US20070270750A1 - Drug delivery device - Google Patents

Drug delivery device Download PDF

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Publication number
US20070270750A1
US20070270750A1 US11/435,906 US43590606A US2007270750A1 US 20070270750 A1 US20070270750 A1 US 20070270750A1 US 43590606 A US43590606 A US 43590606A US 2007270750 A1 US2007270750 A1 US 2007270750A1
Authority
US
United States
Prior art keywords
handpiece
tip
drug
delivery device
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/435,906
Other languages
English (en)
Inventor
Bruno Dacquay
Michael A. Zica
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Priority to US11/435,906 priority Critical patent/US20070270750A1/en
Assigned to ALCON, INC. reassignment ALCON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DACQUAY, BRUNO, ZICA, MICHAEL A.
Priority to US11/688,573 priority patent/US7811252B2/en
Priority to EP07108293A priority patent/EP1857130A1/fr
Priority to CA002588519A priority patent/CA2588519A1/fr
Priority to TW096117365A priority patent/TW200744558A/zh
Priority to MX2007005846A priority patent/MX2007005846A/es
Priority to BRPI0702340-5A priority patent/BRPI0702340A/pt
Priority to KR1020070048065A priority patent/KR20070111394A/ko
Priority to CNA200710104927XA priority patent/CN101073682A/zh
Priority to ARP070102129A priority patent/AR061002A1/es
Priority to IL183295A priority patent/IL183295A0/en
Priority to JP2007131544A priority patent/JP2007307376A/ja
Priority to AU2007202216A priority patent/AU2007202216A1/en
Priority to US11/751,934 priority patent/US20070268340A1/en
Priority to US11/752,011 priority patent/US20070270768A1/en
Priority to US11/751,981 priority patent/US7674243B2/en
Priority to US11/752,064 priority patent/US7862540B2/en
Priority to US11/762,844 priority patent/US7762981B2/en
Priority to US11/777,408 priority patent/US8821440B2/en
Priority to US11/832,364 priority patent/US20070270744A1/en
Priority to US11/832,333 priority patent/US7815603B2/en
Priority to US11/832,243 priority patent/US7871399B2/en
Priority to US11/832,301 priority patent/US7887521B2/en
Priority to US11/833,518 priority patent/US20080021419A1/en
Priority to US11/833,471 priority patent/US20080021412A1/en
Priority to US11/833,668 priority patent/US7887517B2/en
Priority to PCT/US2007/080505 priority patent/WO2008105954A2/fr
Priority to PCT/US2007/080673 priority patent/WO2008105956A2/fr
Priority to US12/443,898 priority patent/US8118790B2/en
Publication of US20070270750A1 publication Critical patent/US20070270750A1/en
Priority to US12/109,079 priority patent/US20080197035A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266—Shape memory materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8262—Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
    • A61M5/484—Regulating injection pressure

