WO2020223275A1

WO2020223275A1 - Sanitizing compositions

Info

Publication number: WO2020223275A1
Application number: PCT/US2020/030356
Authority: WO
Inventors: Paul Wheeler; Lauren OAKES; James Clarke
Original assignee: Lonza Llc
Priority date: 2019-05-01
Filing date: 2020-04-29
Publication date: 2020-11-05

Abstract

Generally, the present disclosure is directed to sanitizing compositions, such as hand washes, that can be applied to a portion of the body as well as concentrates of these sanitizing compositions. The sanitizing composition can be in the form of a liquid or gel that can be pumped using a soap dispenser to provide the sanitizing composition in the form of a liquid, gel, or foam. As an example, a sanitizing composition can include a liquid disinfection product that includes: an oxidizing agent (e.g., hydrogen peroxide), at least one aromatic alcohol (e.g., phenoxyethanol), at least one acyclic organic acid (e.g., lactic acid), and a blend of amphoteric (e.g., amine oxides) and anionic (e.g., sulfates) surfactants.

Description

SANITIZING COMPOSITIONS

BACKGROUND

[0001] Sanitization is required in several industries because of both regulatory and safety concerns. Industries that require employees to consistently maintain anti-microbial sanitization include health systems such as hospitals, doctors’ offices, and emergency medical technician (EMT) units. Additionally, the food industry requires strict sanitization procedures for employees working in restaurants and in factories that prepare and package food items. To maintain sanitization, workers may need to sanitize an area of their body regularly throughout a work day. For example, a healthcare worker at a hospital may be required to wash their hands in between each visit to a new patient, which could lead to 50 or more hand washings in a single day.

[0002] While the goal of sanitization is to deliver an antimicrobial that reduces the likelihood of transmitting a contaminant, there is also a human component that should be addressed when developing sanitization products. For example, sanitization should not be burdensome such that a long time period is required to achieve the required performance. Additionally, sanitization procedures and compositions should have few adverse aspects that would diminish a worker’s desire to maintain regular sanitation. Balancing the delivery of an antimicrobial that has sufficient sanitizing power to remove contaminants while also being fast acting and non-irritating to skin is a challenge.

[0003] Currently, there is a need to develop disinfecting soaps and sanitizing compositions that are fast-acting, mild, and have a desirable cleansing sensation.

SUMMARY

[0004] Generally, the present disclosure is directed to sanitizing compositions, such as hand soaps, that can be applied to a portion of the body, as well as concentrates of these sanitizing compositions. The sanitizing composition can be in the form of a liquid or gel that can be pumped using a soap dispenser to provide the sanitizing composition in the form of a liquid, gel, or foam. As an example, a sanitizing composition of the disclosure can include a liquid disinfection product that includes: an oxidizing agent (e.g., hydrogen peroxide), at least one aromatic alcohol (e.g., phenoxy ethanol), at least one acyclic organic acid (e.g., lactic acid), and a blend of amphoteric (e.g., amine oxides) and anionic (e.g., sulfates) surfactants. Another aspect of sanitizing compositions formulated according to the disclosure can include compositions having a weight ratio of amphoteric surfactant to anionic surfactant of about 3 : 1 to about 10: 1.

[0005] In an example aspect, the sanitizing composition includes the oxidizing agent in an amount of about 0.8% to about 3.5%; at least one aromatic alcohol in an amount of about 0.25% to about 3%; at least one acyclic organic acid in an amount of about 0.25% to about 3%; the amphoteric surfactant in an amount of about 1% to about 5%; and the anionic surfactant in an amount of about 0.1% to about 4%. Percent ranges for components of the sanitizing composition are weight percentages that can be determined based on the total weight of the sanitizing composition.

[0006] Of particular advantage, sanitizing compositions can be formulated in accordance with the present disclosure that display sanitizing efficacy in about 30 seconds or less while still being mild to the skin and displaying both chemical and physical stability. For example, certain sanitizing compositions of the disclosure may provide sanitization in about 15 seconds or less. Additionally, the sanitizing compositions can be formulated without certain compounds such that the compositions are essentially free of compounds that are generally present in sanitizing compositions which include hydrogen peroxide.

[0007] Hydrogen peroxide is a highly reactive compound, and an advantage of sanitizing compositions formulated in accordance with the disclosure is the ability to deliver hydrogen peroxide in the form of a stable sanitizing composition without requiring aryl carboxylic acids or phosphorous containing compounds as stabilizers. Additionally, sanitizing efficacy can be quickly achieved without the need of membrane disrupting compounds, such as quaternary ammonium salts which are known to irritate mucus membranes and can damage the skin.

[0008] Other features and aspects of the present disclosure are set forth in greater detail below.

DETATEED DESCRIPTION

[0009] Reference now will be made to the embodiments of the disclosure, one or more examples of which are set forth below. Each example is provided by way of an explanation, not as a limitation of the disclosure. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made without departing from the scope or spirit of the disclosure. For instance, features illustrated or described as one embodiment can be used on another embodiment to yield still a further embodiment. Thus, it is intended that the present disclosure cover such modifications and variations as come within the scope of the appended claims and their equivalents. It is to be understood by one of ordinary skill in the art that the present discussion is a description of exemplary embodiments only and is not intended as limiting the broader aspects of the present disclosure, which broader aspects are embodied exemplary constructions.

[0010] Generally speaking, the present disclosure is directed to sanitizing compositions, such as hand soaps, that can be applied to a portion of the body (e.g., the hands, face, arms, or other skin regions), as well as concentrates of these sanitizing compositions. As an example, a sanitizing composition can include a liquid disinfection product that includes: an oxidizing agent (e.g., hydrogen peroxide); at least one aromatic alcohol (e.g., phenoxy ethanol); at least one acyclic organic acid (e.g., lactic acid); and a blend of amphoteric (e.g., amine oxides) and anionic (e.g., sulfates) surfactants.

[0011] Surprisingly, a sanitizing composition formulated in accordance with the disclosure can be essentially free or completely free of one or more components (e.g., carboxylate substituted aryl compounds) that are commonly found as active ingredients or stabilizers in sanitizers, without sacrificing anti-microbial efficacy. Additionally, the lack of these components in formulations of the disclosure can provide previously unrecognized advantages such as improved mildness to skin and/or foaming action. For example, a sanitizing composition in accordance with the disclosure can be essentially free of cyclic organic acids, such as carboxylate substituted aryl compounds. As used herein, the term essentially free of may be used to indicate that the composition includes about 0.01% or less of the component by weight (e.g., none, none detectable, about 0.005%, about 0.001% or less than about 0.001.) As an example, a sanitizing composition that is essentially free of carboxylate substituted aryl compounds may include less than about 0.01% of carboxylate substituted aryl compounds by weight, based on the total weight of the sanitizing composition. Several non-limiting examples of carboxylate substituted aryl compounds include benzoic acid, salicylic acid, and derivatives or combinations of these compounds.

[0012] As already stated, even without these components, exemplary sanitizing compositions of the disclosure can display high levels of antimicrobial efficacy while also providing pleasing skin feel and pH compatibility with skin. Generally, antimicrobial efficacy can be determined using a standard test. For example, certain formulations of the disclosure can produce anti -bacterial efficacy in about 45 seconds or less of contact time based on European standard testing protocol EN1499:2013. Some formulations can produce anti-bacterial efficacy in about 30 seconds or less of contact time. Some exemplary formulations can produce anti -bacterial efficacy in about 15 seconds or less of contact time. Information on sanitization efficacy for an example sanitizing composition formulated according to the disclosure can be found in Table 3.

[0013] European standard testing protocol EN1499 is a rigorous test that uses a cohort of volunteers to simulate real-world hand washing conditions. As part of the test, the volunteers’ hands are artificially contaminated. The volunteers are then split into a control group receiving a standard soap and a test group receiving the sanitizing composition. By comparing the two groups, a time for reaching a statistically significant reduction in bacteria can be determined. While other sanitization tests are commonly used in industry, these tests can have drawbacks for adequately modeling real-world conditions. For example, a suspension test involves directly contacting a contaminate solution containing microbes (e.g., E. coli) with a sanitary formula. The direct mixing that occurs in solution does not always display the same results as hand washing tests that use a control group. Additionally, the sensory properties of the sanitary formula (e.g., skin mildness, foaming, etc.) cannot be adequately assessed using these tests. As such, sanitizing compositions may pass a suspension test, but still fail testing protocol EN1499. Alternatively, or additionally, sanitizing compositions may pass as suspension test but require a hazard label such as corrosive or irritating to eyes depending on the concentration and compounds used.

[0014] Further information on tests for determining antimicrobial efficacy may be found in European Patent No. 1,765,081 (EP‘081) which teaches disinfecting solutions for use on skin. While EP’081 teaches a variety of example formulations, the reference teaches several examples that fail European suspension test method EN. 12054. One of the failed examples lacked a carboxylate substituted aryl compound (e.g., salicylic acid) which is a required component of all active formulations. Specifically, EP’081 states, “[s]olution 2 does not contain any cyclic carboxylic acids and is therefore not in accordance with the present invention. This solution (at 55% dilution) failed the in vitro European suspension test method EN. 12054 using a contact time of 1 minute.” In general, sanitizing compositions of the disclosure can include compositions that are essentially free or completely free of components taught as required in many past formulations. For example, it was surprisingly discovered that sanitizing compositions of the present disclosure can be formulated without containing any cyclic carboxylic acids while still having significant antimicrobial efficacy and physical/chemical stability. [0015] In addition to carboxylate substituted aryl compounds, sanitizing compositions of the present disclosure can also be formulated to be essentially free or completely free of compounds including: phosphorous-containing compounds, quaternary ammonium compounds, C1-C5 alcohols or diols, or combinations thereof.

