US20070110719A1 - Novel use of adenoviruses and nucleic acids that code for said viruses - Google Patents
Novel use of adenoviruses and nucleic acids that code for said viruses Download PDFInfo
- Publication number
- US20070110719A1 US20070110719A1 US10/579,507 US57950704A US2007110719A1 US 20070110719 A1 US20070110719 A1 US 20070110719A1 US 57950704 A US57950704 A US 57950704A US 2007110719 A1 US2007110719 A1 US 2007110719A1
- Authority
- US
- United States
- Prior art keywords
- virus
- cells
- use according
- nucleus
- adenovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10353262.5 | 2003-11-14 | ||
DE10353262 | 2003-11-14 | ||
DE102004018099.7 | 2004-04-14 | ||
DE102004018099 | 2004-04-14 | ||
PCT/EP2004/012930 WO2005051430A1 (de) | 2003-11-14 | 2004-11-15 | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/012930 A-371-Of-International WO2005051430A1 (de) | 2003-11-14 | 2004-11-15 | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/699,347 Continuation US20100311145A1 (en) | 2003-11-14 | 2010-02-03 | Novel use of adenoviruses and nucleic acids that code for said viruses |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070110719A1 true US20070110719A1 (en) | 2007-05-17 |
Family
ID=34635105
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/579,507 Abandoned US20070110719A1 (en) | 2003-11-14 | 2004-11-15 | Novel use of adenoviruses and nucleic acids that code for said viruses |
US12/699,347 Abandoned US20100311145A1 (en) | 2003-11-14 | 2010-02-03 | Novel use of adenoviruses and nucleic acids that code for said viruses |
US13/186,248 Abandoned US20110275093A1 (en) | 2003-11-14 | 2011-07-19 | Novel use of adenoviruses and nucleic acids that code for said viruses |
US14/850,373 Active US10300096B2 (en) | 2003-11-14 | 2015-09-10 | Use of adenoviruses and nucleic acids that code for said viruses |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/699,347 Abandoned US20100311145A1 (en) | 2003-11-14 | 2010-02-03 | Novel use of adenoviruses and nucleic acids that code for said viruses |
US13/186,248 Abandoned US20110275093A1 (en) | 2003-11-14 | 2011-07-19 | Novel use of adenoviruses and nucleic acids that code for said viruses |
US14/850,373 Active US10300096B2 (en) | 2003-11-14 | 2015-09-10 | Use of adenoviruses and nucleic acids that code for said viruses |
Country Status (5)
Country | Link |
---|---|
US (4) | US20070110719A1 (de) |
EP (1) | EP1689445B1 (de) |
JP (3) | JP2007511211A (de) |
CA (1) | CA2546178A1 (de) |
WO (1) | WO2005051430A1 (de) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070129290A1 (en) * | 2005-11-18 | 2007-06-07 | Or Yat S | Metabolite derivatives of the HDAC inhibitor FK228 |
US20080124403A1 (en) * | 2006-06-08 | 2008-05-29 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
US20080194690A1 (en) * | 2005-05-13 | 2008-08-14 | Topotarget Uk Limited | Pharmaceutical Formulations Of Hdac Inhibitors |
US20080274120A1 (en) * | 2005-11-10 | 2008-11-06 | Topotarget Uk Limited | Histone Deacetylase (Hdac) Inhibitors (Pxd101) for the Treatment of Cancer Alone or in Combination With Chemotherapeutic Agent |
US20090186382A1 (en) * | 2006-12-29 | 2009-07-23 | Verdine Gregory L | Preparation of Romidepsin |
US20090232800A1 (en) * | 2004-12-31 | 2009-09-17 | Per Sonne Holm | E1-minus adenoviruses and use thereof |
US20090305956A1 (en) * | 2006-04-24 | 2009-12-10 | Gloucester Pharmaceuticals, Inc. | Treatment of Ras-Expressing Tumors |
US20100093610A1 (en) * | 2006-12-29 | 2010-04-15 | Vrolijk Nicholas H | Romidepsin-based treatments for cancer |
US20100190694A1 (en) * | 2009-01-14 | 2010-07-29 | Jan Fagerberg | Methods for identifying patients who will respond well to cancer treatment |
US20100286279A1 (en) * | 2007-09-25 | 2010-11-11 | Topotarget Uk Limited | Methods of Synthesis of Certain Hydroxamic Acid Compounds |
