 30%.
  • a silica-containing dentifrice of the invention comprises a silica starting material that has an AUC 3.95 value of at least 40%. In another embodiment, a silica-containing dentifrice of the invention comprises a silica starting material that has an AUC 3.95 value of at least 42%. In another embodiment, a silica-containing dentifrice of the invention comprises a silica starting material that has an AUC 3.95 value of at least 45%. In another embodiment, a silica-containing dentifrice of the invention comprises a silica starting material that has an AUC 3.95 value of at least 50%. In an aspect of the invention, a silica starting material is a small particle silica.
  • the silica particles have a porosity of less than about 0.45 cc/g in pores of about 600 Angstroms or smaller.
  • the silica is an INEOS (now PQ Corp.) Sorbosil AC43 silica.
  • AC43 silica has properties including, but not limited to, an average particle size of 2.7-4.0 microns (as determined by MALVERN MASTERSIZER), a sieve residue of +45 ⁇ m, a moisture loss at 105° C. of 8.0% max, an ignition loss at 1000° C. of 14.0% max, and a pH of 5.5-7.5 in aqueous suspension.
  • the silica particles may be initially present in the composition having the desired particle size, or may be initially present in the composition at a larger size, so long as the structure of the particles is such that it fractures or breaks into the desired particle size upon application of mechanical force by, e.g., a toothbrush, when brushing.
  • the silica particle may be prepared by any means known or to be developed in the art, and may be surface modified, if desired, to increase the capacity of the particle to adhere to a tooth surface. Examples may be found in, e.g., U.S. patent application Ser. No. 11/271,306, the contents of which are incorporated herein by reference.
  • the silica particle is present in the composition in an amount of 5% or greater by weight of the total composition. Alternatively, the silica particle may be present in an amount of 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20% or 25% by a weight.
  • any abrasive particulates may be used and may be selected from sodium bicarbonate, calcium phosphate (e.g., dicalcium phosphate dihydrate), calcium sulfate, precipitated calcium carbonate, silica (e.g., hydrated silica), iron oxide, aluminium oxide, perlite, plastic particles, e.g., polyethylene, and combinations thereof.
  • the abrasive may be selected from a calcium phosphate (e.g., dicalcium phosphate dihydrate), calcium sulfate, precipitated calcium carbonate, silica (e.g., hydrated silica), calcium pyrophosphate and combinations. Any type of silica may be used, such as precipitated silicas or silica gels.
  • silicas such as INEOS AC43, available from Ineos Silicas, Warrington, United Kingdom, as described elsewhere herein.
  • a silica has a median particle size from 3 ⁇ m to 5 ⁇ m, as described in detail elsewhere herein.
  • a silica and/or silica-containing oral composition provides a fluid flow rate of no greater than about 45% of the fluid flow rate of etched dentin, as described in detail elsewhere herein.
  • abrasives may be used in accordance with the present invention.
  • One class of abrasives comprises silica particles as set forth in detail herein.
  • Another class of abrasives are powdered silicas, particularly, silica xerogels as defined in U.S. Pat. No. 3,538,230. Additionally, as set forth in U.S. Pat. No. 4,358,437, powdered forms of calcium carbonate in an abrasive form is another class of abrasives.
  • the oral compositions of the invention also include an adherent material.
  • the adherent material may be any known or to be developed in the art that attaches to the surface of a mammalian tooth and/or to the heterogenous biofilm which also may be present on a tooth's surface. Attachment may occur by any means, such as ionic interaction, van der Waals forces, hydrophobic-hydrophilic interactions, etc.
  • the adherent material may be, for example, chitosan, chitin, a gum or a marine colloid.
  • Other contemplated adherent materials include any homopolymers or copolymers (hereinafter referred to collectively as a “polymers”) that adhere to the surface of a tooth.
  • Such polymers may include poly (ethylene oxide) polymers (such as POLYOX from Dow Chemical), linear PVP and cross-linked PVP, PEG/PPG copolymers (such as BASF Pluracare L1220), ester gum, shellac, pressure sensitive silicone adhesives (such as BioPSA from Dow-Corning), methacrylates, or mixtures thereof.
