UA92730C2 - Аналоги бензазола и их применение - Google Patents

Аналоги бензазола и их применение

Info

Publication number
UA92730C2
UA92730C2 UAA200707229A UAA200707229A UA92730C2 UA 92730 C2 UA92730 C2 UA 92730C2 UA A200707229 A UAA200707229 A UA A200707229A UA A200707229 A UAA200707229 A UA A200707229A UA 92730 C2 UA92730 C2 UA 92730C2
Authority
UA
Ukraine
Prior art keywords
benzazole
analogues
substituents
salts
compounds
Prior art date
Application number
UAA200707229A
Other languages
English (en)
Ukrainian (uk)
Inventor
Томас Герц
Рольф Краусс
Майкл Куббутат
Мартін Ланг
Крістоф Шехтеле
Стефан Таслер
Франк Тотцке
Original Assignee
4Сц Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Сц Аг filed Critical 4Сц Аг
Publication of UA92730C2 publication Critical patent/UA92730C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение касается соединений за общими формулами (И), (Иа), (II) или их солей, или их физиологически функционирующих производных, в которых заместители Y присоединяются к 5-й или 6-й позиции бензазола. EMBED ISISServer , EMBED ISISServer , EMBED ISISServer .
UAA200707229A 2004-12-27 2005-12-22 Аналоги бензазола и их применение UA92730C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04030819A EP1674466A1 (en) 2004-12-27 2004-12-27 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
UA92730C2 true UA92730C2 (ru) 2010-12-10

Family

ID=34928006

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200707229A UA92730C2 (ru) 2004-12-27 2005-12-22 Аналоги бензазола и их применение

Country Status (15)

Country Link
EP (2) EP1674466A1 (ru)
JP (1) JP5302540B2 (ru)
CN (1) CN101090899B (ru)
AU (1) AU2005321517B2 (ru)
BR (1) BRPI0519479A2 (ru)
CA (1) CA2592509C (ru)
EA (1) EA013863B1 (ru)
IL (1) IL184266A (ru)
MX (1) MX2007007897A (ru)
NO (1) NO20073287L (ru)
NZ (1) NZ555303A (ru)
SG (1) SG178717A1 (ru)
UA (1) UA92730C2 (ru)
WO (1) WO2006069740A1 (ru)
ZA (1) ZA200704313B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1674467A1 (en) * 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
EP2152700B1 (en) 2007-05-21 2013-12-11 Novartis AG Csf-1r inhibitors, compositions, and methods of use
FR2922550B1 (fr) * 2007-10-19 2009-11-27 Sanofi Aventis Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
FR2933982A1 (fr) * 2008-07-18 2010-01-22 Sanofi Aventis Nouveaux derives imidazo°1,2-a!pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
FR2933981A1 (fr) * 2008-07-18 2010-01-22 Sanofi Aventis NOUVEAUX DERIVES IMIDAZO°1,2-a!PYRIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
FR2933980B1 (fr) * 2008-07-18 2011-07-29 Sanofi Aventis Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
WO2010010435A2 (en) * 2008-07-22 2010-01-28 Glenmark Pharmaceutical S.A. Fused oxazole and thiazole derivatives as trpms modulators
WO2011033094A1 (en) 2009-09-18 2011-03-24 4Sc Ag Schedule of administration of benzazole derivatives in the treatment of leukemias
PL2730564T3 (pl) 2010-11-19 2018-09-28 Ligand Pharmaceuticals Inc. Heterocykliczne aminy i ich zastosowania
WO2013174735A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted benzothienopyrimidines
TW201412740A (zh) * 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
KR20180088113A (ko) * 2017-01-26 2018-08-03 한미약품 주식회사 이미다조피리다진 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9900752D0 (en) * 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
US7238813B2 (en) * 2000-11-29 2007-07-03 Smithkline Beecham Corporation Chemical compounds
MXPA04008458A (es) * 2002-03-01 2004-12-06 Smithkline Beecham Corp Diamino pirimidinas y su uso como inhibidores de angiogenesis.
EA007987B1 (ru) * 2002-03-29 2007-02-27 Чирон Корпорейшн Замещённые бензазолы и их применение в качестве ингибиторов киназы raf
US7531553B2 (en) * 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
SI2392565T1 (sl) * 2003-09-26 2014-05-30 Exelixis, Inc. c-Met modulatorji in postopki uporabe
AU2005207946A1 (en) * 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer

Also Published As

Publication number Publication date
IL184266A0 (en) 2007-10-31
EP1674466A1 (en) 2006-06-28
CA2592509C (en) 2015-02-17
NO20073287L (no) 2007-09-25
JP5302540B2 (ja) 2013-10-02
CN101090899A (zh) 2007-12-19
EA200700997A1 (ru) 2007-12-28
NZ555303A (en) 2010-01-29
WO2006069740A1 (en) 2006-07-06
EA013863B1 (ru) 2010-08-30
ZA200704313B (en) 2008-11-26
AU2005321517A1 (en) 2006-07-06
EP1833823A1 (en) 2007-09-19
CN101090899B (zh) 2015-09-09
SG178717A1 (en) 2012-03-29
IL184266A (en) 2013-04-30
MX2007007897A (es) 2008-01-11
BRPI0519479A2 (pt) 2009-02-03
CA2592509A1 (en) 2006-07-06
AU2005321517B2 (en) 2011-09-29
JP2008525361A (ja) 2008-07-17

Similar Documents

Publication Publication Date Title
UA92730C2 (ru) Аналоги бензазола и их применение
NO2017019I2 (no) Enzalutamid eller et farmasøytisk akseptabelt salt derav
MY148429A (en) Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof
PT1940839E (pt) Inibidores de piridopirimidinona pi3k alfa
IL195256A0 (en) Compositions of r(+)and s(-)pramipexole and methods of using the same
EA200870193A1 (ru) Цитотоксические агенты, включающие новые производные томаймицина, и их терапевтическое применение
CR10381A (es) Uso de bifenilamidas de acido arilcarboxilico para el tratamiento de semillas
MX2007004699A (es) Derivados de indol y bencimidazol.
EA200802213A1 (ru) Способы лечения заболеваний крови
UA96785C2 (ru) Замещенные производные оксиндола и их применение как лигандов рецептора вазопрессина
TW200510325A (en) 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
WO2006100081A3 (de) Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
NO20085099L (no) Puritonderivativer som HM74A agonister
NZ552137A (en) New 4-benzylidene-piperidin derivatives
UA99485C2 (ru) Хиназолиндионовые производные, их получение и их применение в терапии
MX2007006387A (es) Derivados de piridina 3-substituidos como antagonistas h3.
UA96994C2 (ru) Производные 7-алкинил-1,8-нафтиридонов, способ их получения и их применения в терапии
UA96277C2 (en) Benzimidazole derivatives
GEP20115201B (en) Cinnamoyl-piperazine derivatives and their use as par- i antagonists
MX2007007027A (es) Derivados piperazinilpiridina como agentes anti-obesidad.
NO20084301L (no) Tetrahydronaftalenderivater, fremgangsmate for deres fremstilling og anvendelse derav som anti-inflammatoriske midler
MX2010001851A (es) Derivados de indol-2-ona disustituidos en 3, su preparacion y uso terapeutico.
SG151306A1 (en) Novel benzothiazoles and the use thereof as medicaments
MX2007004910A (es) Nuevos derivados de indol o benzimidazol.
TNSN08369A1 (en) Benzimidazole derivatives