US20060286184A1 - Composition containing as the active ingredient componantes from salvia sclarea seed - Google Patents

Composition containing as the active ingredient componantes from salvia sclarea seed Download PDF

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Publication number
US20060286184A1
US20060286184A1 US10/570,810 US57081006A US2006286184A1 US 20060286184 A1 US20060286184 A1 US 20060286184A1 US 57081006 A US57081006 A US 57081006A US 2006286184 A1 US2006286184 A1 US 2006286184A1
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US
United States
Prior art keywords
salvia sclarea
oil
seed
salvia
seeds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/570,810
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English (en)
Inventor
Dudai Nativ
Zohara Yaniv-Bacharach
Eli Putievsky
Diah Sa'ady
Dan Schafferman
David Chaimovitsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agricultural Research Organization of Israel Ministry of Agriculture
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Assigned to STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (A.R.O.), VOLCANI CENTER reassignment STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (A.R.O.), VOLCANI CENTER ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: YANIV-BACHARACH, ZOHARA, SCHAFFERMAN, DAN, PUTIEVSKY, ELI, CHAIMOVITSH, DAVID, SA'ADY, DIAH, NATIV, DUDAI
Publication of US20060286184A1 publication Critical patent/US20060286184A1/en
Priority to US13/946,402 priority Critical patent/US9532964B2/en
Priority to US15/353,932 priority patent/US20170065546A1/en
Priority to US15/697,502 priority patent/US10071073B2/en
Abandoned legal-status Critical Current

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81—Aquaculture, e.g. of fish
    • Y02A40/818—Alternative feeds for fish, e.g. in aquacultures

Definitions

  • the present invention relates to food supplements and nutraceutical compositions for raising omega-levels in a subject.
  • omega-3 fatty acids are essential components of the human diet. According to studies published in the British scientific journal Lancet, the observed low incidence of arteriosclerosis (fatty plaques development on the inner walls of the arteries which obstructs the blood flow), including coronary artery disease, and chronic inflammatory disease, and diabetes in Greenland Eskimos has been attributed to their traditional ethnic diet, consisting largely of meat from whale, seals, sea birds and fish. This diet is rich in fat and protein and low in carbohydrates, but it is extremely high in omega-3 polyunsaturated fatty acids, and especially rich in two omega-3 fatty acids: C22:6 and C20:5 (DHA) and (EPA).
  • DHA omega-3 fatty acids
  • Omega-3 fatty acids are eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and ⁇ -linolenic acid (ALA).
  • EPA is a direct source of an important substance called prostaglandin E3, which is directly responsible for making blood platelets less sticky, thus leading to an easier flow of blood.
  • EPA is, therefore, involved in processes that inhibit blood clots whose presence threaten to obstruct the circulation; this mode of action is particularly important in the small capillaries of the heart.
  • DHA (docosahexaenoic acid) is an Omega-3 fatty acid of almost equal importance to EPA. DHA comprises a significant amount of the tissues that make up the human brain as well as a large part of the retina of the eye.
  • omega-3 fatty acids Some of the most dramatic effects of increased intake of omega-3 fatty acids, are the lowering of high blood pressure, reduction of serum triglyceride levels, and an increase in the clotting time, all positive steps in the prevention of heart and blood vessel diseases. These beneficial effects of omega-3 fatty acids have been noted in both clinical trials and epidemiological studies. Omega-3 fatty acids were found to be extremely useful natural substances powerful enough to normalize the high cholesterol and triglyceride levels that are so extensive in modem populations.
  • Omega-3 fatty acids have also been shown to slow down or prevent cancerous tumor growth, prevent blood vessels from closing following vascular surgery, improve inflammatory diseases such as rheumatoid arthritis and relieve symptoms of psoriasis.
  • omega-3 fatty acids are essential for proper vision and brain development in newborns.
  • the average western diet is low in fresh fish and sea food containing EPA and DHA. On the other hand, it is high in refined carbohydrates and saturated fats. This kind of diet can lead to a serious deficiency in the raw materials necessary for proper platelet function in the blood stream.