Definitions

  • the present invention generally pertains to the delivery of ophthalmically acceptable pharmaceutically active agents to the back of the eye and more particularly to an apparatus for delivery of precise amounts of a liquid or phase transition drug under controlled back pressure and flow conditions.
  • Age related macular degeneration is the leading cause of blindness in the elderly. It attacks the center of vision and blurs it, making reading, driving, and other detailed tasks difficult or impossible. Current estimates reveal that approximately forty percent of the population over age 75, and approximately twenty percent of the population over age 60, suffer from some degree of macular degeneration. In “wet” ARMD, the type that most often causes blindness, newly formed choroidal blood vessels (CNV) leak fluid and cause progressive damage to the retina. Two main methods of treatment are currently being performed, (a) photocoagulation and (b) the use of angiogenesis inhibitors.
  • CNV choroidal blood vessels
  • Photocoagulation can be harmful to the retina and is impractical when the CNV is in proximity of the fovea. Furthermore, photocoagulation often results in recurrent CNV over time.
  • Angiogenesis inhibitors may be administered orally, by intraocular injections, by extraocular sub-Tennon injections, or by local implants.
  • a physician disposes the tip of a curved needle externally around the eye near the macula, and releases a precise amount of the drug.
  • a concern with sub-Tenon delivery is that the drug must be administered slowly and under relatively low pressure so as to be retained in the tissue rather than leaking back out, around the needle.
  • the present invention improves upon the prior art by providing a syringe-like device having a drug dispensing tip connected to a motorized handpiece.
  • the tip may be packaged pre-loaded with an amount of a liquid or phase transition drug or may be shipped empty and loaded with a liquid or phase transition drug by the user.
  • the motorized handpiece contains suitable sensors and controllers for precisely actuating the tip for the controlled delivery of the liquid or phase transition drug in the tip.
  • the handpiece may contain an internal power source, such as a battery, or may be connected to an external power source and/or control unit.
  • one objective of the present invention is to provide a syringe-like device having a drug dispensing tip.
  • Another objective of the present invention is to provide a device for the delivery of a drug to the human eye and having a drug dispensing tip actuated by a motorized handpiece.
  • Yet another objective of the present invention is to provide a drug delivery device wherein the flow rate of the drug being delivered can be controlled.
  • FIG. 1 is an enlarged, schematical view of a first embodiment of the drug deliver device of the present invention.
  • FIG. 2 is an enlarged, schematical view of a second embodiment of the drug deliver device of the present invention.
  • drug delivery device 10 of the present invention generally comprises tip 12 and handpiece 14 .
  • Tip 12 generally contains delivery cannula or needle 16 and body 18 .
  • Needle 16 may be any suitably sized needle of conventional construction.
  • Body 18 generally is of a construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic. Body 18 is sized and shaped to hold a suitable amount of a liquid or phase transition drug.
  • Handpiece 14 generally is sized and shape similar to body 18 , e.g., cylindrical, and has distal end 20 adapted to allow tip 12 to be mechanically connected to handpiece 14 .
  • Handpiece 14 contains drive mechanism 22 , with associated driver electronics 24 , to push plunger 21 in body 18 to force the liquid or phase transition drug contained in body 18 out needle 16 .
  • Suitable drive mechanisms include, for example, piezoelectric linear motors, such motors being well-known in the art (as described in U.S. Pat. No. 6,940,209 (Henderson)), and available from sources such as New Scale Technologies, Inc., Victor, N.Y.
  • power for driver 22 and control electronics 24 is provided from power source 26 , such as a battery, located internal to handpiece 14 .
  • power source 26 such as a battery, located internal to handpiece 14 .
  • electronics 24 can provide a feedback mechanism that senses the back pressure being exerted against the expression of the drug out of needle 16 and make appropriate adjustments to the speed and direction of motor 22 .
  • drug delivery device 110 of the present invention may also generally comprise tip 112 and handpiece 114 .
  • Tip 112 generally contains delivery cannula or needle 116 and body 118 .
  • Needle 116 may be any suitably sized needle of conventional construction.
  • Body 118 is generally is of construction similar to a standard hypodermic syringe, e.g., cylindrical and tubular, made from glass, metal or a suitable plastic. Body 118 is sized and shaped to hold a suitable amount of a liquid or phase transition drug.
  • Handpiece 114 generally is sized and shaped similar to body 118 , e.g., cylindrical, and has distal end 120 adapted so allow tip 112 to be mechanically connected to handpiece 114 .
  • Handpiece 114 contains drive mechanism 122 , with associated driver electronics 124 , to push plunger 121 in body 118 to force the liquid or phase transition drug contained in body 118 out needle 116 .
  • control electronics 124 are located external to handpiece 114 and power and control signals are provided to drive mechanism 122 through cable 123 .
  • Power for driver 122 and electronics 124 is provided from external source 126 through electrical cable 128 . Such a construction allows for a smaller handpiece 114 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
US11/435,906 2006-05-17 2006-05-17 Drug delivery device Abandoned US20070270750A1 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
US11/435,906 US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device
US11/688,573 US7811252B2 (en) 2006-05-17 2007-03-20 Dosage control device
EP07108293A EP1857130A1 (fr) 2006-05-17 2007-05-15 Dispositif de livraison de médicaments
CA002588519A CA2588519A1 (fr) 2006-05-17 2007-05-15 Dispositif d'administration de medicaments
BRPI0702340-5A BRPI0702340A (pt) 2006-05-17 2007-05-16 dispositivo de entrega de fármaco
TW096117365A TW200744558A (en) 2006-05-17 2007-05-16 Drug delivery device
MX2007005846A MX2007005846A (es) 2006-05-17 2007-05-16 Dispositivo de administracion de farmacos.
KR1020070048065A KR20070111394A (ko) 2006-05-17 2007-05-17 약물 전달 장치
CNA200710104927XA CN101073682A (zh) 2006-05-17 2007-05-17 药物输送装置
ARP070102129A AR061002A1 (es) 2006-05-17 2007-05-17 Dispositivo de administracion de farmacos
IL183295A IL183295A0 (en) 2006-05-17 2007-05-17 Drug delivery device
JP2007131544A JP2007307376A (ja) 2006-05-17 2007-05-17 薬剤注入器
AU2007202216A AU2007202216A1 (en) 2006-05-17 2007-05-17 Drug delivery device
US11/752,011 US20070270768A1 (en) 2006-05-17 2007-05-22 Mechanical Linkage Mechanism For Ophthalmic Injection Device
US11/752,064 US7862540B2 (en) 2006-05-17 2007-05-22 Ophthalmic injection device using shape memory alloy
US11/751,934 US20070268340A1 (en) 2006-05-17 2007-05-22 Ophthalmic Injection System and Method Using Piezoelectric Array
US11/751,981 US7674243B2 (en) 2006-05-17 2007-05-22 Ophthalmic injection device using piezoelectric array
US11/762,844 US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/832,364 US20070270744A1 (en) 2006-05-17 2007-08-01 Limited Reuse Assembly For Ophthalmic Injection Device
US11/832,333 US7815603B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection method
US11/832,243 US7871399B2 (en) 2006-05-17 2007-08-01 Disposable ophthalmic injection device
US11/832,301 US7887521B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection system
US11/833,518 US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,668 US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US11/833,471 US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
PCT/US2007/080505 WO2008105954A2 (fr) 2006-05-17 2007-10-05 Dispositif d'injection ophtalmique jetable
PCT/US2007/080673 WO2008105956A2 (fr) 2006-05-17 2007-10-08 Dispositif d'injection ophtalmique
US12/443,898 US8118790B2 (en) 2006-05-17 2007-10-09 Battery operated surgical hand piece with disposable end
US12/109,079 US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/435,906 US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device

Related Child Applications (15)

Application Number Title Priority Date Filing Date
US58162906A Continuation-In-Part 2006-05-17 2006-10-16
US92149706P Continuation-In-Part 2006-05-17 2006-10-16
US11/688,573 Continuation-In-Part US7811252B2 (en) 2006-05-17 2007-03-20 Dosage control device
US11/752,064 Continuation-In-Part US7862540B2 (en) 2006-05-17 2007-05-22 Ophthalmic injection device using shape memory alloy
US11/762,844 Continuation-In-Part US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 Continuation-In-Part US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/832,301 Continuation-In-Part US7887521B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection system
US11/832,243 Continuation-In-Part US7871399B2 (en) 2006-05-17 2007-08-01 Disposable ophthalmic injection device
US11/832,364 Continuation-In-Part US20070270744A1 (en) 2006-05-17 2007-08-01 Limited Reuse Assembly For Ophthalmic Injection Device
US11/832,333 Continuation-In-Part US7815603B2 (en) 2006-05-17 2007-08-01 Ophthalmic injection method
US11/833,518 Continuation-In-Part US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,471 Continuation-In-Part US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US11/833,668 Continuation-In-Part US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US12/443,898 Continuation-In-Part US8118790B2 (en) 2006-05-17 2007-10-09 Battery operated surgical hand piece with disposable end
US12/109,079 Continuation-In-Part US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Publications (1)

Publication Number Publication Date
US20070270750A1 true US20070270750A1 (en) 2007-11-22

Family

ID=38420664

Family Applications (7)

Application Number Title Priority Date Filing Date
US11/435,906 Abandoned US20070270750A1 (en) 2006-05-17 2006-05-17 Drug delivery device
US11/762,844 Expired - Fee Related US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 Expired - Fee Related US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/833,471 Abandoned US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US11/833,518 Abandoned US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,668 Expired - Fee Related US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US12/109,079 Abandoned US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Family Applications After (6)

Application Number Title Priority Date Filing Date
US11/762,844 Expired - Fee Related US7762981B2 (en) 2006-05-17 2007-06-14 Temperature release mechanism for injection device
US11/777,408 Expired - Fee Related US8821440B2 (en) 2006-05-17 2007-07-13 Dual thermal coefficient dispensing chamber
US11/833,471 Abandoned US20080021412A1 (en) 2006-05-17 2007-08-03 Plunger Linkage and Seal For Ophthalmic Medical Device
US11/833,518 Abandoned US20080021419A1 (en) 2006-05-17 2007-08-03 Plunger Linkage Method For Ophthalmic Medical Device
US11/833,668 Expired - Fee Related US7887517B2 (en) 2006-05-17 2007-08-03 Drug casting
US12/109,079 Abandoned US20080197035A1 (en) 2006-05-17 2008-04-24 Sharps Container System for Two Piece Injection Device

Country Status (12)

Country Link
US (7) US20070270750A1 (fr)
EP (1) EP1857130A1 (fr)
JP (1) JP2007307376A (fr)
KR (1) KR20070111394A (fr)
CN (1) CN101073682A (fr)
AR (1) AR061002A1 (fr)
AU (1) AU2007202216A1 (fr)
BR (1) BRPI0702340A (fr)
CA (1) CA2588519A1 (fr)
IL (1) IL183295A0 (fr)
MX (1) MX2007005846A (fr)
TW (1) TW200744558A (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060229570A1 (en) * 2002-09-11 2006-10-12 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms
US20070293820A1 (en) * 2006-05-17 2007-12-20 Bruno Dacquay Disposable Ophthalmic Injection Device
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US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
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US20080197035A1 (en) 2008-08-21
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US20080015545A1 (en) 2008-01-17
US20080097311A1 (en) 2008-04-24
JP2007307376A (ja) 2007-11-29
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US20080021419A1 (en) 2008-01-24
US20080021413A1 (en) 2008-01-24
AU2007202216A1 (en) 2007-12-06
US20080021412A1 (en) 2008-01-24
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US7762981B2 (en) 2010-07-27
CA2588519A1 (fr) 2007-11-17
US7887517B2 (en) 2011-02-15

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