US20070237804A1 - Impact of calcium phosphate complex on dental caries - Google Patents

Impact of calcium phosphate complex on dental caries Download PDF

Info

Publication number
US20070237804A1
US20070237804A1 US11/732,855 US73285507A US2007237804A1 US 20070237804 A1 US20070237804 A1 US 20070237804A1 US 73285507 A US73285507 A US 73285507A US 2007237804 A1 US2007237804 A1 US 2007237804A1
Authority
US
United States
Prior art keywords
confectionery
region
calcium phosphate
composition
center
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/732,855
Other languages
English (en)
Inventor
Doris Tancredi
Ding Ming
Jack W. Vincent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intercontinental Great Brands LLC
Original Assignee
Cadbury Adams USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadbury Adams USA LLC filed Critical Cadbury Adams USA LLC
Priority to US11/732,855 priority Critical patent/US20070237804A1/en
Assigned to CADBURY ADAMS USA, LLC reassignment CADBURY ADAMS USA, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MING, DING, TANCREDI, DORIS, VINCENT, JACK W.
Publication of US20070237804A1 publication Critical patent/US20070237804A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/14—Chewing gum characterised by the composition containing organic or inorganic compounds containing peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8135—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to methods for reducing dental caries in mammals, particularly by slowing the progression and enhancing the regression of carious lesions.
  • the methods employ chewing gum or confectionery compositions for delivery of casein phosphopeptide-calcium phosphate into the oral cavity of a mammal.
  • the present invention also relates to chewing gum and confectionery compositions that reduce and prevent dental caries in mammals.
  • Caries are understood to result from the accumulation of plaque on the teeth and the production of organic acids (plaque acids) when plaque microorganisms ferment sugars and starches in food. Before being washed away by saliva, the acids accumulate in the plaque long enough to lower the pH and to cause some of the enamel, a calcium-phosphorous mineral known as hydroxyapatite, to dissolve, that is, demineralize, which can lead to dental caries (tooth decay), and sensitivity.
  • plaque acids organic acids
  • hydroxyapatite a calcium-phosphorous mineral known as hydroxyapatite
  • chewing gum and confectionery products particularly fruit-flavored products
  • contain acids for example, as part of the flavor or taste system.
  • the acids can cause demineralization of the tooth surface, which may lead to dental caries.
  • Casein phosphopeptide-calcium phosphate complexes are known to have anticariogenic teeth strengthening effects when used as dentrifrices.
  • the complexes also known as CPP-ACP complexes or calcium casein peptone-calcium phosphate, are calcium phosphate stabilized by casein phosphopeptides.
  • CPP-ACP counteracts demineralization by enhancing remineralization while buffering plaque acid. It acts by localizing calcium and phosphate ions in dental plaque at the tooth surface. This increased level of calcium and phosphate in dental plaque helps buffer plaque acid and maintain a state of supersaturation of calcium and phosphate in solution, i.e., in the saliva.
  • U.S. Pat. Nos. 5,130,123 and 5,227,154 teach casein phosphopeptides in prevention of dental caries.
  • WO 98/40406 teaches phosphopeptide-calcium phosphate complexes to provide anti-caries efficacy.
  • U.S. Pat. Nos. 6,846,500 and 6,733,818 disclose chewing gum and confectionery products containing a combination of casein phosphopeptide-amorphous calcium phosphate with sodium bicarbonate.
  • a chewing gum composition including a gum base, at least one sweetening agent and casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition, wherein the composition is free of sodium bicarbonate.
  • a chewing gum composition including a gum base, at least one sweetening agent and casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition, wherein the composition is free of mineral filler.
  • Some embodiments provide a chewing gum composition including a gum base, at least one sweetening agent and an anticaries agent consisting essentially of casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition.
  • Some embodiments provide a chewing gum composition consisting essentially of a gum base, at least one sweetening agent, casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition, at least one flavor, at least one coloring agent and at least one surfactant.
  • Some embodiments provide a confectionery composition including a confectionery carrier, at least one sweetening agent and casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition, wherein the composition is free of sodium bicarbonate.
  • a confectionery composition including a confectionery carrier, at least one sweetening agent and casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition, wherein the composition is free of mineral filler.
  • a confectionery composition including a confectionery carrier, at least one sweetening agent and an anticaries agent consisting essentially of casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition.
  • Some embodiments provide a confectionery composition consisting essentially of a confectionery carrier, at least one sweetening agent, casein phosphopeptide-calcium phosphate present in amounts of at least about 3% by weight of the composition, at least one flavor and at least one coloring agent.
  • a method for reducing dental caries in a mammal which includes: (a) applying a chewing gum product into the oral cavity of the mammal, wherein the chewing gum product contains a gum base present in amounts of about 5% to about 95% by weight of the product, at least one sweetening agent present in amounts of about 0.001% to about 95% by weight of the product and casein phosphopeptide-calcium phosphate present in amounts of about 0.5% to about 5% by weight of the product; and (b) chewing the chewing gum product for a time sufficient to reduce caries formation.
  • Some embodiments provide a method for slowing the progression and enhancing the regression of carious lesions in a mammal, which includes: (a) applying a chewing gum product into the oral cavity of the mammal, wherein the chewing gum product contains a gum base present in amounts of about 5% to about 95% by weight of the product, at least one sweetening agent present in amounts of about 0.001% to about 95% by weight of the product and casein phosphopeptide-calcium phosphate present in amounts of about 0.5% to about 5% by weight of the product; and (b) chewing the chewing gum product for a time sufficient to slow the progression and enhance the regression of carious lesions by about 16.9% more than chewing a sugarless chewing gum product which is free of casein phosphopeptide-calcium phosphate.
  • Some embodiments provide a method for reducing dental caries in a mammal, which includes: (a) applying a confectionery product into the oral cavity of the mammal, wherein the confectionery product includes a confectionery carrier present in amounts of about 5% to about 99% by weight of the product, at least one sweetening agent present in amounts of about 0.001% to about 95% by weight of the product and casein phosphopeptide-calcium phosphate present in amounts of about 0.5% to about 5% by weight of the product; and (b) retaining the confectionery product in the oral cavity for a time sufficient to reduce caries formation.
  • a method for slowing the progression and enhancing the regression of carious lesions in a mammal which includes: (a) applying a confectionery product into the oral cavity of the mammal, wherein the confectionery product contains a confectionery carrier present in amounts of about 5% to about 99% by weight of the product, at least one sweetening agent present in amounts of about 0.001% to about 95% by weight of the product and casein phosphopeptide-calcium phosphate present in amounts of about 0.5% to about 5% by weight of the product; and (b) retaining the confectionery product in the oral cavity for a time sufficient to slow the progression and enhance the regression of carious lesions by about 16.9% more than chewing a sugarless confectionery product which is free of casein phosphopeptide-calcium phosphate.
  • a method for preventing dental caries in a mammal which includes: (a) applying a chewing gum product into the oral cavity of the mammal, wherein the chewing gum product includes a gum base present in amounts of about 5% to about 95% by weight of the product, at least one sweetening agent present in amounts of about 0.001% to about 95% by weight of the product and casein phosphopeptide-calcium phosphate present in amounts of about 0.5% to about 5% by weight of the product; and (b) chewing the chewing gum product for a time sufficient to reduce caries formation.
  • a method for preventing dental caries in a mammal which includes: (a) applying a confectionery product into the oral cavity of the mammal, wherein the confectionery product contains a confectionery carrier present in amounts of about 5% to about 99% by weight of the product, at least one sweetening agent present in amounts of about 0.001% to about 95% by weight of the product and casein phosphopeptide-calcium phosphate present in amounts of about 0.5% to about 5% by weight of the product; and (b) retaining the confectionery product in the oral cavity for a time sufficient to reduce caries formation.
  • kits for reducing dental caries in a mammal including: (a) a chewing gum product containing a gum base, casein phosphopeptide-calcium phosphate and at least one sweetening agent; (b) a set of instructions for using the chewing gum product; and (c) a package for housing the chewing gum product and the set of instructions.
  • kits for reducing dental caries in a mammal including: (a) a confectionery product including a confectionery carrier, casein phosphopeptide-calcium phosphate and at least one sweetening agent; (b) a set of instructions for using the confectionery product; and (c) a package for housing the confectionery product and the set of instructions.
  • kits for preventing dental caries in a mammal including: (a) a chewing gum product containing a gum base, casein phosphopeptide-calcium phosphate and at least one sweetening agent; (b) a set of instructions for using the chewing gum product; and (c) a package for housing the chewing gum product and the set of instructions.
  • kits for preventing dental caries in a mammal which includes: (a) a confectionery product including a confectionery carrier, casein phosphopeptide-calcium phosphate and at least one sweetening agent; (b) a set of instructions for using the confectionery product; and (c) a package for housing the confectionery product and the set of instructions.
  • kits for slowing the progression and enhancing the regression of carious lesions in a mammal including: (a) a chewing gum product including a gum base, casein phosphopeptide-calcium phosphate and at least one sweetening agent; (b) a set of instructions for using the chewing gum product; and (c) a package for housing the chewing gum product and the set of instructions.
  • kits for slowing the progression and enhancing the regression of carious lesions in a mammal which includes: (a) a confectionery product including a confectionery carrier, casein phosphopeptide-calcium phosphate and at least one sweetening agent; (b) a set of instructions for using the confectionery product; and (c) a package for housing the confectionery product and the set of instructions.
  • Embodiments described herein provide chewing gum and confectionery products containing casein phosphopeptide-calcium phosphate (CPP-ACP), which is an anticaries agent, and methods of employing such compositions to improve the dental health of mammals.
  • CPP-ACP casein phosphopeptide-calcium phosphate
  • the chewing gum or confectionery composition may include a gum base or confectionery carrier, respectively, at least one sweetening agent and CPP-ACP.
  • High levels of CPP-ACP may be used in the compositions to reduce dental caries.
  • CPP-ACP can also be used with other oral care actives as part of a multi-functional oral care product. These other oral care actives can include, but are not limited to whitening actives, antimicrobial actives, breath freshening actives, de-sensitizing actives, and other remineralizing actives.
  • Methods of reducing dental caries also are described herein employing the chewing gum or confectionery compositions. Such methods may slow the progression and enhance the regression of carious lesions to a substantially greater extent than similar products that are free of CPP-ACP.
  • Some other embodiments described herein provide acid-containing chewing gum or confectionery compositions, particularly sugarless compositions, for remineralizing and/or imparting acid resistance to the tooth surface of a mammal.
  • the chewing gum or confectionery composition may include a gum base or confectionery carrier, respectively, at least one sweetening agent, CPP-ACP and a food-grade acid.
  • Methods of remineralizing and/or imparting acid resistance to the tooth surface of a mammal also are described herein employing the chewing gum and confectionery compositions.
  • transitional term “comprising,” which is synonymous with “including,” “containing,” or “characterized by,” is inclusive or open-ended and does not exclude additional, unrecited elements or method steps, regardless of its use in the preamble or the body of a claim.
  • bubble gum and “chewing gum” are used interchangeably and are both meant to include any gum compositions.
  • food-grade acid encompasses any acid that is acceptable for use in edible compositions.
  • center-fill refers to the innermost region of a center-fill gum or confectionery product.
  • center-fill does not imply symmetry of a gum or confectionery product, only that the “center-fill” is within another region of the product. In some embodiments, more than one center-fill may be present.
  • the term “gum region” or “confectionery region” refers to a region of a center-fill gum or confectionery product, respectively, that may be adjacent to or at least partially surrounding the center-fill, or innermost, region. In some embodiments, the gum region or confectionery region is an intermediate region.
  • coating or “coating region” are used to refer to the outermost region of a center-fill gum or confectionery product.
  • the terms “surround,” “surrounding,” and the like are not limited to encircling. These terms may refer to enclosing or confining on all sides, encircling or enveloping, and are not limited to symmetrical or identical thicknesses for a region in a center-fill gum or confectionery product.
  • compositions and methods for reducing dental caries may be chewing gum or confectionery compositions, which may include CPP-ACP, an anticaries agent. Such compositions may lead to significantly greater reductions in dental caries compared to similar compositions that are free of CPP-ACP.
  • the chewing gum compositions may include a gum base, at least one sweetening agent and CPP-ACP.
  • Chewing gum compositions may be provided in a variety of different forms, such as, for example, slab, pellet, sticks, center-fill gums, deposited gums and compressed gums.
  • the confectionery compositions may include a confectionery carrier, at least one sweetening agent and CPP-ACP.
  • Confectionery compositions may be provided in a variety of different forms, such as, for example, hard candy, soft candy, cotton candy, pressed tablets, lozenges, nougats, caramels, frappes and taffies.
  • the chewing gum and confectionery compositions also may include at least one flavor and a variety of optional additives.