  • Linolenic acid is essential for ensuring healthy skin condition. Moreover, oils containing large amounts of omega-3 fatty acids were shown to be effective in preventing skin wrinkles. The ingestion of these oils markedly lowers the cholesterol content in the blood.
  • ⁇ -Linolenic acid is a fatty acid found in some plants and can be converted by the body to EPA and DHA. Plant sources of ⁇ -linolenic acid include walnuts and walnut oil, flaxseed, rapeseed (used to make canola oil), soybeans, spinach, mustard greens and purslane.
  • ⁇ -linolenic acid is produced in high quantities in several plants, mainly hemp (up to 23% ⁇ -linolenic acid is pressed from hempseed) and flax (50%). These oils normally have an “off” flavor and are seldom used as edible oils due to their bad taste and smell. Conventional food oils, such as rape-seed (canola) and soybean contain only small amounts of linolenic acid (11% and 7% respectively).
  • omega-6 is found primarily in vegetable oils like corn, safflower or sunflower
  • omega-3s and omega-6s continually compete for control of important biochemical reactions in the body.
  • the portion of omega-6 is higher than that of omega-3, it can lead to an overproduction of hormone-like substances called prostaglandins and leukotrienes.
  • prostaglandins and leukotrienes Large amounts of these hormone-like substances can disrupt the immune system, initiate the build-up of plaque formations on artery walls, form blood clots and triggers dangerously irregular heart rhythms.
  • the ratio in the American diet is about 10 omega-6 to 1 omega-3, a ratio, some experts say, which is a dangerous oversupply of omega-6 fatty acids.
  • Dietary fish oils containing omega-3 fatty acids are increasingly recommended for their antithrombic and hypolipidemic (lowering blood lipid) effects (Phillipson, Rothrock, Connor, Harris and Illingworthm, New England J. Med., 312:1210-16, 1985). Additional benefits of these oils are improvement of immunological function and fighting allergies (Leaf and Weber, New England J. Med., 318:549-557, 1988).
  • Omega-3 fatty acids from vegetable oils could provide all the above health benefits without any of the disadvantages of oil from animal source.
  • Aromatic (essential) oil derived from flowers of Salvia sclarea has been used up to date mainly as a perfume; this usage was known from the time of ancient Rome. Other secondary uses for this aromatic oil have been in the tobacco industry, and in herbal remedies to fight infection, and to regulate the digestive system.
  • the natural habitat of the plant is in Iran, Italy and Southern France; and its growth requirements in terms of soil content are not particular.
  • the former Soviet Union, North Africa, and Hungary are the largest producers of this oil, and prices range from $60-90 per liter of oil; The plant can withstand heat, and is found on mountainous terrain, where rainfall is not lower than 400 mm annually.
  • the floral parts alone are used to produce the oil; inclusion of leaves will degrade the oil quality. Typically a single harvest of floral parts is performed. If harvest is performed prematurely, the oil will contain a large percentage of linoleic acetate, which lowers the quality of the oil.
  • WO 99/62356 concerns enhanced food for humans which has significantly higher omega-3 content by the use of oil obtained by Salvia hispanica seed.
  • Salvia Hispanic (Chia) is a summer annual belonging to the Labiate family. It originates in mountain regions extending from west central Mexico to northern Guatemala. Due to its endemic growth restriction to mountain regions of central and southern America and thus its natural habitat is very specific and growth requirements very particular making seed grown from the plant not economical, the plants are not wide spread and has not acquired wide commercial acceptance as a food source.
  • Seed oil of selected lines of Salvia sclarea (also known as “clary sage”) has an average oil content of 25-30%.
  • the inventors now disclose that the seeds of this plant are a rich source of omega-3- ⁇ -linolenic acid (about 55%).
  • the other components of this oil are two important fatty acids: Oleic acid (C18:1), which is present in extremely high levels, and linoleic acid (C18:2). Both acids are unsaturated fatty acids and are essential in the human diet.
  • the present invention hereby discloses whole seeds, or oil, flour/powder, or pulp obtained from Salvia sclarea seeds, having all the health benefits of fish oil but none of its drawbacks (notably its bad taste and distinctive smell).
