US20080057063A1 - Antibodies Directed to AlphaVBeta6 and Uses Thereof - Google Patents

Antibodies Directed to AlphaVBeta6 and Uses Thereof Download PDF

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Publication number
US20080057063A1
US20080057063A1 US11/833,486 US83348607A US2008057063A1 US 20080057063 A1 US20080057063 A1 US 20080057063A1 US 83348607 A US83348607 A US 83348607A US 2008057063 A1 US2008057063 A1 US 2008057063A1
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US
United States
Prior art keywords
seq
binding agent
antibody
αvβ6
targeted binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/833,486
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English (en)
Inventor
Julie Rinkenberger
Ian Foltz
Avril Alfred
Simon Barry
Vahe Bedian
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MedImmune Ltd
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AstraZeneca AB
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Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Priority to US11/833,486 priority Critical patent/US20080057063A1/en
Publication of US20080057063A1 publication Critical patent/US20080057063A1/en
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: AMGEN FREMONT INC
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEDIAN, VAHE, FOLTZ, IAN, ALFRED, AVRIL, RINKENBERGER, JULIE, BARRY, SIMON THOMAS
Priority to US12/782,335 priority patent/US8398975B2/en
Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ASTRAZENECA AB
Priority to US13/760,426 priority patent/US8894998B2/en
Priority to US14/535,894 priority patent/US20150166663A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
US11/833,486 2006-08-03 2007-08-03 Antibodies Directed to AlphaVBeta6 and Uses Thereof Abandoned US20080057063A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/833,486 US20080057063A1 (en) 2006-08-03 2007-08-03 Antibodies Directed to AlphaVBeta6 and Uses Thereof
US12/782,335 US8398975B2 (en) 2006-08-03 2010-05-18 Antibodies directed to αVβ6 and uses thereof
US13/760,426 US8894998B2 (en) 2006-08-03 2013-02-06 Antibodies directed to αVβ6 and uses thereof
US14/535,894 US20150166663A1 (en) 2006-08-03 2014-11-07 Antibodies Directed To Alpha V Beta 6 And Uses Thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83555906P 2006-08-03 2006-08-03
US11/833,486 US20080057063A1 (en) 2006-08-03 2007-08-03 Antibodies Directed to AlphaVBeta6 and Uses Thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/782,335 Continuation US8398975B2 (en) 2006-08-03 2010-05-18 Antibodies directed to αVβ6 and uses thereof

Publications (1)

Publication Number Publication Date
US20080057063A1 true US20080057063A1 (en) 2008-03-06

Family

ID=39146822

Family Applications (4)

Application Number Title Priority Date Filing Date
US11/833,486 Abandoned US20080057063A1 (en) 2006-08-03 2007-08-03 Antibodies Directed to AlphaVBeta6 and Uses Thereof
US12/782,335 Active 2028-08-20 US8398975B2 (en) 2006-08-03 2010-05-18 Antibodies directed to αVβ6 and uses thereof
US13/760,426 Active US8894998B2 (en) 2006-08-03 2013-02-06 Antibodies directed to αVβ6 and uses thereof
US14/535,894 Abandoned US20150166663A1 (en) 2006-08-03 2014-11-07 Antibodies Directed To Alpha V Beta 6 And Uses Thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
US12/782,335 Active 2028-08-20 US8398975B2 (en) 2006-08-03 2010-05-18 Antibodies directed to αVβ6 and uses thereof
US13/760,426 Active US8894998B2 (en) 2006-08-03 2013-02-06 Antibodies directed to αVβ6 and uses thereof
US14/535,894 Abandoned US20150166663A1 (en) 2006-08-03 2014-11-07 Antibodies Directed To Alpha V Beta 6 And Uses Thereof

Country Status (18)

Country Link
US (4) US20080057063A1 (es)
EP (1) EP2064244B1 (es)
JP (2) JP5362563B2 (es)
KR (1) KR20090039739A (es)
CN (2) CN103524619B (es)
AR (1) AR062213A1 (es)
AU (1) AU2007348941B2 (es)
BR (1) BRPI0715141A2 (es)
CA (1) CA2658612C (es)
ES (1) ES2746925T3 (es)
IL (1) IL196848A0 (es)
MX (1) MX2009001293A (es)
NO (1) NO20090877L (es)
RU (1) RU2009107277A (es)
TW (1) TW200815474A (es)
UY (1) UY30524A1 (es)
WO (1) WO2008112004A2 (es)
ZA (1) ZA200900395B (es)

Cited By (27)

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US20100172895A1 (en) * 2008-12-23 2010-07-08 Boone Thomas C Human CGRP Receptor Binding Proteins
US20100330103A1 (en) * 2006-08-03 2010-12-30 Astrazeneca Ab Antibodies Directed to Alpha V Beta 6 And Uses Thereof
CN102858975A (zh) * 2010-02-18 2013-01-02 明治制果药业株式会社 铜绿假单胞菌a血清型脂多糖的抗体
WO2014057074A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
US20140199295A1 (en) * 2011-06-23 2014-07-17 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
WO2014140174A1 (en) 2013-03-13 2014-09-18 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
WO2016037644A1 (en) 2014-09-10 2016-03-17 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
WO2016057306A1 (en) * 2014-10-06 2016-04-14 University Of Houston Rho associated kinase (rock) inhibitors and their use in treating disease
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
WO2016090329A3 (en) * 2014-12-05 2016-07-28 Memorial Sloan-Kettering Cancer Center Antibodies targeting g-protein coupled receptor and methods of use
US9573992B2 (en) 2011-06-23 2017-02-21 Ablynx N.V. Serum albumin binding proteins
EP3042956A4 (en) * 2013-09-05 2017-03-15 University of Miyazaki Antibody which specifically reacts with human integrin a6b4
US9683045B2 (en) 2010-09-30 2017-06-20 Ablynx N.V. Biological materials related to c-Met
WO2018069289A1 (en) 2016-10-11 2018-04-19 Medimmune Limited Antibody-drug conjugates with immune-mediated therapy agents
AU2016244220B2 (en) * 2008-12-23 2018-05-17 Amgen Inc. Human CGRP receptor binding proteins
US10259877B2 (en) 2015-04-24 2019-04-16 Amgen Inc. Methods for treating or preventing migraine headache
CN109843911A (zh) * 2016-08-18 2019-06-04 国家生物技术研究所公司 用于治疗骨相关疾病的组合物和方法
WO2019224275A1 (en) 2018-05-23 2019-11-28 Adc Therapeutics Sa Molecular adjuvant
US20200095317A1 (en) * 2018-05-09 2020-03-26 Legochem Biosciences, Inc. Compositions and methods related to anti-cd19 antibody drug conjugates
US10633426B2 (en) 2014-12-05 2020-04-28 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting G-protein coupled receptor and uses thereof
US10934362B2 (en) 2014-09-15 2021-03-02 Amgen Inc. Bi-specific anti-CGRP receptor/PAC1 receptor antigen binding proteins and uses thereof
CN112533948A (zh) * 2018-05-31 2021-03-19 台湾醣联生技医药股份有限公司 与双触角Lewis B以及Lewis Y抗原结合的治疗性抗体
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
WO2022079211A1 (en) 2020-10-16 2022-04-21 Adc Therapeutics Sa Glycoconjugates
US11407838B2 (en) 2018-04-02 2022-08-09 Amgen Inc. Erenumab compositions and uses thereof
US11644471B2 (en) * 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
US11975076B2 (en) 2015-11-25 2024-05-07 Legochem Biosciences, Inc. Antibody-drug conjugates comprising branched linkers and methods related thereto

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WO2010072741A1 (en) * 2008-12-23 2010-07-01 Astrazeneca Ab TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREFOR
EP2385955B1 (en) * 2009-01-12 2020-08-12 CytomX Therapeutics, Inc. Modified antibody compositions, methods of making and using thereof
SG11201404354UA (en) 2012-02-17 2014-10-30 Seattle Genetics Inc ANTIBODIES TO INTEGRIN αVβ6 AND USE OF SAME TO TREAT CANCER
US8834881B2 (en) 2012-03-08 2014-09-16 Crucell Holland B.V. Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof
EP2784511A1 (en) 2013-03-27 2014-10-01 Universität Zürich Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma
CN106232625B (zh) * 2013-10-01 2020-04-24 免疫医疗有限公司 治疗和诊断过表达α-V-β-6的癌症的方法
WO2015085179A1 (en) * 2013-12-06 2015-06-11 The Regents Of The University Of California Alpha-v beta-6 integrin-binding antibody fragments
US20170233452A1 (en) * 2014-04-23 2017-08-17 Immusoft Corporation Chimeric antigen receptors specific to avb6 integrin and methods of use thereof to treat cancer
TN2018000417A1 (en) * 2016-06-14 2020-06-15 Adimab Llc Anti-coagulation factor xi antibodies.
CN107991481A (zh) * 2016-10-27 2018-05-04 武汉科前生物股份有限公司 一种检测猪伪狂犬病毒和口蹄疫病毒的二联阻断elisa抗体检测试剂盒及其应用
KR102634762B1 (ko) * 2016-11-01 2024-02-06 애로우헤드 파마슈티컬스 인코포레이티드 알파-v 베타-6 인테그린 리간드 및 그의 용도
WO2018106959A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
WO2018112215A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
EP3810085A1 (en) 2018-06-20 2021-04-28 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
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