UA87141C2 - Имидазольные разновидности как модуляторы рецептора гамк для лечения желудочно-кишечных расстройств - Google Patents

Имидазольные разновидности как модуляторы рецептора гамк для лечения желудочно-кишечных расстройств

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Publication number
UA87141C2
UA87141C2 UAA200613007A UAA200613007A UA87141C2 UA 87141 C2 UA87141 C2 UA 87141C2 UA A200613007 A UAA200613007 A UA A200613007A UA A200613007 A UAA200613007 A UA A200613007A UA 87141 C2 UA87141 C2 UA 87141C2
Authority
UA
Ukraine
Prior art keywords
treatment
disorders
modulators
gaba receptor
imidazole
Prior art date
Application number
UAA200613007A
Other languages
English (en)
Ukrainian (uk)
Inventor
Удо Бауер
Вейн Брелсфорд
Вияй Кгайлани
Брайан Эгнер
Ола Фельстрем
Линда Густафссон
Ян Матссон
Каролина Нильссон
Томас Ольссон
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA87141C2 publication Critical patent/UA87141C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Заявленное изобретение касается новых соединений, которые имеют действие положительного аллостерического модулятора рецептора ГАМК(РГВ), способов получения указанных соединений и их применение, как вариант, в комбинации с агонистом ГАМК, для ингибирования преходящей релаксации нижнего пищеводного сфинктера, для лечения болезни желудочно-пищеводный рефлюкс, а также для лечения функциональных желудочно-кишечных расстройств и синдрома раздраженного кишечника (СРК).
UAA200613007A 2004-06-24 2005-06-20 Имидазольные разновидности как модуляторы рецептора гамк для лечения желудочно-кишечных расстройств UA87141C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0401653A SE0401653D0 (sv) 2004-06-24 2004-06-24 New compounds

Publications (1)

Publication Number Publication Date
UA87141C2 true UA87141C2 (ru) 2009-06-25

Family

ID=32733683

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200613007A UA87141C2 (ru) 2004-06-24 2005-06-20 Имидазольные разновидности как модуляторы рецептора гамк для лечения желудочно-кишечных расстройств

Country Status (16)

Country Link
US (1) US7718686B2 (ru)
EP (1) EP1761531A1 (ru)
JP (1) JP2008503571A (ru)
CN (1) CN1972942A (ru)
AU (1) AU2005257706C1 (ru)
BR (1) BRPI0512517A (ru)
CA (1) CA2570619A1 (ru)
IL (1) IL179609A0 (ru)
MX (1) MXPA06015034A (ru)
NO (1) NO20070427L (ru)
NZ (1) NZ551968A (ru)
RU (1) RU2389722C2 (ru)
SE (1) SE0401653D0 (ru)
UA (1) UA87141C2 (ru)
WO (1) WO2006001750A1 (ru)
ZA (1) ZA200610429B (ru)

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SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
JP2009508905A (ja) * 2005-09-19 2009-03-05 エフ．ホフマン−ラ ロシュ アーゲー ＧＡＢＡＡα５逆アゴニストとしてのイソオキサゾロ誘導体
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
CA2632016A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Imidazole derivatives for the treatment of gastrointestinal disorders
AU2006327316A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Imidazoles as GABA-B receptor modulators
AU2006327314A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Pyrazoles for the treatment of GERD and IBS
EP1968947A1 (en) * 2005-12-23 2008-09-17 AstraZeneca AB Gaba-b receptor modulators
US20080312291A1 (en) * 2005-12-23 2008-12-18 Udo Bauer Heterocyclic Gaba-b Modulators
JP5491871B2 (ja) * 2007-02-28 2014-05-14 アドビナス セラピュティックス プライベート リミテッド グルコキナーゼ活性化因子としての２，２，２−三置換アセトアミド誘導体、その方法及び薬学的応用
US20080262064A1 (en) * 2007-04-18 2008-10-23 Astrazeneca Ab Novel Compounds For The Treatment Of GI Disorders 682
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
JP5855095B2 (ja) 2010-06-07 2016-02-09 ノボメディックス, エルエルシーNovomedix, Llc フラニル化合物およびその使用
AR086554A1 (es) 2011-05-27 2014-01-08 Novartis Ag Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina
AU2013255458A1 (en) 2012-05-03 2014-10-09 Novartis Ag L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists
TW201623257A (zh) 2014-05-09 2016-07-01 奧利安公司 藥理活性之喹唑啉二酮衍生物
JPWO2016208592A1 (ja) 2015-06-22 2018-04-05 大日本住友製薬株式会社 二環性複素環アミド誘導体
WO2016208591A1 (ja) 2015-06-22 2016-12-29 大日本住友製薬株式会社 １，４－ジ置換イミダゾール誘導体
US10898469B2 (en) 2016-02-26 2021-01-26 Sumitomo Dainippon Pharma Co., Ltd. Imidazolylamide derivative

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AU2006327314A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Pyrazoles for the treatment of GERD and IBS
AU2006327316A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Imidazoles as GABA-B receptor modulators
CA2632016A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Imidazole derivatives for the treatment of gastrointestinal disorders
EP1968947A1 (en) 2005-12-23 2008-09-17 AstraZeneca AB Gaba-b receptor modulators
US20080262064A1 (en) 2007-04-18 2008-10-23 Astrazeneca Ab Novel Compounds For The Treatment Of GI Disorders 682
US20090023704A1 (en) 2007-04-18 2009-01-22 Astrazeneca Ab Novel Compounds 737

Also Published As

Publication number Publication date
US20080269216A1 (en) 2008-10-30
EP1761531A1 (en) 2007-03-14
WO2006001750A1 (en) 2006-01-05
CA2570619A1 (en) 2006-01-05
ZA200610429B (en) 2008-09-25
AU2005257706A1 (en) 2006-01-05
AU2005257706B2 (en) 2008-08-21
BRPI0512517A (pt) 2008-03-11
MXPA06015034A (es) 2007-02-08
RU2006146871A (ru) 2008-07-27
NZ551968A (en) 2010-07-30
JP2008503571A (ja) 2008-02-07
SE0401653D0 (sv) 2004-06-24
RU2389722C2 (ru) 2010-05-20
AU2005257706C1 (en) 2009-01-29
IL179609A0 (en) 2007-05-15
CN1972942A (zh) 2007-05-30
NO20070427L (no) 2007-03-26
US7718686B2 (en) 2010-05-18

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