US20100310554A1 (en) * | 2004-12-31 | 2010-12-09 | Per Sonne Holm | Methods for Reversing Multiple Resistance in Animal Cells |
US20110003777A1 (en) * | 2008-03-07 | 2011-01-06 | Topotarget A/S | Methods of Treatment Employing Prolonged Continuous Infusion of Belinostat |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
US8980825B2 (en) | 2010-07-12 | 2015-03-17 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US20150087021A1 (en) * | 2012-05-07 | 2015-03-26 | Stefan Kochanek | Nucleic acid construct and use of the same |
US9101579B2 (en) | 2012-11-14 | 2015-08-11 | Celgene Corporation | Inhibition of drug resistant cancer cells |
US9134325B2 (en) | 2012-09-07 | 2015-09-15 | Celgene Corporation | Resistance biomarkers for HDAC inhibitors |
US9463215B2 (en) | 2013-12-27 | 2016-10-11 | Celgene Corporation | Romidepsin formulations and uses thereof |
US10155930B2 (en) | 2002-05-27 | 2018-12-18 | Per Sonne Holm | Use of adenovirus and nucleic acids coding therefor |
US10285959B2 (en) | 2005-02-03 | 2019-05-14 | Topotarget Uk Limited | Combination therapies using HDAC inhibitors |
US10300096B2 (en) | 2003-11-14 | 2019-05-28 | Per Sonne Holm | Use of adenoviruses and nucleic acids that code for said viruses |
US11077156B2 (en) | 2013-03-14 | 2021-08-03 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
US11130968B2 (en) | 2016-02-23 | 2021-09-28 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
US11401529B2 (en) | 2016-02-23 | 2022-08-02 | Salk Institute For Biological Studies | Exogenous gene expression in recombinant adenovirus for minimal impact on viral kinetics |
US11813337B2 (en) | 2016-12-12 | 2023-11-14 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210260216A1 (en) * | 2018-06-25 | 2021-08-26 | Ospedale San Raffaele S.R.L. | Gene therapy |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649158B1 (en) * | 1998-10-15 | 2003-11-18 | Canji, Inc. | Methods and compositions to induce antitumor response |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4947842A (en) | 1988-09-22 | 1990-08-14 | Medical Engineering And Development Institute, Inc. | Method and apparatus for treating tissue with first and second modalities |
ES2259800T3 (es) | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
DE69417734T2 (de) | 1993-02-16 | 1999-10-07 | Onyx Pharma Inc | Cytopathische viren zur therapie und prophylaxe der neoplasie |
US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
ATE336587T1 (de) | 1994-06-10 | 2006-09-15 | Genvec Inc | Adenoviren-vektor systeme und zelllinien |
US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
US6326356B1 (en) | 1996-10-18 | 2001-12-04 | Board Of Regents, The University Of Texas System | Suppression of neu overexpression using a mini-E1A gene |
CA2226833C (en) | 1995-03-24 | 2009-12-15 | Genzyme Corporation | Adenovirus vectors for gene therapy |
US5707618A (en) | 1995-03-24 | 1998-01-13 | Genzyme Corporation | Adenovirus vectors for gene therapy |
US6676935B2 (en) | 1995-06-27 | 2004-01-13 | Cell Genesys, Inc. | Tissue specific adenoviral vectors |
AU7674896A (en) | 1995-10-31 | 1997-05-22 | Board Of Regents, The University Of Texas System | Adenovirus-antisense k-ras expression vectors and their application in cancer therapy |
US6022863A (en) | 1996-05-21 | 2000-02-08 | Yale University | Regulation of gene expression |
US6730662B1 (en) | 1996-07-05 | 2004-05-04 | Mcgill University | Adenovirus E4 proteins for inducing cell death |
JP2000515504A (ja) | 1996-07-05 | 2000-11-21 | フィリップ イー. ブラントン | 細胞死を誘導するアデノウイルスe4蛋白質 |
AU743469C (en) | 1996-08-30 | 2004-02-12 | Rolf Bald | Mirror-symmetrical selection and evolution of nucleic acids |
US5994132A (en) | 1996-10-23 | 1999-11-30 | University Of Michigan | Adenovirus vectors |
