UA83510C2 - N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b - Google Patents

N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b Download PDF

Info

Publication number
UA83510C2
UA83510C2 UAA200605783A UAA200605783A UA83510C2 UA 83510 C2 UA83510 C2 UA 83510C2 UA A200605783 A UAA200605783 A UA A200605783A UA A200605783 A UAA200605783 A UA A200605783A UA 83510 C2 UA83510 C2 UA 83510C2
Authority
UA
Ukraine
Prior art keywords
aai
dar
bibiove
yair
spol
Prior art date
Application number
UAA200605783A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ливен Меерпоель
Марсель Виллевойе
Йоаннес Теодорус Мария Линдерс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA83510C2 publication Critical patent/UA83510C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
UAA200605783A 2003-12-09 2004-06-12 N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b UA83510C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03104601 2003-12-09
PCT/EP2004/053280 WO2005058824A2 (en) 2003-12-09 2004-12-06 N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprote in b

Publications (1)

Publication Number Publication Date
UA83510C2 true UA83510C2 (en) 2008-07-25

Family

ID=34684566

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200605783A UA83510C2 (en) 2003-12-09 2004-06-12 N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b

Country Status (19)

Country Link
US (1) US8772494B2 (ru)
EP (1) EP1694644B1 (ru)
JP (1) JP4790626B2 (ru)
KR (1) KR101125120B1 (ru)
CN (1) CN100548985C (ru)
AT (1) ATE548350T1 (ru)
AU (1) AU2004299295B2 (ru)
BR (1) BRPI0417469B8 (ru)
CA (1) CA2547243C (ru)
EA (1) EA009081B1 (ru)
ES (1) ES2383179T3 (ru)
HK (1) HK1100559A1 (ru)
IL (1) IL176171A (ru)
NO (1) NO337251B1 (ru)
NZ (1) NZ546964A (ru)
SG (1) SG149001A1 (ru)
UA (1) UA83510C2 (ru)
WO (1) WO2005058824A2 (ru)
ZA (1) ZA200604718B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1948629A1 (en) * 2005-10-31 2008-07-30 Janssen Pharmaceutica N.V. Substituted piperazines and piperidines as modulators of the neuropeptide y2 receptor
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
JP5198430B2 (ja) 2006-04-03 2013-05-15 サンタリス ファーマ アー/エス antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物
MY162210A (en) 2006-04-03 2017-05-31 Roche Innovation Ct Copenhagen As Pharmaceutical composition
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
JP2010521193A (ja) 2007-03-22 2010-06-24 サンタリス ファーマ アー/エス Apo−b100発現の阻害のためのrnaアンタゴニスト化合物
WO2008113832A2 (en) 2007-03-22 2008-09-25 Santaris Pharma A/S SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA
ES2463665T3 (es) 2007-10-04 2014-05-28 Stella Aps Tratamiento de combinación para el tratamiento de infección por virus de la hepatitis C
AU2009221064B2 (en) 2008-03-07 2014-12-11 Roche Innovation Center Copenhagen A/S Pharmaceutical compositions for treatment of microRNA related diseases
EP2315832B1 (en) 2008-08-01 2015-04-08 Roche Innovation Center Copenhagen A/S Micro-rna mediated modulation of colony stimulating factors
ES2599979T3 (es) 2009-04-24 2017-02-06 Roche Innovation Center Copenhagen A/S Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón
WO2011009697A1 (en) 2009-07-21 2011-01-27 Santaris Pharma A/S Antisense oligomers targeting pcsk9
RS59986B1 (sr) 2013-06-27 2020-03-31 Roche Innovation Ct Copenhagen As Antisens oligomeri i konjugati koji ciljno deluju na pcsk9

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9826412D0 (en) * 1998-12-03 1999-01-27 Glaxo Group Ltd Chemical compounds
GB0013383D0 (en) * 2000-06-01 2000-07-26 Glaxo Group Ltd Therapeutic benzamide derivatives
GB0013378D0 (en) * 2000-06-01 2000-07-26 Glaxo Group Ltd Use of therapeutic benzamide derivatives
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2390B1 (en) 2001-04-06 2007-06-17 شركة جانسين فارماسوتيكا ان. في Diphenylcarboxamides act as lipid-lowering agents
GB0109287D0 (en) * 2001-04-12 2001-05-30 Glaxo Group Ltd Therapeutic benzamide derivatives
GB0129015D0 (en) * 2001-12-04 2002-01-23 Glaxo Group Ltd Compounds
UA79300C2 (en) * 2002-08-12 2007-06-11 Janssen Pharmaceutica Nv N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion

Also Published As

Publication number Publication date
WO2005058824A2 (en) 2005-06-30
JP2007513921A (ja) 2007-05-31
AU2004299295B2 (en) 2010-07-15
ZA200604718B (en) 2007-10-31
JP4790626B2 (ja) 2011-10-12
EP1694644B1 (en) 2012-03-07
ATE548350T1 (de) 2012-03-15
IL176171A (en) 2013-08-29
CN100548985C (zh) 2009-10-14
BRPI0417469B8 (pt) 2021-05-25
NO337251B1 (no) 2016-02-22
NO20063103L (no) 2006-09-05
KR20060111628A (ko) 2006-10-27
WO2005058824A3 (en) 2005-10-27
US20070099934A1 (en) 2007-05-03
CN1890217A (zh) 2007-01-03
US8772494B2 (en) 2014-07-08
CA2547243A1 (en) 2005-06-30
EP1694644A2 (en) 2006-08-30
AU2004299295A1 (en) 2005-06-30
KR101125120B1 (ko) 2012-03-21
BRPI0417469A (pt) 2007-04-10
SG149001A1 (en) 2009-01-29
HK1100559A1 (en) 2007-09-21
CA2547243C (en) 2012-10-23
EA009081B1 (ru) 2007-10-26
ES2383179T3 (es) 2012-06-18
EA200601120A1 (ru) 2006-10-27
NZ546964A (en) 2009-03-31
IL176171A0 (en) 2006-10-05
BRPI0417469B1 (pt) 2019-06-25

Similar Documents

Publication Publication Date Title
UA83510C2 (en) N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b
ES2431353T3 (es) Monómero de polisiloxano hidrofílico, y método de producción y aplicación del mismo
ES2371754T3 (es) BANDA DE ALEACIÓN AMORFA A BASE DE Fe.
ES2329272T3 (es) Prepolimeros de polisiloxano para dispositivos biomedicos.
ES2387351T3 (es) Lentes oftálmicos para uso extendido
ES2808605T3 (es) Vidrio exento de litio con módulo mejorado
ES2335892T3 (es) Dispersion de poliuretano (pud) con resistencia al isopropanol, flexibilidad y suavidad mejoradas.
US7418231B2 (en) Cleaning blade member
US9045396B2 (en) Hydrolysable linkers and cross-linkers for absorbable polymers
DE602008003124D1 (en) 1-butenethylencopolymere
DE50214303D1 (de) Reaktive polyurethan-zusammensetzungen mit niedrigem restmonomergehalt
JP2009520058A (ja) 硫黄含有オリゴマーおよびそれから調製された高指数ポリウレタン
JP2004505137A5 (ru)
CN102448449A (zh) 粘贴材料
BR0111948A (pt) Composição para entrega de fator de crescimento hematopoiético
CA2449369A1 (en) Synergistic amine chain-extenders in polyurea spray elastomers
RU2012149352A (ru) Полиуретановый балластный слой, способ получения такого слоя и его применение
EP2308914A1 (en) Polycarbonate diol and polycarbonate diol copolymer
ES2672353T3 (es) Composición para la preparación de fibras cerámicas y fibras cerámicas biosolubles preparadas a partir de la misma para un material aislante del calor a alta temperatura
ES2897458T3 (es) Elastómeros termoplásticos de poliuretano-urea procesables por fusión
US20050228160A1 (en) Golf ball compositions with improved temperature performance, heat resistance, and resiliency
Bouraoui et al. Substitution of unsaturated lipid chains by thioether-containing lipid chains in cationic amphiphiles: physicochemical consequences and application for gene delivery
US8501878B2 (en) Method for producing polycarbonate material having excellent solubility and affinity, and contact lens material comprising the same
KR20150095771A (ko) 플루오렌계 중합체, 플루오렌계 디올 화합물 및 그 제조 방법
US20050228146A1 (en) Golf ball compositions with improved temperature performance, heat resistance, and resiliency