US20050255172A1 - Hydrogen peroxide-based skin disinfectant - Google Patents

Hydrogen peroxide-based skin disinfectant Download PDF

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Publication number
US20050255172A1
US20050255172A1 US11/128,223 US12822305A US2005255172A1 US 20050255172 A1 US20050255172 A1 US 20050255172A1 US 12822305 A US12822305 A US 12822305A US 2005255172 A1 US2005255172 A1 US 2005255172A1
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solution
acid
concentration
hydrogen peroxide
chosen
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Navid Omidbakhsh
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Diversey Inc
Diversey US Holdings LLC
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Individual
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Priority to US11/128,223 priority Critical patent/US20050255172A1/en
Assigned to VIROX TECHNOLOGIES INC. reassignment VIROX TECHNOLOGIES INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OMIDBAKHSH, NAVID
Publication of US20050255172A1 publication Critical patent/US20050255172A1/en
Assigned to VIROX TECHNOLOGIES INC. reassignment VIROX TECHNOLOGIES INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GRASCHA, PIERRE
Priority to US13/022,683 priority patent/US8808755B2/en
Priority to US13/832,921 priority patent/US9198935B2/en
Assigned to DIVERSEY US HOLDINGS, LLC reassignment DIVERSEY US HOLDINGS, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VIROX HOLDINGS INC., VIROX HOLDINGS INTERNATIONAL INC., VIROX INTERNATIONAL INC., VIROX TECHNOLOGIES INC.
Assigned to DIVERSEY INC. reassignment DIVERSEY INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DIVERSEY US HOLDINGS, LLC
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the present invention relates to disinfecting solutions or formulations for use on skin containing hydrogen peroxide.
  • Infection control is a major concern for health care professionals. Viruses and bacteria on contaminated hands are easily spread among people in health care facilities such as hospitals. Of course, the risk of infection is also present in public places other than hospitals, such as in gyms, washrooms, restaurants, and schools.
  • washing hands with detergents or soaps is a way to reduce the risk of infection.
  • the level of disinfection required cannot be achieved by most common products. Consequently, hand disinfectants have been developed to achieve higher levels of disinfection where the need exists.
  • These types of products generally contain alcohols, iodinesaodophors, chlorhexidine gluconate (CHG), phenolic compounds, quaternary ammonium compounds or combinations thereof.
  • a problem with existing products is that they often sacrifice disinfectant activity for the sake of skin mildness or vice versa. For example, while raising the concentration of the active ingredient may lead to a higher level of disinfection, such higher concentration frequently leads to increased skin irritation.
  • PCMX Parachlorometaxylenol
  • triclosan are common phenolic compounds used in antiseptic hand wash solutions. See, for example, European patent 505,935 B1, assigned to Becton, Dickinson and Company and granted on Feb. 4, 1998, which discloses an anti-microbial skin formulation containing PCMX, a block copolymer, and a lauryl sulfosuccinate. Although PCMX and triclosan have lower toxicity than other phenols, and are rather mild to the skin, their germicidal activity is low and depends on the formulation ingredients.
  • Iodine and iodophors have been used in antiseptic hand wash formulations for a long time. Their germicidal activities are low and reduced in the presence of organic matter. Furthermore, these ingredients are toxic and can irritate and stain skin.
  • Chlorhexidine gluconate is used as a skin cleanser, pre-surgical scrub, germicidal hand rinse, and wound cleaner. It is less effective against gram-negative bacteria as compared to gram-positive bacteria and exhibits relatively low germicidal activity.
  • Hydrogen peroxide is a broad-spectrum germicide effective against bacteria, yeast, fungi, viruses and spores. It is non-toxic and its breakdown products, oxygen and water, are innocuous thus making it safe to the environment. At low concentrations (e.g. 3% w/w), it is non-irritating to skin, but exhibits low germicidal activity. For example, a solution containing 3% w/w hydrogen peroxide takes 20 minutes to achieve a greater than 6 log reduction in Staphylococcus aureus , which is too long for many applications. Increasing the concentration of hydrogen peroxide will increase the rate of disinfection. For example, a 25% w/w aqueous solution of hydrogen peroxide requires only 20 seconds to achieve a greater than 6 log reduction in Staphylococcus aureus . However, the solution is corrosive at this concentration and requires special handling procedures.
  • the invention provides, in accordance with a first aspect, an aqueous skin disinfecting solution having a pH of from about 2 to about 6, about 2.5 to about 5, or about 3 to about 5, and comprising:
  • Preferred imidazoline derivatives are alkylamphocarboxylates and alkyliminocarboxylates.
  • the hydrogen peroxide stabilizer can be chosen from phosphoric acid, phosphonic acids having 1 to 5 phosphonic acid groups, e.g. 1-hydroxyethylidene-1,1,-diphosphonic acid, amino tri(methylene phosphonic acid), diethylenetriaminepenta(methylene phosphonic acid), 2-hydroxy ethylimino bis(methylene phosphonic acid), and ethylene diamine tetra(methylene phosphonic acid).
  • phosphoric acid phosphonic acids having 1 to 5 phosphonic acid groups, e.g. 1-hydroxyethylidene-1,1,-diphosphonic acid, amino tri(methylene phosphonic acid), diethylenetriaminepenta(methylene phosphonic acid), 2-hydroxy ethylimino bis(methylene phosphonic acid), and ethylene diamine tetra(methylene phosphonic acid).
  • EDTA ethylenediaminetetraacetic acid
  • DTPA diethylenetriaminepentaacetic acid
  • HEDTA N-(hydroxyethyl)-ethylenediaminetriacetic acid
  • NTA nitrilotriacetic acid
  • HEIDA 2-hydroxyethyliminodiacetic acid
  • benzoic acid aminobenzoic acid, citric acid, iminodisuccinic acid, polyaspartic acid, and salts thereof.
  • the cyclic carboxylic acid can be chosen from furan carboxylic acid (e.g. 2-furan carboxylic acid), benzoic acid and salicylic acid.
  • the skin-conditioning agent can be chosen from glycerides, sorbitol, castor oil, allantoin, cationic polymers, lanolin and its derivatives and cetyl alcohol.
  • the solution can further comprise at least one buffer, in a concentration of from about 0.01 to about 5% w/w of the solution, chosen from citric acid, lactic acid, glycolic acid, phosphoric acid, malic acid, succinic acid and tartaric acid.
  • at least one buffer in a concentration of from about 0.01 to about 5% w/w of the solution, chosen from citric acid, lactic acid, glycolic acid, phosphoric acid, malic acid, succinic acid and tartaric acid.
  • the solution can comprise at least one optional hydrogen peroxide compatible surfactant in a concentration of from about 0.01 to about 10% w/w of the solution.
  • exemplary hydrogen peroxide compatible surfactants are alkyl sulfate, alkyl ether sulfates, alkyl benzene sulfonic acids, alkyl sulfonic acids, alkyl diphenyl oxide sulfonic acids, naphthalene sulfonic acids, alkyl or alkenyl esters or diesters of sulfosuccinic acids, and salts thereof, alcohol ethoxylates, alkyl phenol ethoxylates, fatty acid esters, and alkylpolyglucosides.
  • the solution can comprise at least one C1 to C8 alcohol in a concentration of from about 0.01 to about 10% w/w of solution, which may be chosen from benzyl alcohol, ethanol, n-butanol, isopropanol and glycols.
  • the solution can further comprise at least one member chosen from monocarboxylic acids, polycarboxylic acids, and mixtures thereof in a concentration of from about 0.01 to about 3% w/w of the solution.
  • monocarboxylic acids are glycolic acid and acetic acid.
  • a preferred polycarboxylic acid is citric acid.
  • the solution can further comprise at least one thickening agent compatible with hydrogen peroxide (e.g. polyacrylic acid polymers, polysaccharides, and cellulose-based polymers in a concentration of from about 0.01 to about 5% w/w of the solution, and at least one member chosen from dyes and fragrances (as are known in the art) in a concentration of from about 0.001 to about 0.5% w/w of the solution.
  • at least one thickening agent compatible with hydrogen peroxide e.g. polyacrylic acid polymers, polysaccharides, and cellulose-based polymers in a concentration of from about 0.01 to about 5% w/w of the solution
  • dyes and fragrances as are known in the art
  • the balance of the solution consists of deionized water, preferably with a conductivity of less than 20 micro zimens. It will be appreciated that the lower the deionized water conductivity, the longer the shelf life.
  • the solution may be in concentrated liquid form for dilution by the end user.
  • the invention may take the form of a dry powdered formulation, which can be dissolved in water to form a solution according to the first aspect.
  • the expression “consisting essentially of” shall mean—including the listed ingredients and such additional ingredients as would not materially affect the basic and novel properties of the invention—.
  • the basic and novel properties are the disinfecting properties of the invention and the suitability of the invention for use on skin.
  • a “skin-conditioning agent” is any ingredient or compound, which is used to make the solution suitable for use on skin and includes moisturizers, emollients and humectants.
  • phosphoric acid and citric acid are both hydrogen peroxide stabilizers and buffers.
  • benzoic acid is also a hydrogen peroxide stabilizer and a cyclic carboxylic acid, which contributes to disinfecting activity.
  • the inventive solution is able to provide adequate levels of disinfection while not irritating skin.
  • the solution is non-irritating due to the low levels of hydrogen peroxide, mild surfactant package and low concentrations of other mild additives employed.
  • the solution has broad-spectrum activity, the degree of which is unexpected given the germicidal activity of the individual ingredients. A synergy exists amongst the ingredients of the present inventive solution such that an effective disinfectant is provided that is suitable for use on skin.
  • the invention may be in the form of a concentrated liquid for dilution by the end user.
  • it may be in the form of a dry formulation for dissolution in water.
  • the hydrogen peroxide may be supplied by persalt compounds, of which sodium percarbonate and sodium perborate in its monohydrate and tetrahydrate forms are preferred. Since sodium percarbonate contains about 20% hydrogen peroxide by weight, and sodium perborate monohydrate and sodium perborate tetrahydrate contain about 30% and about 20% respectively by weight, proper allowance must be made when blending the dry mixture of components to achieve the desired levels of hydrogen peroxide upon dissolution in water.
  • certain surfactants are essential to the present invention, including, imidazoline derivatives (e.g. alkylamphoacetates, alkylamphopropionates, and alkyliminopropionates), alkylbetaines, alkylamidopropylbetaines, alkyl amidopropyl betaine amides, alkylsulfobetaines, amine oxides and derivatives and mixtures thereof.
  • imidazoline derivatives e.g. alkylamphoacetates, alkylamphopropionates, and alkyliminopropionates
  • alkylbetaines alkylamidopropylbetaines
  • alkyl amidopropyl betaine amides alkylsulfobetaines
  • amine oxides and derivatives and mixtures thereof alkylsulfobetaines
  • Amine oxides useful in this invention are R1R2R3NO wherein each of R1, R2, and R3 is independently a saturated, substituted or unsubstituted linear or branched alkyl group having from 1 to 28 carbon atoms.
  • Preferred imidazoline derivatives are alkylamphocarboxylates and alkyliminocarboxylates having the following structures: wherein R is a saturated, substituted or unsubstituted linear or branched alkyl group having from 1 to 24 carbon atoms.
  • R is a linear alkyl chain having from 8 to 16 carbon atoms and R1 to R5 are saturated, linear alkyl groups having from 1 to 3 carbon atoms.
  • Alkyl amidopropyl betaine amides useful in this invention have a saturated, substituted or unsubstituted linear or branched alkyl group having from 1 to 24 carbon atoms.
  • the alkyl group is preferably a linear chain having from 6 to 16 carbon atoms.
  • Alkyl amidosulfobetaines have the following structure: wherein R is a saturated, substituted or unsubstituted linear or branched alkyl group having from 1 to 24 carbon atoms.
  • the alkyl group is preferably a linear alkyl chain having 8 to 16 carbon atoms.
  • Preferred hydrogen peroxide stabilizers are available from a number of manufacturers including Rhodia under the trademark BRIQUEST, and Solutia under the trademark DEQUEST.
  • the hydrogen peroxide used in all the examples is a 50% w/w technical grade commercial solution sold by Degussa AG.
  • Solution 1 is a hand disinfectant, which, at a 55% dilution achieved a greater than 4 log 10 reduction in Staphylococcus aureus and E. coli at 30 second contact time using European suspension test method EN.12054. The solution was also tested against these organisms in vivo using European fingerpad test method EN.1499.
  • Test method EN.1499 involves preparing 2 liters of a contamination fluid containing from 2 ⁇ 10 8 -2 ⁇ 10 9 test organisms.
  • the test organisms are prepared in Tryptone Soy Broth TSB and pooled overnight. Hands are washed with soft soap and water to remove any soil and then dried. The hands are then immersed up to the mid-metacarpals in the contamination fluid with the fingers spread apart. Immersion is for 5 seconds. The hands are then air dried for 3 minutes while moving the hands to avoid droplet formation.
  • the hands are sampled to establish a baseline or “pre-value” count of test organisms. This is achieved by rubbing the fingertips (including the thumb) against the base of a petri dish containing 10 ml TSB on a neutralization bath (designed to neutralize the activity of the test product) for 60 seconds. A separate petri dish is used for each hand. A series of 10-fold dilutions of the neutralization bath is prepared and each dilution is plated on a well-dried Tryptone Soy Agar (TSA) plate and incubated at 37° C. for 18-24 hours. The number of surviving colony forming units of microorganisms on each plate is then counted and the value is expressed in terms of log 10.
  • TSA Tryptone Soy Agar
  • the product to be tested is poured into cupped hands which had been dipped in the contaminated fluid in the same manner described above.
  • the product is rubbed vigorously into the skin up to the wrists for 60 seconds to ensure total coverage of the hands.
  • the fingers are then rinsed under running tap water for 15 seconds and excess water is shaken off.
  • the hands are then sampled individually to establish a post treatment or “post-value” count of test organisms. This is performed using exactly the same method as that used to establish the pre-value count. That is, the fingertips (including the thumb) are rubbed against the base of a petri dish (one for each hand) containing 10 ml TSB in a neutralization bath for 60 seconds. A series of 10-fold dilutions of the neutralization bath is prepared and each dilution is plated on a well-dried TSA plate and incubated at 37° C. for 18-24 hours. The number of surviving colony forming units of microorganisms on each plate is then counted and the value is expressed in terms of log 10.
  • the number of colony forming units per ml is calculated and expressed in terms of log 10.
  • the mean log counts from left and right hands are used to determine the pre- and post-values.
  • the difference between the mean pre-value and the mean post-value counts is then calculated and a log reduction factor for the test product and the control product is calculated using the WILCOXON's ranked pairs test.
  • Test method EN.12054 is a suspension test method, which entails pipetting 9.0 ml of the test solution into a 25 ml capacity sterile container. 1 ml of a bacterial test suspension is then added and mixed with the test solution. The container is then placed in a water bath at 20 ⁇ 1° C. for a defined contact time. Just before conclusion of the defined contact time, the solution is mixed and 1.0 ml is transferred into a tube containing 8 ml of a neutralizer and 1 ml of water. The solution is then mixed again and the tube is placed in a water bath at 20 ⁇ 1° C. After a neutralization time of 5 minutes ⁇ 10 seconds, a series of ten-fold dilutions of the neutralized mixture is prepared.
  • a sample of 1 ml of the mixture and 1 ml of its 10 ⁇ 1 dilution is taken in duplicate and incubated by using the pour plate or spread plate technique.
  • each 1 ml sample of the mixture is pipetted onto a separate petri dish containing 12 to 15 ml of melted TSA cooled to 45 ⁇ 1° C.
  • each 1 ml sample of the mixture is spread on an appropriate number of oven-dried plates containing TSA.
  • the plates are then incubated at 36 ⁇ 1° C. for 24 hours after which the number of colony forming units for each plate is determined.
  • the plates are incubated for another 24 hours and the colony forming units are recounted.
  • the highest count value for each plate is used to determine the effectiveness of the test solution. Results are expressed in terms of log 10. A 3-log reduction is the criteria for passing this test method.
  • Solution 2 does not contain any cyclic carboxylic acids and is therefore not in accordance with the present invention.
  • This solution failed the in vitro European suspension test method EN.12054 using a contact time of 1 minute.
  • SOLUTION 3 INGREDIENTS % w/w Actual concentration % w/w deionized water Up to 100 Up to 100 citric acid 0.1 0.1 glycerin 1 1
  • Solution 3 does not contain any surfactants which are essential to the present invention and is therefore not in accordance with the present invention. This solution (at 55% dilution) failed the in vitro European suspension test method EN. 12054 using a contact time of 1 minute.
  • Solution 32 was tested for its microbial activity using EN.12054 test method at 55% dilution against S.aureus, P.aeruginosa, E.hirae , and E.coli and showed more than 3 log reduction which is the criteria for a hand antiseptic. This solution was also tested against E.coli using EN.1499 and passed the test.
  • Solution 32 was also tested for its skin irritation using a patch test. In this study, the solution was put on patches and applied on the skin of 11 volunteers for 48 hours. No irritation was observed after the test, indicating that the solution is not a skin irritant.
  • Solution 32 was also tested for its hydrogen peroxide stability using a hot stability test method.
  • the solution was kept at 70° C. for one week, which is equivalent to 1 year at room temperature.
  • the loss for hydrogen peroxide was less than 5% proving remarkable stability of the solution.

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US11/128,223 2004-05-14 2005-05-13 Hydrogen peroxide-based skin disinfectant Abandoned US20050255172A1 (en)

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US11/128,223 US20050255172A1 (en) 2004-05-14 2005-05-13 Hydrogen peroxide-based skin disinfectant
US13/022,683 US8808755B2 (en) 2004-05-14 2011-02-08 Hydrogen peroxide-based skin disinfectant
US13/832,921 US9198935B2 (en) 2004-05-14 2013-03-15 Hydrogen peroxide-based skin disinfectant

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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050058719A1 (en) * 2002-11-15 2005-03-17 Ramirez Jose A. Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
AU2005201048B2 (en) * 2004-04-12 2006-06-15 Weyerhaeuser Company Open web trimmable truss with self locking joint
US20070059380A1 (en) * 2002-02-12 2007-03-15 Ramirez Jose A Enhanced activity hydrogen peroxide disinfectant
WO2007147815A1 (de) * 2006-06-23 2007-12-27 Henkel Ag & Co. Kgaa Zahnbehandlungsmittel mit verstärkter bleichwirkung
US20080305182A1 (en) * 2002-11-15 2008-12-11 Ramirez Jose A Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
US20090043010A1 (en) * 2005-10-28 2009-02-12 Mustafa Kaya Polymeric Compound, Method of Preparing a Polymeric Compound, Use of a Polymeric Compound
US20090041617A1 (en) * 2007-08-07 2009-02-12 Lee James D Purified hydrogen peroxide gas microbial control methods and devices
US20090247485A1 (en) * 2005-07-29 2009-10-01 Ahmed Fahim U Barrier film-forming compositions and methods of use
US20100130770A1 (en) * 2008-11-12 2010-05-27 Irix Pharmaceuticals N-alkanoyl-n,n',n'-alkylenediamine trialkanoic acid esters
WO2010077870A2 (en) * 2008-12-15 2010-07-08 Life Technologies Corporation Stable compositions comprising chromogenic compounds and methods of use
US20100204082A1 (en) * 2009-02-06 2010-08-12 Dober Chemical Corporation Alkaline compositions and methods of producing same
US20100265816A1 (en) * 2009-04-17 2010-10-21 American Superconductor Corporation Monitoring switching networks
US20110033557A1 (en) * 2008-04-04 2011-02-10 Giuseppe Augusto Scigliano Pharmaceutical composition and diagnostic and therapeutic use thereof
US20110182958A1 (en) * 2007-08-15 2011-07-28 Navid Omidbakhsh Antimicrobial compositions
US20120068113A1 (en) * 2009-01-26 2012-03-22 Innospec Limited Chelating agents and methods relating thereto
US20120193575A1 (en) * 2009-10-13 2012-08-02 Verutek, Inc. Stabilized surfactant - oxidant composition and related methods
WO2012125870A1 (en) * 2011-03-15 2012-09-20 Thompson Cooper Laboratories, Llc Compositions and methods for treatment of infections
WO2013096814A1 (en) * 2011-12-22 2013-06-27 Bui Huyen Phuong Non-corrosive stable peracetic acid concentrate solution
US20130259823A1 (en) * 2004-05-14 2013-10-03 Navid Omidbakhsh Hydrogen peroxide-based skin disinfectant
US20140079804A1 (en) * 2012-03-15 2014-03-20 Thompson Cooper Laboratories, Llc Compositions and methods for treatment of infections
WO2014121406A1 (de) * 2013-02-06 2014-08-14 Wetrok Ag Reinigungsmittel
USD744627S1 (en) 2014-07-23 2015-12-01 Lee Antimicrobial Solutions, Llc Air-permeable substrate structure
US9538760B2 (en) 2011-10-05 2017-01-10 Arkema Inc. Disinfectant compositions with hydrogen peroxide
EP3138401A1 (de) * 2015-09-04 2017-03-08 Weidner Chemie-Produktion GmbH Zusammensetzung zur desinfektion
US9737076B2 (en) 2011-10-05 2017-08-22 Arkema Inc. Disinfectant compositions with hydrogen peroxide
US9789005B2 (en) 2009-09-02 2017-10-17 Hyprotek, Inc. Antimicrobial medical dressings and protecting wounds and catheter sites
USD814006S1 (en) 2014-07-18 2018-03-27 Synexis Llc Device for producing non-hydrated purified hydrogen peroxide gas
US9980983B2 (en) 2014-04-21 2018-05-29 Aclaris Therapeutics, Inc. Peroxide formulations and methods and applicators for using the same
US20180235231A1 (en) * 2017-02-17 2018-08-23 Randall Andrew PILON Peroxide-based disinfecting solutions containing inorganic salts
US10080620B2 (en) 2012-02-06 2018-09-25 Hyprotek, Inc. Portable medical device protectors
CN108926494A (zh) * 2018-06-26 2018-12-04 苏州美瑞姿生物科技有限公司 聚天冬氨酸钠盐复配溶液及其制备方法、应用
US10450535B2 (en) 2017-10-18 2019-10-22 Virox Technologies Inc. Shelf-stable hydrogen peroxide antimicrobial compositions
WO2021113292A1 (en) * 2019-12-03 2021-06-10 Diversey, Inc. Peroxygen-based skin disinfectants effective against mycobacteria and yeasts
SE2051346A1 (en) * 2020-11-18 2022-05-19 Lantmaennen Oats Ab Anti-microbial skin-care composition comprising beta-glucan, hydrogen peroxide and lactic acid
IT202100025955A1 (it) * 2021-10-11 2023-04-11 99 Holding S A R L Formulazione igienizzante e disinfettante
WO2023062523A1 (en) * 2021-10-11 2023-04-20 99 Holding S.A.R.L. Sanitizing/cleaning and disinfectant formulation

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007014575A1 (de) * 2005-08-02 2007-02-08 Thomas Besendorfer Zusammensetzung mit bakterizider, fungizider, virozider und insektizider wirkung
US8450378B2 (en) 2006-02-09 2013-05-28 Gojo Industries, Inc. Antiviral method
US8119115B2 (en) 2006-02-09 2012-02-21 Gojo Industries, Inc. Antiviral method
US9629361B2 (en) 2006-02-09 2017-04-25 Gojo Industries, Inc. Composition and method for pre-surgical skin disinfection
US20070185216A1 (en) * 2006-02-09 2007-08-09 Marcia Snyder Antiviral method
CA2671471C (en) * 2006-12-13 2015-11-03 Centennial Ventures B.V. Mild compositions for skin disinfection
EP2022331A1 (de) * 2007-08-02 2009-02-11 Wesso Ag Desinfektionsmittel zur Herabsetzung der Keimzahl und Verringerung von Biofilmen
WO2010003431A1 (en) * 2008-07-07 2010-01-14 Paul Et Karin Herzog Sa Disinfecting composition
JP6943761B2 (ja) 2014-09-17 2021-10-06 ロンザ，エルエルシー 活性化された過酸化水素消毒剤組成物
US20180214481A1 (en) * 2017-01-30 2018-08-02 Spectra Shield Technologies, Llc Ready to use surface disinfectant
CA3088516A1 (en) * 2018-01-15 2019-07-18 Sanit Technologies Llc Anti-microbial soap
US11273229B2 (en) 2019-01-17 2022-03-15 Midlab, Inc. Phosphoric acid free antimicrobial composition
WO2020167933A1 (en) 2019-02-12 2020-08-20 Alden Medical, Llc Alcohol-free hydrogen peroxide disinfectant compositions and methods of use thereof
US20200276099A1 (en) * 2019-02-28 2020-09-03 L'oreal Plant-based cosmetic compositions
WO2020223275A1 (en) 2019-05-01 2020-11-05 Lonza Llc Sanitizing compositions
GB2589862A (en) * 2019-12-09 2021-06-16 Institute Of Tech Sligo Antimicrobial composition
US11484483B2 (en) * 2020-06-29 2022-11-01 Shear Kershman Laboratories, Inc. Topical lotion having sanitizing properties
WO2022000099A1 (es) * 2020-07-02 2022-01-06 Aros Melzer Patricia Magdalena Composición orgánica como desinfectante y sanitizante, inocuo para el ser humano y medio ambiente
US20220079857A1 (en) * 2020-09-14 2022-03-17 Assured Hygiene Products Ltd. Preparation for treating body odor
US20220322672A1 (en) * 2021-04-13 2022-10-13 Metrex Research Llc Hydrogen peroxide disinfectant composition
DE102021129678A1 (de) 2021-11-15 2023-05-17 Knieler & Team Gmbh Gebrauchsfertige Wässrige Desinfektionsmittelzusammensetzung
WO2023198784A1 (en) * 2022-04-14 2023-10-19 Glaxosmithkline Consumer Healthcare (Uk) Ip Limited Cleaning composition

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528378A (en) * 1947-09-20 1950-10-31 John J Mccabe Jr Metal salts of substituted quaternary hydroxy cycloimidinic acid metal alcoholates and process for preparation of same
US4446153A (en) * 1982-09-30 1984-05-01 Ralston Purina Company Skin sanitizing composition and method of using
US5387605A (en) * 1992-07-31 1995-02-07 Eastman Kodak Company Carboxylic acids that are effective against TB
US5736582A (en) * 1996-10-10 1998-04-07 Devillez; Richard L. Method and composition for controlled delivery of nascent oxygen from hydrogen peroxide source for skin treatment
US6096348A (en) * 1996-02-12 2000-08-01 Healthpoint, Ltd. Quick acting chemical sterilant
US6444636B1 (en) * 2001-12-10 2002-09-03 Colgate-Palmolive Company Liquid dish cleaning compositions containing hydrogen peroxide
US6479454B1 (en) * 2000-10-05 2002-11-12 Ecolab Inc. Antimicrobial compositions and methods containing hydrogen peroxide and octyl amine oxide
US20020168422A1 (en) * 2000-04-28 2002-11-14 Hei Robert D.P. Two solvent antimicrobial compositions and methods employing them
US6617294B2 (en) * 2000-10-20 2003-09-09 Vinod K. Narula Waterless sanitizing hand cleanser
US6627589B1 (en) * 2001-05-11 2003-09-30 Colgate-Palmolive Company Mild antibacterial liquid dish cleaning compositions containing peroxide having improved stability and stain removal benefits
US6803057B2 (en) * 1998-12-14 2004-10-12 Virox Technologies Inc. Hydrogen peroxide disinfectant with increased activity
US6841090B1 (en) * 1998-04-08 2005-01-11 The Proctor & Gamble Company Disinfecting composition and process for disinfecting surfaces
US20050019421A1 (en) * 2003-07-23 2005-01-27 3M Innovative Properties Company Disinfecting compositions and methods of making and using same

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629081A1 (de) 1976-06-29 1978-01-12 Peroxid Chemie Gmbh Germizides mittel
DE3229097A1 (de) 1982-08-04 1984-02-09 Schülke & Mayr GmbH, 2000 Hamburg Mikrobizide mittel
DE3543500A1 (de) 1985-12-10 1987-06-11 Schuelke & Mayr Gmbh Waessrige loesung aromatischer percarbonsaeuren und deren verwendung
DE3702983A1 (de) 1986-06-09 1987-12-10 Henkel Kgaa Desinfektionsmittel und ihre verwendung zur haut- und schleimhautdesinfektion
EP0351772A3 (de) 1988-07-19 1990-07-04 HENKEL CORPORATION (a Delaware corp.) Stabilisiertes Wasserstoffoxid
DE4015202A1 (de) 1990-05-11 1991-11-14 Heimo Wessollek Reiniger fuer trinkwasseranlagen
NZ241579A (en) 1991-03-25 1994-04-27 Becton Dickinson Co Antimicrobial formulations for treating the skin
DE4225795C2 (de) 1992-07-31 1994-09-01 Schuelke & Mayr Gmbh Desinfektionsmittel auf Carbonsäurebasis
EP0711253B1 (de) 1993-07-28 1998-01-21 Heimo Wessollek Verwendung eines mittels zur herabsetzung der keimzahl und stabilisierung von trink- und brauchwasser
US5641530A (en) 1995-11-27 1997-06-24 Eka Nobel Inc. Method of disinfection
EP0839900A1 (de) 1996-10-31 1998-05-06 The Procter & Gamble Company Teppichreinigungsmittel und Verfahren zur Teppichreinigung
CN1201594A (zh) 1997-06-06 1998-12-16 王良田 植物灭毒剂
US6114377A (en) 1997-07-17 2000-09-05 E-L Management Corp. Antimicrobial cosmetic compositions
EP1001012A1 (de) * 1998-11-10 2000-05-17 The Procter & Gamble Company Desinfektions- und Reinigungszusammensetzungen
DE60109207T8 (de) 2001-01-16 2006-08-24 Unilever N.V. Orale zusammensetzung
US6555509B2 (en) * 2001-01-29 2003-04-29 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Multi-phase toilet articles and methods for their manufacture
US20030180377A1 (en) 2002-02-12 2003-09-25 Ramirez Jose A. Enhanced activity hydrogen peroxide disinfectant
MXPA04008434A (es) * 2002-03-05 2004-11-26 Colgate Palmolive Co Composiciones limpiadoras de platos liquidas estables de color que contienen una fuente de peroxido.
DE10224979B4 (de) 2002-06-05 2004-07-15 Schülke & Mayr GmbH Verwendung von synergistischen Zubereitungen auf Basis von Gemischen von Glycerinether mit aromatischem Alkohol zur Bekämpfung von Mykobakterien
EP1374679A3 (de) 2002-06-21 2004-01-21 Nippon Peroxide Co., Ltd. Sterilisierende Zusammensetzung und Verfahren zur Sterilisation unter Verwendung derselben
DE10393374D2 (de) 2002-10-14 2005-09-01 Arconia Gmbh Malans Zusammensetzung
NZ550744A (en) * 2004-05-14 2010-11-26 Virox Technologies Inc Hydrogen peroxide-based skin disinfectant

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528378A (en) * 1947-09-20 1950-10-31 John J Mccabe Jr Metal salts of substituted quaternary hydroxy cycloimidinic acid metal alcoholates and process for preparation of same
US4446153A (en) * 1982-09-30 1984-05-01 Ralston Purina Company Skin sanitizing composition and method of using
US5387605A (en) * 1992-07-31 1995-02-07 Eastman Kodak Company Carboxylic acids that are effective against TB
US6096348A (en) * 1996-02-12 2000-08-01 Healthpoint, Ltd. Quick acting chemical sterilant
US5736582A (en) * 1996-10-10 1998-04-07 Devillez; Richard L. Method and composition for controlled delivery of nascent oxygen from hydrogen peroxide source for skin treatment
US6841090B1 (en) * 1998-04-08 2005-01-11 The Proctor & Gamble Company Disinfecting composition and process for disinfecting surfaces
US6803057B2 (en) * 1998-12-14 2004-10-12 Virox Technologies Inc. Hydrogen peroxide disinfectant with increased activity
US20020168422A1 (en) * 2000-04-28 2002-11-14 Hei Robert D.P. Two solvent antimicrobial compositions and methods employing them
US6479454B1 (en) * 2000-10-05 2002-11-12 Ecolab Inc. Antimicrobial compositions and methods containing hydrogen peroxide and octyl amine oxide
US6617294B2 (en) * 2000-10-20 2003-09-09 Vinod K. Narula Waterless sanitizing hand cleanser
US6627589B1 (en) * 2001-05-11 2003-09-30 Colgate-Palmolive Company Mild antibacterial liquid dish cleaning compositions containing peroxide having improved stability and stain removal benefits
US6444636B1 (en) * 2001-12-10 2002-09-03 Colgate-Palmolive Company Liquid dish cleaning compositions containing hydrogen peroxide
US20050019421A1 (en) * 2003-07-23 2005-01-27 3M Innovative Properties Company Disinfecting compositions and methods of making and using same

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632523B2 (en) 2002-02-12 2009-12-15 Virox Technologies Inc. Enhanced activity hydrogen peroxide disinfectant
US8999400B2 (en) 2002-02-12 2015-04-07 Virox Technologies Inc. Enhanced activity hydrogen peroxide disinfectant
US20070059380A1 (en) * 2002-02-12 2007-03-15 Ramirez Jose A Enhanced activity hydrogen peroxide disinfectant
US8637085B2 (en) 2002-02-12 2014-01-28 Virox Technologies Inc. Enhanced activity hydrogen peroxide disinfectant
US20100330196A1 (en) * 2002-02-12 2010-12-30 Ramirez Jose A Enhanced activity hydrogen peroxide disinfectant
US20100003343A1 (en) * 2002-02-12 2010-01-07 Ramirez Jose A Enhanced activity hydrogen peroxide disinfectant
US9233180B2 (en) 2002-11-15 2016-01-12 Virox Technologies Inc. Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
US20050058719A1 (en) * 2002-11-15 2005-03-17 Ramirez Jose A. Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
US20080305182A1 (en) * 2002-11-15 2008-12-11 Ramirez Jose A Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
US7354604B2 (en) 2002-11-15 2008-04-08 Virox Technologies Inc. Hydrogen peroxide disinfectant containing a cyclic carboxylic acid and/or aromatic alcohol
AU2005201048B2 (en) * 2004-04-12 2006-06-15 Weyerhaeuser Company Open web trimmable truss with self locking joint
US20130259823A1 (en) * 2004-05-14 2013-10-03 Navid Omidbakhsh Hydrogen peroxide-based skin disinfectant
US9198935B2 (en) * 2004-05-14 2015-12-01 Virox Technologies Inc. Hydrogen peroxide-based skin disinfectant
US20090247485A1 (en) * 2005-07-29 2009-10-01 Ahmed Fahim U Barrier film-forming compositions and methods of use
US8778369B2 (en) 2005-07-29 2014-07-15 Delaval Holding Ab Barrier film-forming compositions and methods of use
US20090043010A1 (en) * 2005-10-28 2009-02-12 Mustafa Kaya Polymeric Compound, Method of Preparing a Polymeric Compound, Use of a Polymeric Compound
US8664295B2 (en) * 2005-10-28 2014-03-04 Nutripol Capital Sarl Polymeric compound, method of preparing a polymeric compound, use of a polymeric compound
WO2007147815A1 (de) * 2006-06-23 2007-12-27 Henkel Ag & Co. Kgaa Zahnbehandlungsmittel mit verstärkter bleichwirkung
US11992573B2 (en) 2007-08-07 2024-05-28 Synexis Llc Purified hydrogen peroxide gas microbial control methods and devices
US20090041617A1 (en) * 2007-08-07 2009-02-12 Lee James D Purified hydrogen peroxide gas microbial control methods and devices
US8168122B2 (en) 2007-08-07 2012-05-01 Lee Antimicrobial Solutions Llc Purified hydrogen peroxide gas microbial control methods and devices
US10188766B2 (en) 2007-08-07 2019-01-29 Synexis Llc Purified hydrogen peroxide gas microbial control methods and devices
US8685329B2 (en) 2007-08-07 2014-04-01 Lee Antimicrobial Solutions Llc Purified hydrogen peroxide gas microbial control methods and devices
US9370592B2 (en) 2007-08-07 2016-06-21 Lee Antimicrobial Solutions Llc Purified hydrogen peroxide gas microbial control methods and devices
US10940223B2 (en) 2007-08-07 2021-03-09 Synexis Llc Purified hydrogen peroxide gas microbial control methods and devices
US9034255B2 (en) 2007-08-07 2015-05-19 Lee Antimicrobial Solutions Llc Purified hydrogen peroxide gas microbial control methods and devices
US11207436B2 (en) 2007-08-07 2021-12-28 Synexis Llc Purified hydrogen peroxide gas microbial control methods and devices
US20110182958A1 (en) * 2007-08-15 2011-07-28 Navid Omidbakhsh Antimicrobial compositions
US8865196B2 (en) 2007-08-15 2014-10-21 Virox Technologies Inc. Antimicrobial compositions
US20110033557A1 (en) * 2008-04-04 2011-02-10 Giuseppe Augusto Scigliano Pharmaceutical composition and diagnostic and therapeutic use thereof
US8258334B2 (en) 2008-11-12 2012-09-04 Irix Pharmaceuticals, Inc. N-alkanoyl-N,N′,N′-alkylenediamine trialkanoic acid esters
US20100130770A1 (en) * 2008-11-12 2010-05-27 Irix Pharmaceuticals N-alkanoyl-n,n',n'-alkylenediamine trialkanoic acid esters
WO2010077870A2 (en) * 2008-12-15 2010-07-08 Life Technologies Corporation Stable compositions comprising chromogenic compounds and methods of use
WO2010077870A3 (en) * 2008-12-15 2010-10-28 Life Technologies Corporation Stable compositions comprising chromogenic compounds and methods of use
US8801962B2 (en) * 2009-01-26 2014-08-12 Innospec Limited Chelating agents and methods relating thereto
US20120068113A1 (en) * 2009-01-26 2012-03-22 Innospec Limited Chelating agents and methods relating thereto
US20100204082A1 (en) * 2009-02-06 2010-08-12 Dober Chemical Corporation Alkaline compositions and methods of producing same
US8293696B2 (en) * 2009-02-06 2012-10-23 Ecolab, Inc. Alkaline composition comprising a chelant mixture, including HEIDA, and method of producing same
US20100265816A1 (en) * 2009-04-17 2010-10-21 American Superconductor Corporation Monitoring switching networks
US9789005B2 (en) 2009-09-02 2017-10-17 Hyprotek, Inc. Antimicrobial medical dressings and protecting wounds and catheter sites
US20120193575A1 (en) * 2009-10-13 2012-08-02 Verutek, Inc. Stabilized surfactant - oxidant composition and related methods
EP2685820A1 (de) * 2011-03-15 2014-01-22 Thompson Cooper Laboratories, LLC Zusammensetzungen und verfahren zur behandlung von infektionen
WO2012125870A1 (en) * 2011-03-15 2012-09-20 Thompson Cooper Laboratories, Llc Compositions and methods for treatment of infections
US20140044658A1 (en) * 2011-03-15 2014-02-13 Thompson Cooper Laboratories, Llc Compositions and Methods for Treatment of Infections
EP2685820A4 (de) * 2011-03-15 2014-08-27 Thompson Cooper Lab Llc Zusammensetzungen und verfahren zur behandlung von infektionen
US9538760B2 (en) 2011-10-05 2017-01-10 Arkema Inc. Disinfectant compositions with hydrogen peroxide
US9737076B2 (en) 2011-10-05 2017-08-22 Arkema Inc. Disinfectant compositions with hydrogen peroxide
WO2013096814A1 (en) * 2011-12-22 2013-06-27 Bui Huyen Phuong Non-corrosive stable peracetic acid concentrate solution
US10617472B2 (en) 2012-02-06 2020-04-14 Hyprotek, Inc. Adhesive patch with antimicrobial composition
US10080620B2 (en) 2012-02-06 2018-09-25 Hyprotek, Inc. Portable medical device protectors
US20140079804A1 (en) * 2012-03-15 2014-03-20 Thompson Cooper Laboratories, Llc Compositions and methods for treatment of infections
WO2014121406A1 (de) * 2013-02-06 2014-08-14 Wetrok Ag Reinigungsmittel
US9980983B2 (en) 2014-04-21 2018-05-29 Aclaris Therapeutics, Inc. Peroxide formulations and methods and applicators for using the same
US10098910B2 (en) 2014-04-21 2018-10-16 Aclaris Therapeutics, Inc. Peroxide formulations and methods and applicators for using the same
US10493103B2 (en) 2014-04-21 2019-12-03 Aclaris Therapeutics, Inc. Peroxide formulations and methods and applicators for using the same
US10653721B2 (en) 2014-04-21 2020-05-19 Aclaris Therapeutics, Inc. Peroxide formulations and methods and applicators for using the same
US10729720B2 (en) 2014-04-21 2020-08-04 Aclaris Therapeutics, Inc. Peroxide formulations and methods and applicators for using the same
USD814006S1 (en) 2014-07-18 2018-03-27 Synexis Llc Device for producing non-hydrated purified hydrogen peroxide gas
USD744627S1 (en) 2014-07-23 2015-12-01 Lee Antimicrobial Solutions, Llc Air-permeable substrate structure
EP3138401A1 (de) * 2015-09-04 2017-03-08 Weidner Chemie-Produktion GmbH Zusammensetzung zur desinfektion
US20180235231A1 (en) * 2017-02-17 2018-08-23 Randall Andrew PILON Peroxide-based disinfecting solutions containing inorganic salts
US11076598B2 (en) * 2017-02-17 2021-08-03 Diversey, Inc. Peroxide-based disinfecting solutions containing inorganic salts
US10450535B2 (en) 2017-10-18 2019-10-22 Virox Technologies Inc. Shelf-stable hydrogen peroxide antimicrobial compositions
US10968417B2 (en) 2017-10-18 2021-04-06 Diversey, Inc. Shelf-stable hydrogen peroxide antimicrobial compositions
CN108926494A (zh) * 2018-06-26 2018-12-04 苏州美瑞姿生物科技有限公司 聚天冬氨酸钠盐复配溶液及其制备方法、应用
CN115087350A (zh) * 2019-12-03 2022-09-20 戴弗西公司 对分枝杆菌和酵母菌有效的基于过氧的皮肤消毒剂
WO2021113292A1 (en) * 2019-12-03 2021-06-10 Diversey, Inc. Peroxygen-based skin disinfectants effective against mycobacteria and yeasts
SE2051346A1 (en) * 2020-11-18 2022-05-19 Lantmaennen Oats Ab Anti-microbial skin-care composition comprising beta-glucan, hydrogen peroxide and lactic acid
SE544655C2 (en) * 2020-11-18 2022-10-04 Lantmaennen Oats Ab Anti-microbial skin-care composition comprising beta-glucan, hydrogen peroxide and lactic acid
IT202100025955A1 (it) * 2021-10-11 2023-04-11 99 Holding S A R L Formulazione igienizzante e disinfettante
WO2023062523A1 (en) * 2021-10-11 2023-04-20 99 Holding S.A.R.L. Sanitizing/cleaning and disinfectant formulation

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AU2005244462B2 (en) 2010-12-16
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CA2564763A1 (en) 2005-11-24
US20130259823A1 (en) 2013-10-03
US9198935B2 (en) 2015-12-01
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