  • the oil or flour/powder has the additional above-mentioned benefits over other vegetable oils, and can be used for dietary supplements, as an active ingredient in pharmaceutical and cosmetic compositions, and for industrial uses.
  • This vegetable oil is its use as a drying oil for painting and lubrication, due to its high content of polyunsaturated fatty acids, namely linolenic acid.
  • vegetative drying oil has been obtained from crops such as flax seeds and Tong trees. These crops do not lend themselves to mechanical harvesting and cleaning.
  • Salvia sclarea seed oil is useful for industry, and is relatively easy to obtain.
  • the prior art discloses (WO 99/62356) oil, rich in omega-3 obtained from Salvia hispanica , which is an endemic plant restricted in its growth to the high mountain area of central and south America.
  • the present invention is based on the surprising finding that seeds obtained from another variant of Salvia , i.e. being Salvia sclarea , had better nutritional value than oil, or crushed seed, obtained from Salvia hispanica as will be shown in the detailed description part of the invention.
  • the present invention is based on the realization that not only the oil or crushed flour/powder of Salvia sclarea has higher nutritional value than the oil of Salvia hispanica , but also the growth of the plant of the Salvia sclarea variety, as compared to the Salvia hispanica variety is more economical.
  • the Saliva sclarea plants can grow in any Mediterranean climate such as in the middle east, in Europe, (including southern European countries such as Italy, Spain and Southern France as well as Northern and eastern European countries such as Finland and Russia), North Africa, California and Australia; and its growth requirements in terms of soil content are not particular.
  • the plant can withstand both heat and cold (even snow), and is found on mountainous terrain, where rainfall is even lower than 400 mm annually.
  • the present invention is further based on the surprising finding that from among several species of different Salvia the specific Salvia sclarea of the present invention was found to have an extremely high nutritional value.
  • compositions for use as a food supplement comprising as an active ingredient a composition of matter selected from:
  • composition of matter refers to several components (fatty acids, proteins, minerals, vitamins, dietary fibers) present as a mixture with specific ratios between the components.
  • Salvia sclarea seed refers to the whole seed essentially in an unprocessed form as separated from the full plant.
  • Salvia sclarea seed oil in an essentially pure form refers to oil obtained from the seed which is essentially free from other components.
  • the oil may be obtained by various manners known to separate oil from plant-seeds without damaging their nutritional value.
  • Salvia sclarea seed, crushed or milled to form flour or powder refers to crushing or milling of the seed to fine particles by any mechanical milling means known in the art in order to break the seed into smaller fragments such as crumbs of flour or particles of powder, and in those flour/powder forms, most of the nutrients are more available to the subject than in the whole seed.
  • Salvia sclarea seed pulp refers in fact also to “defatted Salvia sclarea seed flour”. These two alternative terms refer to the seed after the oily fraction has been extracted there from, which pulp is especially rich in dietary fibers, minerals, vitamins and proteins and poor in fatty acids and calories.
  • extract of Salvia sclarea seed refers to any compound that is extracted from the seed by using aqueous or alcohol, or other organic extracts. Typically, where the extracting liquid is water mostly to fibers (dietary fibers).
  • the food supplement consists essentially of:
  • composition of matter is Salvia sclarea oil or Salvia sclarea flour or powder.
  • the food supplement further comprises a “carrier” suitable for consumption in food products.
  • the carrier is chosen as a carrier known in the art for the specific type of composition of matter of the invention.
  • composition of matter of the invention is oil
  • the carrier may be other types of vegetable oils such as olive oil, rape-seed (canola) oil, corn oil, soy oil, wheat germ oil, coconut oil, peanut oil, sesame oil, palm oil, almond oil, nut oil walnut etc.
  • composition of matter of the invention is powder or flour
  • carrier may be other types of flour/powder such as wheat, barley, corn, soy flour, oat flour, rice flour, tapioca, rye flour.
  • the food supplement contains only one of the ingredients (a-e) above without any “carrier”.