  • chewing gum compositions may include a gum base.
  • the gum base may include any component known in the chewing gum art. Such components may be water soluble, water-insoluble or a combination thereof.
  • the gum base may include elastomers, bulking agents, waxes, elastomer solvents, emulsifiers, plasticizers, fillers and mixtures thereof.
  • the elastomers (rubbers) employed in the gum base will vary greatly depending upon various factors such as the type of gum base desired, the consistency of gum composition desired and the other components used in the composition to make the final chewing gum product.
  • the elastomer may be any water-insoluble polymer known in the art, and includes those gum polymers utilized for chewing gums and bubble gums.
  • suitable polymers in gum bases include both natural and synthetic elastomers.
  • those polymers which are suitable in gum base compositions include, without limitation, natural substances (of vegetable origin) such as chicle, natural rubber, crown gum, nispero, rosidinha, jelutong, perillo, niger gutta, tunu, balata, guttapercha, lechi capsi, sorva, gutta kay, and the like, and mixtures thereof.
  • synthetic elastomers include, without limitation, styrene-butadiene copolymers (SBR), polyisobutylene, isobutylene-isoprene copolymers, polyethylene, polyvinyl acetate and the like, and mixtures thereof.
  • the amount of elastomer employed in the gum base may vary depending upon various factors such as the type of gum base used, the consistency of the gum composition desired and the other components used in the composition to make the final chewing gum product.
  • the elastomer will be present in the gum base in an amount from about 10% to about 60% by weight, desirably from about 35% to about 40% by weight.
  • the gum base may include wax. It softens the polymeric elastomer mixture and improves the elasticity of the gum base.
  • the waxes employed will have a melting point below about 60° C., and preferably between about 45° C. and about 55° C.
  • the low melting wax may be a paraffin wax.
  • the wax may be present in the gum base in an amount from about 6% to about 10%, and preferably from about 7% to about 9.5%, by weight of the gum base.
  • waxes having a higher melting point may be used in the gum base in amounts up to about 5%, by weight of the gum base.
  • high melting waxes include beeswax, vegetable wax, candelilla wax, camuba wax, most petroleum waxes, and the like, and mixtures thereof.
  • the gum base may include a variety of other ingredients, such as components selected from elastomer solvents, emulsifiers, plasticizers, fillers, and mixtures thereof.
  • the gum base may contain elastomer solvents to aid in softening the elastomer component.
  • elastomer solvents may include those elastomer solvents known in the art, for example, terpinene resins such as polymers of alpha-pinene or beta-pinene, methyl, glycerol and pentaerythritol esters of rosins and modified rosins and gums such as hydrogenated, dimerized and polymerized rosins, and mixtures thereof.
  • Examples of elastomer solvents suitable for use herein may include the pentaerythritol ester of partially hydrogenated wood and gum rosin, the pentaerythritol ester of wood and gum rosin, the glycerol ester of wood rosin, the glycerol ester of partially dimerized wood and gum rosin, the glycerol ester of polymerized wood and gum rosin, the glycerol ester of tall oil rosin, the glycerol ester of wood and gum rosin and the partially hydrogenated wood and gum rosin and the partially hydrogenated methyl ester of wood and rosin, and the like, and mixtures thereof.
  • the elastomer solvent may be employed in the gum base in amounts from about 2% to about 15%, and preferably from about 7% to about 11%, by weight of the gum base.
  • the gum base may also include emulsifiers which aid in dispersing the immiscible components into a single stable system.
  • the emulsifiers useful in this invention include glyceryl monostearate, lecithin, fatty acid monoglycerides, diglycerides, propylene glycol monostearate, and the like, and mixtures thereof.
  • the emulsifier may be employed in amounts from about 2% to about 15%, and more specifically, from about 7% to about 11%, by weight of the gum base.
  • the gum base may also include plasticizers or softeners to provide a variety of desirable textures and consistency properties. Because of the low molecular weight of these ingredients, the plasticizers and softeners are able to penetrate the fundamental structure of the gum base making it plastic and less viscous.
  • plasticizers and softeners include lanolin, palmitic acid, oleic acid, stearic acid, sodium stearate, potassium stearate, glyceryl triacetate, glyceryl lecithin, glyceryl monostearate, propylene glycol monostearate, acetylated monoglyceride, glycerine, and the like, and mixtures thereof.
  • Waxes for example, natural and synthetic waxes, hydrogenated vegetable oils, petroleum waxes such as polyurethane waxes, polyethylene waxes, paraffin waxes, microcrystalline waxes, fatty waxes, sorbitan monostearate, tallow, propylene glycol, mixtures thereof, and the like, may also be incorporated into the gum base.
  • the plasticizers and softeners are generally employed in the gum base in amounts up to about 20% by weight of the gum base, and more specifically in amounts from about 9% to about 17%, by weight of the gum base.
  • Plasticizers also include hydrogenated vegetable oils, such as soybean oil and cottonseed oils, which may be employed alone or in combination. These plasticizers provide the gum base with good texture and soft chew characteristics. These plasticizers and softeners are generally employed in amounts from about 5% to about 14%, and more specifically in amounts from about 5% to about 13.5%, by weight of the gum base.
  • Anhydrous glycerin may also be employed as a softening agent, such as the commercially available United States Pharmacopeia (USP) grade.
  • Glycerin is a syrupy liquid with a sweet warm taste and has a sweetness of about 60% of that of cane sugar. Because glycerin is hygroscopic, the anhydrous glycerin may be maintained under anhydrous conditions throughout the preparation of the chewing gum composition.
  • the gum base may also include effective amounts of bulking agents such as mineral adjuvants which may serve as fillers and textural agents.
  • mineral adjuvants include calcium carbonate, magnesium carbonate, alumina, aluminum hydroxide, aluminum silicate, talc, tricalcium phosphate, dicalcium phosphate, calcium sulfate and the like, and mixtures thereof.
  • These fillers or adjuvants may be used in the gum base compositions in various amounts.
  • the amount of filler, when used will be present in an amount from about 15% to about 40%, and desirably from about 20% to about 30%, by weight of the gum base.
  • a variety of traditional ingredients may be optionally included in the gum base in effective amounts such as flavor agents and coloring agents, antioxidants, preservatives, and the like.
  • titanium dioxide and other dyes suitable for food, drug and cosmetic applications known as F. D. & C. dyes, may be utilized.
  • An anti-oxidant such as butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), propyl gallate, vitamin E and mixtures thereof, may also be included.
  • BHT butylated hydroxytoluene
  • BHA butylated hydroxyanisole
  • propyl gallate vitamin E and mixtures thereof
  • Other conventional chewing gum additives known to one having ordinary skill in the chewing gum art may also be used in the gum base.
  • the gum base is present in amounts of about 5% to about 95% by weight of the chewing gum composition. More specifically, the gum base may be present in amounts of about 20% to about 60% by weight of the chewing gum composition.
  • Chewing gum products may be prepared using standard techniques and equipment known to those skilled in the art.
  • the apparatus useful in accordance with the embodiments described herein includes mixing and heating apparatus well known in the chewing gum manufacturing arts, and therefore the selection of the specific apparatus will be apparent to the artisan.
  • For general chewing gum preparation processes see U.S. Pat. No. 4,271,197 to Hopkins et al, U.S. Pat. No. 4,352,822 to Cherukuri et al and U.S. Pat. No. 4,497,832 to Cherukuri et al, each of which is incorporated herein by reference in its entirety.
  • the gum base may be in a particulate form, such as, but not limited to, a powdered or granular gum base, as opposed to molten or thermoplastic gum base.
  • the particulate gum base may be essentially free of water and can readily be formed into any desired shape, such as by compression.
  • the particulate gum base may be formed using standard grinding techniques known in the art.
  • the starting material may be any conventional gum base, such as those used to produce molten gum bases.
  • the particulate gum base may be formed, for example, by shredding, grinding or crushing the gum base or other processes, as described in U.S. Pat. Nos. 3,262,784, 4,405,647, 4,753,805 and 6,290,985 and U.S. Publication No. 2003/00276871, all of which are incorporated herein by reference in their entirety.
  • the particulate gum base is ground or the like into a particulate form that is similar in particle size to the tableting powder.
  • a homogenous mix of gum base and tableting powder may be achieved, which may provide a gum tablet of similar homogenous make-up.
  • the gum base and tableting powder may have a particle size of about 4 to about 100 mesh, desirably about 8 to about 25 mesh, and more desirably about 12 to about 20 mesh.
  • the particulate gum base may be present in amounts of about 10% to about 80% by weight of the chewing gum composition, or tablet, desirably about 20% to about 50% by weight, and more desirably about 30% to about 40% by weight.
  • the particulate gum base may be combined with a tableting powder to form the pressed gum tablet.
  • the tableting powder can be in a dry, finely-divided form. Desirable particle size is provided above.
  • the tableting powder may be a sucrose-based, dextrose-based or polyol-based powder, or combinations thereof.
  • the polyol-based powder may be a sorbitol or mannitol powder.
  • the tableting powder may include other optional ingredients, such as flavor agents, color agents, sugar and/or sugarless sweeteners, and the like and combinations thereof.
  • a food-grade lubricant may assist in processing the gum composition into pressed tablets. More specifically, lubricants are used to prevent excess wear on dies and punches in tableting manufacture. Lubricants may be useful immediately after compression of the tablet within the die to reduce friction between the tablet and inner die wall.
  • the food-grade lubricant may be added separately or it may be included with the tableting powder, as in some commercially available tableting powders.
  • suitable food-grade lubricants include: metallic stearates; fatty acids; hydrogenated vegetable oil; partially hydrogenated vegetable oils; animal fats; polyethylene glycols; polyoxyethylene monostearate; talc; silicon dioxide; and combinations thereof.
  • Food-grade lubricants may be present in amounts of about 0-6% by weight of the gum composition.
  • a compressible chewing gum composition can be formed by preparing a chewing gum composition and then grinding the mixture.
  • the chewing gum composition can be prepared by mixing together molten gum base, bulk sweeteners, softeners, plasticizers, other sweeteners, colors, and the like by any known mixing technique such as dough mixing.
  • the chewing gum mixture can be formed into a particulate chewing gum composition using standard grinding techniques known in the art.
  • the particulate chewing gum may be formed, for example, by shredding, grinding or crushing the chewing gum or other processes, as described in U.S. Pat. Nos. 3,262,784, 4,405,647, 4,753,805 and 6,290,985 and U.S. Publication No. 2003/00276871, all of which are incorporated herein by reference in their entirety.
  • the compressible chewing gum composition can be in the form of a pressed gum tablet.
  • the particulate gum base and modified release ingredients are pressed into a tablet form.
  • the pressed gum tablet consolidates into a soft chewy substance.
  • the compressible chewing gum composition is a single-layer pressed tablet. In some embodiments, the compressible chewing gum composition is a multi-layer pressed tablet. Multi-layer tablet embodiments may have any desirable number of layers. Different layers may have the same or different thicknesses. In addition, different layers may include the same or different ingredients.
  • the pressed gum tablet also may have a coating layer surrounding the tablet.
  • the coating layer may contain any ingredients conventionally used in the chewing gum art.
  • the coating may contain sugar, polyols or high intensity sweeteners or the like, coloring agents, flavor agents and warming and/or cooling agents, among others.
  • the compressible chewing gum compositions, or pressed tablets desirably have a very low moisture content.
  • the tablets are essentially free of water. Accordingly, some embodiments have a total water content of greater than about 0% to about 5% by weight of the composition.
  • the density of the composition, or tablet may be about 0.2 to about 0.8 g/cc.
  • the compressible chewing gum compositions, or tablets may have a dissolution rate of about 1 to about 20 minutes. When in a pressed tablet form, the chewing gum may have a Shore hardness of about 30 to about 200.
  • compressed chewing gum temperatures can remain around ambient temperature (23° C. to 25° C.).
  • subjecting the compressible chewing gum compositions to lower temperatures can protect temperature sensitive ingredients from thermal degradation.
  • the absence of intimate mixing at temperatures above ambient can protect delivery systems that include temperature sensitive ingredients or ingredients subject to degradation from gum ingredients such as flavors, plasticizers, etc.
  • ingredients susceptible to thermal or chemical degradation due to conventional dough mixing can be less likely to experience degradation in compressed chewing gum systems.
  • Confectionery compositions include confections other than chewing gum compositions. Instead of a gum base, confectionery compositions may include a confectionery carrier.
  • the confectionery carrier may be selected from a variety of well-known carriers in the art. Selection of suitable carriers depends upon the type of confection being prepared.
  • a hard boiled candy confection has a base composed of a mixture of sugar or sugarless sweetening agents and other carbohydrate bulking agents kept in an amorphous or glassy condition.
  • the at least one sweetening agent itself may act as the carrier for the confectionery composition, or additional carrier components may be employed. Any of the sweetening agents set forth below may be used.
  • a general discussion of the composition and preparation of hard confections may be found in E. B. Jackson, Ed. “Sugar Confectionery Manufacture”, 2nd edition, Blackic Academic & Professional Press, Glasgow UK, (1990), at pages 129-169, as well as in H. A. Lieberman, Pharmaceutical Dosage Forms: Tablets, Volume 1 (1980), Marcel Dekker, Inc., New York, N.Y. at pages 339 to 469, which disclosure is incorporated herein by reference.
  • Such confectionery compositions may be routinely prepared by conventional methods such as those involving fire cookers, vacuum cookers, and scraped-surface cookers also referred to as high speed atmospheric cookers.
  • Fire cookers involve the traditional method of making a candy base.
  • the desired quantity of carbohydrate bulking agent is dissolved in water by heating the agent in a kettle until the bulking agent dissolves. Additional bulking agent may then be added and cooking continued until a final temperature of 145° C. to 156° C. is achieved.
