UA83549C2 - Тетрагідрохінолінони та їх застосування як антагоністів метаботропних глутаматних рецепторів - Google Patents
Тетрагідрохінолінони та їх застосування як антагоністів метаботропних глутаматних рецепторів Download PDFInfo
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- UA83549C2 UA83549C2 UAA200610294A UAA200610294A UA83549C2 UA 83549 C2 UA83549 C2 UA 83549C2 UA A200610294 A UAA200610294 A UA A200610294A UA A200610294 A UAA200610294 A UA A200610294A UA 83549 C2 UA83549 C2 UA 83549C2
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- Prior art keywords
- aai
- bzitezi
- aeiabev
- aeazavi
- abev
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C07D221/04—Ortho- or peri-condensed ring systems
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54878804P | 2004-02-27 | 2004-02-27 | |
| PCT/GB2005/000717 WO2005082856A2 (en) | 2004-02-27 | 2005-02-25 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA83549C2 true UA83549C2 (uk) | 2008-07-25 |
Family
ID=34911013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200610294A UA83549C2 (uk) | 2004-02-27 | 2005-02-25 | Тетрагідрохінолінони та їх застосування як антагоністів метаботропних глутаматних рецепторів |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7598384B2 (enExample) |
| EP (1) | EP1723116B1 (enExample) |
| JP (1) | JP4712027B2 (enExample) |
| KR (1) | KR100846347B1 (enExample) |
| CN (1) | CN1922146A (enExample) |
| AR (1) | AR049006A1 (enExample) |
| AT (1) | ATE409182T1 (enExample) |
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| WO2007023242A1 (en) * | 2005-08-24 | 2007-03-01 | Merz Pharma Gmbh & Co. Kgaa | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
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| AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| AU2006303037A1 (en) * | 2005-10-21 | 2007-04-26 | Merz Pharma Gmbh & Co Kgaa | Chromenones and their use as modulators of metabotropic glutamate receptors |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| AR057218A1 (es) * | 2005-12-15 | 2007-11-21 | Astra Ab | Compuestos de oxazolidinona y su uso como pontenciadores del receptor metabotropico de glutamato |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| BRPI0716604A2 (pt) | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2008061795A2 (en) | 2006-11-24 | 2008-05-29 | Ac Immune Sa | N- (methyl) -1h- pyrazol- 3 -amine, n- (methyl) -pyridin-2-amine and n- (methyl) -thiaz0l-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
| EP2367826A4 (en) * | 2008-11-06 | 2012-07-04 | Astrazeneca Ab | MODULATORS OF THE PROTEIN -AMYLOID |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| EP2311823A1 (en) * | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
| AU2010332811B2 (en) | 2009-12-18 | 2014-07-24 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric modulators of mGluR5 receptors |
| EP2513118B1 (en) | 2009-12-18 | 2013-09-18 | Janssen Pharmaceutica, N.V. | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
| GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
| WO2012052451A1 (en) | 2010-10-18 | 2012-04-26 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| BR112013011984A2 (pt) * | 2010-11-16 | 2016-08-30 | Ge Healthcare Ltd | composto, composição farmacêutica, e, métodos para fabricar um composto, para formação de imagem e para detectar agregados tau in vitro e/ou in vivo |
| WO2012139876A1 (en) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Enteric formulations of metabotropic glutamate receptor modulators |
| WO2014034898A1 (ja) * | 2012-08-30 | 2014-03-06 | 日本新薬株式会社 | ピリジン誘導体及び医薬 |
| AU2014211727B2 (en) | 2013-02-04 | 2018-07-26 | Prexton Therapeutics Sa | Positive allosteric modulators of mGluR3 |
| CN104513200B (zh) * | 2013-09-26 | 2017-05-03 | 江苏苏中药业集团股份有限公司 | 取代丁烯酰胺的马来酸盐及其晶型 |
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
| JP6684516B2 (ja) | 2015-05-15 | 2020-04-22 | オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited | Rorガンマ調節物質としての置換型テトラヒドロキノリン化合物 |
| SG11201803242TA (en) | 2015-10-29 | 2018-05-30 | Effector Therapeutics Inc | Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2 |
| WO2017087808A1 (en) | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
| WO2017189553A1 (en) * | 2016-04-25 | 2017-11-02 | Everon Biosciences, Inc. | Removal of senescence-associated macrophages |
| KR20190117013A (ko) | 2017-02-14 | 2019-10-15 | 이펙터 테라퓨틱스, 인크. | 피페리딘-치환된 Mnk 억제제 및 그와 관련된 방법 |
| BR112021007745A2 (pt) | 2018-10-24 | 2021-07-27 | Effector Therapeutics, Inc. | formas cristalinas de inibidores de mnk |
| GB2600384A (en) | 2020-09-30 | 2022-05-04 | Vaderis Therapeutics Ag | Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia |
| JP2025521593A (ja) * | 2022-06-23 | 2025-07-10 | ザ クリーヴランド クリニック ファウンデーション | 3βHSD1阻害剤及び組成物ならびにそれらの使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3501479A (en) * | 1967-05-19 | 1970-03-17 | American Cyanamid Co | Dihydroquinolines and substituted dihydroquinolines and method of preparing the same |
| DE2001572A1 (de) | 1970-01-15 | 1971-07-22 | Agfa Gevaert Ag | Spektral sensibilisiertes lichtempfindliches Material |
| DE2449030A1 (de) * | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
| WO1988002251A1 (en) | 1986-09-26 | 1988-04-07 | Ici Australia Operations Proprietary Limited | Sunscreen compositions and compounds for use therein |
| US5216164A (en) * | 1990-12-03 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds |
| US5110815A (en) * | 1990-12-03 | 1992-05-05 | Hoechst-Roussel Pharmaceuticals Inc. | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use |
| CA2316944A1 (en) * | 1998-02-20 | 1999-08-26 | Mitsuru Shiraishi | Aminoguanidinehydrazone derivative, production and use thereof |
| GB0003632D0 (en) * | 2000-02-16 | 2000-04-05 | Univ Hong Kong Science & Techn | Dimeric compounds |
| EE05195B1 (et) | 2000-10-02 | 2009-08-17 | Janssen Pharmaceutica N.V. | Kinoliini ja kinolinooni derivaadid glutamaatretseptori antagonistidena, nende saamine ja kasutamine ravimite valmistamiseks ning neid sisaldav farmatseutiline kompositsioon |
| CA2479109C (en) * | 2002-03-29 | 2011-08-02 | Janssen Pharmaceutica N.V. | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands |
-
2005
- 2005-02-24 TW TW094105679A patent/TWI301760B/zh not_active IP Right Cessation
- 2005-02-25 ES ES05717798T patent/ES2315853T3/es not_active Expired - Lifetime
- 2005-02-25 PL PL05717798T patent/PL1723116T3/pl unknown
- 2005-02-25 WO PCT/GB2005/000717 patent/WO2005082856A2/en not_active Ceased
- 2005-02-25 DK DK05717798T patent/DK1723116T3/da active
- 2005-02-25 US US11/066,899 patent/US7598384B2/en not_active Expired - Fee Related
- 2005-02-25 DE DE602005009929T patent/DE602005009929D1/de not_active Expired - Lifetime
- 2005-02-25 SI SI200530520T patent/SI1723116T1/sl unknown
- 2005-02-25 AU AU2005217199A patent/AU2005217199B2/en not_active Ceased
- 2005-02-25 AR ARP050100694A patent/AR049006A1/es unknown
- 2005-02-25 CA CA2556653A patent/CA2556653C/en not_active Expired - Fee Related
- 2005-02-25 BR BRPI0508225-0A patent/BRPI0508225A/pt not_active Application Discontinuation
- 2005-02-25 EA EA200601556A patent/EA010656B1/ru not_active IP Right Cessation
- 2005-02-25 KR KR1020067017249A patent/KR100846347B1/ko not_active Expired - Fee Related
- 2005-02-25 UA UAA200610294A patent/UA83549C2/uk unknown
- 2005-02-25 JP JP2007500295A patent/JP4712027B2/ja not_active Expired - Fee Related
- 2005-02-25 CN CNA2005800060497A patent/CN1922146A/zh active Pending
- 2005-02-25 UY UY28775A patent/UY28775A1/es unknown
- 2005-02-25 AT AT05717798T patent/ATE409182T1/de active
- 2005-02-25 PT PT05717798T patent/PT1723116E/pt unknown
- 2005-02-25 EP EP05717798A patent/EP1723116B1/en not_active Expired - Lifetime
-
2006
- 2006-08-11 ZA ZA200606686A patent/ZA200606686B/xx unknown
- 2006-08-16 IL IL177524A patent/IL177524A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005009929D1 (de) | 2008-11-06 |
| CA2556653A1 (en) | 2005-09-09 |
| CN1922146A (zh) | 2007-02-28 |
| EA200601556A1 (ru) | 2007-02-27 |
| BRPI0508225A (pt) | 2007-07-17 |
| AR049006A1 (es) | 2006-06-21 |
| AU2005217199B2 (en) | 2008-06-26 |
| ES2315853T3 (es) | 2009-04-01 |
| KR20070001975A (ko) | 2007-01-04 |
| CA2556653C (en) | 2011-08-16 |
| JP4712027B2 (ja) | 2011-06-29 |
| JP2007524710A (ja) | 2007-08-30 |
| EP1723116B1 (en) | 2008-09-24 |
| WO2005082856A3 (en) | 2005-11-24 |
| EP1723116A2 (en) | 2006-11-22 |
| TW200534857A (en) | 2005-11-01 |
| US20050197361A1 (en) | 2005-09-08 |
| ATE409182T1 (de) | 2008-10-15 |
| PL1723116T3 (pl) | 2009-04-30 |
| US7598384B2 (en) | 2009-10-06 |
| PT1723116E (pt) | 2009-01-02 |
| IL177524A0 (en) | 2006-12-10 |
| TWI301760B (en) | 2008-10-11 |
| EA010656B1 (ru) | 2008-10-30 |
| UY28775A1 (es) | 2005-04-29 |
| WO2005082856A2 (en) | 2005-09-09 |
| DK1723116T3 (da) | 2009-02-02 |
| AU2005217199A1 (en) | 2005-09-09 |
| SI1723116T1 (sl) | 2009-04-30 |
| IL177524A (en) | 2012-02-29 |
| KR100846347B1 (ko) | 2008-07-15 |
| ZA200606686B (en) | 2008-01-30 |
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