  • the present invention further concerns the use of an agent selected from
  • the food supplement above may be used for human or non human consumption, preferably in order to increase the level of at least one omega-3 fatty acid in the subject.
  • the non-human animal may be a farm animal such as cattle (cow, goat, and sheep), poultry (hens, ducks, turkeys) as well as fish grown in fish ponds such as carp, bass, tilapia, trout, and pond-raised salmons.
  • farm animal such as cattle (cow, goat, and sheep), poultry (hens, ducks, turkeys) as well as fish grown in fish ponds such as carp, bass, tilapia, trout, and pond-raised salmons.
  • the food supplement of the present invention is expected to raise the level of at least one omega-3 fatty acid in the meat of the non-human animal (cow, sheep, hens, fish), as well as to raise the level of at least one omega-3 fatty acid in the products of the animals such as milk and eggs.
  • the present invention concerns a method for increasing at least one omega-3 fatty acid level in a subject the method comprising: administering to the subject an effective amount of the food supplement of the present invention.
  • the subject may be as defined above and may be a human or non-human animal.
  • the term “effective amount” is an amount that increases the level of at least one omega-3 fatty acid, acid in a statistically significant manner as compared to a control subject not fed with the food supplement of the present invention.
  • the raise in the animal may be adjusted in accordance with the types of subject, and the desired level but typically for example in egg yolks is a raise of 2 to 10 fold, preferably a raise of more than 4 fold, more preferably a raise of more than 6 fold.
  • the present invention concerns a method for increasing the level of at least one omega-3 fatty acid in egg yolks or in the meat of hens, the method comprising: administering to the p hens an effective amount the food supplement of the present invention.
  • the present invention further concerns a nutraceutical composition
  • a nutraceutical composition comprising a nutraceutically acceptable carrier and as an active ingredient a composition of matter selected from:
  • Salvia sclarea seed pulp Salvia sclarea seed oil in an essentially pure form.
  • the salvia seed oil is prepared by as disclosed above.
  • the nutraceutical composition consists essentially of a composition of matter selected from:
  • Salvia sclarea seed pulp Salvia sclarea seed oil in an essentially pure form:
  • composition refers to any substance that is a food or a part of a food and provides medical or health benefits, including the prevention and treatment of disease or disorder.
  • the present invention further concerns a nutraceutical composition as defined above for the treatment of a disease or a disorder wherein a therapeutically beneficial effect may be evident by increasing the level of at least one omega-3 fatty acid.
  • treatment . . . therapeutically beneficial effect may refer to at least one of the following: decrease in at least one undesirable affect of the disease; slowing the deterioration of the disease; increase in the diseased-free time period; or prevention of the disease altogether.
  • the disease or disorder is selected from: arthrosclerosis, coronary artery disease, chronic inflammatory disease such as rheumatoid arthritis and IBD, diabetes, cancer, prevention of blood vessels from closing after vascular surgery, relieving symptoms of psoriasis, skin wrinkles and depression and mood disorders.
  • the disease may be any disease or condition which is known scientifically, or is discovered empirically to benefit from the increase in the level of at least one omega-3 fatty acid in the subject.
  • the nutraceutical composition is typically taken orally for example in the form of gel-capsules containing the oil, liquid formulation containing the oil, tablets containing the flour/powder as known in the art for preparing such compositions, but for several indications such as psoriasis, and other dermal conditions (wrinkles, dry skin) the oil containing formulations (gel-caps, oil) may also be topically applied.
  • the present invention further concerns a cosmetic composition
  • a cosmetic composition comprising a cosmetically acceptable carrier and as an active ingredient Salvia Sclarea seed oil in an essentially pure form.
  • the cosmetic composition is for prevention of wrinkles of the skin and/or ensuring skin health.
  • omega-3 fatty acid refers to any unsaturated fatty acid with its first double bond at the third carbon atom from the methyl-end.
  • These fatty acids may be such as essential fatty acid, ⁇ -linoleic acid (ALA) as well as non essential fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).
  • ALA essential fatty acid
  • DHA docosahexaenoic acid
  • EPA eicosapentaenoic acid
  • the present invention further concerns a food product comprising the food supplement of the present invention.
  • Examples of food products are as follows:
  • Salvia sclarea has an average oil content of 25-30% in the seeds, with maximum levels of 60% omega-3-linolenic acid of the total fatty acids in the oil.
  • Salvia sclarea lines were tested and evaluated as a potential new oil crop for dietary supplement for humans and animals, for use as an active ingredient in pharmaceutical and cosmetic compositions and mixtures and for industrial uses.
  • Omega-3 fatty acids from vegetable oils could provide all the above health and cosmetic benefits without any of the disadvantages of oil from animal source.
  • Another important aspect of this vegetable oil is its quality as drying oil, for painting and lubrication, due to the high content of polyunsaturated fatty acids, namely linolenic acid.
  • vegetative drying oil is obtained from crops such as flax seeds and Tong trees. These crops do not lend themselves to mechanical harvesting and cleaning.
  • Salvia sclarea seeds 11 kg were milled into crude flour, and mixed into standard hen feed at a concentration of 13.75% w/w. Concentrations of 15-17% of the Salvia sclarea flour would also have been appropriate, though they were not included in this experiment.
  • the feed containing the Salvia sclarea flour was stored and used for the duration of the experiment, though typically hen feed is prepared immediately before use.
  • Salvia sclarea seeds are a viable source of Omega-3 fatty acids and that consumption of Salvia sclarea seed flour results in a direct positive effect on the level of Omega-3 fatty acids in the consumer.
  • Dietary supplements containing Salvia sclarea seed flour or oil are thus nutritionally recommended, and could aid in preventing or ameliorating arteriosclerosis and other conditions where high levels of Omega-3 fatty acids have been found to be beneficial.
  • Salvia sclarea seeds can be regarded as almost a nutritionally complete foodstuff.
  • the Salvia sclarea seeds are also free of trans-fatty acids and gluten, and absorb approx. 8 times their weight in water making them ideal for diet-low calorie foods, as fat replacement products and water binders.
  • Salvia sclarea seeds are ground into meal, blended with natural antioxidants to prevent oil oxidation(rancidity) and to prolong the shelf life of the product and then formulated as an ingredient into weight reducing, nutritionally balanced powdered drink mixes, bars and low-cal/low carbohydrates baked goods.
  • the Salvia sclarea seeds are ground into meal, partially blended with whole seeds, formulated with other grains flours such as wheat barley, soy or corn together with natural binders and fibers, and then extruded by cooking extruders into flakes for breakfast cereals, and other shapes for snacks then flavored, spiced, oil coated and baked (or fried) in oils blended with Salvia sclarea Omega 3 enriched vegetable oils.
  • a dry blend of Salvia meal and other ingredients are cooked together under high pressure, using a single or twin co-rotating screws inside a barrel with injection ports. Water and/or other liquids are injected into the barrel during the cooking and blending process.
  • the extruded product is baked or air-dried, fried, and then flavored.
  • Formulations for cold extruded pasta products include usage of special natural colorings, dough improvers, spices, flavorings, fibers, etc. that render natural, omega-3 enriched pastas of various shapes and colors.
  • the extruded products can be used as such (without further processing) or mixed with other ingredients for production of health oriented dry or cooked meals, breakfast cereals, granola mixes, etc.
  • Omega-3 enriched pasta is obtained in various shapes and colors (using natural colors also with antioxidant activities).
  • Salvia sclarea whole seeds are pretreated by soaking in water or other suitable liquids or marinades, and then formulated into low-calorie, nutritionally enhanced baked goods.
  • low-calorie, nutritionally enhanced baked goods For example, in one embodiment a 250 calorie per 100 gram standard bread has its energy reduced by 40% to a 150 calorie per 100 gram diet bread. Similarly, a substantial reduction in calories applies to buns and rolls, biscuits, bagels.
  • These low-calorie baked goods which are also enriched, Omega 3 enriched, are suitable also for fast food chains (buns for hotdogs or hamburgers), sandwiches, etc.
  • Salvia sclarea seeds are marinated in buffered, flavored and naturally colored solutions for varying lengths of time as desired. Temperature and pH are controlled.
  • the marinated seeds and also Salvia sclarea flour/powder are mixed into bread dough and other bakery products- and baked accordingly.
  • the marinated seeds will render products containing them low calorie products and also low-carbohydrates (low-carb.) since the bound water marinade will react with the Salvia sclarea fibers to form a soft jelly-type mixture.
  • Salvia sclarea seed oil is extracted from seeds, blended with other oils, vegetable proteins, water, natural emulsifying and stabilizing ingredients and then homogenized by an homogenizer and formed into a butter-margarine like flavored spreads, free of trans fatty acids, very low in saturated fats, and high in Omega-3 and Oleic fatty acids.
  • Salvia sclarea seed oil is extracted from Salvia seeds by a multi-stage press-extractor. Prior to extraction the seeds are lightly heated and wetted for maximum yields.
  • the excess water is then removed by a decanting centrifuge.
  • the omega-3 rich and oleic acid rich oil is collected, blended with natural oxidants and bottled as such or blended with other oils (see also Example 8), bottled or blended with other ingredients (emulsifiers, stabilizers, water, etc.) and then homogenized under vacuum to produce high omega-3 and oleic acids butter-like spreads, vegetarian mayonnaise, etc.
  • Salvia sclarea seeds, rich in proteins, omega-3 oil and soluble fibers are roasted and ground into a very fine paste by proprietary equipment.
  • the paste may be packed as is, as a high nutritional base that can be used for thickening gravies, soups and preparation of many oriental and Indian type dishes such as meat or vegetarian Satay, curries, Hummus etc.
  • dips such as tehini dip, prepared in conjunction with sesame paste or oil, water, garlic, lemon juice, spices and herbs.
  • the Tehini Dip can be used as is or made into salad dressings, etc.
  • a sesame/coffee type roaster is used for roasting and controlled temperature heating of the Salvia sclarea seeds, which are then ground and homogenized into an omega-3 rich tehini-type paste.
  • Salvia sclarea whole seeds are washed and soaked in a water solution of salts, acid regulators, natural antioxidants, natural flavors and natural colors. Soaking times vary according to the desired formulations. The soaked seeds are thoroughly drained of excess solution.
  • the treated and drained seeds are blended with Fish oils, and natural marine flavors omega-3 EPA and DHA fatty Acids in desired ratios according to product recipe.
  • the finished product is packed in glass, plastic or metal packaging and processed to render shelf stable or chilled products with long shelf lives.
  • These products are actually described as vegetarian caviar (fish roe) like products with high nutritional values that include all the nutritional factors of Salvia sclarea seeds, and in addition the full group of omega-3 fatty Acids (ALA ,DHA and EPA) from Vegetable and Marine sources.
  • ALA ,DHA and EPA omega-3 fatty Acids
  • the Salvia sclarea whole seeds are treated by soaking using a multi-stage battery of variable speed mixers.
  • the differential soaking solutions contain osmotic and acid regulations, and natural antioxidants, flavors and colors. Time and temperatures are controlled and the solutions treated seeds are dewatered by low-speed centrifuges. The seeds are blended as described, and then processed by pasteurization/sterilization (according to pH of product) to yield shelf stable products.
  • Salvia sclarea seeds are milled and blended at various ratios into fish feed formulations.
  • This embodiment provides sweet water or salty water fish with the entire range of nutritional benefits of Salvia sclarea special oil rich in omega-3 alpha linolenic acid, omega-6 linoleic acid and oleic acid.
  • the fish formulations are then extruded into floating or sinking pellets according to the type of fish to be fed.
  • the raised fish will contain in their fillets a relatively higher concentration of omega-3 fatty Acids, which in turn can be controlled by the concentration of ALA (c18:3) which is also a precursor for natural synthesis of DHA (c 22:6) in animal, poultry and fish flesh
  • Salvia sclarea seed oil rich in omega-3 ALA is extracted from seeds.
  • the oil is blended with olive and other vegetable oils, rich in monounsaturated and omega-6 fatty acids and fortified with natural proprietary antioxidants that will prevent the oil mixture from oxidation and also will provide beneficial antioxidants (such as Vitamin E Vitamin C and others) to the user.
  • the ratio of monounsaturated fatty acids to omega-3 f.a. and omega-6 f.a is calculated to be 1 to 1 ⁇ 2 to 1 ⁇ 2, in order to maintain the recommended ratio of 1 ⁇ 3 monousaturated f.a, 1 ⁇ 3 poly unsaturated f.a (with a ratio of 1 to 1 between omega-3 f.a and omega-6 f.a) and 1 ⁇ 3 saturated fatty acids of vegetable or animal origin (such as palm oil, coconut oil, butter, etc.). All fats and oils should be trans free.
  • the total fats/oil per daily use is calculated to be 60 gr. Or 75 gr. (i.e. 27% of diets with 2000 calorie/day or 2500 calorie/day respectively).
  • omega-3 DHA and EPA PUFA About 2-3 grams a day of fish oils containing 1000 mg. omega-3 DHA and EPA PUFA, are enclosed separately to the package, in order to supply daily the whole range of omega-3 PUFA: ALA, EPA & DHA.
  • the entire fatty acids/oils daily portion is packed in a 3 compartment package which will include in comp. 1 the fluid oils blend (to be used in salads, cooking, etc.), in comp. 2a spreadable sat. fatty acids mix (to be used by spreading on crackers, bread slices, etc.) and In comp. 3, the omega-3 PUFA rich, fish oils (to be used with fish salads, dishes, etc. or any other food with a compatible flavor).
  • the fish oil may also be encapsulated.

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US20100144878A1 (en) * 2005-04-29 2010-06-10 Popp Michael A Nutritional supplement or functional food comprising oil combination
US20100310719A1 (en) * 2009-06-08 2010-12-09 Finney John M Manufacture of seed derivative compositions
US20110044964A1 (en) * 2009-08-24 2011-02-24 Hero Nutritionals, LLC Plant-based omega chewable supplement
WO2011136885A2 (en) * 2010-03-23 2011-11-03 Jeffrey Walters Texture and flavor enhancer and use in food preparation
US20120015075A1 (en) * 2010-07-13 2012-01-19 Hero Nutritionals, LLC Chewable supplement with live microorganisms
US20120015076A1 (en) * 2010-07-12 2012-01-19 Hero Nutritionals, LLC Chocolate delivery system for live microorganisms
US20120149766A1 (en) * 2006-11-24 2012-06-14 Dsm Ip Assets B.V. Dietary and pharmaceutical compositions comprising a sage extract containing a mixture of tricyclic diterpenes and their derivatives and their uses
US20120164291A1 (en) * 2009-09-16 2012-06-28 Morinaga & Co., Ltd. Soft candy and soft candy production method
WO2012156970A1 (en) 2011-05-04 2012-11-22 Magnetika Interactive Ltd. Salvia sclarea seed oil for use in the treatment of cardiovascular diseases or anxiety disorders
US20130149399A1 (en) * 2010-05-31 2013-06-13 Shiseido Company ,Ltd. Skin temperature elevating agent, and cosmetic composition, food and sundry article containing the same
US8748491B2 (en) 2006-11-24 2014-06-10 Dsm Ip Assets B.V. Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivatives and their uses
US9452135B2 (en) 2012-03-20 2016-09-27 Particle Dynamics International, Llc Gelling agent-based dosage form
CN110973328A (zh) * 2019-11-22 2020-04-10 吉林省蚕业科学研究院 一种蚕蛹α-亚麻酸凝胶糖果及其生产工艺

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JP6072202B2 (ja) * 2015-03-12 2017-02-01 太陽油脂株式会社 脱脂種子
MX2018014531A (es) 2016-06-05 2019-02-21 Mondelez Europe Gmbh Composicion alimenticia salada horneada que comprende verduras de raiz ralladas y metodo para fabricarla.
GB201611503D0 (en) * 2016-06-30 2016-08-17 Devenish Nutrition Ltd Compositions for use in enriching animal meat with omega-3 polyunsaturated fatty acids
JP2018057392A (ja) * 2017-11-21 2018-04-12 モンサント テクノロジー エルエルシー 有益な脂肪酸を含む家禽肉および家禽卵
USD864516S1 (en) 2018-05-14 2019-10-29 Intercontinental Great Brands Llc Thin food cluster
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Cited By (19)

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Publication number Priority date Publication date Assignee Title
US20100144878A1 (en) * 2005-04-29 2010-06-10 Popp Michael A Nutritional supplement or functional food comprising oil combination
US20090162455A1 (en) * 2006-02-07 2009-06-25 Trouw International B.V. Feed for fish
US10537602B2 (en) 2006-02-07 2020-01-21 Nutreco Ip Assets B.V. Feed for fish
US10265366B2 (en) 2006-02-07 2019-04-23 Nutreco Ip Assets B.V. Feed for fish
US8951584B2 (en) * 2006-02-07 2015-02-10 Trouw International B.V. Feed for fish
US8748491B2 (en) 2006-11-24 2014-06-10 Dsm Ip Assets B.V. Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivatives and their uses
US20120149766A1 (en) * 2006-11-24 2012-06-14 Dsm Ip Assets B.V. Dietary and pharmaceutical compositions comprising a sage extract containing a mixture of tricyclic diterpenes and their derivatives and their uses
US20100310719A1 (en) * 2009-06-08 2010-12-09 Finney John M Manufacture of seed derivative compositions
US8252354B2 (en) 2009-06-08 2012-08-28 Mas Marketing Holding Company, Llc Manufacture of seed derivative compositions
US20110044964A1 (en) * 2009-08-24 2011-02-24 Hero Nutritionals, LLC Plant-based omega chewable supplement
US20120164291A1 (en) * 2009-09-16 2012-06-28 Morinaga & Co., Ltd. Soft candy and soft candy production method
WO2011136885A2 (en) * 2010-03-23 2011-11-03 Jeffrey Walters Texture and flavor enhancer and use in food preparation
WO2011136885A3 (en) * 2010-03-23 2012-01-12 Jeffrey Walters Texture and flavor enhancer and use in food preparation
US20130149399A1 (en) * 2010-05-31 2013-06-13 Shiseido Company ,Ltd. Skin temperature elevating agent, and cosmetic composition, food and sundry article containing the same
US20120015076A1 (en) * 2010-07-12 2012-01-19 Hero Nutritionals, LLC Chocolate delivery system for live microorganisms
US20120015075A1 (en) * 2010-07-13 2012-01-19 Hero Nutritionals, LLC Chewable supplement with live microorganisms
WO2012156970A1 (en) 2011-05-04 2012-11-22 Magnetika Interactive Ltd. Salvia sclarea seed oil for use in the treatment of cardiovascular diseases or anxiety disorders
US9452135B2 (en) 2012-03-20 2016-09-27 Particle Dynamics International, Llc Gelling agent-based dosage form
CN110973328A (zh) * 2019-11-22 2020-04-10 吉林省蚕业科学研究院 一种蚕蛹α-亚麻酸凝胶糖果及其生产工艺

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CA2578834C (en) 2015-01-20
WO2005023019A1 (en) 2005-03-17
CY1109905T1 (el) 2014-09-10
JP2007503827A (ja) 2007-03-01
JP4540672B2 (ja) 2010-09-08
US10071073B2 (en) 2018-09-11
US9532964B2 (en) 2017-01-03
PL1662904T3 (pl) 2010-08-31
US20170065546A1 (en) 2017-03-09
DE602004025010D1 (de) 2010-02-25
US20130303617A1 (en) 2013-11-14
US20170360738A1 (en) 2017-12-21
ATE454049T1 (de) 2010-01-15
IL157785A0 (en) 2004-03-28
EP1662904A1 (de) 2006-06-07
EP1662904B1 (de) 2010-01-06
DK1662904T3 (da) 2010-05-17
CA2578834A1 (en) 2005-03-17
ES2340495T3 (es) 2010-06-04
PT1662904E (pt) 2010-04-08

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