  • the batch is then cooled and worked as a plastic-like mass to incorporate additives such as flavors, colorants and the like.
  • a high-speed atmospheric cooker uses a heat-exchanger surface which involves spreading a film of candy on a heat exchange surface, the candy is heated to 165° C. to 170° C. in a few minutes. The candy is then rapidly cooled to 100° C. to 120° C. and worked as a plastic-like mass enabling incorporation of the additives, such as flavors, colorants and the like.
  • the carbohydrate bulking agent is boiled to 125° C. to 132° C., vacuum is applied and additional water is boiled off without extra heating.
  • the mass is a semi-solid and has a plastic-like consistency.
  • flavors, colorants, and other additives are admixed in the mass by routine mechanical mixing operations.
  • the optimum mixing required to uniformly mix the flavors, colorants and other additives during conventional manufacturing of hard confectionery is determined by the time needed to obtain a uniform distribution of the materials. Normally, mixing times of from 4 to 10 minutes have been found to be acceptable.
  • the candy mass may be cut into workable portions or formed into desired shapes. A variety of forming techniques may be utilized depending upon the shape and size of the final product desired.
  • Soft candy confectionery compositions includes fondants, caramels toffees, fudge, marshmallows and nougats and the like and may also include jams and jellies.
  • the preparation of soft confectionery compositions, such as nougat involves conventional methods, such as the combination of two primary components, namely (1) a high boiling syrup, and (2) a relatively light textured frappe, generally prepared from egg albumin, gelatin, vegetable proteins, such as soy derived compounds, milk derived compounds such as milk proteins, and mixtures thereof.
  • a general discussion of the composition and preparation of such confections may be found in E. B. Jackson. Ed. “Sugar Confectionery Manufacture”, 2nd edition, Blackie Academic & Professional Press. Glasgow UK (1990), at pages 170-235.
  • the high boiling syrup, or “bob syrup”, of the soft confectionery is relatively viscous and has a higher density than the frappe component, and frequently contains a substantial amount of carbohydrate bulking agent such as a hydrogenated starch hydrolysate.
  • carbohydrate bulking agent such as a hydrogenated starch hydrolysate.
  • the final nougat composition is prepared by the addition of the “bob syrup” to the frappe under agitation, to form the basic nougat mixture. Further ingredients such as flavoring, additional carbohydrate bulking agent, colorants, preservatives, medicaments, mixtures thereof and the like may be added thereafter also under agitation.
  • a general discussion of the composition and preparation of nougat confections may be found in B. W. Minifie, Chocolate, Cocoa and Confectionery: Science and Technology, 2nd edition, AVI Publishing Co., Inc., Westport, Conn. (1980), at pages 424-425, which disclosure is incorporated herein by reference.
  • the procedure for preparing the soft confectionery involves known procedures.
  • the frappe component is prepared first and thereafter the syrup component is slowing added under agitation at a temperature of at least about 65° C., and preferably at least about 100° C.
  • the mixture of components is continued to be mixed to form a uniform mixture, after which the mixture is cooled to a temperature below 80° C., at which point, the flavor may be added.
  • the mixture is further mixed for an additional period until it is ready to be removed and formed into suitable confectionery shapes.
  • Compressed tablet confectionery compositions contain particular materials and are formed into structures under pressure. These confections generally contain sugar or sugar substitutes in amounts up to about 95%, by weight of the composition, and typical tablet excipients such as binders and lubricants.
  • the confectionery carrier is present in amounts of about 5% to about 99% by weight of the confectionery composition. More specifically, the confectionery carrier may be present in amounts of about 80% to about 99% by weight of the confectionery composition.
  • Both the chewing gum and confectionery compositions described herein may include at least one sweetening agent.
  • Sweetening agents include sugars, sugarless bulk sweeteners, high intensity sweeteners, or the like, or mixtures thereof.
  • Suitable sugar sweeteners generally include mono-saccharides, di-saccharides and poly-saccharides such as but not limited to, sucrose (sugar), dextrose, maltose, dextrin, xylose, ribose, glucose, mannose, galactose, fructose (levulose), invert sugar, fructo oligo saccharide syrups, partially hydrolyzed starch, corn syrup solids and mixtures thereof.
  • Suitable sugarless bulk sweeteners include sugar alcohols (or polyols) such as, but not limited to, sorbitol, xylitol, mannitol, galactitol, maltitol, hydrogenated isomaltulose (ISOMALT), lactitol, erythritol, hydrogenated starch hydrolysates, and mixtures thereof.
  • sugar alcohols or polyols
  • sorbitol xylitol
  • mannitol galactitol
  • maltitol hydrogenated isomaltulose
  • ISOMALT isomaltulose
  • lactitol lactitol
  • erythritol hydrogenated starch hydrolysates
  • Suitable hydrogenated starch hydrolysates include those disclosed in U.S. Pat. No. 4,279,931 and various hydrogenated glucose syrups and/or powders which contain sorbitol, maltitol, hydrogenated disaccharides, hydrogenated higher polysaccharides, or mixtures thereof.
  • Hydrogenated starch hydrolysates are primarily prepared by the controlled catalytic hydrogenation of corn syrups. The resulting hydrogenated starch hydrolysates are mixtures of monomeric, dimeric, and polymeric saccharides. The ratios of these different saccharides give different hydrogenated starch hydrolysates different properties.
  • high-intensity sweeteners may be used. Without being limited to particular sweeteners, representative categories and examples include:
  • water-soluble sweetening agents such as dihydrochalcones, monellin, steviosides, glycyrrhizin, dihydroflavenol, and sugar alcohols such as sorbitol, mannitol, maltitol, xylitol, erythritol, and L-aminodicarboxylic acid aminoalkenoic acid ester amides, such as those disclosed in U.S. Pat. No. 4,619,834, which disclosure is incorporated herein by reference, and mixtures thereof;
  • water-soluble sweetening agents such as dihydrochalcones, monellin, steviosides, glycyrrhizin, dihydroflavenol, and sugar alcohols such as sorbitol, mannitol, maltitol, xylitol, erythritol, and L-aminodicarboxylic acid aminoalkenoic acid ester amide
  • water-soluble artificial sweeteners such as soluble saccharin salts, i.e., sodium or calcium saccharin salts, cyclamate salts, the sodium, ammonium or calcium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide, the potassium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide (Acesulfame-K), the free acid form of saccharin, and mixtures thereof;
  • dipeptide based sweeteners such as L-aspartic acid derived sweeteners, such as L-aspartyl-L-phenylalanine methyl ester (Aspartame), N-[N-(3,3-dimethylbutyl)-L- ⁇ -aspartyl]-L-phenylalanine 1-methyl ester (Neotame), and materials described in U.S. Pat. No.
  • water-soluble sweeteners derived from naturally occurring water-soluble sweeteners such as chlorinated derivatives of ordinary sugar (sucrose), e.g., chlorodeoxysugar derivatives such as derivatives of chlorodeoxysucrose or chlorodeoxygalactosucrose, known, for example, under the product designation of Sucralose
  • chlorodeoxysucrose and chlorodeoxygalactosucrose derivatives include but are not limited to: 1-chloro-1′-deoxysucrose; 4-chloro-4-deoxy-alpha-D-galactopyranosyl-alpha-D-fructofuranoside, or 4-chloro-4-deoxygalactosucrose; 4-chloro-4-deoxy-alpha-D-galactopyranosyl-1-chloro-1-deoxy-beta-D-fructo-furanoside, or 4,1′-dichloro-4,1′-dideoxygal
  • protein based sweeteners such as thaumaoccous danielli (Thaumatin I and II) and talin;
  • Lo han guo (sometimes also referred to as “Lo han kuo”).
  • the intense sweetening agents may be used in many distinct physical forms well-known in the art to provide an initial burst of sweetness and/or a prolonged sensation of sweetness.
  • physical forms include free forms, such as spray dried, powdered, beaded forms, encapsulated forms, and mixtures thereof.
  • the at least one sweetening agent is present in amounts of about 0.001% to about 95% by weight of the chewing gum or confectionery composition. More specifically, bulk sweeteners (sugars and sugarless bulk sweeteners) may be present in amounts of about 5% to about 95% by weight of the chewing gum or confectionery compositions. In some embodiments, bulk sweeteners may be present in amounts of about 40% to about 90% by weight of the chewing gum or confectionery composition. Intense sweeteners may be present in amounts from about 0.001% to about 3%, by weight of the composition, depending upon the sweetener or combination of sweeteners used. The exact range of amounts for each type of sweetener may be selected by those skilled in the art.
  • the chewing gum and confectionery compositions include CPP-ACP.
  • CPP-ACP is an anticaries agent.
  • CPP-ACP may be present in amounts of about 0.5% to about 5% by weight of the chewing gum or confectionery composition.
  • high levels of CPP-ACP may be used to reduce dental caries, for example by about 16.9% over a chewing gum or confectionery that is free of CPP-ACP.
  • CPP-ACP may be present in amounts of at least about 3% by weight of the chewing gum or confectionery composition.
  • the chewing gum or confectionery composition may include an anticaries agent, which consists essentially of CPP-ACP.
  • the anticaries agent may be present in amounts of about 0.5% to about 5% by weight of the chewing gum or confectionery composition.
  • the anticaries agent may be present in amounts of at least about 3% by weight of the chewing gum or confectionery composition.
  • other oral care actives may be included with CPP-ACP in the chewing gum or confectionery composition.
  • CPP-ACP may be incorporated into the chewing gum or confectionery composition in a modified release form.
  • CPP-ACP may be encapsulated to provide modified release characteristics to the component.
  • partially or completely encapsulating CPP-ACP with an encapsulating material may delay release of the ingredient during consumption of the chewing gum or confectionery composition, thereby delaying when the ingredient becomes available inside the consumer's mouth, throat, and/or stomach, available to react or mix with another ingredient, and/or available to provide some sensory experience and/or functional or therapeutic benefit. This can be particularly true when the ingredient is water soluble or at least partially water soluble.
  • CPP-ACP may be used in its encapsulated and/or its unencapsulated (sometimes referred to as “free”) forms.
  • CPP-ACP may be incorporated into one or more regions of the center-fill product in its encapsulated and/or unencapsulated forms.
  • encapsulated CPP-ACP may be included in the gum region and unencapsulated CPP-ACP may be included in the center-fill region.
  • a combination of encapsulated CPP-ACP and unencapsulated CPP-ACP may be included in the same region of the product.
  • the encapsulated and unencapsulated forms may be used in the same or different amounts.
  • Suitable encapsulating materials for CPP-ACP may include water insoluble polymers, co-polymers, or other materials capable of forming a strong matrix, solid coating, or film as a protective barrier with or for the ingredient.
  • the encapsulating material may completely surround, coat, cover, or enclose the CPP-ACP. In other embodiments, the encapsulating material may only partially surround, coat, cover, or enclose the CPP-ACP. Different encapsulating materials may provide different release rates or release profiles for the encapsulated CPP-ACP.
  • encapsulating material used in a delivery system may include one or more of the following: polyvinyl acetate, polyethylene, crosslinked polyvinyl pyrrolidone, polymethylmethacrylate, polylactidacid, polyhydroxyalkanoates, ethylcellulose, polyvinyl acetatephthalate, polyethylene glycol esters, methacrylicacid-co-methylmethacrylate, ethylene-vinylacetate (EVA) copolymer, and the like, and combinations thereof.
  • the chewing gum and confectionery compositions also may include amounts of conventional additives selected from the group consisting of plasticizers, softeners, emulsifiers, waxes, fillers, bulking agents (carriers, extenders, bulk sweeteners), mineral adjuvants, flavor agents and coloring agents, physiological cooling agents, warming agents, tingling agents, antioxidants, acidulants, thickeners, medicaments, oral care actives, such as other remineralization agents, antimicrobials and tooth whitening agents, as described in assignee's co-pending U.S.
  • a sweetener such as maltitol or other sugar alcohol, may also function as a bulking agent.
  • the chewing gum or confectionery composition may include at least one flavor (flavorant, flavoring or flavor agent).
  • the at least one flavor may include those flavors known to the skilled artisan, such as natural and artificial flavors.
  • These flavorings may be chosen from synthetic flavor oils and flavoring aromatics and/or oils, oleoresins and extracts derived from plants, leaves, flowers, fruits, and so forth, and combinations thereof.
  • Nonlimiting representative flavor oils include spearmint oil, cinnamon oil, oil of wintergreen (methyl salicylate), peppermint oil, Japanese mint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, oil of nutmeg, allspice, oil of sage, mace, oil of bitter almonds, and cassia oil.
  • sweetenings are artificial, natural and synthetic fruit flavors such as vanilla, and citrus oils including lemon, orange, lime, grapefruit, yazu, sudachi, and fruit essences including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, melon, apricot, ume, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya and so forth.
  • fruit flavors such as vanilla, and citrus oils including lemon, orange, lime, grapefruit, yazu, sudachi, and fruit essences including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, watermelon, apricot, banana, melon, apricot, ume, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya and so forth.
  • Other potential flavors whose release profiles can be managed include a milk flavor, a butter flavor, a cheese flavor, a cream flavor, and a yogurt flavor; a vanilla flavor; tea or coffee flavors, such as a green tea flavor, a oolong tea flavor, a tea flavor, a cocoa flavor, a chocolate flavor, and a coffee flavor; mint flavors, such as a peppermint flavor, a spearmint flavor, and a Japanese mint flavor; spicy flavors, such as an asafetida flavor, an ajowan flavor, an anise flavor, an angelica flavor, a fennel flavor, an allspice flavor, a cinnamon flavor, a camomile flavor, a mustard flavor, a cardamom flavor, a caraway flavor, a cumin flavor, a clove flavor, a pepper flavor, a coriander flavor, a sassafras flavor, a savory flavor, a Zanthoxyli Fructus flavor, a perilla flavor, a
  • flavoring agents may be used in liquid or solid form and may be used individually or in admixture.
  • Commonly used flavors include mints such as peppermint, menthol, spearmint, artificial vanilla, cinnamon derivatives, and various fruit flavors, whether employed individually or in admixture. Flavors may also provide breath freshening properties, particularly the mint flavors when used in combination with the cooling agents, described herein below.