  • a copolymer comprises poly(methylvinylether/maleic anhydride).
  • a copolymer comprises poly(methylvinylether/maleic acid).
  • a copolymer comprises poly(methylvinylether/maleic acid) half esters.
  • a copolymer comprises poly(methylvinylether/maleic acid) mixed salts.
  • Polymers of any molecular weight may be used, including, for example molecular weights of 50,000 to 500,000, 500,000 to 2,500,000 or 2,500,000 to 10,000,000 (calculated by either number average or weight average).
  • a polymer has a molecular weight of 130,000.
  • a polymer has a molecular weight of 200,000.
  • a polymer has a molecular weight of 690,000.
  • a polymer has a molecular weight of 1,000,000.
  • a polymer has a molecular weight of 1,250,000.
  • a polymer has a molecular weight of 1,980,000.
  • a polymer has a molecular weight of 2,500,000.
  • a polymer has a molecular weight of 5,000,000.
  • a copolymer of methyl vinyl ether and maleic anhydride may be used at a monomer ratio of from 1:4 to 4:1.
  • Other polymers that may be used as adherent materials include those recited in United States Patent Application Publication No. 2006/0024246, the contents of which is incorporated herein by reference.
  • Dentin that is treated with the combination of the invention produce a fluid flow rate of no greater than 45%, 25%, 20%, 15% or 10% of the flow rate value of the etched dentin, as determined by the Dentin Conductance Procedure.
  • Dentin Conductance Procedure The reduction in sensitivity of a tooth is demonstrated herein by a reduction in the measured fluid flow rate, a measure of conductance of dentin.
  • Extracted human molars are cut at the crown and roots using a diamond saw.
  • the pulp is removed and the resulting dentin segment is stably mounted, such as onto an acrylic block.
  • Tubing is connected from a hole in the acrylic block mounting just below %, the pulp chamber.
  • the dentin segment is connected to an apparatus that measures the rate of fluid flour (hydraulic conductance). See, Zhang et al., “The effects of pain free desensitizer on dentine permeability and tubule occlusion over time, in vitro”, Journal of Clinical Periodontol, 25(11 Pt 1): 884-91 (November 1998), the contents of which are incorporated herein by reference.
  • the top surface of the dentin is etched with citric acid.
  • the fluid flow rate across the etched dentin is measured under 70 cm water pressure.
  • the dentin surface is then treated with a slurry of the oral composition of the invention diluted with 3 parts deionized water and the fluid flow rate is measured again. See Pashley et al., “Effects of desensitizing dentifrices in vitro,” J. Periodontol., 55 (9): 522-525 (September 1984).
  • silica-containing compositions of the invention can desensitize a tooth.
  • silica-containing compositions of the invention provide tooth desensitization that is superior to conventional desensitizing dentifrices.
  • a silica-containing dentifrice of the invention provides tooth desensitization by providing a greater desensitization than a conventional dentifrice or a conventional desensitizing dentifrice, by providing desensitization more rapidly than a conventional dentifrice or a conventional desensitizing dentifrice, or by a combination of greater desensitization and more rapid desensitization, among other effects.
  • a silica-containing composition of the invention provides desensitization and/or superior desensitization in the absence of any other desensitizing agent.
  • a silica-containing composition of the invention provides desensitization and/or superior desensitization, and may contain one or more additional desensitizing agents, as described elsewhere herein.
  • the invention also encompasses methods of use and/or application of a silica-containing desensitizing composition.
  • a silica-containing composition may be applied to the tooth via conventional brushing techniques (e.g., use of a toothbrush).
  • a silica-containing composition may be applied to the tooth via a method other than conventional brushing techniques.
  • Other methods of application include manual application (e.g., applying a composition to a tooth using one or more fingers, rubbing onto the tooth surface, rubbing in a circular motion, etc. . . . ), or application using any known dental appliance or applicator. It will be understood, based on the disclosure set forth herein, that any method of smearing a composition onto a tooth, optionally using varying degrees of physical pressure, is encompassed by the invention.
  • Desensitization of a tooth according to the invention may be measured by any technique set forth herein, or any technique known to the skilled artisan.
  • the extent of desensitization of a tooth according to a composition of the invention may be ascertained by measuring the potassium flux, as described in detail elsewhere herein.
  • the invention provides compositions and methods for augmenting, enhancing and/or supplementing the desensitization obtained using potassium-based desensitizing dentifrices.
  • a composition of the invention is used to occlude a dentin tubule to inhibit outward fluid flow while at the same time allowing inward flux of potassium ions into the tubule.
  • the invention provides compositions and methods of desensitizing a tooth, wherein the degree of desensitization is ascertained by measuring potassium flux as 20 cm pulpal pressure, as described in detail elsewhere herein.
  • a composition of the invention has a potassium flux value at 20 cm pulpal pressure that is greater than 20% of the potassium flux value obtained for the composition at zero pulpal pressure.
  • the combination of the small particle silica/polymer occlusion composition with a potassium desensitizing agent enhanced the delivery of potassium inward through the dentin tubules.
  • the invention provides compositions and methods for increasing the potassium flux value measured upon use of a conventional potassium-containing dentifrice applied to a tooth. Such a potassium flux change can be measured as described in detail elsewhere herein.
  • the invention encompasses any increase of the potassium flux obtained when using a conventional potassium-containing dentifrice, as mediated by co-application of a conventional potassium-containing dentifrice and a silica-containing composition of the invention, by application of a conventional potassium-containing dentifrice subsequent to application of a silica-containing composition of the invention, or by application of a mixture comprising a conventional potassium-containing dentifrice and a silica-containing composition of the invention.
  • the invention includes a method of increasing the potassium flux in one or more dentin tubules of a tooth, the method comprising applying to the tooth surface a composition as provided for herein.
  • Application of the composition to the tooth surface results in the introduction of the composition into one or more dentin tubules.
  • the composition is applied to the teeth by any method set forth herein or known in the art.
  • the potassium flux, the rate of potassium flux, and the change in rate of potassium flux can be ascertained as set forth in detail elsewhere herein.
  • a method of increasing the potassium flux of a conventional potassium-containing desensitizing dentifrice comprising applying to the tooth surface a composition as provided for herein.
  • a method of increasing the potassium flux of a conventional potassium-containing desensitizing dentifrice comprises applying to the tooth surface the composition as provided for herein, wherein the composition is applied either prior to application of the conventional dentifrice to the tooth, concomitant with application of the conventional dentifrice to the tooth, concomitant with application of the conventional dentifrice to the tooth in a mixture with the conventional dentifrice, or by way of any combination thereof.
  • the oral care composition may include any other therapeutic, cosmetic, and/or aesthetic materials as may be desired.
  • examples include non-silica desensitizing agents (E.g., a nitrate salt, an arginine ester, a bicarbonate salt, potassium nitrate, an arginine-bicarbonate-phytate complex, potassium citrate, and arginine, among others), a chemical whitening agent (such as a peroxide releasing compound), an opaque whitening agent (such as hydroxyapetite) and an anticalculus agent.
  • non-silica desensitizing agents E.g., a nitrate salt, an arginine ester, a bicarbonate salt, potassium nitrate, an arginine-bicarbonate-phytate complex, potassium citrate, and arginine, among others
  • a chemical whitening agent such as a peroxide releasing compound
  • an opaque whitening agent such as hydroxyapetite
  • triclosan stannous ion agents
  • chlorhexidine alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agents; copper ion agents; essential oils; furanones; bacteriocins, ethyl lauroyl arginate, extracts of magnolia, a metal ion source, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, an enzyme, a Camellia
  • compositions described herein may be formulated into any delivery form that permits contact of the adherent material and the particles, to the tooth surface.
  • the compositions may be formulated into a mouth rinse, a paste, a gel, a lozenge (dissolvable or chewable), a spray, a gum, and a film (wholly or partially dissolvable, or indissoluble).
  • the composition may contain any conventional excipients or carriers, although these will vary depending on the dosage form or means of dosage selected.
  • Excipents or carriers can include, for example, humectants, colorants, flavorants, glycerin, sorbitol, xylitol, and/or propylene glycol, water or other solvents, gum bases, thickening agents, surfactants, carrageenan (rich moss), xanthan gum and sodium carboxymethyl cellulose, starch, polyvinyl pyrrolidone, hydroxyethyl propyl cellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, and hydroxylethyl cellulose and amorphous silicas.
  • surfactants may be included, if desired.
  • suitable surfactants include water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of monosulfated monoglyceride of hydrogenated coconut oil fatty acids; higher alkyl sulfates such as sodium lauryl sulfate; alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate; higher alkyl sulfoacetates, such as sodium lauryl sulfoacetate; higher fatty acid esters of 1,2-dihydroxypropane sulfonate; and the substantially saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic compounds, such as those having 12-16 carbons in the fatty acid, alkyl or acyl radicals; and the like.
  • amides examples include N-lauryl sarcosine, and the sodium, potassium and ethanolamine salts of N-lauryl, N-myristoyl, or N-palmitoyl sarcosine.
  • Others include, for example, nonanionic polyoxyethylene surfactants, such as Polyoxamer 407, Steareth 30, Polysorbate 20, and castor oil; and amphoteric surfactants, such as cocamidopropyl betaine (tegobaine), and cocamidopropyl betaine lauryl glucoside; condensation products of ethylene oxide with various hydrogen containing compounds that are reactive therewith and have long hydrocarbon chains (e.g., aliphatic chains of from 12 to 20 carbon atoms), which condensation products (ethoxamers) contain hydrophilic polyoxyethylene moieties, such as condensation products of poly (ethylene oxide) with fatty acids, fatty, alcohols, fatty amides and other fatty moieties, and with propylene oxide and polypropylene
  • the oral composition includes a surfactant system that is sodium laurel sulfate (SLS) and tauranol. If desired, the SLS and tauranol may be present in a ratio of 1:5 to 1:3.
  • SLS sodium laurel sulfate
  • tauranol may be present in a ratio of 1:5 to 1:3.
  • the oral care composition of the invention may be prepared by any means known in the art.
  • preparation methods for dentifrices are well known, for example, as described in U.S. Pat. Nos. 3,966,863; 3,980,767; 4,328,205; and 4,358,437, the contents of which are incorporated herein by reference.
  • any humectant e.g., glycerin, sorbitol, propylene glycol, and/or polyethylene glycol
  • any humectant e.g., glycerin, sorbitol, propylene glycol, and/or polyethylene glycol
  • the thickeners such as carboxylmethyl cellulose (CMC), carrageenan, or xanthan gum; any anionic polycarboxylate; any salts, such as sodium fluoride anticaries agents; and any sweeteners.
  • CMC carboxylmethyl cellulose
  • carrageenan carrageenan
  • xanthan gum any anionic polycarboxylate
  • any salts such as sodium fluoride anticaries agents
  • sweeteners such as sodium fluoride anticaries agents.
  • the resultant mixture is agitated until a homogeneous gel phase is formed.
  • any pigments utilized such as TiO 2 , and additionally any acid or base required to adjust the pH of the composition. These ingredients are mixed until a homogeneous phase is obtained.
  • the mixture is then transferred to a high speed/vacuum mixer, wherein the surfactant ingredients are added to the mixture.
  • the silicas utilized are added subsequently. Any water insoluble agents, such as triclosan, are solubilized in the flavor oils to be included in the dentifrice, and that solution is added along with the surfactants to the mixture, which is then mixed at high speed in the range from 5 to 30 minutes, under a vacuum of 20 to 50 mm of Hg.
  • the resultant product is a homogeneous, semi-solid, extrudable paste or gel product.
  • the invention also includes within its scope several related methods.
  • the invention includes within its scope methods of reducing and methods of occluding a dentin tubule of a mammalian tooth, methods of protecting dentin from acid-mediated degradation, and methods of reducing dental sensitivity.
  • Each of these methods includes the steps of applying any of the compositions described above to the tooth surface.
  • Application may be carried out by any method, so long as the adherent material and the particles are placed in contact with the tooth surface.
  • Application may be accomplished by brushing, flossing, prophylaxis, irrigating, wiping, rinsing (lavage of oral cavity), foam/gel and in-tray application, masticating, spraying, painting, etc., or applied by film or strip.
  • Dental sensitivity may be reduced according to a method of the invention by applying a composition of the invention to a tooth surface.
  • a composition may be applied using a traditional method, as described in detail elsewhere herein, or by any appliance or applicator, whether or not typically associated with dental use.
  • one or more human fingers is used to apply a dental sensitivity-reducing composition to one or more teeth.
  • a finger can be used to smear the composition on the surface of a tooth, or to otherwise apply the composition to the surface of a tooth.
  • the invention includes methods to increase or maintain the systemic health of a mammal by applying a composite to an oral surface (both hard and soft tissues of the oral cavity).
  • the composition for use in this method may be any described above, provided that it contains at least one of triclosan; triclosan monophosphate; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4-ethylpyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agent; copper ion agent; essential oils; furanones; bacteriocins, ethyl lauroyl arginate, extracts of magnolia, a metal ion source,
  • composition A is a control composition that does not contain the specified silica particle.
  • Triclosan was dissolved in the flavor component.
  • Premix flavor and triclosan and sodium sulphate powder were added. It was mixed for 10 minutes at medium speed under full vacuum. The vacuum was released and the whole batch was inspected for uniformity.
  • Fluid flow across dentin samples using each composition (A-D) was measured using the procedure described above.
  • compositions C-D (polymer and small particle silica) produced a fluid flow rate that was 5-22% of the fluid flow value of etched dentin which was significantly lower than that of composition A with polymer alone. Values for tropical commercial dentifrices without the small particle silica/polymer would be 50-100% of the value of etched dentin (ref: Pashley D H et al, Effect of desensitizing dentrifices. J. Periodontol, 1984:55:522-525). Thus, compositions C-D produced significant reductions in fluid flow rate.
  • confocal microscopy images taken of etched dentin treated with Composition C showed significant occlusion/coating of the open dentin tubules when compared to etched dentin treated with Composition A.
  • the occlusive coating produced by Composition C was resistant to acid dissolution by cola.
  • Duplicate dentin blocks were divided into three groups and treated for one minute with either PBS, a conventional dentifrice, or the Test Dentifrice set forth herein, comprising triclosan/copolymer/small particle silica/NaF, wherein the silica particle size distribution was between 2 ⁇ m and 8 ⁇ m.
  • Both the conventional dentifrice and the Test Dentifrice according to the present invention contained 1100 ppm NaF.
  • the dentin blocks were rinsed and incubated in PBS for 30 minutes. The cycle was repeated for a total of 6 treatments, followed by a 3-minute acid challenge in 6% citric acid.
  • the citric acid challenge solution was analyzed for soluble calcium concentration with atomic absorption spectrophotometry.
  • Dentin treated with the triclosan/copolymer/small particle silica/NaF oral composition of the present invention provided significantly better protection against acid attack compared to dentin treated with a conventional fluoride dentifrice.
  • Test Dentifrice group Eighty-two subjects completed all study visits. At both the four-week and the eight-week examinations, the Test Dentifrice group exhibited statistically significantly more favorable tactile hypersensitivity scores than did the Control Dentifrice group, with improvements of 31.6% and 52.1%, respectively. Additionally, at both the four-week and eight-week examinations, the Test Dentifrice group exhibited statistically significantly more favorable air blast hypersensitivity scores than did the Control Dentifrice group, with improvements of 17.8% and 23.6%, respectively.
  • an oral composition of the invention in the form of a dentifrice containing 0.3% triclosan, 2.0% copolymer, small particle silica and 0.243% NaF in a silica base provides (1) a significant reduction of hypersensitivity after four and eight weeks of product use, and provides (2) significant improvements in dentinal hypersensitivity as compared to the commercially-available non-desensitizing fluoride dentifrice after four and eight weeks of product use.
  • Test Dentifrice group exhibited statistically significantly more favorable tactile hypersensitivity scores than did the Control Dentifrice group, with improvements of 11.5% and 17.9%, respectively. Additionally, at both the four-week and eight-week examinations, the Test Dentifrice group exhibited statistically significantly more favorable air blast hypersensitivity scores than did the Control Dentifrice group, with improvements of 16.1% and 23.3%, respectively.
  • compositions of the invention for dental sensitivity relief by use of a dentin tubule occlusion system in combination with conventional potassium desensitizing agents, and in particular, an oral composition of the invention comprising a silica having a particle size characterized by the parameters of a median particle size of about 2 ⁇ m to about 4 ⁇ m, a d 10 of about 0.5 ⁇ m to about 2 ⁇ m, and a d 90 of about 5 ⁇ m to about 10 ⁇ m, and a polymethylvinylether/maleic anhydride copolymer having a median molecular weight of 2,000,000 (“Test Dentifrice”) and the desensitizer potassium nitrate.
  • “Composition E” Table 4
  • composition E Ingredient Wt % Glycerin 19.74 Water QS Gantrez 13% solution 15.00 Sorbitol 15.00 Sorbosil AC43 silica 10.00 Thickening silica 8.00 Potassium nitrate 5.00 PEG600 3.00 SLS 1.50 Sodium hydroxide 50% 1.45 Flavor 1.10 Sodium phosphate tribasic 1.00 Titanium dioxide 1.00 Poloxomer 407 1.00 Saccharin 0.40 Sodium CMC 0.40 Sodium Fluoride 0.243 Xanthan Gum 0.17
  • a dose-response study of the silica of the Test Dentifrice regarding occlusion efficacy was examined using confocal microscopy, at three different levels of silica particles, 5%, 7.5% and 10% (w/w). Ten percent silica particles showed superior occlusion effect after 14 brushing treatments and 2 acid-challenge exposures in comparison to conventional commercial desensitizing products. Dentin disks were treated 14 times to mimic a 7-day brushing regimen. Cola challenge was performed in order to have a clear distinction amongst the tested products.
  • the confocal microscopy, images are displayed in FIG. 1 (zoom 50 ⁇ 50 ⁇ m), demonstrating superior protective/desensitizing effect of The Test Dentifrice.
  • the occlusion effect of The Test Dentifrice is preserved after the cola challenge, as indicated by no changes on the surface image (see column 2 in FIG. 1 ).
  • Hydraulic Conductance testing was performed to evaluate the degree of occlusion taking place on a dentin segment attached to a sensor that measures the displacement of water over time.
  • the occlusion efficacy is related to a decrease in the hydraulic conductance, or water permeability of dentin segments after treatment with dentifrice.
  • the baseline was measured on a dentin segment previously etched to have the maximum open tubules and higher permeability (“0% occlusion”).
  • a decrease in the hydraulic conductance after treatment with dentifrice indicates the occlusion effect, calculated in the percentage of permeability reduction.
  • the Test Dentifrice was shown to be 50% better than conventional commercial desensitizing products in this test.
  • FIG. 2 illustrates the percentage of occlusion observed with each composition in comparison to its own baseline as determined using hydraulic conductance. This result is in agreement with the confocal microscopy results, namely, higher occlusion percentage is observed for the Test Dentifrice.
  • Composition E the hydraulic conductance testing procedure was modified to allow testing of an alternative application method for instant relief which involves rubbing/smearing the toothpaste onto a sensitive tooth with one finger.
  • the surface of dentin segments was wetted with 10 ⁇ l PBS buffer to simulate a moist tooth in the mouth.
  • Composition E was applied to the dentin segments undiluted (“neat”) with one finger and rubbed in a circular motion for 1 minute.
  • the sample was rinsed with distilled, deionized water and the hydraulic conductance measured at 70 cm water pressure.
  • the procedure was repeated using a conventional non-desensitizing dentifrice (Control Dentifrice, Table 5).
  • K flux potassium flux
  • FIG. 4 shows a comparison of the two products investigated and a control.
  • Each composition was evaluated in triplicate and one disk was studied per day.
  • the experiment was carried out as follows: The dentin disk was mounted in the Pashley's split chamber and brushed respectively with either the Test Dentifrice, a conventional commercial dental desensitizing product, or Phosphate buffer (PBS). After brushing, the disk (in the chamber) was rinsed thoroughly and the chamber was connected to the experimental system. A constant water flow was provided by a syringe pump at 0.2 mL/minute and the fraction collector changed every 10 minute.
  • PBS Phosphate buffer
  • a respective potassium source was added, i.e., toothpaste slurry of the study products and KNO3 solution for PBS treated samples. Chamber and collector were aligned to have a final pressure of zero cm H 2 0 for 18 fractions or 180 minutes.
  • the occlusion efficacy can be inferred by the potassium diffusion (as ⁇ 10 ⁇ 10 mol/cm 2 ⁇ s), where the PBS-treated disk results in higher K flux due its lack of occlusion.
  • the chamber is lowered with respect to the collector, simulating an in vivo situation, with a pulpal pressure of 20 cm H 2 O.
  • the potassium flow was expected to decrease due to the opposed pressure created by the difference of height chamber/collector.
  • the disk which presents the smallest change or the higher potassium flux under the pulpal pressure will be more effective on delivering potassium ions to a tooth with exposed dentin tubules.
  • An occlusion system that diminishes the negative effect of the water pressure on the ion diffusion will result in higher potassium flux at the end.
  • the results in FIG. 4 show clearly that The Test Dentifrice presents the highest potassium flux under 20 cm H 2 O in comparison to conventional commercial desensitizing product and PBS-brushed disks. A comparison of the average flux under pulpal pressure is plotted for the two studied products and PBS in FIG. 5 .
  • FIG. 6 illustrates the same trend in terms of percentage of potassium flux after the simulated pulpal pressure had been applied.
  • Table 6 illustrates the AUC 3.95 values measured for various silica-containing compositions and silica starting materials, including silica-containing compositions of the invention and silica starting materials used in silica-containing compositions of the invention.

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US12/356,837 US20090186090A1 (en) 2007-04-30 2009-01-21 Oral Care Composition to Reduce or Eliminate Dental Sensitivity
SG2011046182A SG172780A1 (en) 2009-01-21 2010-01-21 Oral care composition to reduce or eliminate dental sensitivity
RU2011134912/15A RU2011134912A (ru) 2009-01-21 2010-01-21 Композиция для ухода за полостью рта для снижения или устранения чувствительности зубов
BRPI1007053-2A BRPI1007053B1 (pt) 2009-01-21 2010-01-21 Composition for oral care, use of an adherent material and silica particles and method to increase the flow of potassium
PCT/US2010/021582 WO2010090855A2 (en) 2009-01-21 2010-01-21 Oral care composition to reduce or eliminate dental sensitivity
CA2749189A CA2749189C (en) 2009-01-21 2010-01-21 Oral care composition to reduce or eliminate dental sensitivity
ARP100100134A AR075043A1 (es) 2009-01-21 2010-01-21 Composicon de cuidado oral para reducir o eliminar sensibilidad dental
TW099101691A TWI558419B (zh) 2009-01-21 2010-01-21 用於降低或減少牙齒敏感性之口腔保健組成物
JP2011548085A JP5865081B2 (ja) 2009-01-21 2010-01-21 歯の敏感性を低減する、または除去するための口腔ケア組成物
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AU2010210890A AU2010210890B2 (en) 2009-01-21 2010-01-21 Oral care composition to reduce or eliminate dental sensitivity
MYPI2011002993A MY159576A (en) 2009-01-21 2010-01-21 Oral care composition to reduce or eliminate dental sensitivity
CN2010800054232A CN102292125A (zh) 2009-01-21 2010-01-21 减轻或消除牙齿敏感性的口腔护理组合物
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