[0016] Certain sanitizing compositions formulated according to the disclosure can be essentially free of quaternary ammonium compounds. As used herein, a quaternary ammonium compound is defined as a nitrogen bonded to 4 groups, where none of the groups is an oxygen. For example, a quaternary ammonium compound can be bonded to four groups that are independently alkyl or aromatic carbon chains. The carbon chains can be substituted with a halogen, an alcohol, or other chemical groups; however, the carbon chains should not include another ionizable group (i.e., the quaternary ammonium group is the sole ionizable group). As an example implementation, quaternary ammonium compounds can include alkylbenzyldimethylammonium salts, which can be used as biocides to disrupt the cell membrane. However, these compounds have the potential to irritate and damage skin because of their mechanism of action, and so may be excluded in certain formulations disclosed herein.

[0017] For some sanitizing compositions formulated in accordance with the disclosure, the sanitizing compositions can be essentially free of phosphorous-containing compounds. As used herein, a phosphorous compound is defined as phosphoric acid, inorganic phosphate salts including diphosphate and triphosphates, phosphonic acids, or molecules that having a structure that includes a covalent, ionic, or other bond to any of these phosphorous compounds. While phosphorous compounds have been used as stabilizers to reduce degradation of hydrogen peroxide, the compounds may be used by bacteria or other organisms to promote growth, rather than promoting sanitization, and so may be excluded in certain formulations disclosed herein.

[0018] Additionally, or alternatively, a sanitizing composition formulated in accordance with the disclosure can be essentially free of a short chain alcohol (e.g., a C1-C5 mono-alcohol or diol). As used herein a short chain alcohol is defined as an organic compound including an alcohol (C- OH) moiety that has a boiling point of less than about 140 °C at standard temperature and pressure. Example short chain alcohols include: methanol, ethanol, propanol, isopropanol, butanol, pentanol, and isoamyl alcohol. While these alcohols can be used as sanitizing agents due to their dehydrating properties, their mechanism of action can negatively impact skin leading to dryness or redness. Additionally, short chain alcohols can disrupt surfactants to diminish foaming, which may cause users of sanitization products to be unsure if the product is working or is effective. In certain formulations, sanitization can be effectively achieved using compositions that are essentially free of short chain alcohols and without the drawbacks. Thus, short chain alcohols may be excluded in some formulations disclosed herein.

[0019] In addition to antimicrobial efficacy, sanitizing compositions formulated according to the disclosure may display chemical stability such that active ingredients (e.g., hydrogen peroxide) do not significantly degrade even at elevated temperatures. For example, certain formulations may display a chemical stability such that less than 10% weight reduction in hydrogen peroxide is detected after 2 weeks at 54 °C. In some formulations, the chemical stability can result in less than 10% weight reduction in hydrogen peroxide after 3 months at 40 °C.

[0020] A further benefit of sanitizing compositions of the disclosure includes the physical stability of the compositions. Generally, separation of a sanitizing formulation is undesirable since it may signal an issue to users or may result in delivery of only some of the sanitization mixture. Thus, separation can lead to incomplete sanitization and/or skin irritation due to the incomplete delivery of the composition. An aspect of sanitizing compositions formulated according to the disclosure can also include physically stable compositions, such that the compositions do not phase separate into two layers at a storage temperature. For liquids, miscibility normally improves as temperature increases. Certain formulations of the disclosure can display physical stability even when stored at lower than ambient temperatures. As an example, some formulations can display physical stability at temperatures less than 15 °C (e.g., 5 °C).

[0021] The sanitizing compositions formulated according to the disclosure may include an attribute related to the physical stability, chemical stability, antimicrobial efficacy, viscosity, or combinations thereof. For instance, an example sanitizing composition can contain: hydrogen peroxide, an aromatic alcohol, an acyclic organic acid, and a blend of amphoteric and anionic surfactants, the sanitizing composition displaying a chemical stability where greater than about 90% of the hydrogen peroxide concentration remains after a time at a temperature. As an example, the sanitizing composition can display greater than about 90% of the hydrogen peroxide concentration (less than 10% reduction) after 2 weeks (14 days) at 54 °C. As another example implementation, the sanitizing composition can display greater than about 90% of the hydrogen peroxide concentration after 3 months (about 90 days) at 40 °C. As another example, a sanitizing composition containing: hydrogen peroxide, an aromatic alcohol, an acyclic organic acid, and a blend of amphoteric and anionic surfactants, where the sanitizing composition can be formulated to have a viscosity between about 120 to about 1000 cps.

[0022] For certain applications, sanitizing compositions formulated according to the disclosure may provide particular advantages by providing a suitably-thickened liquid having a viscosity greater than or equal to about 100 cps, such as greater than or equal to about 150 cps, or greater than or equal to about 200 cps. In these sanitizing compositions, a thickener such as a polymer can be included to modify the viscosity. Several non-limiting examples of thickeners include: polyacrylic acid, polystyrene, polyvinyl alcohol, agar, alginate, carrageenan, gum tragacanth, xanthan gum, collagen, glyceryl monostearate, an esterified ethoxylated methyl glucose ether, polyethylene glycol (PEG), and polyvinylpyrrolidone. Though not required for sanitizing compositions of the disclosure, suitably-thickened compositions can be conveniently used with most liquid soap dispensers and can provide users with a pleasing skin feel that readily coats the area to be sanitized without running, thus ensuring more complete sanitization.

[0023] Example sanitizing compositions may include a formulation pH. Generally, the formulation pH can include a lower pH and an upper pH that together define a range of formulation pH in accordance with the disclosure. For example, an aspect of the disclosure can include sanitizing compositions having a lower pH of about 2.5, 2.8, 3.0, 3.2, 3.5, or 3.7. Another aspect of the disclosure can include sanitizing compositions having an upper pH of about 4.3, 4.5, 4.7, 5.0, 5.3, 5.6, 6.0. Sanitizing compositions formulated according to the disclosure can have a formulation pH within the range of any one lower pH to any one upper pH inclusive of the end values. Several non-limiting examples of ranges for the formulation pH in accordance with the disclosure can include: about 2.5 to about 6.0, about 3.2 to about 5.0, and about 3.7 to about 4.3

[0024] Maintaining pH stability can be important for certain sanitizing compositions formulated in accordance with the disclosure. For certain formulations, the sanitizing composition may further include one or more buffers for maintaining the formulation pH. Several non-limiting examples of solution buffers can include: glycine-HCl, acetic acid, citric acid, lactic acid, glycolic acid, malic acid, succinic acid and tartaric acid, as well as the conjugates bases for these acids.

[0025] Aspects of the present disclosure may be better understood with reference to example weight ranges that may be practiced with formulations of the disclosure. In an example formulation, the oxidizing agent can include hydrogen peroxide or a precursor or adduct that forms hydrogen peroxide (e.g., sodium percarbonate). Generally, the concentration of the oxidizing agent should be within an active range having a lower bound and an upper bound. An aspect of the disclosure can include sanitizing compositions having a lower bound of about 0.8%, 1.0%, 1.2%, or 1.5%. Another aspect of the disclosure can include sanitizing conditions having an upper bound of about 2.5%, 2.8%, 3.0%, or 3.5%. Sanitizing compositions formulated according to the disclosure can have a concentration of the oxidizing agent based on the total weight of the sanitizing composition within the range of any one lower bound to any one upper bound inclusive of the end values. Several non-limiting examples of ranges for the concentration of the oxidizing agent in accordance with the disclosure can include: about 0.8% to about 3.5%, about 1.0% to about 3.0%, and aboutl .5% to about 2.8%.

[0026] In combination with the oxidizing agent, an aromatic alcohol may be present. Generally, the concentration of the aromatic alcohol should be within an active range having a lower value and an upper value. An aspect of the disclosure can include sanitizing compositions having a lower value of about 0.25%, 0.5%, 0.8%, or 1.0%. Another aspect of the disclosure can include sanitizing conditions having an upper value of about 1.5%, 2.0%, 2.5%, or 3.0%. Sanitizing compositions formulated according to the disclosure can have a concentration of the aromatic alcohol based on the total weight of the sanitizing composition within the range of any one lower bound to any one upper bound inclusive of the end values. Several non-limiting examples of ranges for the concentration of the aromatic alcohol in accordance with the disclosure can include: about 0.25% to about 3.0%, about 0.5% to about 2.0%, and about 0.8% to about 1.5%. In general, an aromatic alcohol is defined in the present application as a compound having a structure that includes at least one aromatic group (e.g., phenyl, benzyl, naphthyl, etc.) substituted with a carbon chain including an alcohol group. Several non-limiting examples of aromatic alcohols that can be included in formulations of the disclosure include: benzyl alcohol, Propylenglycol-1 -phenylether.

[0027] In combination with the oxidizing agent and aromatic alcohol, an acyclic organic acid may be present. Generally, the concentration of the acyclic organic acid should be within an active range having a lower point and an upper point. An aspect of the disclosure can include sanitizing compositions having a lower point of about 0.25%, 0.5%, 0.8%, or 1.0%. Another aspect of the disclosure can include sanitizing conditions having an upper point of about 1.8%, 2.5%, 3.0%, or 3.5%. Sanitizing compositions formulated according to the disclosure can have a concentration of the acyclic organic acid based on the total weight of the sanitizing composition within the range of any one lower point to any one upper point inclusive of the end values. Several non-limiting examples of ranges for the concentration of the acyclic organic acid in accordance with the disclosure can include: about 0.25% to about 3.5%, about 0.5% to about 3%, and about 0.8% to about 1.8%.

[0028] Generally, an acyclic organic acid is defined in the present application as a compound having a structure that includes at least one carboxylic acid group on a linear or branched carbon chain. The carbon chain may include heteroatoms (e.g., O, N, and S) and/or be substituted with a halogen, an oxygen, or a sulfur, but the carbon chain may not be substituted with a cyclic group. As an example, the acyclic organic acid can include an alpha-hydroxy acid such as glycolic acid, citric acid, lactic acid, malic acid, mandelic acid, ascorbic acid, alpha-hydroxybutyric acid, alpha- hydroxyisobutyric acid, alphahydroxyisocaproic acid, atrrolactic acid, alpha-hydroxyisovaleric acid, ethyl pyruvate, galacturonic acid, glucopehtonic acid, glucopheptono 1,4-lactone, gluconic acid, gluconolactone, glucuronic acid, glucurronolactone, glycolic acid, isopropyl pyruvate, methyl pyruvate, mucic acid, pyruvia acid, saccharic acid, saccaric acid 1,4-lactone, tartaric acid, and tartronic acid. Additionally, or alternatively, the acyclic organic acid can include a beta- hydroxy acid such as beta-hydroxybutyric acid, beta-phenyl -lactic acid, and beta-phenylpyruvic acid. For formulations of the disclosure, the acyclic organic acid may be present in the form of an acid or a carboxylate salt depending on the pH of the sanitizing composition. Further, the acyclic organic acid can also include a dicarboxylic acid such as succinic acid.

[0029] In combination with the oxidizing agent, aromatic alcohol, and acyclic organic acid, one or more amphoteric surfactant may be present. Generally, the concentration of the amphoteric surfactant should be within an active range having a lower percent and an upper percent. An aspect of the disclosure can include sanitizing compositions having a lower percent of about 1.0%, 2.0%, 2.5%, or 3.0%. Another aspect of the disclosure can include sanitizing conditions having an upper percent of about 3.5%, 4.0%, 4.5%, or 5.0%. Sanitizing compositions formulated according to the disclosure can have a concentration of the amphoteric surfactant based on the total weight of the sanitizing composition within the range of any one lower percent to any one upper percent inclusive of the end values. Several non-limiting examples of ranges for the concentration of the amphoteric surfactant in accordance with the disclosure can include: about 1% to about 5%, about 2% to about 4.5%, and about 3% to about 4%. Several non-limiting examples of amphoteric surfactants that can be included in formulations of the disclosure include: amine oxides (e.g., lauryldimethylamine oxide, Barlox^® 12, and Barlox^® 14) and betaines (e.g., lauramidopropyl betaine, Cocoamidopropyl betaine, and Dehyton^® PK 45.)

[0030] In combination with the oxidizing agent, aromatic alcohol, acyclic organic acid, and amphoteric surfactant, an anionic surfactant may be present. Generally, the concentration of the anionic surfactant should be within an active range having a low percent and a high percent. An aspect of the disclosure can include sanitizing compositions having a low percent of about 0.1%, 0.2%, 0.4%, or 0.5%. Another aspect of the disclosure can include sanitizing conditions having a high percent of about 1.0%, 2.0%, 3.0%, or 4.0%. Sanitizing compositions formulated according to the disclosure can have a concentration of the anionic surfactant based on the total weight of the sanitizing composition within the range of any one low percent to any one high percent inclusive of the end values. Several non-limiting examples of ranges for the concentration of the anionic surfactant in accordance with the disclosure can include: about 0.1% to about 4%, about 0.4% to about 2%, 0.5% to about 1%. Several non-limiting examples of anionic surfactants that can be included in formulations of the disclosure include sulfates (e.g., sodium laureth sulfate 2EO, sodium dodecyl sulfate, alkyl ether sulfate, and disodium laureth sulfosuccinate.)

[0031] In certain implementations that include an alkyl ether sulfate, the alkyl ether sulfate can have an average degree of ethoxylation. For example, the average degree of ethoxylation (EO) can be in the range of about 1 to about 12. In some implementations, the degree of ethoxylation can be in the range of about 1 to about 8. In certain implementations, the degree of ethoxylation can be in the range of about 1 to about 4 (e.g., about 1 to about 3). In general, the average degree of ethoxylation is used to describe the number of ethoxy groups ((OC2H4)n) present on the alkyl ether sulfate.

[0032] An aspect of sanitizing compositions formulated according to the disclosure includes a weight ratio of amphoteric surfactant to anionic surfactant of about 1 : 1 to about 14: 1. In an example implementation, the weight ratio of amphoteric surfactant to anionic surfactant can be about 2: 1 to about 12: 1. In certain formulations, the weight ratio of amphoteric surfactant to anionic surfactant can be about 3 : 1 to about 10: 1, such as about 4.5: 1 to about 9: 1, about 5: 1 to about 8: 1, and about 5 : 1 to about 6: 1.

[0033] Generally, the combination of both an amphoteric and an anionic surfactant can provide additive benefits such as foaming with pleasing skin feel; however, the weight ratio can also affect the stability and harshness of sanitizing compositions. One aspect of sanitizing compositions formulated according to the disclosure includes compositions having lower anionic surfactant concentrations that can still achieve fast sanitizing efficacy while maintaining pleasing skin feel. Anionic surfactants such as sulfates are known to be harsh to skin especially for prolonged use. An advantage of sanitizing compositions disclosed herein is the ability to balance cleaning efficacy with pleasing sensorial feel by including both an amphoteric surfactant and an anionic surfactant in amounts where the weight ratio is about 1 : 1 to about 14: 1 (amphoteric surfactant: anionic surfactant.)

[0034] A further aspect of certain compositions formulated according to the disclosure can include a total surfactant concentration relative to the total weight of the sanitizing composition. For example, some compositions may include less than about 10% total surfactant (anionic surfactant + amphoteric surfactant.) For instance, Table 1 includes several example formulations of which Example 3 includes an anionic surfactant, sodium laureth sulfate 2eo = 0.7 wt%, and amphoteric surfactants: cocoamidopropyl betaine = 0.9; cl2 amine oxide = 1.44; cl4 amine oxide = 1.44. In total, the weight percentage of total surfactant for Example 3 is about 4.48% total surfactant. Due to the lower surfactant amounts and usage of lower amounts of anionic surfactant, an advantage of certain sanitizing compositions formulated according to the disclosure can include low hazard formulations that do not require the label corrosive to the skin or eyes. Additionally, certain formulations may display low or no irritation to skin and/or mucous membranes. In some of the formulations, the sanitizing compositions can include less than about 7.5% total surfactant. In certain formulations, that sanitizing compositions can include less than about 5.0% total surfactant.

[0035] In certain sanitizing compositions formulated in accordance with the disclosure, a humectant (e.g., glycerol) may also be included in the sanitizing composition. In an example, the humectant can be present at a concentration of about 3% to about 7% by weight. In another example, the humectant can be present at a concentration of about 4% to about 6% by weight. In a further example, the humectant can be present at a concentration of about 4.2% to about 5.5% by weight.

[0036] A chelating agent (e.g., methylglycinediacetic acid or a salt thereof) may also be included in a sanitizing composition formulated in accordance with the disclosure. As an example, the chelating agent can be present at a concentration of about 0.01% to about 0.1%. In another example, the chelating agent can be present at a concentration of about 0.03% to about 0.08%. In a further example, the chelating agent can be present at a concentration of about 0.04% to about 0.06%. Several non-limiting examples of chelating agents that can be used to formulate sanitizing compositions in accordance with the disclosure include: methyleneglycine diacetic acid, ethylene diamine tetraacetic acid, glutamic acid diacetic acid, or ethylene diamine disuccinic acid.

[0037] In accordance with the disclosure, some formulations may further include a fragrance such as an essential oil. Generally, a fragrance can be any compound or combinations of compounds that produce an odor that can be detected by a person. For some formulations, the fragrance can be synthetically derived (i.e., produced through chemical synthesis rather than obtained from a living organism.) In other formulations, the fragrance can be naturally derived (e.g., by extraction of the fragrance from a plant.) Several non-limiting examples of fragrances (natural or synthetic) that can be used to formulate sanitizing compositions in accordance with the disclosure include: vanilla, lemon, lavender, cedar, cardamom, cinnamon, sage, rose and rosemary.

[0038] In accordance with the disclosure, some formulations may also include a product appearance modifier. Aspects of the product appearance modifier can include adjusting the color, luster, and/or opacity of the sanitizing composition. For example, a sanitizing composition formulated in accordance with the disclosure can include at least one product appearance modifier such as a pearliser. An example pearliser may contains one or more fatty esters of ethylene glycol. Additionally, or alternatively, the pearliser can contain one or more coated micas.

EXAMPLE 1

[0039] Example 1 discusses various methods and procedures and provides exemplary formulations and attributes of the formulations that may be understood in conjunction with the Description provided herein.

PROCEDURES

Viscosity Measurement

[0040] Viscosity was assessed by measuring the viscosity of freshly-made product using a Brookfield LV viscometer, spindle 62, lOrpm at a temperature of 20 °C. In general, products demonstrating a viscosity of at least 200cps display desirable characteristics for use as a disinfection soap that can be delivered through a liquid pump. Products demonstrating a viscosity below lOOcps were deemed less desirable for applications using a non-foaming dispenser; being too thin to be held between the fingers during product use. Products demonstrating a viscosity between lOOcps and 200cps are intermediate, being thinner than would ideally be desired for some non-foaming dispensers, but still being useable.

Chemical Stability

[0041] Chemical stability was assessed by measuring hydrogen peroxide content using a standard ceric sulfate titration method; see for example: https:/7www.solvay.us/en/¾inaries/H202 Determin by Ceric Suifate-236750.pdf. The stability criterion applied was that the level of hydrogen peroxide in the product should fall by less than 10% in a stipulated period of time, which is temperature-dependent. At a storage temperature of 54C, the stability criterion must be met after 2 weeks’ storage. At 40C, the stability criterion must be met after 3 months’ storage. If more than 10% of the hydrogen peroxide incorporated into the formulation was lost during the designated storage period, the formulation was deemed to have failed on the grounds of unacceptable chemical stability. If approximately 10% of the hydrogen peroxide incorporated into the formulation was lost during the designated storage period, the formulation was deemed to have marginal chemical stability. If less than 10% of the hydrogen peroxide incorporated into the formulation was lost during the designated storage period, the formulation was deemed to be chemically stable.

Physical Stability

[0042] Physical stability was assessed by visual assessment after storage at a range of temperatures (5 °C, ambient, 40 °C, 54 °C). Generally, the criterion for acceptable physical stability was no gross separation of product and no significant loss of transparency.

EN13727 Suspension test

[0043] The product was evaluated using the European norm ΈN13727:2013+A1 :2015 - Chemical disinfectants and antiseptics. Quantitative suspension test for the evaluation of bactericidal activity in the medical area. Test method and requirements (phase 2, step 1)’ protocol. (Link:

[0044] Generally the protcol entailed preparing a 1ml stock solution organism to a known population value. To this stock solution a 1ml aliquote of simulated soil (3 g/1 Bovine serum albumin + 3 g/1 Erythrocytes) is added and the solution mixed. To this, 8 ml of test product is added and a timer started. After achieving the target contact time 1ml of the product is taken and neutralised, following neutralisation the remaining organisms are enumerated.

[0045] In order to calculate the log reduction, the following equation was used, Eq. 1 : [0046] A - B = C Eq. 1

[0047] where,

[0048] A = log cfu/ml organism stock;

[0049] B = log cfu/ml remaining after test; and

[0050] C = total log reduction.

EN1499 Suspension test

[0051] The product was also evaluated using the European norm ΈN1499:2013 - Chemical disinfectants and antiseptics. Hygienic handwash. Test method and requirements (phase 2/step 2)’ (Link: https://shop.bsi group. com/Produ

RESULTS

[0052] Results provided demonstrate example compositions and aspects of the compositions. These results are provided as examples of compositions formulated according to the disclosure as well as compositions formulated not according to the disclosure. Generally, compositions formulated according to the disclosure include a weight ratio of amphoteric to anionic surfactant of about 3: 1 to about 10: 1 (see Table 1) and display appropriate chemical and physical stability (see Table 2.)

Formulations

[0053] Table 1 provides several example formulations prepared in accordance with the disclosure. Each of the formulations of table 1 has a composition that includes an amount of the ingredient on the left expressed as a percentage based on the total weight of the composition.

Table 1. Example formulations.

Ingredient Example 1 Example 2 Example 3 Example 4 Example 5

(% by weight) (not according (not according (according to (not according (not according to disclosure) to disclosure) disclosure) to disclosure) to disclosure)

Cocoamidopropyl

betaine (b) 2.25 0.9 0.9 0.9 1.125 C12 amine oxide

(c) 2.7 2.7 1.44 2.22 0.90

C14 amine oxide

(d) 2.7 2.7 1.44 0.90

Hydrogen

peroxide 2.0 2.0 2.0 2.0 2.0

Lactic acid

5.0 1.84 1.16 1.16 1.84

2-phenoxyethanol

1.0 1.0 1.0 1.0 1.0

Glycerol

5.0 5.0 5.0 5.0 5.0

PEG120 methyl

glucose trioleate

and propanediol 2.0 1.0 1.0 1.0 1.25

(e)

MGDA (f)

0.04 0.04

pH 3.3 4.1 4.0 4.1 4.0

Amphoteric:

11:1 9:1 5.4:1 4.5:1 3.2:1 anionic ratio

(a) Available from Sasol under the tradename Marlinat 242/70

(b) Available from BASF under the tradename Dehyton PK45

(c) Available from Lonza under the tradename Barlox 12

(d) Available from Lonza under the tradename Barlox 14

(e) Available from Lubrizol under the tradename Glucamate VLT

(f) Available from BASF under the tradename Trilon M

Stability Characterization

[0054] Table 2 provides characterization for the example formulations tested in accordance with the disclosure for viscosity, chemical stability and physical stability. Product viscosity for Examples 1-5 was determined in accordance with the viscosity measurement section of the Procedures as disclosed herein.

Table 2. Characterization of Example formulations.

Stability Example 1 Example 2 Example 3 Example 4 Example 5

Attributes (not according (not according (according to (not according (not according to disclosure) to disclosure) disclosure) to disclosure) to disclosure)

Viscosity- 90 cps 120 cps 250 cps 200 cps 250 cps build Chemical Fails at 40 °C at Fails at 40 °C at Stable - less than

stability 1 month. 3 months. 10% reduction in

Fails at Marginal at 54 hydrogen peroxide

54 °C at 2 °C at 2 weeks. level after 2 weeks

weeks. at 54 °C and after

3 months at 40c

Physical slight cloudiness slight cloudiness Stable becomes cloudy separates into 2 stability at 5°C at 5 °C then separates layers

Efficacy Characterization

[0055] Table 3 provides characterization for the formulation of Example 3, as implemented using test protocols: EN13727:2013+A1 :2015 and EN1499:2013. Note that as used herein, Dirty Medical conditions refers to the inclusion of interfering substance(s) (e.g., 3 g/1 Bovine serum albumin + 3 g/1 Erythrocytes) as described in the EN13727 Suspension test section of the Procedures as disclosed herein.

Table 3. Antimicrobial performance of Example 3 formulation.

Claims

CLAIMS:

1. A disinfection product comprising:

hydrogen peroxide;

at least one aromatic alcohol;

at least one acyclic organic acid; and

a blend of at least one amphoteric surfactant and at least one anionic surfactant, the blend having a weight ratio of amphoteric surfactant to anionic surfactant of about 3 : 1 to about 10: 1, wherein

the disinfection product is essentially free of cyclic organic acids.

2. The disinfection product of claim 1, wherein anti -bacterial efficacy is achieved in about 30 seconds or less contact time according to European standard testing protocol EN1499.

3. The disinfection product of any one of the preceding claims, wherein anti -bacterial

efficacy is achieved in about 15 seconds or less contact time according to European standard testing protocol EN1499.

4. The disinfection product of any one of the preceding claims, wherein the disinfection product is essentially free of a phosphorus-containing compound.

5. The disinfection product of any one of the preceding claims, wherein the disinfection product is essentially free of: biocidal quaternary ammonium compounds that contain a sole ionisable group, and wherein the sole ionizable group is one or more quaternary nitrogen atoms.

6. The disinfection product of any one of the preceding claims, wherein the disinfection product is essentially free of lower (C1-C5) monohydroxyl alcohols and/or diols.

7. The disinfection product of any one of the preceding claims having a formulation pH, wherein the formulation pH is about pH 3 to about pH 5.

8. The disinfection product of any one of the preceding claims, wherein the at least one aromatic alcohol comprises phenoxy ethanol.

9. The disinfection product of any one of the preceding claims, wherein the at least one acyclic organic acid comprises lactic acid.

10. The disinfection product of any one of the preceding claims, wherein the amphoteric surfactant comprises at least one amine oxide.

11. The disinfection product of claim 10, wherein the amphoteric surfactant comprises a mixture of C10-C16 amine oxides and C10-C16 amidopropylbetaines.

12. The disinfection product of any one of the preceding claims, wherein the anionic

surfactant comprises an alkyl sulfate or an alkyl ether sulfate.

13. The disinfection product of any one of the preceding claims, wherein the anionic

surfactant comprises an alkyl ether sulfate with average degree of ethoxylation in the range 1-3.

14. The disinfection product of any one of the preceding claims, further comprising at least one chelating agent.

15. The disinfection product of claim 14, wherein the at least one chelating agent comprises one of more of methyleneglycine diacetic acid, ethylene diamine tetraacetic acid, glutamic acid diacetic acid or ethylene diamine disuccinic acid.

16. The disinfection product of any one of the preceding claims, further comprising a

fragrance.

17. The disinfection product of any one of the preceding claims, further comprising at least one thickener.

18. The disinfection product of claim 17, wherein the at least one thickener comprises at least one esterified ethoxylated methyl glucose ether.

19. The disinfection product of any one of the preceding claims, further comprising at least one product appearance modifier.

20. The disinfection product of claim 19, wherein the at least one product appearance

modifier is a pearliser comprising one or more fatty esters of ethylene glycol.

21. The disinfection product of one of claims 19-20, wherein the at least one product

appearance modifier comprises one or more coated micas.

22. The disinfection product of any one of the preceding claims, further comprising at least one humectant.

23. The disinfection product of claim 22, wherein the at least one humectant comprises

glycerol.

24. The disinfection product of any one of the preceding claims, wherein the blend of at least one amphoteric surfactant and at least one anionic surfactant comprises less than about 10 wt% of the disinfection product.

25. The disinfection product of any one of the preceding claims, wherein the disinfection product provides sanitizing efficacy to a portion of a human body.

26. The disinfection product of claim 25, wherein the portion of the human body comprises a hand.

27. The disinfection product of any one of the preceding claims, wherein the disinfection product has a viscosity of greater than or equal to about 200 cps.

28. A disinfection product comprising:

hydrogen peroxide;

at least one aromatic alcohol;

at least one acyclic organic acid; and

anti -bacterial efficacy is achieved in about 15 seconds or less contact time according to European standard testing protocol EN1499.