  • other flavorings include aldehydes and esters such as cinnamyl acetate, cinnamaldehyde, citral diethylacetal, dihydrocarvyl acetate, eugenyl formate, p-methylamisol, and so forth may be used.
  • aldehydes and esters such as cinnamyl acetate, cinnamaldehyde, citral diethylacetal, dihydrocarvyl acetate, eugenyl formate, p-methylamisol, and so forth may be used.
  • any flavoring or food additive such as those described in Chemicals Used in Food Processing, publication 1274, pages 63-258, by the National Academy of Sciences, may be used. This publication is incorporated herein by reference. These may include natural as well as synthetic flavors.
  • aldehyde flavorings include but are not limited to acetaldehyde (apple), benzaldehyde (cherry, almond), anisic aldehyde (licorice, anise), cinnamic aldehyde (cinnamon), citral, i.e., alpha-citral (lemon, lime), neral, i.e., beta-citral (lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla, cream), heliotrope, i.e., piperonal (vanilla, cream), vanillin (vanilla, cream), alpha-amyl cinnamaldehyde (spicy fruity flavors), butyraldehyde (butter, cheese), valeraldehyde (butter, cheese), citronellal (modifies, many types), decanal (citrus fruits), aldehyde C-8 (citrus fruits),
  • a flavoring agent may be employed in either liquid form and/or dried form. When employed in the latter form, suitable drying means such as spray drying the liquid may be used.
  • the flavoring agent may be absorbed onto water soluble materials, such as cellulose, starch, sugar, maltodextrin, gum arabic and so forth or may be encapsulated.
  • the flavoring agent may be adsorbed onto silicas, zeolites, and the like.
  • the flavoring agents may be used in many distinct physical forms.
  • such physical forms include free forms, such as spray dried, powdered, beaded forms, encapsulated forms, and mixtures thereof.
  • the at least one flavor is present in amounts of about 0.1% to about 15% by weight of the chewing gum or confectionery composition. More specifically, flavors may be present in amounts of about 0.5% to about 5.0% by weight of the chewing gum or confectionery compositions.
  • Coloring agents may be used in amounts effective to produce the desired color.
  • the coloring agents may include pigments which may be incorporated in amounts up to about 6%, by weight of the chewing gum or confectionery composition.
  • titanium dioxide may be incorporated in amounts up to about 2%, and preferably less than about 1%, by weight of the composition.
  • the colorants may also include natural food colors and dyes suitable for food, drug and cosmetic applications. These colorants are known as F.D.& C. dyes and lakes.
  • the materials acceptable for the foregoing uses are preferably water-soluble.
  • Illustrative nonlimiting examples include the indigoid dye known as F.D.& C. Blue No. 2, which is the disodium salt of 5,5-indigotindisulfonic acid.
  • the dye known as F.D.& C. Green No. 1 comprises a triphenylmethane dye and is the monosodium salt of 4-[4-(N-ethyl-p-sulfoniumbenzylamino)diphenylmethylene]-[1-(N-ethyl-N-p-sulfoniumbenzyl)-delta-2,5-cyclohexadieneimine].
  • F.D.& C. colorants and their corresponding chemical structures may be found in the Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Edition, in volume 5 at pages 857-884, which text is incorporated herein by reference.
  • cooling agents may be employed.
  • the useful cooling agents include menthol, xylitol, erytifritol, menthane, menthone, menthyl acetate, menthyl salicylate, N,2,3-trimethyl-2-isopropyl butanamide (WS-23), N-ethyl-p-menthane-3-carboxamide (WS-3), menthyl succinate, 3,1-menthoxypropane1,2-diol and glutarate esters, among others, and combinations thereof.
  • menthol xylitol
  • erytifritol erytifritol
  • menthane menthone
  • menthyl acetate menthyl salicylate
  • WS-23 N,2,3-trimethyl-2-isopropyl butanamide
  • WS-3 N-ethyl-p-menthane-3-carboxamide
  • menthyl succinate 3,1-menthoxypropane1,
  • Warming agents may be selected from a wide variety of compounds known to provide the sensory signal of warming to the individual user. These compounds offer the perceived sensation of warmth, particularly in the oral cavity, and often enhance the perception of flavors, sweeteners and other organoleptic components.
  • Useful warming agents include those having at least one allyl vinyl component, which may bind to oral receptors.
  • Suitable warming agents include, but are not limited to: vanillyl alcohol n-butylether (TK-1000, supplied by Takasago Perfumery Company Ltd., Tokyo, Japan); vanillyl alcohol n-propylether; vanillyl alcohol isopropylether; vanillyl alcohol isobutylether; vanillyl alcohol n-aminoether; vanillyl alcohol isoamylether; vanillyl alcohol n-hexylether; vanillyl alcohol methylether; vanillyl alcohol ethylether; gingerol; shogaol; paradol; zingerone; capsaicin; dihydrocapsaicin; nordihydrocapsaicin; homocapsaicin; homodihydrocapsaicin; ethanol; isopropyl alcohol; iso-amylalcohol; benzyl alcohol; glycerine; chloroform; eugenol; cinnamon oil;
  • Tingling agents may be employed to provide a tingling, stinging or numbing sensation to the user.
  • Tingling agents include, but are not limited to: Jambu Oleoresin or para cress ( Spilanthes sp.), in which the active ingredient is Spilanthol; Japanese pepper extract ( Zanthoxylum peperitum ), including the ingredients known as Saanshool-I, Saanshool-II and Sanshoamide; black pepper extract ( piper nigrum ), including the active ingredients chavicine and piperine; Echinacea extract; Northern Prickly Ash extract; red pepper oleoresin; and effervescing agents, such as edible acids and bases, which may be encapsulated.
  • Tingling agents are described in U.S. Pat. No. 6,780,443 to Nakatsu et al., U.S. Pat. No. 5,407,665 to McLaughlin et al., U.S. Pat. No. 6,159,509 to Johnson et al. and U.S. Pat. No. 5,545,424 to Nakatsu et al., each of which is incorporated by reference herein in its entirety.
  • the chewing gum or confectionery composition may be free of sodium bicarbonate. More specifically, some known chewing gums and confections have included sodium bicarbonate with CPP-ACP to reduce plaque upon consumption. Sodium bicarbonate also may be used as a filler. Embodiments described herein, however, may be free of sodium bicarbonate, and the CPP-ACP alone may reduce dental caries. In particular, CPP-ACP in amounts of at least about 3% by weight of the chewing gum or confectionery composition may reduce caries by about 16.9% over chewing gum and confectionery compositions that are free of CPP-ACP. Similarly, some embodiments described herein may be free of any mineral fillers.
  • a chewing gum composition for reducing dental caries may consist essentially of a gum base, at least one sweetening agent, CPP-ACP present in amounts of at least about 3% by weight of the chewing gum composition, at least one flavor, at least one coloring agent and at least one surfactant.
  • a confectionery composition may consist essentially of a confectionery carrier, at least one sweetening agent, CPP-ACP present in amounts of at least about 3% by weight of the confectionery composition, at least one flavor and at least one coloring agent.
  • the chewing gum compositions may be provided as a variety of different products, such as, slab, pellet, sticks, center-fill gums, deposited gums and compressed gums.
  • the confectionery compositions also may be provided as a variety of different products, such as, hard candy, soft candy, center-fill candy, cotton candy, pressed tablets, lozenges, edible films, nougats, caramels, frappes and taffies. Any of the chewing gum or confectionery products may have a coating thereon, which may at least partially surround or enrobe the product.
  • the chewing gum or confectionery product may include a chewing gum or confectionery region and a coating region.
  • the chewing gum region may be formed from any of the chewing gum compositions described above.
  • the confectionery region may be formed from any of the confectionery compositions described above.
  • the coating region may at least partially surround the chewing gum or confectionery region.
  • CPP-ACP may be located in the chewing gum or confectionery region, in the coating region or in both regions.
  • Center-fill chewing gums may include a center-fill region and a gum region at least partially surrounding or positioned adjacent to the center-fill region.
  • the gum region may be formed from any of the chewing gum compositions described above.
  • Center-fill confectioneries such as, for example, center-fill candy, may include a center-fill region and a confectionery region, such as a hard or chewy candy region, at least partially surrounding or positioned adjacent to the center-fill region.
  • the confectionery region may be formed from any of the confectionery compositions described above.
  • CPP-ACP may be located in the gum or confectionery region, the center-fill region or in both regions.
  • the center-fill region of the gum or confectionery product may be a liquid, solid or semi-solid, gas, or the like.
  • Embodiments that include a liquid center-fill composition, as well as some semi-solid center-fill compositions may involve concerns regarding retention of the liquid center during manufacturing and shelf-life, as mentioned above.
  • center-fill products also may include a coating region, which at least partially surrounds the gum or confectionery region.
  • the outer coating may be soft, hard or crunchy. Any suitable coating materials known to those skilled in the art may be employed.
  • the outer coating may include sorbitol, maltitol, xylitol, isomalt, erythritol and other crystallizable polyols; sucrose may also be used.
  • the coating may include several opaque layers, such that the chewing gum or confectionery composition is not visible through the coating itself, which can optionally be covered with a further one or more transparent layers for aesthetic, textural and protective purposes.
  • the outer coating may also contain small amounts of water and gum arabic.
  • the coating can be further coated with wax.
  • the coating may be applied in a conventional manner by successive applications of a coating solution, with drying in between each coat. As the coating dries it usually becomes opaque and is usually white, though other colorants may be added.
  • a polyol coating can be further coated with wax.
  • the coating can further include colored flakes or speckles. If the composition includes a coating, it is possible that one or more oral care actives can be dispersed throughout the coating. This is especially preferred if one or more oral care actives is incompatible in a single phase composition with another of the actives. Flavors may also be added to yield unique product characteristics.
  • materials may be added to the coating to achieve desired properties. These materials may include without limitations, cellulosics such as carboxymethyl cellulose, gelatin, xanthan gum and gum arabic.
  • the coating composition may be applied by any method known in the art including the method described above.
  • the coating composition may be present in an amount from about 2% to about 60%, more specifically from about 25% to about 45% by weight of the total chewing gum or confectionery product.
  • Center-fill products may be formed by any technique known in the art, which includes the method described by U.S. Pat. No. 6,280,780 to Degady et al. (“Degady”), which is incorporated by reference herein in its entirety.
  • any of the chewing gum or confectionery products described above may be applied into the oral cavity of a mammal.
  • the product may include a gum base, for chewing gums, or a confectionery carrier, for confectioneries, at least one sweetening agent and CPP-ACP, as described herein. Any of the other optional additives described above also may be included.
  • the chewing gum product Once the chewing gum product is applied into the oral cavity, it may be chewed for a time sufficient to reduce caries formation. Similarly, once the confectionery product is applied into the oral cavity, it may be retained therein for a time sufficient to reduce caries formation. More specifically, in some embodiments, such time periods may be sufficient to slow the progression and enhance the regression of carious lesions. Such time periods may be at least 1 minute, more specifically, at least 10 minutes in some embodiments.
  • These methods may reduce or prevent caries formation to a greater extent than chewing a sugarless chewing gum product which is free of CPP-ACP for the same period of time. More specifically, chewing one of the chewing gum products described herein may reduce caries formation by about 16.9% over chewing sugarless chewing gum products which are free of CPP-ACP. Similarly, retaining one of the confectionery products described herein in the oral cavity may reduce caries formation by about 16.9% over confectioneries which are free of CPP-ACP.
  • the chewing gum or confectionery product may display a brand or logo (e.g., slogans, trademarks, terms and colors) that communicates the presence of CPP-ACP in an amount sufficient to reduce or prevent dental caries.
  • the chewing gum or confectionery product itself may display the brand or logo.
  • the chewing gum or confectionery product may be housed within packaging that displays the brand or logo.
  • the brand or logo that communicates the presence of CPP-ACP further may be marketed to consumers in a variety of manners. Suitable marketing strategies, include, for example, print, radio, satellite radio, television, movie theater and online advertising campaigns, point-of-purchase advertisements, billboard advertisements, public transportation and telephone booth advertisements, instant messaging, ringtones, and the like.
  • kits for addressing the problem of dental caries in mammals may be provided.
  • a kit may be provided for reducing dental caries in a mammal.
  • the kit may include any of the chewing gum or confectionery products described herein.
  • the kit also may include a set of instructions for using the chewing gum or confectionery product and a package for housing the chewing gum or confectionery product and the set of instructions.
  • Similar kits for preventing dental caries in a mammal or for slowing the progression and enhancing the regression of carious lesions in a mammal also may be provided.
  • Acids may be used in chewing gums and confections for a variety of reasons. Sometimes acids are used to add flavor, such as in fruit-flavored gums, to add sourness, or to promote mouth-moistening, or the like. As mentioned above, however, acid-containing gums can lead to demineralization of the tooth surfaces.
  • compositions for remineralizing and/or imparting acid resistance to the tooth surface of a mammal.
  • these compositions may be chewing gum or confectionery products employing CPP-ACP in combination with a food-grade acid. Such products may remineralize and/or impart a greater degree of acid resistance to tooth surfaces than similar compositions that are free of CPP-ACP.
  • the chewing gum compositions may include a gum base, at least one sweetening agent, CPP-ACP and at least one food-grade acid.
  • the chewing gum compositions may be provided in any of the forms described above.
  • the confectionery compositions may include a confectionery carrier, at least one sugarless sweetening agent, CPP-ACP and at least one food-grade acid.
  • the confectionery compositions also may be provided in any of the forms described above.
  • the chewing gum or confectionery compositions also may include additional oral care actives, such as but not limited to, whitening actives, antimicrobial actives, breath freshening actives, de-sensitizing actives, and other remineralizing actives.
  • additional oral care actives such as but not limited to, whitening actives, antimicrobial actives, breath freshening actives, de-sensitizing actives, and other remineralizing actives.
  • the chewing gum and confectionery compositions also may include at least one flavor and a variety of optional additives.
  • Sugarless compositions may be desirable and include sugarless sweetening agents, as set forth above.
  • compositions and Methods for Reducing Dental Caries are described above in the section entitled “Compositions and Methods for Reducing Dental Caries.” These components may be used in the same amounts described above.
  • the chewing gum and confectionery compositions also include CPP-ACP and at least one food-grade acid.
  • CPP-ACP generally may be present in amounts of about 0.5% to about 5% by weight of the chewing gum or confectionery composition. More specifically, in some chewing gum and confectionery embodiments for remineralizing and/or imparting acid resistance to tooth surfaces, CPP-ACP may be present in amounts of about 0.5% to about 1.5% by weight of the composition.
  • the at least one food-grade acid included in the chewing gum and confectionery compositions may include, but is not limited to: acetic acid; adipic acid; ascorbic acid; butyric acid; citric acid; formic acid; fumaric acid; glyconic acid; lactic acid; malic acid; phosphoric acid; oxalic acid; succinic acid; tartaric acid; and combinations thereof.
  • Food-grade acids may be present in amounts of about 0.01% to about 20% by weight of the chewing gum or confectionery composition. More specifically, in some embodiments, food-grade acids may be present in amounts of about 0.5% to about 5% by weight of the chewing gum or confectionery composition, and even more specifically about 2.5% to about 5% by weight of the chewing gum or confectionery composition.
  • the chewing gum and confectionery compositions may include any of the other additives described above.
  • the chewing gum and confectionery compositions may be provided in any of the product forms discussed above, such as, for example, center-fill gums and confectioneries.
  • the CPP-ACP may be present in a variety of different regions of the product in some embodiments.
  • the CPP-ACP may be used in its encapsulated and/or unencapsulated form.
  • the at least one food-grade acid also may be used in its encapsulated and/or unencapsulated form.
  • the CPP-ACP and food-grade acid may be encapsulated separately or together as a mixture. In some embodiments in which the CPP-ACP and food-grade acid are separately encapsulated, the same or different encapsulating materials may be used.
  • CPP-ACP and at least one food-grade acid may be incorporated into one or more regions of the center-fill product in their encapsulated and/or unencapsulated forms.
  • encapsulated CPP-ACP may be included in the gum region and an encapsulated food-grade acid may be included in the center-fill region.
  • a mixture of CPP-ACP and a food-grade acid may be encapsulated together and incorporated into one or more regions of the product.
  • at least one of the components may be used in its encapsulated and unencapsulated forms.
  • CPP-ACP may be included in its encapsulated and unencapsulated forms in combination with a food-grade acid, which may or may not be encapsulated.
  • the encapsulated and unencapsulated forms may be used in the same or different amounts.
  • the chewing gum or confectionery product also may display a brand or logo, or be housed within packaging that displays a brand or logo, as described above.
  • Some embodiments described herein extend to methods of remineralizing tooth surfaces of mammals, as well as methods of imparting acid resistance to tooth surfaces of mammals. Such methods may be particularly useful for remineralizing and/or imparting acid resistance to tooth surfaces of humans.
  • any of the chewing gum or confectionery products described above may be applied into the oral cavity of a mammal.
  • the product may include a gum base, for chewing gums, or a confectionery carrier, for confectioneries, at least one sweetening agent, CPP-ACP and at least one food-grade acid, as described herein. Any of the other optional additives described above also may be included.
  • the chewing gum product Once the chewing gum product is applied into the oral cavity, it may be chewed for a time sufficient to remineralize the tooth surface of the mammal. Similarly, once the confectionery product is applied into the oral cavity, it may be retained therein for a time sufficient to reduce caries formation. Such time periods may be at least 1 minute, more specifically, at least 10 minutes in some embodiments.
  • chewing one of the chewing gum products described above may lead to at least about 10% more remineralization than chewing gums which include a food-grade acid, but are free of CPP-ACP.
  • chewing one of the chewing gums described above may cause at least 3% more remineralization than chewing gums which are free of both CPP-ACP and food-grade acid.
  • the same remineralization benefits may be achieved with the confectionery products described above. These benefits may be particularly applicable in sugarless gums and confectionery products.
  • chewing one of the chewing gums or confectioneries described above may impart a greater amount of acid resistance to tooth surfaces than a chewing gum product which is free of CPP-ACP for the same period of time. More specifically, the chewing gum products described above may impart at least about 13% more acid resistance than chewing gums which include a food-grade acid, but are free of CPP-ACP. Additionally, the chewing gums described above may impart at least 4% more acid resistance than chewing gums which are free of both CPP-ACP and food-grade acid. The same acid resistance benefits may be achieved with the confectionery products described above. These benefits also may be particularly applicable in sugarless gums and confectionery products.
  • kits for addressing the problem of demineralization of tooth surfaces in mammals may be provided.
  • a kit may be provided for remineralizing tooth surfaces.
  • the kit may include any of the chewing gum or confectionery products described above, which may include CPP-ACP and food-grade acid(s).
  • the kit also may include a set of instructions for using the chewing gum or confectionery product and a package for housing the chewing gum or confectionery product and the set of instructions. Similar kits for imparting acid resistance to tooth surfaces in a mammal also may be provided.
  • This example shows the anticariogenicity of sugarless chewing gum containing CPP-ACP as compared to that of a control sugarless chewing gum in a sample of adolescents employing usual oral hygiene practices.
  • a sugarless chewing gum slab containing CPP-ACP was prepared according to the formulation in Table 1 below.
  • a control sugarless chewing gum slab, which is free of CPP-ACP, was prepared according to the formulation in Table 2 below.
  • the sugarless chewing gum containing CPP-ACP and the control gum were used in a two-year double-blind, randomized trial designed to measure the comparative reduction in dental caries.
  • the trial was conducted using 2,720 adolescents (aged approximately 12 years) who were subjected to usual oral care hygiene over the two-year period, including normal dental visits and fluoride-containing drinking water.
  • the gums were chewed three times a day for 10 minutes per session.
  • the test group chewed the sugarless gum containing CPP-ACP and the control group chewed the control gum.
  • Standardized digital radiographs (bitewing radiographs) of each subject's teeth were taken at the baseline and at the completion of the study (24 months) using the Dexis digital X-ray system.
  • the radiographs were scored and assessed for approximal surface dental caries at both the enamel and dentine level. Analysis of caries progression or regression was undertaken using a transition matrix. The results evidenced a statistically significant difference in the distributions of the transition scores between the two groups.
  • the sugarless gum containing CPP-ACP slowed the progression of carious lesion as compared with the control gum.
  • 814 (4.41%) of approximal surfaces experienced caries progression compared to 932 (5.31%) approximal surfaces in the control group, which is a reduction of 16.9% as compared to the control group.
  • the trial also showed that the sugarless gum containing CPP-ACP enhanced regression of carious lesions compared to the control gum.
  • 56 (0.30%) of approximal surfaces experienced caries regression with the sugarless gum containing CPP-ACP compared to 36 (0.21%) approximal surfaces with the control gum.
  • a greater percentage of approximal surfaces remained unchanged with the sugarless gum containing CPP-ACP than with the control gum.
  • transition scores represent the transition from the baseline measurement to the measurement at the completion of the trial.
  • Negative transition scores represent regression of dental caries
  • positive transition scores represent progression of dental caries.
  • the control gum resulted in 0.21% regression of dental caries
  • the CPP-ACP containing gum resulted in 0.3% regression of dental caries, as mentioned above.
  • the sugarless chewing gum containing 54.4 mg (3% by weight) of CPP-ACP significantly slowed progression and enhanced regression of dental caries in a two-year trial relative to a normal sugarless chewing gum.
  • This example shows the remineralization and acid resistance effects of sugarless chewing gum containing CPP-ACP and a food-grade acid as compared to that of control sugarless chewing gums.
  • a sugarless chewing gum pellet containing CPP-ACP and citric acid was prepared according to the first formulation in Table 4 below. Two control sugarless chewing gum pellets were also prepared.
  • the first control gum contained citric acid, but was free of CPP-ACP, as indicated by the second formulation in Table 4 below (“Control with acid”).
  • the second control gum was free of both citric acid and CPP-ACP, as indicated by the third formulation in Table 4 below (“Control without acid”).
  • the sugarless gum of the first formulation (2 pellets) contained 18.8 mg of CPP-ACP and 20 mg citric acid.
  • the sugarless gum of the second formulation (2 pellets) contained 20 mg citric acid alone.
  • the sugarless gum of the third formulation (2 pellets) contained no CPP-ACP or citric acid.
  • the three different sugarless chewing gums were used in a 14-day double-blind, randomized test designed to measure the remineralization and acid resistance effects of a CPP-ACP and acid-containing gum.
  • the test was conducted using 10 subjects wearing removable palatal appliances.
  • the palatal appliances each had 4 half-slab insets of human enamel containing demineralized subsurface lesions.
  • the gums (2 pellets) were chewed 4 times a day for 20 minutes per session.
  • the enamel half-slabs were removed and half of the remineralized lesion was treated with carbopol/lactic acid for 16 hours.
  • the enamel slabs subsequently were embedded, sectioned and subjected to microradiography to determine the level of remineralization.
  • modified release i.e., encapsulated, forms of CPP-ACP and several food-grade acids (adipic, citric and malic).
  • the encapsulated CPP-ACP of Example 3 may be used in chewing gum or confectionery compositions for reducing dental caries.
  • the encapsulated CPP-ACP also may be used in combination with one or more of the encapsulated acids of Examples 4-6 to provide chewing gum or confectionery compositions for remineralizing and/or imparting acid resistance to tooth surfaces.
  • each of the encapsulated components of Examples 3-6 may be incorporated into chewing gum or confectionery compositions in combination with the unencapsulated form of the component.
  • the CPP-ACP of Example 3 may be combined with unencapsulated CPP-ACP for use in chewing gum or confectionery compositions for reducing dental caries.
  • the encapsulated and unencapsulated forms may be used in the same or different amounts.
  • each of the encapsulated acids of Examples 4-6 may be combined with free amounts of the same acid for use in chewing gum or confectionery compositions for remineralizing and/or imparting acid resistance to tooth surfaces. Combinations of different acids also may be used.
  • the encapsulated and unencapsulated forms may be used in the same or different amounts.
  • Composition Ingredient Weight percent Polyvinyl Acetate 55.00% Hydrogenated Oil 3.75% Glycerol Monostearate 1.25% CPP-ACP 40.00% Total 100.00%
  • Polyvinyl acetate is melted at a temperature of about 80° C. in a high shear mixer such as extruder (single or twin screw) or sigma or Banbury mixer.
  • the hydrogenated oil and glycerol monostearate are then added to the molten polyvinyl acetate.
  • CPP-ACP is then added to the resulting mixture and mixed under high shear to completely disperse the ingredients.
  • the resulting filled polymer melt is cooled and ground to produce a powdered material with a particle size of less than 420 microns.
  • the encapsulated matrix is stored in air tight containers with low humidity below 35° C.
  • composition Ingredient Weight percent Polyvinyl Acetate 60.00% Hydrogenated Oil 3.75% Glycerol Monostearate 1.25% Adipic acid 35.00% Total 100.00%
  • Polyvinyl acetate is melted at a temperature of about 110° C. in a high shear mixer such as extruder (single or twin screw) or sigma or Banbury mixer.
  • the hydrogenated oil and glycerol monostearate are then added to the molten polyvinyl acetate.
  • Adipic acid is then added to the resulting mixture and mixed under high shear to completely disperse the ingredients.
  • the resulting filled polymer melt is cooled and ground to produce a powdered material with a particle size of less than 420 microns.
  • the encapsulated adipic acid matrix is stored in air tight containers with low humidity below 35° C.
  • composition Ingredient Weight percent Polyvinyl Acetate 55.00% Hydrogenated Oil 3.75% Glycerol Monostearate 1.25% Citric Acid 40.00% Total 100.00%
  • Polyvinyl acetate is melted at a temperature of about 110° C. in a high shear mixer such as extruder (single or twin screw) or sigma or Banbury mixer.
  • a high shear mixer such as extruder (single or twin screw) or sigma or Banbury mixer.
  • the hydrogenated oil and glycerol monostearate are then added to the molten polyvinyl acetate.
  • Citric acid is then added to the resulting mixture and mixed under high shear to completely disperse the ingredients.
  • the resulting filled polymer melt is cooled and ground to produce a powdered material with a particle size of less than 420 microns.
  • the encapsulated citric acid matrix is stored in air tight containers with low humidity below 35° C.
  • Composition Ingredient Weight percent Polyvinyl Acetate 55.00% Hydrogenated Oil 3.75% Glycerol Monostearate 1.25% Malic acid 40.00% Total 100.00%
  • Polyvinyl acetate is melted at a temperature of about 110° C. in a high shear mixer such as extruder (single or twin screw) or sigma or Banbury mixer.
  • the hydrogenated oil and glycerol monostearate are then added to the molten polyvinyl acetate.
  • Malic acid are then added to the resulting mixture and mixed under high shear to completely disperse the ingredients.
  • the resulting filled polymer melt is cooled and ground to produce a powdered material with a particle size of less than 420 microns.
  • the malic acid encapsulation matrix is stored in air tight containers with low humidity below 35° C.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US11/732,855 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries Abandoned US20070237804A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/732,855 US20070237804A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78952506P 2006-04-05 2006-04-05
US11/732,855 US20070237804A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries

Publications (1)

Publication Number Publication Date
US20070237804A1 true US20070237804A1 (en) 2007-10-11

Family

ID=38581656

Family Applications (4)

Application Number Title Priority Date Filing Date
US11/732,855 Abandoned US20070237804A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries
US11/732,958 Abandoned US20070237729A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries
US11/732,854 Abandoned US20070237856A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries
US12/851,012 Expired - Fee Related US8252269B2 (en) 2006-04-05 2010-08-05 Impact of calcium phosphate complex on dental caries

Family Applications After (3)

Application Number Title Priority Date Filing Date
US11/732,958 Abandoned US20070237729A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries
US11/732,854 Abandoned US20070237856A1 (en) 2006-04-05 2007-04-05 Impact of calcium phosphate complex on dental caries
US12/851,012 Expired - Fee Related US8252269B2 (en) 2006-04-05 2010-08-05 Impact of calcium phosphate complex on dental caries

Country Status (10)

Country Link
US (4) US20070237804A1 (ja)
EP (2) EP2046278A4 (ja)
JP (4) JP5336354B2 (ja)
CN (3) CN101415397A (ja)
AU (4) AU2007235360B2 (ja)
BR (2) BRPI0709875A2 (ja)
CA (2) CA2646283C (ja)
MX (2) MX2008012520A (ja)
RU (2) RU2437652C2 (ja)
WO (2) WO2007117628A2 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301513A3 (en) * 2009-09-29 2011-04-06 GC Corporation Tooth coating composition
US10111831B2 (en) 2011-02-28 2018-10-30 Technologies Khloros Inc. Chewable vehicle for mouth absorption

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5633998B2 (ja) 2006-09-27 2014-12-03 三栄源エフ・エフ・アイ株式会社 歯の再石灰化促進剤およびこれを含む口腔または経口用組成物
JP5437692B2 (ja) * 2009-04-30 2014-03-12 インターコンチネンタル グレート ブランズ エルエルシー チューインガム組成物、チューインガム製品、及びこれらの製造方法
JP5812657B2 (ja) * 2011-04-14 2015-11-17 小川香料株式会社 飲料又は食品の苦渋味抑制剤
JP6649251B2 (ja) 2013-09-25 2020-02-19 クレデンティス・アクチェンゲゼルシャフトＣｒｅｄｅｎｔｉｓ ＡＧ 歯を白くするためのデンタルケア製品
EP2853256A1 (en) 2013-09-25 2015-04-01 Credentis AG Dental care product for tooth whitening
JP5764712B1 (ja) * 2014-12-16 2015-08-19 株式会社松風 歯質再生剤
GB2535989A (en) * 2015-02-26 2016-09-07 Dr Heff's Products Ltd Dental product, use of a dental product and methods of use of a dental product
KR102195356B1 (ko) * 2019-08-19 2020-12-24 김영용 구강용 인산칼슘 복합체의 제조방법 및 이를 포함하는 구강케어제
US11154470B1 (en) 2020-07-31 2021-10-26 vVardis AG Anti-inflammatory and senolytic dental care product with tooth whitening characteristics
EP3984517A1 (en) 2020-10-19 2022-04-20 Credentis AG Accelerating tooth remineralisation and bone regeneration with self-assembling peptides and amorphous calcium phosphate
CN116473852A (zh) * 2023-04-14 2023-07-25 南昌大学 一种抗菌防龋再矿化泡沫材料及其制备方法与应用

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US325711A (en) * 1885-09-08 Confection capsule
US810210A (en) * 1905-05-10 1906-01-16 Benjamin A Laws Article of chewing-gum.
US943945A (en) * 1907-09-03 1909-12-21 Julius Liebich Liquor-containing confection.
US1771982A (en) * 1928-09-10 1930-07-29 Gilbert B Mustin Chewing gum and method of making same
US1771506A (en) * 1926-11-10 1930-07-29 Gilbert B Mustin Method of making chewing-gum sandwiches
US2004957A (en) * 1934-04-25 1935-06-18 Elmer L Schumacher Capsule
US2448786A (en) * 1946-06-08 1948-09-07 Charles E Faxon Confectionery forming mechanism
US2973273A (en) * 1959-02-11 1961-02-28 Salvatore G Militana Sponge chewing gum and method of making the same
US3071476A (en) * 1960-05-12 1963-01-01 August R Werft Chewing device
US3795748A (en) * 1971-09-08 1974-03-05 Karlschloss Anstalt Method of manufacturing liquid-filled chocolate candies
US3806290A (en) * 1972-07-12 1974-04-23 Warner Lambert Co Apparatus for center-filled chewing gum
US3857963A (en) * 1972-07-12 1974-12-31 Warner Lambert Co Method for forming center-filled chewing gum
US3894154A (en) * 1974-01-14 1975-07-08 Warner Lambert Co Center-filled gum
US4150161A (en) * 1977-03-15 1979-04-17 General Foods Corporation Carbonated chewing gum
US4156740A (en) * 1978-02-02 1979-05-29 Warner-Lambert Company Sugarless center-filled chewing gum
US4157402A (en) * 1977-11-22 1979-06-05 Lotte Co., Ltd. Center-filled chewing gum
US4224345A (en) * 1978-10-16 1980-09-23 Lotte Co., Ltd Chewing gum base and a combination of a chewing gum with fatty matter
US4250196A (en) * 1979-10-09 1981-02-10 Life Savers, Inc. Center-filled chewing gums
US4251201A (en) * 1978-09-18 1981-02-17 Krysiak Janusz D Extrusion apparatus
US4252829A (en) * 1978-03-13 1981-02-24 Perfetti S.P.A. Chewing gum with flavoured liquid filling
US4269860A (en) * 1979-09-21 1981-05-26 Lotte Co. Ltd. Process for preparing a gas-developing chewing gum
US4271198A (en) * 1979-12-10 1981-06-02 Life Savers, Inc. Chewing gum having a soft texture
US4271197A (en) * 1979-06-21 1981-06-02 Walter Hopkins Chewing gum containing sugar substitute
US4292329A (en) * 1978-02-06 1981-09-29 Lotte Co., Ltd. Center-filled chewing gum
US4301178A (en) * 1980-05-02 1981-11-17 Life Savers, Inc. Liquid-filled chewing gum and method
US4316915A (en) * 1979-10-01 1982-02-23 Life Savers, Inc. Center-filled chewing gums
US4317838A (en) * 1979-09-24 1982-03-02 Life Savers, Inc. Method for applying sugarless coating to chewing gum and confections
US4328249A (en) * 1981-01-30 1982-05-04 Life Savers, Inc. Method for treating gum base to improve shelf-life without need for antioxidants
US4329369A (en) * 1980-03-03 1982-05-11 Lotte Co., Ltd. Process for preparation of chewing gum
US4352823A (en) * 1981-04-13 1982-10-05 Nabisco Brands, Inc. Coextruded chewing gum containing a soft non-SBR gum core portion
US4352825A (en) * 1981-02-23 1982-10-05 Nabisco Brands, Inc. Coextruded chewing gum containing a soft core portion
US4352824A (en) * 1980-03-27 1982-10-05 Nabisco Brands, Inc. Chewing gum containing fatty or gelatinous sweetener and method
US4374858A (en) * 1979-10-04 1983-02-22 Warner-Lambert Company Aspartame sweetened chewing gum of improved sweetness stability
US4382962A (en) * 1979-06-15 1983-05-10 Societe Roquette Freres Sugarless-type chewing gum
US4399154A (en) * 1980-06-30 1983-08-16 Nabisco Brands Inc. Coextruded chewing gum
US4421773A (en) * 1981-05-05 1983-12-20 Akutagawa Chocolate Co., Ltd. Process for molding chocolate to make chocolate block having ornamental pattern and internal hollow cavity
US4430351A (en) * 1981-04-24 1984-02-07 Ferrero S.P.A. Confectionary product with a filling
US4466983A (en) * 1983-02-04 1984-08-21 Warner-Lambert Company Substantially non-aqueous semi-liquid center-fill
US4485118A (en) * 1983-04-21 1984-11-27 Warner-Lambert Company Gum composition with plural time releasing flavors and method of preparation
US4513012A (en) * 1983-05-13 1985-04-23 Warner-Lambert Company Powdered center-filled chewing gum compositions
US4543769A (en) * 1980-07-05 1985-10-01 Rose Verpackungsmaschinenfabrik Theegarten Method and apparatus for forming and wrapping objects of a soft mass
US4563345A (en) * 1984-01-23 1986-01-07 Arrick Robert A Chewing gum
US4601907A (en) * 1985-05-03 1986-07-22 Warner-Lambert Company Chewy confection
US4614654A (en) * 1984-08-24 1986-09-30 Wm. Wrigley Jr. Company Taffy-like chewing gum confection and method
US4614658A (en) * 1985-02-22 1986-09-30 Peerless Confection Company Filled sugar candies and a method of remelting and remolding such candies to produce home made molded hard sugar candies
US4642235A (en) * 1984-10-26 1987-02-10 Wm. Wrigley Jr. Company Chewing gum with center fill comprising thaumatin or monellin and method
US4647450A (en) * 1983-07-20 1987-03-03 Warner-Lambert Company Chewing gum compositions containing magnesium trisilicate absorbates
US4656039A (en) * 1985-07-11 1987-04-07 Nabisco Brands, Inc. Layered chewing gum with moisture impervious outer layer
US4683138A (en) * 1986-09-08 1987-07-28 Warner-Lambert Company Low moisture, sugarless, center-filled chewing gum
US4707363A (en) * 1983-11-25 1987-11-17 Lotte Co., Ltd. Soft starchy chewing gum
US4738854A (en) * 1984-12-04 1988-04-19 Nabisco Brands, Inc. Comestible containing moisture and shelf storage stabilized L-aspartic acid derivative
US4741905A (en) * 1986-06-19 1988-05-03 Warner-Lambert Company Chewing gum candy
US4753806A (en) * 1985-03-29 1988-06-28 Nabisco Brands, Inc. Flexible sugarless chewing gum
US4762719A (en) * 1986-08-07 1988-08-09 Mark Forester Powder filled cough product
US4872884A (en) * 1986-12-10 1989-10-10 Warner-Lambert Company Reduced calorie chewing gum base and compositions containing the same
US4938128A (en) * 1988-10-28 1990-07-03 Warner-Lambert Company Apparatus for forming a confectionary rope having a viscous center
US4949630A (en) * 1988-10-04 1990-08-21 Warner-Lambert Company Apparatus for forming a fold-over soft center-filled confection
US4971806A (en) * 1984-01-31 1990-11-20 Warner-Lambert Company Multi-layered chewing gum composition having different rates of flavor release
US4975288A (en) * 1987-12-08 1990-12-04 Warner-Lambert Company Method for making center-filled chewing gum
US4997659A (en) * 1989-03-28 1991-03-05 The Wm. Wrigley Jr. Company Alitame stability in chewing gum by encapsulation
US5045326A (en) * 1989-11-22 1991-09-03 Warner-Lambert Company Non-staling aerated bubble gum
US5116626A (en) * 1991-07-25 1992-05-26 Wm. Wrigley Jr. Company Transparent base and gum composition
US5125819A (en) * 1987-11-24 1992-06-30 Warner-Lambert Company Apparatus for making center-filled chewing gum
US5139797A (en) * 1990-04-27 1992-08-18 Leaf, Inc. Stabilized sweetener compositions, chewing gum compositions containing same and methods for their preparation
US5156866A (en) * 1990-06-01 1992-10-20 Lotte Company Limited Flavor and taste composition for a chewing gum
US5227154A (en) * 1991-08-22 1993-07-13 The University Of Melbourne Phosphopeptides for the treatment of dental calculus
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
US5279842A (en) * 1989-03-20 1994-01-18 Ramon Escola Gallart Confection filled gasified caramel and process for obtaining the same
US5344659A (en) * 1991-08-02 1994-09-06 Yoshie Kurihara Chewing gum
US5399365A (en) * 1991-06-19 1995-03-21 Wm. Wrigley Jr. Company Chewing gum containing palatinose and/or palatinose oligosaccharide
US5425961A (en) * 1991-09-30 1995-06-20 Wm. Wrigley Jr. Company Chewing gum products using fructooligosaccharides
US5431929A (en) * 1994-07-28 1995-07-11 Wm. Wrigley Jr. Company Chewing gum products using oligofructose
US5458892A (en) * 1991-09-27 1995-10-17 Wm. Wrigley Jr. Company Chewing gum and other comestibles containing indigestible dextrin
US5498429A (en) * 1994-10-12 1996-03-12 Warner-Lambert Company Fruit juice center-filled chewing gum
US5502045A (en) * 1991-05-03 1996-03-26 Raision Tehtaat Oy Ab Use of a stanol fatty acid ester for reducing serum cholesterol level
US5525360A (en) * 1992-12-18 1996-06-11 Wm. Wrigley Jr. Company Chewing gum products using polydextrose
US5612070A (en) * 1992-12-23 1997-03-18 Wm. Wrigley Jr. Co. Chewing gums containing natural carbohydrate gum hydrolyzate
US5626896A (en) * 1994-12-09 1997-05-06 A.E. Staley Manufacturing Co. Method for making liquid-centered jelly candies
US5626892A (en) * 1993-11-24 1997-05-06 Nabisco, Inc. Method for production of multi-flavored and multi-colored chewing gum
US5637334A (en) * 1993-09-30 1997-06-10 Wm. Wrigley Jr. Company Chewing gum containing maltitol
US5670163A (en) * 1994-06-20 1997-09-23 Kv Pharmaceuticals Company Long acting GI and esophageal protectant
US5672367A (en) * 1994-10-14 1997-09-30 Rijksuniversiteit Te Groningen Biodegradable chewing gum
US5833954A (en) * 1996-08-20 1998-11-10 American Dental Association Health Foundation Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
US5879728A (en) * 1996-01-29 1999-03-09 Warner-Lambert Company Chewable confectionary composition and method of preparing same
US5952019A (en) * 1996-03-14 1999-09-14 Wm. Wrigley Jr. Company Chewing gum containing gum talha
US6054144A (en) * 1998-02-19 2000-04-25 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
US6087353A (en) * 1998-05-15 2000-07-11 Forbes Medi-Tech Inc. Phytosterol compositions and use thereof in foods, beverages, pharmaceuticals, nutraceuticals and the like
US6242019B1 (en) * 1997-08-14 2001-06-05 Warner-Lambert Company Taste modified hard confectionery compositions containing functional ingredients
US6264999B1 (en) * 1993-09-30 2001-07-24 Wm. Wrigley Jr. Company Chewing gum containing erythritol and method of making
US6280780B1 (en) * 2000-08-24 2001-08-28 Warner-Lambert Company Method and apparatus for continuously forming coated center-filled gum products
US6280762B1 (en) * 1997-04-21 2001-08-28 The Procter & Gamble Company Center filled confectionery
US6284291B1 (en) * 1999-08-09 2001-09-04 Warner-Lambert Company Method and apparatus for continuously forming center-filled gum
US6306429B1 (en) * 1997-04-21 2001-10-23 The Procter & Gamble Company Confectionery compositions
US20020004083A1 (en) * 1999-12-30 2002-01-10 Wm. Wrigley Jr. Company Controlled release perillartine in chewing gum
US6375997B1 (en) * 2000-03-16 2002-04-23 Bestfoods Process for making snack foods having two or more filled axial cavities
US6780844B1 (en) * 1997-03-13 2004-08-24 The University Of Melbourne Calcium phosphopeptide complexes
US20050089481A1 (en) * 2003-10-23 2005-04-28 Gc Corporation Composition for caries prevention

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2197719A (en) 1938-12-07 1940-04-16 Wrigley W M Jun Co Chewing gum
US3052552A (en) 1959-09-16 1962-09-04 Beech Nut Life Savers Inc Printing on confection items and the resulting product
US3912817A (en) 1973-10-03 1975-10-14 Topps Chewing Gum Inc Gum product and method of making the same
CA1063357A (en) * 1974-05-21 1979-10-02 James J. Benedict Abrasive composition
US4291045A (en) 1976-05-04 1981-09-22 Life Savers, Inc. Method of reducing dental caries
US4217368A (en) 1977-07-08 1980-08-12 Life Savers, Inc. Long-lasting chewing gum and method
US4160054A (en) 1977-11-28 1979-07-03 General Mills, Inc. Plaque inhibiting composition and method
US4156716A (en) 1977-11-28 1979-05-29 General Mills, Inc. Plaque inhibiting composition and method
US4157385A (en) 1977-11-28 1979-06-05 General Mills, Inc. Plaque inhibiting composition and method
US4148872A (en) 1977-11-28 1979-04-10 General Mills, Inc. Plaque inhibiting composition and method
US4160820A (en) 1977-11-28 1979-07-10 General Mills, Inc. Plaque inhibiting composition and method
US4150112A (en) 1977-11-28 1979-04-17 General Mills, Inc. Plaque inhibiting composition and method
US4156715A (en) 1977-11-28 1979-05-29 General Mills, Inc. Plaque inhibiting composition and method
US4159315A (en) 1977-11-28 1979-06-26 General Mills, Inc. Plaque inhibiting composition and method
US4208431A (en) 1978-05-05 1980-06-17 Life Savers, Inc. Long-lasting chewing gum having good processibility and method
US4271199A (en) 1979-11-23 1981-06-02 Life Savers, Inc. Sugar-containing chewing gum having smooth texture and long-lasting sweetness
US4352822A (en) 1980-12-15 1982-10-05 Nabisco Brands Inc. Gum base, chewing gum containing same and method
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4585649A (en) 1984-12-21 1986-04-29 Ici Americas Inc. Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation
US4711784A (en) * 1986-01-07 1987-12-08 Warner-Lambert Company Encapsulation composition for use with chewing gum and edible products
EP0273962A4 (en) 1986-07-11 1988-07-27 Oral Res Lab Inc COMPOSITIONS FOR THE PROLONGED ACTION OF ANTIPLATE AGENTS.
US4828845A (en) 1986-12-16 1989-05-09 Warner-Lambert Company Xylitol coated comestible and method of preparation
US4753790A (en) 1986-12-16 1988-06-28 Warner-Lambert Company Sorbitol coated comestible and method of preparation
US4981698A (en) * 1986-12-23 1991-01-01 Warner-Lambert Co. Multiple encapsulated sweetener delivery system and method of preparation
US4952407A (en) 1988-09-12 1990-08-28 Wm. Wrigley Jr. Company Chewing gum containing glycerol mono laurate
US5057328A (en) 1988-11-14 1991-10-15 Warner-Lambert Company Food acid delivery systems containing polyvinyl acetate
EP0370296B1 (en) 1988-11-25 1994-01-19 The Procter & Gamble Company Chewing gum
GB9001621D0 (en) 1990-01-24 1990-03-21 Procter & Gamble Confectionery product
ATE157392T1 (de) 1990-09-28 1997-09-15 Procter & Gamble Polyhydroxyfettsäureamide und ein oder mehrere zusätzliche nichtionische tenside enthaltende nichtionische tensidsysteme
US5256402A (en) 1991-09-13 1993-10-26 Colgate-Palmolive Company Abrasive tooth whitening dentifrice of improved stability
US5380530A (en) 1992-12-29 1995-01-10 Whitehill Oral Technologies Oral care composition coated gum
USH1513H (en) 1994-06-01 1996-01-02 The Procter & Gamble Company Oleoyl sarcosinate with polyhydroxy fatty acid amides in cleaning products
GB9425934D0 (en) 1994-12-22 1995-02-22 Procter & Gamble Oral compositions
FR2729967A1 (fr) 1995-01-30 1996-08-02 Oreal Compositions a base d'un systeme abrasif et d'un systeme tensio-actif
AU2814995A (en) 1995-05-26 1996-12-11 Angelo A. Caputo Chewing gum with fluoride and citric acid
GB9513694D0 (en) 1995-07-05 1995-09-06 Procter & Gamble Oral compositions
US5645821A (en) 1995-10-06 1997-07-08 Libin; Barry M. Alkaline oral hygiene composition
US5713738A (en) 1995-12-12 1998-02-03 Britesmile, Inc. Method for whitening teeth
US5629035A (en) 1995-12-18 1997-05-13 Church & Dwight Co., Inc. Chewing gum product with encapsulated bicarbonate and flavorant ingredients
US5736175A (en) 1996-02-28 1998-04-07 Nabisco Technology Co. Chewing gums containing plaque disrupting ingredients and method for preparing it
WO1998018339A1 (fr) 1996-10-31 1998-05-07 Hideki Aoki Composition de chewing-gum et procede de production
EP0969733B1 (en) 1996-11-27 2006-06-21 Wm. Wrigley Jr. Company Method of controlling release of caffeine in chewing gum and gum produced thereby
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
FI970012A (fi) 1997-01-03 1998-07-04 Rinne Ari E Kysteiiniproteinaasien ja niiden inhibiittoreiden käyttö suuhygieniatuotteissa
US5824291A (en) 1997-06-30 1998-10-20 Media Group Chewing gum containing a teeth whitening agent
CA2310492A1 (en) 1997-12-03 1999-06-10 Wm. Wrigley Jr. Company Improved chewing gum formulations including aspartame and sodium bicarbonate
RU2202220C2 (ru) 1997-12-30 2003-04-20 Вм. Ригли Дж. Компани Способ получения готовой жевательной резинки, содержащей антибактериальный агент с контролируемым высвобождением (варианты), и готовая жевательная резинка
AUPP494798A0 (en) * 1998-07-29 1998-08-20 Pacific Biolink Pty Limited Protective protein formulation
WO2000057842A2 (en) 1999-03-25 2000-10-05 Warner-Lambert Company Oral care chewing gums and confections
US6846500B1 (en) * 1999-03-25 2005-01-25 Cadbury Adams Usa Llc Oral care chewing gums and method of use
AU3903500A (en) 1999-04-15 2000-11-02 Wm. Wrigley Jr. Company Chewing gum with dental benefits including calcium in a food grade acid
JP5001484B2 (ja) * 2000-07-05 2012-08-15 株式会社ロッテ チューインガム形態の白板症および粘膜下線維症用治療剤
AU2002236210A1 (en) 2001-02-28 2002-09-12 Ezaki Glico Co., Ltd. Compositions having anti-dental caries function
AUPR517701A0 (en) 2001-05-21 2001-06-14 University Of Melbourne, The Dental restorative materials
US6837696B2 (en) 2001-09-28 2005-01-04 Mcneil-Ppc, Inc. Apparatus for manufacturing dosage forms
US7244455B2 (en) * 2002-01-16 2007-07-17 Warner-Lambert Company Center-filled chewing gum containing a deliverable form of calcium
RU2239413C1 (ru) 2003-06-24 2004-11-10 Закрытое акционерное общество "Невская косметика" Средство для ухода за зубами
AU2003903325A0 (en) * 2003-07-01 2003-07-10 Yndk Pty Ltd Chewable dental product
DE10349050A1 (de) 2003-10-17 2005-05-12 Nova Dentalia Zahnpflege Gmbh Kaumasse zur Remineralisation von Zahnschmelz
JP2005145952A (ja) * 2003-10-23 2005-06-09 Gc Corp う蝕予防用組成物
US9271904B2 (en) * 2003-11-21 2016-03-01 Intercontinental Great Brands Llc Controlled release oral delivery systems
JP2007515382A (ja) 2003-12-08 2007-06-14 キャドベリー シュウェップス パブリック リミテッド カンパニー 固形、経口用の歯を白くする組成物
MX2007006254A (es) 2004-11-25 2007-09-07 Univ Melbourne Complejos de fosfato de calcio estabilizados.
CN101208070B (zh) * 2005-06-24 2011-08-31 墨尔本大学 离子络合物

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US325711A (en) * 1885-09-08 Confection capsule
US810210A (en) * 1905-05-10 1906-01-16 Benjamin A Laws Article of chewing-gum.
US943945A (en) * 1907-09-03 1909-12-21 Julius Liebich Liquor-containing confection.
US1771506A (en) * 1926-11-10 1930-07-29 Gilbert B Mustin Method of making chewing-gum sandwiches
US1771982A (en) * 1928-09-10 1930-07-29 Gilbert B Mustin Chewing gum and method of making same
US2004957A (en) * 1934-04-25 1935-06-18 Elmer L Schumacher Capsule
US2448786A (en) * 1946-06-08 1948-09-07 Charles E Faxon Confectionery forming mechanism
US2973273A (en) * 1959-02-11 1961-02-28 Salvatore G Militana Sponge chewing gum and method of making the same
US3071476A (en) * 1960-05-12 1963-01-01 August R Werft Chewing device
US3795748A (en) * 1971-09-08 1974-03-05 Karlschloss Anstalt Method of manufacturing liquid-filled chocolate candies
US3806290A (en) * 1972-07-12 1974-04-23 Warner Lambert Co Apparatus for center-filled chewing gum
US3857963A (en) * 1972-07-12 1974-12-31 Warner Lambert Co Method for forming center-filled chewing gum
US3894154A (en) * 1974-01-14 1975-07-08 Warner Lambert Co Center-filled gum
US4150161A (en) * 1977-03-15 1979-04-17 General Foods Corporation Carbonated chewing gum
US4157402A (en) * 1977-11-22 1979-06-05 Lotte Co., Ltd. Center-filled chewing gum
US4156740A (en) * 1978-02-02 1979-05-29 Warner-Lambert Company Sugarless center-filled chewing gum
US4292329A (en) * 1978-02-06 1981-09-29 Lotte Co., Ltd. Center-filled chewing gum
US4252829A (en) * 1978-03-13 1981-02-24 Perfetti S.P.A. Chewing gum with flavoured liquid filling
US4251201A (en) * 1978-09-18 1981-02-17 Krysiak Janusz D Extrusion apparatus
US4224345A (en) * 1978-10-16 1980-09-23 Lotte Co., Ltd Chewing gum base and a combination of a chewing gum with fatty matter
US4382962A (en) * 1979-06-15 1983-05-10 Societe Roquette Freres Sugarless-type chewing gum
US4271197A (en) * 1979-06-21 1981-06-02 Walter Hopkins Chewing gum containing sugar substitute
US4269860A (en) * 1979-09-21 1981-05-26 Lotte Co. Ltd. Process for preparing a gas-developing chewing gum
US4317838A (en) * 1979-09-24 1982-03-02 Life Savers, Inc. Method for applying sugarless coating to chewing gum and confections
US4316915A (en) * 1979-10-01 1982-02-23 Life Savers, Inc. Center-filled chewing gums
US4374858A (en) * 1979-10-04 1983-02-22 Warner-Lambert Company Aspartame sweetened chewing gum of improved sweetness stability
US4250196A (en) * 1979-10-09 1981-02-10 Life Savers, Inc. Center-filled chewing gums
US4271198A (en) * 1979-12-10 1981-06-02 Life Savers, Inc. Chewing gum having a soft texture
US4329369A (en) * 1980-03-03 1982-05-11 Lotte Co., Ltd. Process for preparation of chewing gum
US4352824A (en) * 1980-03-27 1982-10-05 Nabisco Brands, Inc. Chewing gum containing fatty or gelatinous sweetener and method
US4301178A (en) * 1980-05-02 1981-11-17 Life Savers, Inc. Liquid-filled chewing gum and method
US4399154A (en) * 1980-06-30 1983-08-16 Nabisco Brands Inc. Coextruded chewing gum
US4543769A (en) * 1980-07-05 1985-10-01 Rose Verpackungsmaschinenfabrik Theegarten Method and apparatus for forming and wrapping objects of a soft mass
US4328249A (en) * 1981-01-30 1982-05-04 Life Savers, Inc. Method for treating gum base to improve shelf-life without need for antioxidants
US4352825A (en) * 1981-02-23 1982-10-05 Nabisco Brands, Inc. Coextruded chewing gum containing a soft core portion
US4352823A (en) * 1981-04-13 1982-10-05 Nabisco Brands, Inc. Coextruded chewing gum containing a soft non-SBR gum core portion
US4430351A (en) * 1981-04-24 1984-02-07 Ferrero S.P.A. Confectionary product with a filling
US4421773A (en) * 1981-05-05 1983-12-20 Akutagawa Chocolate Co., Ltd. Process for molding chocolate to make chocolate block having ornamental pattern and internal hollow cavity
US4466983A (en) * 1983-02-04 1984-08-21 Warner-Lambert Company Substantially non-aqueous semi-liquid center-fill
US4485118A (en) * 1983-04-21 1984-11-27 Warner-Lambert Company Gum composition with plural time releasing flavors and method of preparation
US4513012A (en) * 1983-05-13 1985-04-23 Warner-Lambert Company Powdered center-filled chewing gum compositions
US4647450A (en) * 1983-07-20 1987-03-03 Warner-Lambert Company Chewing gum compositions containing magnesium trisilicate absorbates
US4707363A (en) * 1983-11-25 1987-11-17 Lotte Co., Ltd. Soft starchy chewing gum
US4563345A (en) * 1984-01-23 1986-01-07 Arrick Robert A Chewing gum
US4971806A (en) * 1984-01-31 1990-11-20 Warner-Lambert Company Multi-layered chewing gum composition having different rates of flavor release
US4614654A (en) * 1984-08-24 1986-09-30 Wm. Wrigley Jr. Company Taffy-like chewing gum confection and method
US4642235A (en) * 1984-10-26 1987-02-10 Wm. Wrigley Jr. Company Chewing gum with center fill comprising thaumatin or monellin and method
US4738854A (en) * 1984-12-04 1988-04-19 Nabisco Brands, Inc. Comestible containing moisture and shelf storage stabilized L-aspartic acid derivative
US4614658A (en) * 1985-02-22 1986-09-30 Peerless Confection Company Filled sugar candies and a method of remelting and remolding such candies to produce home made molded hard sugar candies
US4753806A (en) * 1985-03-29 1988-06-28 Nabisco Brands, Inc. Flexible sugarless chewing gum
US4601907A (en) * 1985-05-03 1986-07-22 Warner-Lambert Company Chewy confection
US4656039A (en) * 1985-07-11 1987-04-07 Nabisco Brands, Inc. Layered chewing gum with moisture impervious outer layer
US4741905A (en) * 1986-06-19 1988-05-03 Warner-Lambert Company Chewing gum candy
US4762719A (en) * 1986-08-07 1988-08-09 Mark Forester Powder filled cough product
US4683138A (en) * 1986-09-08 1987-07-28 Warner-Lambert Company Low moisture, sugarless, center-filled chewing gum
US4872884A (en) * 1986-12-10 1989-10-10 Warner-Lambert Company Reduced calorie chewing gum base and compositions containing the same
US4980178A (en) * 1986-12-10 1990-12-25 Warner-Lambert Company Reduced calorie center-filled chewing gum compositions having improved stability
US5125819A (en) * 1987-11-24 1992-06-30 Warner-Lambert Company Apparatus for making center-filled chewing gum
US4975288A (en) * 1987-12-08 1990-12-04 Warner-Lambert Company Method for making center-filled chewing gum
US4949630A (en) * 1988-10-04 1990-08-21 Warner-Lambert Company Apparatus for forming a fold-over soft center-filled confection
US4938128A (en) * 1988-10-28 1990-07-03 Warner-Lambert Company Apparatus for forming a confectionary rope having a viscous center
US5279842A (en) * 1989-03-20 1994-01-18 Ramon Escola Gallart Confection filled gasified caramel and process for obtaining the same
US4997659A (en) * 1989-03-28 1991-03-05 The Wm. Wrigley Jr. Company Alitame stability in chewing gum by encapsulation
US5045326A (en) * 1989-11-22 1991-09-03 Warner-Lambert Company Non-staling aerated bubble gum
US5139797A (en) * 1990-04-27 1992-08-18 Leaf, Inc. Stabilized sweetener compositions, chewing gum compositions containing same and methods for their preparation
US5156866A (en) * 1990-06-01 1992-10-20 Lotte Company Limited Flavor and taste composition for a chewing gum
US5502045A (en) * 1991-05-03 1996-03-26 Raision Tehtaat Oy Ab Use of a stanol fatty acid ester for reducing serum cholesterol level
US5399365A (en) * 1991-06-19 1995-03-21 Wm. Wrigley Jr. Company Chewing gum containing palatinose and/or palatinose oligosaccharide
US5116626A (en) * 1991-07-25 1992-05-26 Wm. Wrigley Jr. Company Transparent base and gum composition
US5344659A (en) * 1991-08-02 1994-09-06 Yoshie Kurihara Chewing gum
US5227154A (en) * 1991-08-22 1993-07-13 The University Of Melbourne Phosphopeptides for the treatment of dental calculus
US5458892A (en) * 1991-09-27 1995-10-17 Wm. Wrigley Jr. Company Chewing gum and other comestibles containing indigestible dextrin
US5425961A (en) * 1991-09-30 1995-06-20 Wm. Wrigley Jr. Company Chewing gum products using fructooligosaccharides
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
US5525360A (en) * 1992-12-18 1996-06-11 Wm. Wrigley Jr. Company Chewing gum products using polydextrose
US5612070A (en) * 1992-12-23 1997-03-18 Wm. Wrigley Jr. Co. Chewing gums containing natural carbohydrate gum hydrolyzate
US6264999B1 (en) * 1993-09-30 2001-07-24 Wm. Wrigley Jr. Company Chewing gum containing erythritol and method of making
US5637334A (en) * 1993-09-30 1997-06-10 Wm. Wrigley Jr. Company Chewing gum containing maltitol
US5955116A (en) * 1993-11-24 1999-09-21 Nabisco Technology Company Method and apparatus for production of multi-flavored and multi-colored chewing gum
US5626892A (en) * 1993-11-24 1997-05-06 Nabisco, Inc. Method for production of multi-flavored and multi-colored chewing gum
US5670163A (en) * 1994-06-20 1997-09-23 Kv Pharmaceuticals Company Long acting GI and esophageal protectant
US5431929A (en) * 1994-07-28 1995-07-11 Wm. Wrigley Jr. Company Chewing gum products using oligofructose
US5498429A (en) * 1994-10-12 1996-03-12 Warner-Lambert Company Fruit juice center-filled chewing gum
US5672367A (en) * 1994-10-14 1997-09-30 Rijksuniversiteit Te Groningen Biodegradable chewing gum
US5626896A (en) * 1994-12-09 1997-05-06 A.E. Staley Manufacturing Co. Method for making liquid-centered jelly candies
US5879728A (en) * 1996-01-29 1999-03-09 Warner-Lambert Company Chewable confectionary composition and method of preparing same
US5952019A (en) * 1996-03-14 1999-09-14 Wm. Wrigley Jr. Company Chewing gum containing gum talha
US5833954A (en) * 1996-08-20 1998-11-10 American Dental Association Health Foundation Anti-carious chewing gums, candies, gels, toothpastes and dentifrices
US6780844B1 (en) * 1997-03-13 2004-08-24 The University Of Melbourne Calcium phosphopeptide complexes
US6280762B1 (en) * 1997-04-21 2001-08-28 The Procter & Gamble Company Center filled confectionery
US6306429B1 (en) * 1997-04-21 2001-10-23 The Procter & Gamble Company Confectionery compositions
US6242019B1 (en) * 1997-08-14 2001-06-05 Warner-Lambert Company Taste modified hard confectionery compositions containing functional ingredients
US6054144A (en) * 1998-02-19 2000-04-25 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
US6087353A (en) * 1998-05-15 2000-07-11 Forbes Medi-Tech Inc. Phytosterol compositions and use thereof in foods, beverages, pharmaceuticals, nutraceuticals and the like
US6284291B1 (en) * 1999-08-09 2001-09-04 Warner-Lambert Company Method and apparatus for continuously forming center-filled gum
US20020004083A1 (en) * 1999-12-30 2002-01-10 Wm. Wrigley Jr. Company Controlled release perillartine in chewing gum
US6375997B1 (en) * 2000-03-16 2002-04-23 Bestfoods Process for making snack foods having two or more filled axial cavities
US6280780B1 (en) * 2000-08-24 2001-08-28 Warner-Lambert Company Method and apparatus for continuously forming coated center-filled gum products
US20050089481A1 (en) * 2003-10-23 2005-04-28 Gc Corporation Composition for caries prevention

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2301513A3 (en) * 2009-09-29 2011-04-06 GC Corporation Tooth coating composition
US10111831B2 (en) 2011-02-28 2018-10-30 Technologies Khloros Inc. Chewable vehicle for mouth absorption

Also Published As

Publication number Publication date
RU2008133369A (ru) 2010-05-10
US20100297203A1 (en) 2010-11-25
EP2046278A2 (en) 2009-04-15
JP2011116778A (ja) 2011-06-16
CA2646283C (en) 2014-10-07
AU2007235269B2 (en) 2011-02-10
AU2011202154A1 (en) 2011-06-02
WO2007117628A2 (en) 2007-10-18
AU2007235269A1 (en) 2007-10-18
CA2646283A1 (en) 2007-10-18
EP2004153A2 (en) 2008-12-24
AU2011200798B2 (en) 2012-05-03
RU2437646C2 (ru) 2011-12-27
CN101415398A (zh) 2009-04-22
EP2046278A4 (en) 2013-11-27
EP2004153A4 (en) 2013-11-27
RU2437652C2 (ru) 2011-12-27
AU2011200798A1 (en) 2011-03-24
AU2007235360A1 (en) 2007-10-18
WO2007117629A2 (en) 2007-10-18
RU2008133368A (ru) 2010-05-10
US8252269B2 (en) 2012-08-28
MX2008012521A (es) 2008-10-10
BRPI0709875A2 (pt) 2011-07-26
US20070237729A1 (en) 2007-10-11
WO2007117628A3 (en) 2008-11-27
AU2007235360B2 (en) 2010-11-25
JP2011116779A (ja) 2011-06-16
WO2007117629A3 (en) 2008-01-10
CN101415397A (zh) 2009-04-22
BRPI0710245A2 (pt) 2011-08-09
JP2009532066A (ja) 2009-09-10
CA2648473C (en) 2013-09-10
CN101426467A (zh) 2009-05-06
CN101415398B (zh) 2013-01-09
CA2648473A1 (en) 2007-10-18
JP5336354B2 (ja) 2013-11-06
US20070237856A1 (en) 2007-10-11
JP2009532067A (ja) 2009-09-10
MX2008012520A (es) 2008-10-10

Similar Documents

Publication Publication Date Title
US8252269B2 (en) Impact of calcium phosphate complex on dental caries
US8133475B2 (en) Calcium phosphate complex in acid containing chewing gum
EP2001436B1 (en) Calcium phosphate complex and salts in oral delivery systems

Legal Events

Date Code Title Description
AS Assignment

Owner name: CADBURY ADAMS USA, LLC, NEW JERSEY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TANCREDI, DORIS;MING, DING;VINCENT, JACK W.;REEL/FRAME:019200/0109

Effective date: 20070403

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION