US20030206881A1 - Phospholipidic composition as well as the use thereof - Google Patents
Phospholipidic composition as well as the use thereof Download PDFInfo
- Publication number
- US20030206881A1 US20030206881A1 US09/871,589 US87158901A US2003206881A1 US 20030206881 A1 US20030206881 A1 US 20030206881A1 US 87158901 A US87158901 A US 87158901A US 2003206881 A1 US2003206881 A1 US 2003206881A1
- Authority
- US
- United States
- Prior art keywords
- weight
- composition according
- phospholipidic
- glycerophosphatidylcholine
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
Definitions
- the present invention relates to a phospholipidic composition having the features of the generic part of patent claim 1 and use of such a phospholipidic composition,
- Phospholipid compositions with a concentration of more than 10% by weight L- ⁇ -glycerophosphatidylcholine, preferably with a glycerophosphatidylcholine concentration of approximately 30% by weight or More are known. These phospholipidic compositions are used as effective and valuable ingredients in pharmaceutical products, cosmetic preparations as well as dietary preparations because of their glycerophosphatidylcholine content.
- glycerophosphatidylcholine is strongly hygroscopic, so that such compositions are very difficult to handle, especially when the glycerophosphatidylcholine concentration is high, and thus storage and accurate metered addition are difficult accordingly.
- glycerophosphatidylcholine or the corresponding phospholipidic composition containing glycerophosphatidylcholine may be granulated using a binder, so that this binder provides the glycerophosphatidylcholine particles with an outer coating which prevents water from gaining access to the glycerophosphatidylcholine, so that the corresponding hygroscopic properties of these phospholipidic composition are reduced.
- Such a granulation method is very time-consuming and energy-intensive, especially since the binder, which later forms the coating around the glycerophosphatidylcholine, is added during granulation in the form of a dilute solution. Due to the fact that overmoistening during application of the coating leads to collapse of the granular structure, the binder solution must be added slowly and cautiously, while the solvent is removed continuously at the same time.
- glycerophosphatidyl solutions may be sprayed onto a sorbent carrier, said carrier having only a limited uptake capacity for glycerophosphatidylcholine without the carrier thus loaded with glycerophosphatidylcholine becoming hygroscopic itself.
- the hygroscopic glycerophosphatidylcholine may be bound to a matrix by spray drying, in which case the substances forming the matrix are usually water soluble, so the expenditure of energy required to accomplish this is especially high, and the glycerophosphatidylcholine composition prepared in this way has only a limited glycerophosphatidylcholine concentration.
- the object of the present invention is to make available a phospholipidic composition which contains glycerophosphatidylcholine and whose hygroscopic properties are decreased to such an extent that such a phospholipidic composition can be processed satisfactorily, in particular even at a high glycerophosphatidylcholine concentration,
- the phospholipidic composition according to this invention has a minimum glycerophosphatidylcholine concentration of at least 10% by weight, where the composition according to this invention is granular and also contains, in addition to the glycerophosphatidylcholine, a granulation aid selected from the group comprising a monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof.
- the phospholipidic composition according to this invention in which the glycerophosphatidylcholine concentration amounts to at least 10% by weight, preferably at least 30% by weight and especially up to 80% by weight glycerophosphatidylcholine, differs from the state of the art cited in the preamble in that the composition according to this invention is not in the form of hygroscopic granules, and the granules are also mixed with at least one granulation aid selected from the group consisting of a monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof.
- the specific granulation aids mentioned above (monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof) which is provided in the phospholipidic composition according to this invention in addition to the at least one glycerophosphatidylcholine especially effectively and this invention in addition to the at least one glycerophosphatidylcholine especially effectively and permanently suppresses the hygroscopic properties of the granulated phospholipidic composition, especially when the composition according to this invention has a high glycerophosphatidylcholine concentration.
- composition according to this invention when using the composition according to this invention, it is not necessary to use flow regulating substances such as those that are always required with the known phospholipidic compositions containing glycerophosphatidylcholine. Due to the fact that in the best case the composition according to this invention has a high concentration of glycerophosphatidylcholine and contains only a small amount of granulation aid, the composition according to this invention can be processed especially well into a variety of consecutive products, because the additives which might cause problems in such products are present only in low concentrations.
- composition according to this invention is further reinforced in the composition according to this invention by the fact that the products (monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof) which are present as granulation aids in the composition according to this invention have been approved worldwide, including the United States of America, according to both type and amount for use in pharmaceutical products, cosmetic preparations and food applications, and specifically also for dietetic products, whereas this is often not the case with the substances mentioned at the beginning which are present in the known phospholipidic compositions to suppress the hygroscopic properties of glycerophosphatidylcholine.
- the granulated phospholipidic composition according to this invention can be formulated without any additional complicated process steps to yield end products that are stable in storage, in particular granules, hard capsules or tablets.
- another advantage is that the production process for the phospholipidic composition according to this invention is especially simple and thus can also be carried out inexpensively and is not susceptible to problems, because in the simplest case, the components of the phospholipidic composition here can be mixed dry in a suitable mixer to form a powder mixture, after which a granulation liquid is added, preferably a low monohydric alcohol, and the moist granules thus produced then need only be dried, whereupon the granulation liquid may optionally be recovered.
- a granulation liquid preferably a low monohydric alcohol
- the concentration of the granulation aid present in the composition according to this invention depends on the concentration of glycerophosphatidylcholine in the respective preparation and in particular it also depends on which hygroscopic properties the phospholipidic composition may have in this regard.
- composition according to this invention it is desirable for the composition according to this invention to have little or no hygroscopic property, so high concentrations of granulation aids are provided especially when the concentration of glycerophosphatidylcholine is high, so that between 2% by weight and 50% by weight granulation aid is provided accordingly for such compositions in which the concentration of glycerophosphatidylcholine is varied between 50% by weight and 98% by weight.
- Such compositions then have no hygroscopic properties at all, so that a free-flowing phospholipidic granular product is made available which can be processed satisfactorily without lumping and can also be stored without requiring any special safety measures.
- the composition according to this invention preferably contains the granulation aid in a minimum concentration of 2% by weight and especially between 2% by weight and 50% by weight, and it has surprisingly been found that granulation aid concentrations between 10% by weight and 30% by weight are especially suitable.
- Such granulation aid concentrations i.e., concentrations between 10% by weight and 30% by weight in particular, ensure that in further processing of the granulated phospholipidic composition according to this invention to follow-up (consecutive) products, especially for use in the food industry or in the pharmaceutical industry, not too much granulation aid is present, and might yield adverse reactions with other components or active ingredients
- An especially suitable embodiment of the phospholipidic composition according to this invention provides for the granules to have a particle size between 0.063 mm and 5 mm, preferably between 1.2 mm and 3 mm, and if such a particle size is maintained, the composition according to this invention can be metered in an especially simple and reproducible manner when it is being processed to follow-up products.
- an embodiment of a composition according to this invention provides that the composition also contains cellulose and/or silicon dioxide in addition to glycerophosphatidylcholine and the granulation aids mentioned above.
- the cellulose concentration in the inventive composition preferably varies between 0.5% by weight and 30% by weight, especially between 5% by weight and 20% by weight.
- the cellulose used preferably has an average particle size between 60 ⁇ m and 150 ⁇ m, preferably between 90 ⁇ m and 120 ⁇ m.
- Such a powdered cellulose having the particle size defined above ensures in particular that a free-flowing granular product is obtained in the granulation which is required to produce the composition according to this invention, and that the granules will remain permanently hygroscopic and can be processed without the use of flow control agents.
- the phospholipidic composition also contains silicon dioxide, the concentration of this silicon dioxide in the composition varying between 0.5% by weight and 3% by weight, preferably between 1% by weight and 2% by weight.
- this silicon dioxide in the composition results in the production of relatively hard granules which thus have a low dust burden, and the properties of such granules are not altered even in the case of storage under extreme atmospheric humidity.
- the granulated phospholipidic composition according to this invention contains the silicon dioxide described above in the concentrations mentioned above in a particle size which is preferably between 5 nm and 25 nm, especially between 10 nm and 20 nm, the properties with regard to the hardness and freedom from dust of such a composition are especially permanent, so that such a composition can be obtained very easily and simply even when the glycerophosphatidylcholine concentration is high.
- the composition according to this invention contains a granulation aid, preferably a calcium salt of phosphoric acid and in particular tricalcium phosphate as the granulation aid.
- the granulated phospholipidic composition according to this invention contains tricalcium phosphate as the granulation aid, containing less than 10% by weight monocalcium phosphate and/or less than 10% by weight dicalcium phosphate, each based on the total amount of tricalcium phosphate, such a composition has extremely low hygroscopic properties so that it has an unlimited stability in storage without the risk of lumping of the granules in an undesirable manner due to uptake of moisture.
- the phospholipidic composition according to this invention is free of the usual binders in particular, because due to the presence of the minimum of one granulation aid which is present in the composition according to this invention, its properties, in particular the hygroscopic properties, are influenced in a positive sense to such an extent that the hygroscopic properties of the glycerophosphatidylcholine are completely or almost completely suppressed by a phospholipidic composition having such a formulation.
- the composition according to this invention preferably has a relatively high concentration of glycerophosphatidylcholine, and in particular the glycerophosphatidylcholine concentration in the composition according to this invention is greater than 70% by weight and preferably varies between 80% by weight and 95% by weight.
- this invention thus makes available a phospholipidic composition having a high glycerophosphatidylcholine concentration, whereby surprisingly due to the use of low concentrations of the above-mentioned special granulation aids, the hygroscopic properties of the glycerophosphatidylcholine are effectively and permanently suppressed, thus making available free-flowing compositions which can thus be metered reproducibly and are suitable for use in pharmaceutical preparations, food preparations and cosmetic preparations in particular or for the production of derivatives of glycerophosphatidylcholine.
- composition to contain:
- the phospholipidic composition according to this invention it is desirable for the phospholipidic composition according to this invention to be in the form of a hard product which has a high glycerophosphatidylcholine content and is easy to process, can be used in a variety of ways, so another special embodiment of the composition according to this invention has a formulation comprising:
- Such a composition is free-flowing even without the use of other additives and can be metered in a reproducible manner, in particular by weighing, so that it can be used to produce a variety of end products in the cosmetic, pharmaceutical or food industries.
- Glycerophosphatidylcholine in the present description refers in particular to L- ⁇ -glycerophosphatidylcholine which is also referred to as (R)-1,2-glycero-3-phosphatidylcholine.
- glycerophosphatidylcholine as used here also includes derivatives of glycerophosphatidylcholine, n particular the ethers and esters of glycerophosphatidylcholine, in particular in so far as these derivatives are hygroscopic.
- the granulated phospholipidic composition according to this invention contains in particular an L- ⁇ -glycerophosphatidylcholine which is derived from a vegetable source and is isolated from soybeans in particular.
- the phospholipidic composition according to this invention can be used in particular in foods, cosmetics or pharmaceutical products. Due to the fact that the phospholipidic composition according to this invention is in the form of a relatively stable granular product which has a high hardness and low dust burden while on the other hand having little or no hygroscopic property, the phospholipidic composition according to this invention can be metered in an especially reproducible and dust-free manner and it has an extremely great stability in storage, so that even when stored in relatively high atmospheric humidity, there is little or no increase in weight and no lumping, which is also regarded as another special advantage of the composition according to this invention.
- composition according to this invention has the above-mentioned ingredients as granulation aids which are approved internationally in terms of both type and quantity for use in foods, pharmaceutical products and cosmetic products, there are no problems in using the composition according to this invention for the production of pharmaceutical or cosmetic preparations or for the production of dietary products, foods and/or food supplements, so that the composition according to this invention can be used in a variety of ways.
- composition according to this invention is explained in greater detail below on several embodiments.
- Example 5 is used only for the sake of comparison because it does not contain any granulation aid based on tricalcium phosphate.
- TABLE 1 Example Ingredients 1 2 3 4 5 in % by weight Glycerophosphatidylcholine 50 60 70 90 90 Cellulose 25 25 15 2 5 Tricalcium phosphate 18 10 10 6 — Silicon dioxide 7 5 5 2 5
- Glycerophosphatidylcholine in Table 1 is L- ⁇ -glycerophosphatidylcholine isolated from soybeans, purity at least 95% by weight glycerophosphatidylcholine, melting point 230-245° C.
- Cellulose in Table 1 is microcrystalline, purified and partially depolymerized cellulose with an average particle size of 100 ⁇ m.
- Tricalcium phosphate in Table 1 is a tricalcium phosphate containing a maximum of 10% by weight monocalcium phosphate and a maximum of 10% by weight dicalcium phosphate.
- Silicon dioxide in Table 1 is a highly dispersed silicon dioxide with an average particle size of 15 nm and a surface area of 200 m 2 /g.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/871,589 US20030206881A1 (en) | 2001-05-31 | 2001-05-31 | Phospholipidic composition as well as the use thereof |
DE10221863A DE10221863A1 (de) | 2001-05-31 | 2002-05-15 | Phospholipidische Zusammensetzung sowie deren Verwendung |
EP02010853A EP1262105A1 (de) | 2001-05-31 | 2002-05-15 | Phospholipidische Zusammensetzung sowie deren Verwendung |
JP2002155857A JP2002370969A (ja) | 2001-05-31 | 2002-05-29 | 燐脂質組成物とその使用法 |
MXPA02005317A MXPA02005317A (es) | 2001-05-31 | 2002-05-29 | Composicion de fosfolipido y uso de la misma. |
CA002388169A CA2388169A1 (en) | 2001-05-31 | 2002-05-30 | Phospholipid composition and use of same |
US10/614,585 US6797835B2 (en) | 2001-05-31 | 2003-07-07 | Phospholipid composition and use of same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/871,589 US20030206881A1 (en) | 2001-05-31 | 2001-05-31 | Phospholipidic composition as well as the use thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/614,585 Continuation US6797835B2 (en) | 2001-05-31 | 2003-07-07 | Phospholipid composition and use of same |
Publications (1)
Publication Number | Publication Date |
---|---|
US20030206881A1 true US20030206881A1 (en) | 2003-11-06 |
Family
ID=25357747
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/871,589 Abandoned US20030206881A1 (en) | 2001-05-31 | 2001-05-31 | Phospholipidic composition as well as the use thereof |
US10/614,585 Expired - Lifetime US6797835B2 (en) | 2001-05-31 | 2003-07-07 | Phospholipid composition and use of same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/614,585 Expired - Lifetime US6797835B2 (en) | 2001-05-31 | 2003-07-07 | Phospholipid composition and use of same |
Country Status (6)
Country | Link |
---|---|
US (2) | US20030206881A1 (es) |
EP (1) | EP1262105A1 (es) |
JP (1) | JP2002370969A (es) |
CA (1) | CA2388169A1 (es) |
DE (1) | DE10221863A1 (es) |
MX (1) | MXPA02005317A (es) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005048731A2 (en) * | 2003-11-17 | 2005-06-02 | Cargill, Incorporated | Lecithin-containing granular compositions and methods of their preparation |
WO2015059697A1 (en) * | 2013-10-21 | 2015-04-30 | Enzymotec Ltd. | Compositions comprising choline and derivatives thereof, uses thereof and processes for their preparation |
WO2016170388A1 (en) | 2015-04-21 | 2016-10-27 | Enzymotec Ltd. | Compositions comprising choline and derivatives thereof, uses thereof and processes for their preparation |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004038442A1 (de) * | 2004-08-07 | 2006-03-16 | Bioghurt Biogarde Gmbh & Co. Kg | Verfahren zur Herstellung nicht klebender Phospholipid-Granulate |
US8535750B2 (en) * | 2005-05-17 | 2013-09-17 | Cargill, Incorporated | Granular lecithins, granular lysolecithins, process for their production and compositions containing them |
US9468668B2 (en) * | 2011-08-11 | 2016-10-18 | Allergy Research Group, Llc | Flavored chewable lipid supplements for maintaining health and the treatment of acute and chronic disorders |
US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
US11253531B2 (en) | 2011-08-11 | 2022-02-22 | Nutritional Therapeutics, Inc. | Lipid supplements for reducing nerve action potentials |
US10117885B2 (en) | 2011-08-11 | 2018-11-06 | Allergy Research Group, Llc | Chewable lipid supplements for treating pain and fibromyalgia |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3920857A (en) * | 1974-10-21 | 1975-11-18 | Central Soya Co | Method of preparing a granular free-flowing lecithin product |
US4472437A (en) * | 1983-03-01 | 1984-09-18 | Warner-Lambert Company | Dicalcium phosphate as gum base filler |
US4762658A (en) * | 1986-10-08 | 1988-08-09 | Central Soya Company, Inc. | Method of tableting of de-oiled phosphatides (lecithin) |
DK0521398T3 (da) * | 1991-07-05 | 1999-07-05 | Rhone Poulenc Rorer Gmbh | Phospholipidsammensætning |
JPH08311086A (ja) * | 1995-05-12 | 1996-11-26 | Nippon Oil & Fats Co Ltd | リン脂質混合物の製造方法 |
DE19527965C2 (de) * | 1995-07-29 | 1999-08-19 | Rhone Poulenc Rorer Gmbh | Verfahren zur Herstellung einer pulverisierten und/oder granulierten phospholipidischen Zusammensetzung |
JP3611382B2 (ja) * | 1995-11-08 | 2005-01-19 | ミヨシ油脂株式会社 | レシチン含有粉末 |
-
2001
- 2001-05-31 US US09/871,589 patent/US20030206881A1/en not_active Abandoned
-
2002
- 2002-05-15 DE DE10221863A patent/DE10221863A1/de not_active Withdrawn
- 2002-05-15 EP EP02010853A patent/EP1262105A1/de not_active Withdrawn
- 2002-05-29 MX MXPA02005317A patent/MXPA02005317A/es unknown
- 2002-05-29 JP JP2002155857A patent/JP2002370969A/ja active Pending
- 2002-05-30 CA CA002388169A patent/CA2388169A1/en not_active Abandoned
-
2003
- 2003-07-07 US US10/614,585 patent/US6797835B2/en not_active Expired - Lifetime
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005048731A2 (en) * | 2003-11-17 | 2005-06-02 | Cargill, Incorporated | Lecithin-containing granular compositions and methods of their preparation |
WO2005048731A3 (en) * | 2003-11-17 | 2005-09-15 | Cargill Inc | Lecithin-containing granular compositions and methods of their preparation |
US20050214369A1 (en) * | 2003-11-17 | 2005-09-29 | Ko Myong K | Lecithin-containing granular compositions and methods of their preparation |
CN1882251B (zh) * | 2003-11-17 | 2011-09-28 | 嘉吉公司 | 含卵磷脂的粒状组合物及其制备方法 |
WO2015059697A1 (en) * | 2013-10-21 | 2015-04-30 | Enzymotec Ltd. | Compositions comprising choline and derivatives thereof, uses thereof and processes for their preparation |
CN105682481A (zh) * | 2013-10-21 | 2016-06-15 | 酶学技术有限公司 | 包含胆碱及其衍生物的组合物、其用途以及其制备方法 |
WO2016170388A1 (en) | 2015-04-21 | 2016-10-27 | Enzymotec Ltd. | Compositions comprising choline and derivatives thereof, uses thereof and processes for their preparation |
CN107529805A (zh) * | 2015-04-21 | 2018-01-02 | 酶学技术有限公司 | 包含胆碱及其衍生物的组合物,其制备方法和用途 |
Also Published As
Publication number | Publication date |
---|---|
US20040096512A1 (en) | 2004-05-20 |
JP2002370969A (ja) | 2002-12-24 |
MXPA02005317A (es) | 2002-12-09 |
CA2388169A1 (en) | 2002-11-30 |
EP1262105A1 (de) | 2002-12-04 |
US6797835B2 (en) | 2004-09-28 |
DE10221863A1 (de) | 2002-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: AMERICAN LECITHIN COMPANY, CONNECTICUT Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FUSSBROICH, PETER;GAREISS, JOHANNES;REEL/FRAME:012135/0201 Effective date: 20010711 |
|
AS | Assignment |
Owner name: AMERICAN LECITHIN COMPANY, CONNECTICUT Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FUSSBROICH, PETER;GAREISS, JOHANNES;REEL/FRAME:014272/0450 Effective date: 20010711 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |