US20080023367A1 - Support Structure for a Medicament - Google Patents

Support Structure for a Medicament Download PDF

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Publication number
US20080023367A1
US20080023367A1 US11/571,073 US57107305A US2008023367A1 US 20080023367 A1 US20080023367 A1 US 20080023367A1 US 57107305 A US57107305 A US 57107305A US 2008023367 A1 US2008023367 A1 US 2008023367A1
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US
United States
Prior art keywords
moisture
cavity
base
support structure
lid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/571,073
Other languages
English (en)
Inventor
Orest Lastow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LASTOW, OREST
Publication of US20080023367A1 publication Critical patent/US20080023367A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/34—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents and having several recesses to accommodate a series of articles or quantities of material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/062—Desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the present invention relates to a support structure for a medicament in the form of, for example, a blister pack for a drug or an injection moulded drug dosing element as used in an inhalation device.
  • a typical blister pack for a medicament is described in WO 01/45777 and a typical drug dosing element is described in U.S. Pat. No. 5,590,645.
  • the lid sealing region which is typically a heat seal.
  • the base of the blister pack is made from a plastic material then there will also be moisture ingress through the base material to the medicament.
  • the support structure is in the form of an injection moulded dosing element, the injection moulded base will be made from a moisture permeable material whereas the lid will typically have an aluminium layer making it moisture impermeable. In this case, there will also be moisture ingress through both the heat seal between the lid and base and through the base material.
  • the present invention seeks to provide moisture protection for the medicament and to maximise the number of doses arranged on the support structure.
  • a support structure for a medicament comprising a base with at least one cavity for the medicament and a lid for sealing the medicament within the cavity characterised in that each moisture permeable region of the structure is protected against the ingress of moisture by locating a moisture absorbing sink between that region and the ambient air outside the structure.
  • the sink reduces the relative humidity (RH) of the air passing through it to substantially the relative humidity (RH) of the air within the cavity so that there is minimal diffusion of moisture from the sink to the cavity.
  • RH relative humidity
  • each moisture permeable region comprises an inner moisture permeable barrier located adjacent to the cavity and an outer moisture permeable barrier, the moisture absorbing sink being located between the inner and outer barriers.
  • the base and the lid are moisture impermeable and the moisture permeable region of the structure is located where the lid is sealed to the base.
  • the moisture absorbing sink between the lid and the base is spaced from the periphery of the cavity thereby forming an inner moisture permeable region and an outer moisture permeable region, the sink breaking the moisture ingress path so that there is minimal diffusion of moisture through the inner moisture permeable region to the cavity.
  • the moisture absorbing sink comprises a channel in the base surrounding the cavity which contains dry air.
  • a plurality of cavities each having a channel filled with dry air.
  • each channel is connected to a single desiccant source which dries the air in all the channels.
  • the moisture absorbing sink comprises a polymer ring surrounding the cavity and located between the lid and the base.
  • a plurality of cavities each having a polymer ring.
  • the base and the lid have an aluminium layer for moisture impermeability, the lid being heat sealed to the base.
  • the lid is moisture impermeable and the base material is moisture permeable, the moisture permeable regions being located where the lid is sealed to the base and within the base material of the cavity walls.
  • a first moisture absorbing sink is located between the lid and the base and is spaced from the periphery of the cavity and a second moisture absorbing sink is located within the base material of the cavity walls thereby forming inner moisture permeable barriers and outer moisture permeable barriers, the sink breaking the moisture ingress path so that there is minimal diffusion of moisture through the inner moisture permeable barriers to the cavity.
  • the moisture absorbing sink comprises a channel containing dry air surrounding the cavity opening where the lid is sealed to the base and passing through the cavity walls.
  • a plurality of cavities each having a channel containing dry air.
  • each channel is connected to a single desiccant source which dries the air in all the channels.
  • the base is injection moulded and the lid has an aluminium layer for moisture impermeability, the lid being heat sealed to the base.
  • the base comprises cooperating stackable elements, each element having a plurality of cavities, the cavities within one of the elements sitting between the cavities within another element when stacked, a moisture absorbing sink being formed by the spacing between the cooperating elements.
  • FIG. 1 is a graphic representation of the relative humidity gradient across a barrier for a drug with conventional moisture protection
  • FIG. 2 is a graphic representation of the relative humidity gradient across a barrier arrangement with moisture protection according to the present invention
  • FIG. 3 is a section through one blister in a blister pack with moisture protection according to a preferred embodiment of the present invention
  • FIGS. 4A , 4 B and 4 C depict preferred embodiments of blister packs with multiple cavities having moisture protection
  • FIG. 5 is a plan view of a section of a dosing element for an inhalation device having moisture protection according to a preferred embodiment of the present invention
  • FIG. 6 is a sectional view in direction X-X through the dosing element in FIG. 5 ;
  • FIG. 7 depicts a further preferred embodiment of a dosing element having moisture protection
  • FIG. 8 depicts the underside of annular ring 111 b in FIG. 7 ;
  • FIG. 9 is an enlarged view of part of the annular ring in FIG. 8 .
  • FIG. 1 depicts the relative humidity (RH) gradient across a barrier which is moisture permeable.
  • the barrier could be, for example, the material from which the base of the support structure is made or the heat seal between the lid and base of the support structure.
  • the moisture ingress through the barrier arises because the relative humidity in the ambient air outside the support structure is typically 70% whereas the relative humidity of the air and powdered drug within a cavity is typically 20%.
  • the moisture ingress arises both from the ambient air and from neighbouring cavities which have already been emptied.
  • the powdered drug is protected only by a single barrier and moisture is continually transported through the barrier by gradient driven diffusion. The transport of moisture continues until the relative humidity inside a cavity reaches the ambient level. Moisture protection can only be improved by increasing the barrier thickness or modifying the properties of the barrier material.
  • FIG. 2 depicts a preferred arrangement where the sink effectively breaks the moisture ingress path.
  • the relative humidity gradient across the outer barrier is high giving moisture diffusion as in FIG. 1 .
  • any moisture diffusion through the inner barrier will be low.
  • the relative humidity of the air in the sink could fall to 20% (which is a similar level to that within the cavity) with the result that the relative humidity gradient would be very low across the inner barrier and the moisture ingress path could be broken.
  • FIG. 3 depicts a first preferred embodiment of the present invention where the support structure is in the form of a blister pack 1 having a base 2 with at least one cavity 3 holding a medicament and a lid 4 which is sealed to the base 2 by way of heat seals 5 and 6 .
  • a moisture absorbing sink in the form of a channel 7 which surrounds the cavity 3 .
  • the channel 7 could contain dry air to remove moisture in the region of the lid 4 .
  • the moisture ingress path M for this support structure will only be through the heat seals 5 and 6 as the blister pack base 2 and lid 4 would typically be manufactured from a moisture impermeable material having an aluminium component.
  • the moisture ingress path M would result in a relative humidity gradient similar to that depicted in FIG.
  • the outer barrier would be heat seal 5 and the inner barrier would be heat seal 6 .
  • the dry air in channel 7 would be dried by way of a desiccant. If the dry air reduces the relative humidity in the channel 7 to approximately 20% then there will only be minimal moisture diffusion through the heat seal 6 to the cavity 3 assuming that the relative humidity within cavity 3 is also approximately 20%.
  • FIGS. 4A , 4 B and 4 C depict three configurations for a blister pack having a plurality of cavities 3 .
  • each cavity 3 is surrounded by a dry air channel 7 .
  • the channels 7 are all connected to a desiccant 8 which ensures that air within the channels is continually dried to the required level.
  • the channels and desiccant reservoir would typically be cold formed in the same manufacturing process step as the cavities.
  • FIG. 4B depicts a further modification using a rectangular channel configuration.
  • FIG. 4C depicts a preferred configuration when the moisture absorbing sink for each cavity 3 is a moisture absorbing material, e.g., a polymer in the form of a nylon ring 9 . In this case, there is no need for a desiccant and each cavity 3 has a dedicated nylon ring which sits between the base 2 and lid 4 of the support structure.
  • the support structure for the medicament is in the form of an annular drug dosing element 101 .
  • This type of dosing element typically sits within an inhalation device which is able to index the drug cavities 103 a, 103 b and 103 c past a mechanism which ruptures the lid 104 and allows the user to draw the drug from each cavity.
  • FIG. 5 shows a segment of the annular dosing element 101 containing three adjacent cavities 103 a, 103 b, 103 c. One of the cavities 103 a is empty whereas the other two cavities 103 b and 103 c still contain the powdered drug.
  • FIG. 6 is a sectional view taken in direction X-X through the dosing element in FIG. 5 .
  • the base 102 of the dosing element 101 would typically be injection moulded and hence would be moisture permeable. With this arrangement, moisture protection is needed both where the lid 104 is heat sealed to the base 102 and within the base material. There are channels 107 running between adjacent cavities and beneath each cavity through the base 102 .
  • the channels 107 all connect to a desiccant 108 which dries the air in the channels to reduce the relative humidity to that within the cavities.
  • the outer heat seal 105 runs around the outer and inner peripheries of the annular dosing disc. There is also an outer moisture barrier 109 in the base 102 .
  • the channel 107 creates the inner barriers in the form of the inner heat seal 106 and the inner moisture barrier 110 in the base 102 .
  • the inner heat seal 106 for that cavity becomes the outer heat seal 105 for cavity 103 b thereby ensuring that the empty cavity 103 b is not a source for moisture ingress.
  • FIG. 7 depicts a preferred construction for the dosing element 101 which comprises two cooperating annular rings 111 a and 111 b which sit one above the other within a containing tray 112 .
  • the spacing between the annular rings 111 a and 111 b forms channels 107 .
  • each cavity can be spaced from an adjacent cavity by as little as 1 mm.
  • 60 cavities can be arranged on a dosing disc 101 with a diameter of 72 mm.
  • a desiccant 108 (not shown) to dry the air in the channels 107 between components 111 a, 111 b and 112 sits on the underside of annular ring 111 b (see FIGS. 8 and 9 ) in a groove 113 .
  • a lid 104 would be heat sealed to the arrangement shown in FIG. 7 .
  • the annular ring 111 a has a plurality of cavities 114 and the annular ring 111 b has a plurality of cavities 115 .

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)
  • Catching Or Destruction (AREA)
  • Drying Of Gases (AREA)
US11/571,073 2004-06-24 2005-06-21 Support Structure for a Medicament Abandoned US20080023367A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE040654-9 2004-06-24
SE0401654A SE0401654D0 (sv) 2004-06-24 2004-06-24 A support structure for a medicament
PCT/GB2005/002440 WO2006000758A1 (en) 2004-06-24 2005-06-21 A support structure for a medicament

Publications (1)

Publication Number Publication Date
US20080023367A1 true US20080023367A1 (en) 2008-01-31

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US11/571,073 Abandoned US20080023367A1 (en) 2004-06-24 2005-06-21 Support Structure for a Medicament

Country Status (15)

Country Link
US (1) US20080023367A1 (ru)
EP (1) EP1761441A1 (ru)
JP (1) JP2008503405A (ru)
KR (1) KR20070024635A (ru)
CN (1) CN1972850A (ru)
AU (1) AU2005256805A1 (ru)
BR (1) BRPI0512561A (ru)
CA (1) CA2570779A1 (ru)
IL (1) IL179746A0 (ru)
MX (1) MXPA06015033A (ru)
NO (1) NO20070426L (ru)
RU (1) RU2006146876A (ru)
SE (1) SE0401654D0 (ru)
WO (1) WO2006000758A1 (ru)
ZA (1) ZA200610292B (ru)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110083667A1 (en) * 2007-12-20 2011-04-14 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
US20110203586A1 (en) * 2008-02-20 2011-08-25 Boehringer Ingelheim International Gmbh Powder Inhalers
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
CN110395428A (zh) * 2018-07-26 2019-11-01 乌尔曼包装系统有限责任及合伙两合公司 生产用于医药产品的泡罩包装的方法以及泡罩包装
US20220332483A1 (en) * 2021-04-16 2022-10-20 Tsang-Hung Hsu Elastic stretchable lid capable of absorbing moisture

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015043D0 (en) 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
DE102006045171A1 (de) * 2006-09-25 2008-04-03 Robert Bosch Gmbh Blisterpackung und Verfahren zur Herstellung der Blisterpackung
AU2009213181B2 (en) 2008-02-12 2012-02-23 Astrazeneca Ab Inhaler comprising a base having at least one sealed cavity containing medicament
AU2009213182B2 (en) * 2008-02-12 2012-06-07 Astrazeneca Ab Inhaler comprising a base having a plurality of medicament containing sealed cavities
ES2579902T3 (es) 2008-10-08 2016-08-17 Astrazeneca Ab Dispositivo de inhalación para administrar un medicamento
MX2011003799A (es) * 2008-10-08 2011-06-16 Astrazeneca Ab Inhalador con medio indicador audible.
CN102176940B (zh) 2008-10-08 2014-10-01 阿斯利康(瑞典)有限公司 具有与盖移动相关的索引的吸入器
KR20110074765A (ko) 2008-10-08 2011-07-01 아스트라제네카 아베 호흡으로 활성화되는 흡입기
US20110240511A1 (en) * 2008-12-10 2011-10-06 Merck Sharp & Dohme Corp. Packaging for oxygen-sensitive pharmaceutical products
PL2400950T3 (pl) 2009-02-26 2019-12-31 Glaxo Group Limited Preparaty farmaceutyczne zawierające 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzylo)oksy]etoksy}heksylo)amino]-1-hydroksyetylo}-2-(hydroksymetylo)fenol
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
CN103434754B (zh) * 2013-08-14 2015-05-27 苏州华日金菱机械有限公司 一种吸塑包装盒

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
US6132394A (en) * 1994-05-31 2000-10-17 Leiras Oy Medicament chamber in an inhalation apparatus
US6234343B1 (en) * 1999-03-26 2001-05-22 Papp Enterprises, Llc Automated portable medication radial dispensing apparatus and method
US20040089293A1 (en) * 2000-10-13 2004-05-13 Paul Johnson Medicament dispenser
US6905016B2 (en) * 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2593152B1 (fr) * 1986-01-22 1988-12-23 Adir Conditionnement etanche sous forme de plaquettes alveolaire permettant des echanges gazeux entre les alveoles.
SE9602352D0 (sv) * 1996-06-14 1996-06-14 Astra Ab Catheter package
JP3391333B2 (ja) * 1999-03-23 2003-03-31 東ソー株式会社 ゼオライト吸着剤の包装方法及びこれを用いた充填方法
GB0015043D0 (en) * 2000-06-21 2000-08-09 Glaxo Group Ltd Medicament dispenser
JP3467035B1 (ja) * 2002-06-13 2003-11-17 プロモツール株式会社 商品見本収納方法およびその容器

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
US6132394A (en) * 1994-05-31 2000-10-17 Leiras Oy Medicament chamber in an inhalation apparatus
US6234343B1 (en) * 1999-03-26 2001-05-22 Papp Enterprises, Llc Automated portable medication radial dispensing apparatus and method
US6905016B2 (en) * 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
US20040089293A1 (en) * 2000-10-13 2004-05-13 Paul Johnson Medicament dispenser

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110083667A1 (en) * 2007-12-20 2011-04-14 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
US9283337B2 (en) * 2007-12-20 2016-03-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
US20110203586A1 (en) * 2008-02-20 2011-08-25 Boehringer Ingelheim International Gmbh Powder Inhalers
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
CN110395428A (zh) * 2018-07-26 2019-11-01 乌尔曼包装系统有限责任及合伙两合公司 生产用于医药产品的泡罩包装的方法以及泡罩包装
US20220332483A1 (en) * 2021-04-16 2022-10-20 Tsang-Hung Hsu Elastic stretchable lid capable of absorbing moisture
US20230039575A1 (en) * 2021-04-16 2023-02-09 Tsang-Hung Hsu Elastic stretchable lid capable of absorbing moisture

Also Published As

Publication number Publication date
BRPI0512561A (pt) 2008-03-18
SE0401654D0 (sv) 2004-06-24
CN1972850A (zh) 2007-05-30
WO2006000758A1 (en) 2006-01-05
ZA200610292B (en) 2010-05-26
CA2570779A1 (en) 2006-01-05
EP1761441A1 (en) 2007-03-14
KR20070024635A (ko) 2007-03-02
AU2005256805A1 (en) 2006-01-05
RU2006146876A (ru) 2008-07-27
MXPA06015033A (es) 2007-02-08
NO20070426L (no) 2007-01-23
JP2008503405A (ja) 2008-02-07
IL179746A0 (en) 2007-05-15

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