UA98631C2 - Способ очистки (s)-n-метил-3-(1-нафтилокси)-3-( 2-тиенил)пропиламина гидрохлорида (дулоксетина) - Google Patents
Способ очистки (s)-n-метил-3-(1-нафтилокси)-3-( 2-тиенил)пропиламина гидрохлорида (дулоксетина)Info
- Publication number
- UA98631C2 UA98631C2 UAA200906998A UAA200906998A UA98631C2 UA 98631 C2 UA98631 C2 UA 98631C2 UA A200906998 A UAA200906998 A UA A200906998A UA A200906998 A UAA200906998 A UA A200906998A UA 98631 C2 UA98631 C2 UA 98631C2
- Authority
- UA
- Ukraine
- Prior art keywords
- naphtyloxy
- thienyl
- purification
- formula
- methy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 230000009466 transformation Effects 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Способ очистки (S)-N-метил-3-(1-нафтилокси)-3-(2-тиенил)пропиламина гидрохлорида формулы I, который включает(a) преобразование вещества формулы I в ее свободное основание под действием органического или неорганического основания в водной среде; и(b) преобразование основания вещества формулы I в кристаллический гидрохлорид под действием хлороводородной кислоты или газообразной Hcl в органическом растворителе или смеси органических растворителей.Способ очиски (S)-N-метил-3-(1-нафтилокси)-3-(2-тиенил)пропиламина гидрохлорида формулы I, который включает растворение этого вещества в минимальном количестве метанола, который содержит от 0 до 50 % воды, и ее преобразование назад в твердую фазу (осаждение) путем добавления менее полярного растворителя.(I)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20060773A CZ300116B6 (cs) | 2006-12-05 | 2006-12-05 | Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
Publications (1)
Publication Number | Publication Date |
---|---|
UA98631C2 true UA98631C2 (ru) | 2012-06-11 |
Family
ID=39366525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200906998A UA98631C2 (ru) | 2006-12-05 | 2007-12-05 | Способ очистки (s)-n-метил-3-(1-нафтилокси)-3-( 2-тиенил)пропиламина гидрохлорида (дулоксетина) |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100069649A1 (ru) |
EP (1) | EP2089375B1 (ru) |
CZ (1) | CZ300116B6 (ru) |
EA (1) | EA017168B1 (ru) |
UA (1) | UA98631C2 (ru) |
WO (1) | WO2008067781A2 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4177C1 (ru) * | 2011-01-14 | 2013-02-28 | Национальный Центр Общественного Здоровья Министерства Здравоохранения Республики Молдова | Метод вакцинации против гепатита В лиц с иммунодефицитом |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110150942A1 (en) * | 2008-06-13 | 2011-06-23 | Natalija Zajc | Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives |
CZ304602B6 (cs) * | 2009-09-02 | 2014-07-30 | Zentiva, K. S. | Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu) |
JP2016222628A (ja) * | 2015-06-03 | 2016-12-28 | 株式会社トクヤマ | デュロキセチン塩酸塩の製造方法 |
CN113429380B (zh) * | 2021-07-14 | 2022-07-01 | 新发药业有限公司 | 一种度洛西汀的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL27173A (en) * | 1966-01-12 | 1972-08-30 | Sumitomo Chemical Co | 1-carboxylic acyl-3-indolyl alkanoic acid derivatives and method for their preparation |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
GB0410470D0 (en) * | 2004-05-11 | 2004-06-16 | Cipla Ltd | Pharmaceutical compound and polymorphs thereof |
CZ297555B6 (cs) * | 2004-10-26 | 2007-02-07 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu) |
WO2006099433A1 (en) * | 2005-03-14 | 2006-09-21 | Teva Pharmaceutical Industries Ltd. | Pure duloxetine hydrochloride |
-
2006
- 2006-12-05 CZ CZ20060773A patent/CZ300116B6/cs not_active IP Right Cessation
-
2007
- 2007-12-05 UA UAA200906998A patent/UA98631C2/ru unknown
- 2007-12-05 US US12/517,358 patent/US20100069649A1/en not_active Abandoned
- 2007-12-05 WO PCT/CZ2007/000109 patent/WO2008067781A2/en active Application Filing
- 2007-12-05 EA EA200900708A patent/EA017168B1/ru not_active IP Right Cessation
- 2007-12-05 EP EP07846243.9A patent/EP2089375B1/en active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4177C1 (ru) * | 2011-01-14 | 2013-02-28 | Национальный Центр Общественного Здоровья Министерства Здравоохранения Республики Молдова | Метод вакцинации против гепатита В лиц с иммунодефицитом |
Also Published As
Publication number | Publication date |
---|---|
EA200900708A1 (ru) | 2009-12-30 |
US20100069649A1 (en) | 2010-03-18 |
CZ2006773A3 (cs) | 2008-06-18 |
EP2089375A2 (en) | 2009-08-19 |
WO2008067781A3 (en) | 2008-07-24 |
CZ300116B6 (cs) | 2009-02-11 |
EP2089375B1 (en) | 2013-07-31 |
WO2008067781A2 (en) | 2008-06-12 |
WO2008067781B1 (en) | 2008-10-02 |
EA017168B1 (ru) | 2012-10-30 |
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