AU5253998A (en) | 1996-11-13 | 1998-06-03 | Board Of Regents, The University Of Texas System | Diminishing viral gene expression by promoter replacement |
US6080578A (en) | 1996-12-31 | 2000-06-27 | Onyx Pharmaceuticals, Inc. | Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia |
US6100086A (en) | 1997-04-14 | 2000-08-08 | Genzyme Corporation | Transgene expression systems |
DE69838584T2 (de) | 1997-08-04 | 2008-06-26 | Cell Genesys, Inc., Foster City | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
IL135507A0 (en) | 1997-10-09 | 2001-05-20 | Pro Virus Inc | Treatment of neoplasms with viruses |
AU1092500A (en) * | 1998-10-15 | 2000-05-01 | Canji, Inc. | Recombinant e1a deleted adenoviral vectors |
DE19860602A1 (de) | 1998-12-29 | 2000-07-06 | Max Delbrueck Centrum | Gentransfervektor für die Diagnostik und die Therapie von malignen Tumoren |
US6428968B1 (en) | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
GB9906815D0 (en) | 1999-03-24 | 1999-05-19 | Isrec | Anti-neoplastic viral agents |
DE19929569A1 (de) | 1999-06-21 | 2000-12-28 | Holm Per Sonne | Mittel zur Behandlung maligner Erkrankungen unter Verwendung des Proteins YB-1 |
DE10031122A1 (de) | 1999-06-30 | 2001-03-22 | Max Delbrueck Centrum | Mittel zur Diagnose und Therapie maligner Erkrankungen |
US6955808B2 (en) | 1999-09-24 | 2005-10-18 | Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
US6635476B1 (en) * | 1999-10-15 | 2003-10-21 | Canji, Inc. | Targeted vectors |
US6140126A (en) | 1999-10-26 | 2000-10-31 | Isis Pharmaceuticals Inc. | Antisense modulation of Y-box binding protein 1 expression |
ES2288488T3 (es) | 1999-11-15 | 2008-01-16 | Onyx Pharmaceuticals, Inc. | Adenovirus oncoliticos. |
DE10015413A1 (de) | 2000-03-23 | 2001-09-27 | Max Delbrueck Centrum | Mittel zur Diagnose und Therapie viraler Erkrankungen |
JP2003534806A (ja) | 2000-05-31 | 2003-11-25 | ジェンベク、インコーポレイティッド | アデノウイルスベクターのターゲティングの方法および組成物 |
AU784975B2 (en) | 2000-10-11 | 2006-08-10 | Sumitomo Chemical Company, Limited | DNA-binding protein YB-1-containing collagen accumulation inhibitors |
WO2002042468A2 (en) | 2000-11-27 | 2002-05-30 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
US20030095989A1 (en) | 2000-12-18 | 2003-05-22 | Irving John M. | Chimeric cytolytic viruses for cancer treatment |
DE10150945A1 (de) | 2001-10-16 | 2003-04-17 | Holm Per Sonne | Adenovirale Systeme und deren Anwendungen |
DE50112463D1 (de) * | 2000-12-28 | 2007-06-14 | Per Sonne Holm | Adenovirale systeme und deren anwendungen |
US20030138405A1 (en) | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
WO2003025190A1 (fr) * | 2001-09-14 | 2003-03-27 | The New Industry Research Organization | Agent promoteur de tumeur specifique et utilisation associee |
DE10150984A1 (de) | 2001-10-16 | 2003-04-17 | Holm Per Sonne | Verwendung des adenoviralen E2-late-Promotors |
CA2478508C (en) | 2002-04-25 | 2013-07-02 | Crucell Holland B.V. | Stable adenoviral vectors and methods for propagation thereof |
CN1655827B (zh) * | 2002-05-27 | 2010-06-23 | 佩尔·松内·霍尔姆 | 腺病毒和编码其的核酸的新应用 |
DK1554375T3 (en) | 2002-10-15 | 2018-12-17 | Per Sonne Holm | Adenovirus expressing genes in reverse order and use thereof |
KR101123510B1 (ko) | 2002-10-15 | 2012-04-12 | 페르 손네 홀름 | 신규한 아데노바이러스, 이를 암호화하는 핵산 및 이들의 조성물 |
WO2004083404A2 (en) | 2003-03-19 | 2004-09-30 | Isogenis, Inc. | Gene therapy vectors having reduced immunogenicity based on cd8 alpha-chain |
CA2590257A1 (en) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Novel adenoviruses, nucleic acids that code for the same and the use of said viruses |
WO2005051430A1 (de) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
WO2006065827A2 (en) | 2004-12-13 | 2006-06-22 | Canji, Inc. | Cell lines for production of replication-defective adenovirus |
WO2006070023A2 (en) | 2004-12-31 | 2006-07-06 | Per Sonne Holm | Method for reversing multiple resistance in animal cells |
CA2610360A1 (en) | 2004-12-31 | 2006-07-06 | Per Sonne Holm | E1-minus adenoviruses and use thereof |
US20070292396A1 (en) | 2006-03-02 | 2007-12-20 | Juan Fueyo | Combination therapy with oncolytic adenovirus |
-
2004
- 2004-11-15 WO PCT/EP2004/012930 patent/WO2005051430A1/de active Application Filing
- 2004-11-15 EP EP04797900.0A patent/EP1689445B1/de active Active
- 2004-11-15 JP JP2006538817A patent/JP2007511211A/ja active Pending
- 2004-11-15 US US10/579,507 patent/US20070110719A1/en not_active Abandoned
- 2004-11-15 CA CA002546178A patent/CA2546178A1/en not_active Abandoned
-
2010
- 2010-02-03 US US12/699,347 patent/US20100311145A1/en not_active Abandoned
-
2011
- 2011-04-26 JP JP2011098212A patent/JP5675481B2/ja active Active
- 2011-07-19 US US13/186,248 patent/US20110275093A1/en not_active Abandoned
-
2014
- 2014-05-16 JP JP2014102460A patent/JP5873893B2/ja active Active
-
2015
- 2015-09-10 US US14/850,373 patent/US10300096B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649158B1 (en) * | 1998-10-15 | 2003-11-18 | Canji, Inc. | Methods and compositions to induce antitumor response |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11268073B2 (en) | 2002-05-27 | 2022-03-08 | Per Sonne Holm | Use of adenovirus and nucleic acids coding therefor |
US10731136B2 (en) | 2002-05-27 | 2020-08-04 | Per Sonne Holm | Use of adenovirus and nucleic acids coding therefor |
US10538744B2 (en) | 2002-05-27 | 2020-01-21 | Per Sonne Holm | Use of adenovirus and nucleic acids coding therefor |
US10155930B2 (en) | 2002-05-27 | 2018-12-18 | Per Sonne Holm | Use of adenovirus and nucleic acids coding therefor |
US10300096B2 (en) | 2003-11-14 | 2019-05-28 | Per Sonne Holm | Use of adenoviruses and nucleic acids that code for said viruses |
US20100310554A1 (en) * | 2004-12-31 | 2010-12-09 | Per Sonne Holm | Methods for Reversing Multiple Resistance in Animal Cells |
US11369650B2 (en) | 2004-12-31 | 2022-06-28 | Per Sonne Holm | Methods for reversing multiple resistance in animal cells |
US20090232800A1 (en) * | 2004-12-31 | 2009-09-17 | Per Sonne Holm | E1-minus adenoviruses and use thereof |
US10799469B2 (en) | 2005-02-03 | 2020-10-13 | Topotarget Uk Limited | Combination therapies using HDAC inhibitors |
US10285959B2 (en) | 2005-02-03 | 2019-05-14 | Topotarget Uk Limited | Combination therapies using HDAC inhibitors |
US9856211B2 (en) | 2005-05-13 | 2018-01-02 | Topotarget Uk Limited | Pharmaceutical formulations of HDAC inhibitors |
US20080194690A1 (en) * | 2005-05-13 | 2008-08-14 | Topotarget Uk Limited | Pharmaceutical Formulations Of Hdac Inhibitors |
US8835501B2 (en) | 2005-05-13 | 2014-09-16 | Topotarget Uk Limited | Pharmaceutical formulations of HDAC inhibitors |
US9957227B2 (en) | 2005-05-13 | 2018-05-01 | Topotarget Uk Limited | Pharmaceutical formulations of HDAC inhibitors |
US20080274120A1 (en) * | 2005-11-10 | 2008-11-06 | Topotarget Uk Limited | Histone Deacetylase (Hdac) Inhibitors (Pxd101) for the Treatment of Cancer Alone or in Combination With Chemotherapeutic Agent |
US8828392B2 (en) | 2005-11-10 | 2014-09-09 | Topotarget Uk Limited | Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent |
US9603926B2 (en) | 2005-11-10 | 2017-03-28 | Topotarget Uk Limited | Histone deacetylase (HDAC) inhibitors for the treatment of cancer |
US20070129290A1 (en) * | 2005-11-18 | 2007-06-07 | Or Yat S | Metabolite derivatives of the HDAC inhibitor FK228 |
US20090305956A1 (en) * | 2006-04-24 | 2009-12-10 | Gloucester Pharmaceuticals, Inc. | Treatment of Ras-Expressing Tumors |
US9539303B2 (en) | 2006-04-24 | 2017-01-10 | Celgene Corporation | Treatment of Ras-expressing tumors |
US9259452B2 (en) | 2006-06-08 | 2016-02-16 | Gelgene Corporation | Deacetylase inhibitor therapy |
US20080124403A1 (en) * | 2006-06-08 | 2008-05-29 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
US8957027B2 (en) | 2006-06-08 | 2015-02-17 | Celgene Corporation | Deacetylase inhibitor therapy |
US20090209616A1 (en) * | 2006-12-29 | 2009-08-20 | Verdine Gregory L | Preparation of romidepsin |
US8691534B2 (en) | 2006-12-29 | 2014-04-08 | Celgene Corporation | Preparation of romidepsin |
US20090186382A1 (en) * | 2006-12-29 | 2009-07-23 | Verdine Gregory L | Preparation of Romidepsin |
US20100093610A1 (en) * | 2006-12-29 | 2010-04-15 | Vrolijk Nicholas H | Romidepsin-based treatments for cancer |
US8642809B2 (en) | 2007-09-25 | 2014-02-04 | Topotarget Uk Ltd. | Methods of synthesis of certain hydroxamic acid compounds |
US20100286279A1 (en) * | 2007-09-25 | 2010-11-11 | Topotarget Uk Limited | Methods of Synthesis of Certain Hydroxamic Acid Compounds |
US20110003777A1 (en) * | 2008-03-07 | 2011-01-06 | Topotarget A/S | Methods of Treatment Employing Prolonged Continuous Infusion of Belinostat |
US20100190694A1 (en) * | 2009-01-14 | 2010-07-29 | Jan Fagerberg | Methods for identifying patients who will respond well to cancer treatment |
US8980825B2 (en) | 2010-07-12 | 2015-03-17 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US9518094B2 (en) | 2010-07-12 | 2016-12-13 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US9624271B2 (en) | 2010-07-12 | 2017-04-18 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
US20150087021A1 (en) * | 2012-05-07 | 2015-03-26 | Stefan Kochanek | Nucleic acid construct and use of the same |
US9534233B2 (en) * | 2012-05-07 | 2017-01-03 | Stefan Kochanek | Nucleic acid construct and use of the same |
US9134325B2 (en) | 2012-09-07 | 2015-09-15 | Celgene Corporation | Resistance biomarkers for HDAC inhibitors |
US9101579B2 (en) | 2012-11-14 | 2015-08-11 | Celgene Corporation | Inhibition of drug resistant cancer cells |
US11077156B2 (en) | 2013-03-14 | 2021-08-03 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
US9782451B2 (en) | 2013-12-27 | 2017-10-10 | Celgene Corporation | Romidepsin formulations and uses thereof |
US9795650B2 (en) | 2013-12-27 | 2017-10-24 | Celgene Corporation | Romidepsin formulations and uses thereof |
US9463215B2 (en) | 2013-12-27 | 2016-10-11 | Celgene Corporation | Romidepsin formulations and uses thereof |
US9468664B2 (en) | 2013-12-27 | 2016-10-18 | Celgene Corporation | Romidepsin formulations and uses thereof |
US11130968B2 (en) | 2016-02-23 | 2021-09-28 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
US11401529B2 (en) | 2016-02-23 | 2022-08-02 | Salk Institute For Biological Studies | Exogenous gene expression in recombinant adenovirus for minimal impact on viral kinetics |
US11813337B2 (en) | 2016-12-12 | 2023-11-14 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
JP2007511211A (ja) | 2007-05-10 |
EP1689445A1 (de) | 2006-08-16 |
EP1689445B1 (de) | 2015-02-25 |
JP2014177481A (ja) | 2014-09-25 |
JP5873893B2 (ja) | 2016-03-01 |
US10300096B2 (en) | 2019-05-28 |
JP2011201889A (ja) | 2011-10-13 |
WO2005051430A1 (de) | 2005-06-09 |
US20160074447A1 (en) | 2016-03-17 |
CA2546178A1 (en) | 2005-06-09 |
US20110275093A1 (en) | 2011-11-10 |
JP5675481B2 (ja) | 2015-02-25 |
US20100311145A1 (en) | 2010-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10300096B2 (en) | Use of adenoviruses and nucleic acids that code for said viruses | |
US11268073B2 (en) | Use of adenovirus and nucleic acids coding therefor | |
US20220339219A1 (en) | Method for reversing multiple resistance in animal cells | |
US8586354B2 (en) | Adenoviruses, nucleic acids that code for the same and the use of said viruses | |
US20170190752A1 (en) | E1-minus adenoviruses and use thereof | |
AU2015201828B2 (en) | Novel use of adenoviruses and nucleic acids coding therefor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |