UA80888C2 - Imidazole derivatives as glutmate receptor antagonists - Google Patents
Imidazole derivatives as glutmate receptor antagonists Download PDFInfo
- Publication number
- UA80888C2 UA80888C2 UAA200512695A UAA200512695A UA80888C2 UA 80888 C2 UA80888 C2 UA 80888C2 UA A200512695 A UAA200512695 A UA A200512695A UA A200512695 A UAA200512695 A UA A200512695A UA 80888 C2 UA80888 C2 UA 80888C2
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- UA
- Ukraine
- Prior art keywords
- formula
- compound
- ylethynyl
- methyl
- pyridine
- Prior art date
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- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract description 4
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 34
- 150000003839 salts Chemical class 0.000 claims abstract description 32
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- 150000001875 compounds Chemical class 0.000 claims description 192
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Psychiatry (AREA)
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- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03012200 | 2003-06-05 | ||
| PCT/EP2004/005881 WO2004108701A1 (en) | 2003-06-05 | 2004-06-01 | Imidazole derivatives as glutmate receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA80888C2 true UA80888C2 (en) | 2007-11-12 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| UAA200512695A UA80888C2 (en) | 2003-06-05 | 2004-01-06 | Imidazole derivatives as glutmate receptor antagonists |
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| JP (1) | JP4401384B2 (hr) |
| KR (1) | KR100778948B1 (hr) |
| CN (1) | CN100408572C (hr) |
| AR (1) | AR044478A1 (hr) |
| AT (1) | ATE377008T1 (hr) |
| AU (1) | AU2004245208B2 (hr) |
| BR (1) | BRPI0411095B8 (hr) |
| CA (1) | CA2527315C (hr) |
| CL (1) | CL2004001347A1 (hr) |
| CR (1) | CR8094A (hr) |
| CY (1) | CY1107856T1 (hr) |
| DE (1) | DE602004009796T2 (hr) |
| DK (1) | DK1636206T3 (hr) |
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| EC (1) | ECSP056202A (hr) |
| ES (1) | ES2294504T3 (hr) |
| GT (1) | GT200400117A (hr) |
| HK (1) | HK1093070A1 (hr) |
| HN (1) | HN2004000208A (hr) |
| HR (1) | HRP20070529T3 (hr) |
| IL (1) | IL171930A (hr) |
| MA (1) | MA27881A1 (hr) |
| MX (1) | MXPA05013149A (hr) |
| MY (2) | MY137272A (hr) |
| NO (1) | NO332143B1 (hr) |
| NZ (1) | NZ543637A (hr) |
| PA (1) | PA8604101A1 (hr) |
| PE (1) | PE20050162A1 (hr) |
| PL (1) | PL1636206T3 (hr) |
| PT (1) | PT1636206E (hr) |
| RS (1) | RS53183B (hr) |
| SI (1) | SI1636206T1 (hr) |
| TN (2) | TNSN05309A1 (hr) |
| TW (1) | TWI338007B (hr) |
| UA (1) | UA80888C2 (hr) |
| WO (1) | WO2004108701A1 (hr) |
| ZA (2) | ZA200509807B (hr) |
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| US7531529B2 (en) | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7452909B2 (en) | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
| NZ551253A (en) * | 2004-06-01 | 2010-07-30 | Hoffmann La Roche | Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| DE102006011574A1 (de) * | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| NZ577440A (en) * | 2006-12-21 | 2011-12-22 | Hoffmann La Roche | Polymorphs of a mglur5 receptor antagonist |
| US8334287B2 (en) * | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| US20120040008A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| US20120039999A1 (en) | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| CA2830458A1 (en) | 2011-03-18 | 2012-09-27 | Novartis Ag | Combinations of alpha 7 nicotinic acetylcholine receptor activators and mglur5 antagonists for use in dopamine induced dyskinesia in parkinson's disease |
| MY168937A (en) * | 2012-10-18 | 2019-01-10 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
| NZ703537A (en) * | 2012-10-18 | 2018-06-29 | Hoffmann La Roche | Ethynyl derivatives |
| PL3436009T3 (pl) * | 2016-03-30 | 2024-05-06 | Sinntaxis AB | Ujemne modulatory allosteryczne mglur5 do użycia w leczeniu rozwiniętych uszkodzeń mózgu |
| KR20230027145A (ko) | 2020-06-05 | 2023-02-27 | 노에마 파르마 아게 | 결절성 경화증 복합증의 치료 방법 |
| JP2023540849A (ja) | 2020-07-30 | 2023-09-27 | ノエマ ファーマ アクツィエンゲゼルシャフト | 三叉神経痛の治療方法 |
| WO2024163890A1 (en) | 2023-02-02 | 2024-08-08 | Noema Pharma Ag | Methods of treatment of dravet syndrome |
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| US4508560A (en) | 1981-11-11 | 1985-04-02 | Ciba Geigy Corporation | Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| JP4815083B2 (ja) * | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
| ES2346513T3 (es) * | 2000-07-24 | 2010-10-18 | Krenitsky Pharmaceuticals, Inc. | 5-alquinil pirimidinas sustituidas que tienen actividad neurotrofica. |
| WO2002046166A1 (en) * | 2000-12-04 | 2002-06-13 | F. Hoffmann-La Roche Ag | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
| JP2005516950A (ja) * | 2001-12-19 | 2005-06-09 | メルク エンド カムパニー インコーポレーテッド | 代謝型グルタミン酸受容体−５のヘテロアリール置換イミダゾールモジュレータ |
| WO2004038374A2 (en) * | 2002-10-24 | 2004-05-06 | Merck & Co., Inc. | Alkyne derivatives as tracers for metabotropic glutamate receptor binding |
| TWI292318B (en) * | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7091222B2 (en) * | 2003-07-03 | 2006-08-15 | Hoffmann-La Roche Inc. | Imidazole derivatives |
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- 2004-06-01 EP EP04739484A patent/EP1636206B1/en not_active Expired - Lifetime
- 2004-06-01 WO PCT/EP2004/005881 patent/WO2004108701A1/en active IP Right Grant
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2005
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2006
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2007
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