UA83467C2 - Соединения пиперидинила, которые селективно связывают рецепторы интегрина - Google Patents
Соединения пиперидинила, которые селективно связывают рецепторы интегрина Download PDFInfo
- Publication number
- UA83467C2 UA83467C2 UAA200502396A UA2005002396A UA83467C2 UA 83467 C2 UA83467 C2 UA 83467C2 UA A200502396 A UAA200502396 A UA A200502396A UA 2005002396 A UA2005002396 A UA 2005002396A UA 83467 C2 UA83467 C2 UA 83467C2
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- vaveze
- aai
- azabzsi
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- oei
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- 125000003386 piperidinyl group Chemical group 0.000 title abstract description 3
- 102000006495 integrins Human genes 0.000 title abstract 3
- 108010044426 integrins Proteins 0.000 title abstract 3
- 230000004438 eyesight Effects 0.000 claims description 2
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- 230000001404 mediated effect Effects 0.000 abstract 1
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Classifications
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
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- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Surgery (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40423902P | 2002-08-16 | 2002-08-16 | |
PCT/US2003/025782 WO2004020435A1 (en) | 2002-08-16 | 2003-08-15 | Piperidinyl compounds that selectively bind integrins |
Publications (1)
Publication Number | Publication Date |
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UA83467C2 true UA83467C2 (ru) | 2008-07-25 |
Family
ID=31978252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200502396A UA83467C2 (ru) | 2002-08-16 | 2003-08-15 | Соединения пиперидинила, которые селективно связывают рецепторы интегрина |
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US (1) | US20040077684A1 (ru) |
EP (1) | EP1539739B1 (ru) |
JP (1) | JP4554364B2 (ru) |
KR (1) | KR20050031464A (ru) |
CN (1) | CN100506815C (ru) |
AR (1) | AR041010A1 (ru) |
AT (1) | ATE489378T1 (ru) |
AU (2) | AU2003259891A1 (ru) |
BR (1) | BR0313534A (ru) |
CA (1) | CA2496127C (ru) |
CR (1) | CR7692A (ru) |
CY (1) | CY1111194T1 (ru) |
DE (1) | DE60335118D1 (ru) |
DK (1) | DK1539739T3 (ru) |
ES (1) | ES2355139T3 (ru) |
IL (1) | IL166534A (ru) |
MX (1) | MXPA05001859A (ru) |
NO (1) | NO332036B1 (ru) |
PL (1) | PL219749B1 (ru) |
PT (1) | PT1539739E (ru) |
RU (1) | RU2333210C2 (ru) |
SI (1) | SI1539739T1 (ru) |
UA (1) | UA83467C2 (ru) |
WO (1) | WO2004020435A1 (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040224986A1 (en) * | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
US7351711B2 (en) | 2003-07-31 | 2008-04-01 | Janssen Pharmaceutical, N.V. | Tricyclic indanyls as integrin inhibitors |
US20050226865A1 (en) * | 2004-04-02 | 2005-10-13 | Regents Of The University Of California | Methods and compositions for treating and preventing diseases associated with alphavbeta5 integrin |
CN101107021A (zh) * | 2004-12-30 | 2008-01-16 | 金文申有限公司 | 包含信号提供试剂、植入物材料和药物的组合 |
US8236283B2 (en) * | 2005-01-06 | 2012-08-07 | Ge Healthcare As | Optical imaging |
US8636995B2 (en) * | 2006-08-31 | 2014-01-28 | Cardiac Pacemakers, Inc. | Methods and devices to regulate stem cell homing |
US20080058922A1 (en) * | 2006-08-31 | 2008-03-06 | Cardiac Pacemakers, Inc. | Methods and devices employing vap-1 inhibitors |
US8372399B2 (en) * | 2006-08-31 | 2013-02-12 | Cardiac Pacemakers, Inc. | Bispecific antibodies and agents to enhance stem cell homing |
BRPI0814182A2 (pt) * | 2007-08-02 | 2015-01-27 | Recordati Ireland Ltd | Compostos heterocíclocos inéditos como antagonistas de mglu5 |
JP2011519340A (ja) * | 2007-10-30 | 2011-07-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換アルカン酸調製のためのエナンチオ選択的プロセスこの米国特許正規出願は、2007年10月30日に提出された米国特許仮出願第61/001,004号、及び2008年2月29日に提出された米国特許仮出願第61/067,842号の権利を主張する。 |
EP2217238B1 (en) * | 2007-11-08 | 2014-03-12 | The General Hospital Corporation | Methods and compositions for the treatment of proteinuric diseases |
BR112012001463A2 (pt) | 2009-07-24 | 2016-03-15 | Univ California | métodos e composições para tratar e prevenir doença associada à integrina alfavbeta5 |
JP6215335B2 (ja) | 2013-09-24 | 2017-10-18 | 富士フイルム株式会社 | 新規な含窒素化合物もしくはその塩またはそれらと金属との錯体 |
WO2018053446A1 (en) | 2016-09-18 | 2018-03-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Yap1 inhibitors that target the interaction of yap1 with oct4 |
LT3538528T (lt) * | 2016-11-08 | 2021-03-10 | Bristol-Myers Squibb Company | Pirolo amidai, kaip alfa v integrino inhibitoriai |
MA46746A (fr) * | 2016-11-08 | 2019-09-18 | Bristol Myers Squibb Co | Amides d'azole et amines en tant qu'inhibiteurs d'intégrine alpha v |
MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
EP4159727A1 (en) | 2017-02-28 | 2023-04-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
CN111989100A (zh) | 2018-03-14 | 2020-11-24 | H·李·莫菲特癌症中心研究有限公司 | 靶向yap1与oct4的相互作用的yap1抑制剂 |
PE20211640A1 (es) | 2018-08-29 | 2021-08-24 | Morphic Therapeutic Inc | INHIBICION DE LA INTEGRINA xvß6 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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IN148482B (ru) * | 1977-06-03 | 1981-03-07 | Pfizer | |
EP1306095A3 (en) * | 1992-03-05 | 2003-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
US5902795A (en) * | 1992-06-16 | 1999-05-11 | Trustees Of Tufts College | Oligosaccharides reactive with hyaluronan-binding protein and their methods of use |
US5340798A (en) * | 1992-10-14 | 1994-08-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5700801A (en) * | 1994-12-23 | 1997-12-23 | Karl Thomae, Gmbh | Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
DE19613933A1 (de) * | 1996-04-06 | 1997-10-09 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
US5919792A (en) * | 1996-10-30 | 1999-07-06 | Merck & Co., Inc. | Integrin antagonists |
US6211191B1 (en) * | 1997-12-17 | 2001-04-03 | Merck & Co., Inc. | Integrin receptor antagonists |
AU738452B2 (en) * | 1997-12-17 | 2001-09-20 | Merck & Co., Inc. | Integrin receptor antagonists |
WO2000000481A1 (en) * | 1998-06-29 | 2000-01-06 | Du Pont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as iib/iiia antagonists |
CA2372053C (en) * | 1999-04-28 | 2008-09-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
-
2003
- 2003-08-15 US US10/641,964 patent/US20040077684A1/en not_active Abandoned
- 2003-08-15 RU RU2005104115/04A patent/RU2333210C2/ru not_active IP Right Cessation
- 2003-08-15 WO PCT/US2003/025782 patent/WO2004020435A1/en active Application Filing
- 2003-08-15 DK DK03791686.3T patent/DK1539739T3/da active
- 2003-08-15 CA CA2496127A patent/CA2496127C/en not_active Expired - Fee Related
- 2003-08-15 SI SI200331951T patent/SI1539739T1/sl unknown
- 2003-08-15 JP JP2004532905A patent/JP4554364B2/ja not_active Expired - Fee Related
- 2003-08-15 AR ARP030102976A patent/AR041010A1/es unknown
- 2003-08-15 CN CNB038240904A patent/CN100506815C/zh not_active Expired - Fee Related
- 2003-08-15 MX MXPA05001859A patent/MXPA05001859A/es active IP Right Grant
- 2003-08-15 PT PT03791686T patent/PT1539739E/pt unknown
- 2003-08-15 DE DE60335118T patent/DE60335118D1/de not_active Expired - Lifetime
- 2003-08-15 AU AU2003259891A patent/AU2003259891A1/en not_active Abandoned
- 2003-08-15 PL PL375562A patent/PL219749B1/pl unknown
- 2003-08-15 EP EP03791686A patent/EP1539739B1/en not_active Expired - Lifetime
- 2003-08-15 ES ES03791686T patent/ES2355139T3/es not_active Expired - Lifetime
- 2003-08-15 KR KR1020057001657A patent/KR20050031464A/ko not_active Application Discontinuation
- 2003-08-15 BR BR0313534-9A patent/BR0313534A/pt not_active IP Right Cessation
- 2003-08-15 AT AT03791686T patent/ATE489378T1/de active
- 2003-08-15 UA UAA200502396A patent/UA83467C2/ru unknown
-
2005
- 2005-01-27 IL IL166534A patent/IL166534A/en not_active IP Right Cessation
- 2005-02-15 CR CR7692A patent/CR7692A/es unknown
- 2005-03-11 NO NO20051273A patent/NO332036B1/no not_active IP Right Cessation
-
2010
- 2010-10-25 AU AU2010236002A patent/AU2010236002B2/en not_active Ceased
-
2011
- 2011-02-09 CY CY20111100158T patent/CY1111194T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL219749B1 (pl) | 2015-07-31 |
ATE489378T1 (de) | 2010-12-15 |
CN100506815C (zh) | 2009-07-01 |
IL166534A0 (en) | 2006-01-15 |
JP4554364B2 (ja) | 2010-09-29 |
AU2010236002A1 (en) | 2010-11-11 |
US20040077684A1 (en) | 2004-04-22 |
DE60335118D1 (de) | 2011-01-05 |
AU2010236002B2 (en) | 2012-05-03 |
RU2333210C2 (ru) | 2008-09-10 |
CY1111194T1 (el) | 2015-06-11 |
CA2496127C (en) | 2012-05-29 |
EP1539739B1 (en) | 2010-11-24 |
ES2355139T3 (es) | 2011-03-23 |
MXPA05001859A (es) | 2005-06-03 |
BR0313534A (pt) | 2005-07-12 |
IL166534A (en) | 2012-05-31 |
NO332036B1 (no) | 2012-06-04 |
AR041010A1 (es) | 2005-04-27 |
CA2496127A1 (en) | 2005-02-16 |
RU2005104115A (ru) | 2005-08-27 |
JP2005539049A (ja) | 2005-12-22 |
NO20051273L (no) | 2005-05-10 |
EP1539739A1 (en) | 2005-06-15 |
KR20050031464A (ko) | 2005-04-06 |
CR7692A (es) | 2009-01-14 |
CN1688572A (zh) | 2005-10-26 |
WO2004020435A1 (en) | 2004-03-11 |
DK1539739T3 (da) | 2011-03-07 |
PL375562A1 (en) | 2005-11-28 |
AU2003259891A1 (en) | 2004-03-19 |
PT1539739E (pt) | 2011-01-05 |
SI1539739T1 (sl) | 2011-04-29 |
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